• VLPs are highly immunogenic and can induce elevated titers of neutralizing antibodies, even without adjuvants, thanks to the maintenance of the native conformation of viral proteins presenting repetitive epitopes to the host immune system cells. (nature.com)
  • In the present study, we evaluated the content of oxidized proteins and phospholipid fatty acid profiles of EVs released by human bronchial epithelial BEAS-2B cells treated with CSE. (izon.com)
  • We have made methodological advances that address one of the main bottlenecks: sampling the vast number of conformations accessible to proteins. (ucsf.edu)
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
  • Brush AH (1980b) Patterns in the amino acid compositions of avian epidermal proteins. (springer.com)
  • In: Conformation in fibrous proteins and related synthetic polypeptides. (springer.com)
  • Changes in temperature are typically sensed as a result of conformation changes of protein structure as well as misfolded proteins. (springer.com)
  • For example, all simulated regions are composed of pseudoatoms of a given radius (3.5A for proteins and 7.5A for nucleic acids). (genesilico.pl)
  • 18 DERs and DEDs were identified in the PTM vs. PM, 87 in the TM vs. PTM, and 87 in the TM vs. PM. Those DERs and DEDs participated in the regulation of gene expression at the levels of chromatin conformation, gene activation and silencing, splicing and degradation of mRNA, biogenesis of piRNA and miRNA, ribosome assemble, and translation of proteins. (peerj.com)
  • This regulation included whole process of biological genetic information transmission from chromatin conformation to gene activation and silencing to mRNA splicing to ribosome assemble to translation of proteins and degradation of mRNA. (peerj.com)
  • The ionizable amino acid side chains of proteins are usually located at the surface. (lu.se)
  • The single molecule approach is potentially of great technological interest as a complementary means to obtain information about protein conformation or molecular interaction. (techconnect.org)
  • Various interior dynamics including self organization of macromolecules, protein conformation, movement of human thoracic diaphragm, formation of logarithmic spiral in nature were discussed in the light of potential energy of self gravity and kinetic energy of metabolic energy. (webmedcentral.com)
  • The particularly created single-stranded primer is included develop double-stranded DNA throughout PCR and the fluorescence signal from the PdCs included in the guide is appropriately decreased because of its conformation-dependent fluorescence properties. (worthseal.us)
  • This approach is more advanced than the first one considering that it produces signal-on fluorescence action and permits making use of a single PdC-incorporated DNA probe for the detection of numerous target nucleic acids, incredibly reducing the assay expense. (worthseal.us)
  • Time-resolved pump-probe measurements and excitation spectra reveal the coexistence of conformations, including mainly stacked TO dimers and partially unstacked ones, which yield exciton and excimer contributions to the fluorescence, respectively. (uni-regensburg.de)
  • Molecular dynamics study of 2rotaxanes: influence of solvation and cation on co-conformation. (irbbarcelona.org)
  • Linear response theory: an alternative to PB and GB methods for the analysis of molecular dynamics trajectories? (irbbarcelona.org)
  • Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
  • Members of the institute have published in a wide range of peer-reviewed journals, including Nature, Molecular Cell, Angewandte Chemie, JACS, Science Advances, Proceedings of the National Academy of Sciences USA, Nucleic Acids Research, Chemical Science and many others. (le.ac.uk)
  • Much recent interest has focussed on applications of DNA in nanotechnology, while chemical biologists have adapted evolutionary processes to generate aptamers, folded nucleic acids with molecular recognition properties similar to protein antibodies. (techconnect.org)
  • Background: Single-stranded nucleic acids (ssNAs) have important biological roles and a high biotechnological potential linked to their ability to bind to numerous molecular targets. (mysciencework.com)
  • and imaging and tracking systems, biosensor systems, and biomarker finding.7,16,17,18 Moreover, the nature of nucleic acid provides another bonus that the function of aptamers can be 176644-21-6 IC50 modulated for desired therapy and drug delivery applications using the complementary oligo antidote strategy. (scienceexhibitions.org)
  • The dictionary stores information about monomers which represent the constitutive building blocks of biological macromolecules (amino acids, nucleic acids and saccharides) and about numerous organic/inorganic compounds commonly found in macromolecular crystallography. (iucr.org)
  • The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA. (lookformedical.com)
  • Isolated nucleic acid molecules encoding the peptides are also disclosed. (justia.com)
  • many molecules have several possible three-dimensional structures, so predicting these structures remains out of reach unless obvious sequence and functional similarity to a known class of nucleic acid molecules, such as transfer RNA (tRNA) or microRNA (miRNA), is observed. (wikipedia.org)
  • VLPs self-assembled into empty shells can be used safely as vaccines without the risk of replication or infection due to the lack of viral nucleic acid. (nature.com)
  • Significant efforts are now being made for the development of non-viral gene-delivery techniques as alternatives to the viral vectors for basic research and clinical medicine. (techconnect.org)
  • This allowed us to determine that the heparan sulfate pathway and the conserved oligomeric Golgi complex are key determinants allowing entry of both dsRNA and viral nucleic acid leading to cell death. (cnrs.fr)
  • This is partly because the extra oxygen in RNA increases the propensity for hydrogen bonding in the nucleic acid backbone. (wikipedia.org)
  • Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids. (ub.es)
  • Our predictions generate hypotheses on protein conformations controlling biological processes - such as protein recognition, signal transduction, and enzyme active site gating - and are laying the foundation for our work reengineering and "reshaping" protein interfaces and active sites for new functions. (ucsf.edu)
  • Secondary structure can be predicted from one or several nucleic acid sequences. (wikipedia.org)
  • Amino acid substitutions on protein sequences are generally harmless, but a significant proportion of them can cause diseases. (mysciencework.com)
  • The third class of thermosensing is based on the temperature-dependent conformation of specific RNA sequences, which are termed RNA-thermometer (RNAT). (springer.com)
  • In DNA a sequence of three bases, which is called a codon, is responsible for the encoding of a single amino acid. (wikibooks.org)
  • Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties. (irbbarcelona.org)
  • hnRNP A1 and secondary structure coordinate alternative splicing of Mag. (umassmed.edu)
  • With a simplified design, we demonstrated the potential of ED spectrometry as an alternative for secondary structural analysis of biomolecules, their conformation and chirality. (izon.com)
  • Nucleic acid structure prediction is a computational method to determine secondary and tertiary nucleic acid structure from its sequence. (wikipedia.org)
  • A common problem for researchers working with RNA is to determine the three-dimensional structure of the molecule given only a nucleic acid sequence. (wikipedia.org)
  • 1999. Sequence-specific and conformation-dependent binding of yeast telomerase RNA to single-stranded telomeric DNA. . (cornell.edu)
  • His research interests include structure-based design of functional nucleic acids useful in medicine and nanotechnology. (asiaresearchnews.com)
  • The discrimination between functionally neutral amino acid substitutions and non-neutral mutations, affecting protein function, is very important for our understanding of diseases. (rostlab.org)
  • Moreover, 1% CSE induced only few changes in the fatty acid asset in BEAS-2B cell membrane phospholipids, whereas several rearrangements were observed in EVs released by CSE-treated cells. (izon.com)
  • Nucleic Acids Research, 50 (20). (cshl.edu)
  • Weissmann noted that an alternative interpretation of the results is that infectious prions are naturally present in the brain at levels not detectable by conventional methods, and are normally destroyed at the same rate they are created. (scienceagogo.com)
  • For experimental methods, see Nucleic acid structure determination . (wikipedia.org)
  • We introduce a lightweight framework for semantic segmentation that utilizes structured classifiers as an alternative to deep learning methods. (mysciencework.com)
  • The yield improvement is achieved by comparing the alternative docking poses against the negative image of the target protein's ligand-binding cavity. (omicsdi.org)
  • This article is about the computational prediction of nucleic acid structure. (wikipedia.org)
  • The amino acid is added to a growing protein during the process of translation. (wikibooks.org)
  • The m(6)A-modified hairpin has a predisposed conformation that resembles the hairpin conformation in the RNA-HNRNPC complex more closely than the unmodified hairpin. (nih.gov)
  • Its activation through the classical, alternative or lectin pathways leads to the generation of anaphylatoxic peptides C3a and C5a and formation of the C5b-9 membrane attack complex. (justia.com)
  • Following prion infection, the abnormal or misfolded prion protein (PrPSc) converts PrPC into a likeness of itself, by causing it to change its conformation or shape. (scienceagogo.com)
  • Plants are being considered as an alternative vaccine/mAb production system, especially in unexpected or emergency situations that cannot be solved by existing systems. (nature.com)
  • Sequential amino acid exchange across b(0,+)-like system in chicken brush border jejunum. (irbbarcelona.org)
  • single-stranded conformation polymorphism (SSCP), restriction enzyme digestion analysis, denaturing high-performance liquid chromatography (DHPLC) analysis and liquid microbead arrays. (biomedcentral.com)
  • Each nanocluster is tightly wrapped and almost completely shielded by two DNA strands in a horseshoe conformation. (asiaresearchnews.com)
  • These nucleic acid polymers encode for the all of the materials an organism needs to live in the form of genes. (wikibooks.org)
  • If you choose this alternative, we'll highlight resorts and features popular with business travelers. (worthseal.us)
  • In its automatic mode, MuD is comparable to alternative tools in performance. (rostlab.org)