- Perphenazine is a phenothiazine antipsychotic that blocks postsynaptic dopaminergic receptors and has alpha-adrenergic blocking effects. (medscape.com)
- Through its action on alpha-adrenergic receptors, epinephrine lessens the vasodilation and increased vascular permeability that occurs during anaphylaxis, which can lead to loss of intravascular fluid volume and hypotension. (ncats.io)
- However, each drug in this class has various effects on other receptors, such as serotonin type 2 (5-HT2), alpha1, histaminic, and muscarinic receptors. (medscape.com)
- Loxapine's mechanism of action is unknown but probably involves antagonism of central dopamine D2 and serotonin 5-HT2A receptors. (medscape.com)
- Although how it works is not entirely clear, it blocks dopamine and serotonin receptors. (wikipedia.org)
- Disturbed dopaminergic function, with presynaptic striatal hyperdopaminergia, is the most replicated neurochemical finding in psychosis, and all antipsychotic drugs antagonize dopaminergic transmission at the dopaminergic type 2 (D 2 ) receptors in the CNS. (medscape.com)
- In psychosis, the dopaminergic transmission in the mesolimbic system is dysregulated and stimuli induce inappropriate dopamine release, leading to an abnormal salience of both external and internal stimuli, whereby insignificant events and stimuli grab the attention of the patient. (medscape.com)
- Later versions of the dopamine hypothesis of schizophrenia have emphasized much more complex alterations in the dopaminergic system than mere hyperdopaminergic functioning in the striatum. (medscape.com)
- Fluphenazine is a high-potency typical antipsychotic that blocks postsynaptic dopaminergic D1 and D2 receptors. (medscape.com)
- Trifluoperazine is a piperazine phenothiazine agent that is an antagonist at the postsynaptic mesolimbic dopaminergic D2 receptors. (medscape.com)
- [ 42 ] Furthermore, other drug targets are probably to be involved in the mediation of the effects of antipsychotic drugs, as antipsychotics have affinities for a broad display of receptors in the CNS ( Table 1 ) (see [ 48 ] for an overview). (medscape.com)
- First-generation (conventional or typical) antipsychotics, are strong dopamine D2 antagonists. (medscape.com)
- Second-generation (novel or atypical) antipsychotics, with the exception of aripiprazole, are dopamine D2 antagonists, but are associated with lower rates of extrapyramidal adverse effects and TD than the first-generation antipsychotics. (medscape.com)
- Haloperidol is a dopamine D2 antagonist noted for high potency and low potential for causing orthostasis. (medscape.com)
- Thiothixene is a dopamine D2 antagonist with anticholinergic and alpha-blocking effects. (medscape.com)