• In contrast a number of other functionally characterized genes associated with benzylisoquinoline alkaloid synthesis, including Berberine Bridge Enzyme ( BBE ), Tetrahydroprotoberberine cis-N-MethylTransferase ( TNMT ), Salutaridine Reductase ( SalR ), Salutaridinol 7-O-AcetylTransferase ( SalAT ) and Thebaine 6-O-demethylase ( T6ODM ) were expressed in all three varieties ( Fig. 1B ). (ampliconexpress.com)
  • Noscapine is an antitumor alkaloid from opium poppy that binds tubulin, arrests metaphase, and induces apoptosis in dividing human cells. (ampliconexpress.com)
  • The demonstration in 1998 that noscapine acts as a potent antitumor agent that binds to tubulin, affecting its polymerisation, arresting cell division and inducing apoptosis ( 4 ) was followed by its antitumor activity being demonstrated in various forms of cancer ( 5 - 8 ). (ampliconexpress.com)
  • The history of safe use as an anti-tussive, rapid absorption after oral administration and apoptosis-inducing effect on a number of cancer cell lines, may place noscapine at an advantage over other tubulin binding anticancer natural products such as the well established taxanes ( 9 ). (ampliconexpress.com)