• complications
  • With thalassemia, the red blood cells are destroyed at a faster rate, leading to anemia , a condition that can cause fatigue and other complications. (kidshealth.org)
  • All people with thalassemia are susceptible to health complications that involve the spleen (which is often enlarged and frequently removed) and gallstones. (wikipedia.org)
  • In this case the person produces the associated hemoglobin variant and may have the symptoms and complications that are associated with they specific hemoglobin variant they have. (wikipedia.org)
  • Thalassaemias
  • Alpha thalassaemias are diagnosed by the presence of Hb H bodies (tetramers of beta globin). (edu.au)
  • Homozygote α0 thalassaemias, where numerous γ4 but no α-globins occur at all (referred to as Hb Barts), often result in death soon after birth. (wikipedia.org)
  • embryonic
  • A tandem pair of α-globin genes is located on chromosome 16, downstream from two embryonic α-like genes called zet a (ζ). (mhmedical.com)
  • The arrangement of the genes directly reflects the temporal differentiation of their expression during development, with the early-embryonic stage version of the gene located closest to the LCR. (wikipedia.org)
  • Phenotype
  • The patients with HbE β thalassaemia who had co-inherited α thalassaemia all showed an extremely mild phenotype and reduced levels of HbF and there was a highly significant paucity of α(+) thalassaemia in these patients compared with the normal population. (ox.ac.uk)
  • The degree of impairment is based on which clinical phenotype is present (how many genes are affected). (wikipedia.org)

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