DNA DamageDNA RepairComet AssayAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsUltraviolet RaysTumor Suppressor Protein p53DeoxyguanosineDNA-Binding ProteinsCheckpoint Kinase 2Oxidative StressProtein-Serine-Threonine KinasesDNA Breaks, Double-StrandedCell CycleMutationTumor Suppressor ProteinsApoptosisGamma RaysDNAHistonesNuclear ProteinsMethyl MethanesulfonateMutagensGenomic InstabilityCell Line, TumorPhosphorylationG2 PhaseDNA ReplicationCell LineSignal TransductionCell SurvivalReactive Oxygen SpeciesCells, CulturedDose-Response Relationship, RadiationDNA Repair EnzymesHydrogen PeroxideTime FactorsDNA AdductsProtein KinasesDNA BreaksMolecular Sequence DataRadiation TolerancePoly(ADP-ribose) PolymerasesCell Cycle CheckpointsHeLa CellsGenes, cdcFibroblastsDNA Breaks, Single-StrandedRad51 RecombinaseSaccharomyces cerevisiae ProteinsDNA GlycosylasesS PhaseCell NucleusCell AgingBRCA1 ProteinModels, BiologicalMitosisSaccharomyces cerevisiaeBase SequenceAntioxidantsChromatinMicronucleus TestsProtein BindingIntracellular Signaling Peptides and ProteinsBlotting, WesternOxidation-ReductionDose-Response Relationship, DrugHydroxyureaMice, Inbred C57BLDisease Models, AnimalX-RaysMice, KnockoutAlkylating AgentsG2 Phase Cell Cycle CheckpointsGene Expression RegulationDNA-Activated Protein KinaseCell DeathRNA, MessengerGenes, p53RNA, Small InterferingDNA, NeoplasmReplication Protein AAmino Acid SequenceChromosome AberrationsRecombinational DNA RepairRecombination, GeneticProto-Oncogene Proteins c-mdm2DNA HelicasesTranscription, GeneticPoly Adenosine Diphosphate RiboseLymphocytesGene DeletionTumor Cells, CulturedCell ProliferationRats, Sprague-DawleyCyclin-Dependent Kinase Inhibitor p21PhenotypeTelomereSOS Response (Genetics)Micronuclei, Chromosome-Defective