• complications
  • With thalassemia, the red blood cells are destroyed at a faster rate, leading to anemia , a condition that can cause fatigue and other complications. (kidshealth.org)
  • However, complications from thalassemias and their treatments are frequent. (nih.gov)
  • All people with thalassemia are susceptible to health complications that involve the spleen (which is often enlarged and frequently removed) and gallstones. (wikipedia.org)
  • In this case the person produces the associated hemoglobin variant and may have the symptoms and complications that are associated with they specific hemoglobin variant they have. (wikipedia.org)
  • subunits
  • Hemoglobin consists of four subunits, each with a cofactor called a heme group that has an iron atom center. (wikibooks.org)
  • Cooperation among the four subunits of the hemoglobin molecule is necessary for the efficient transportation of O 2 . (wikibooks.org)
  • The four subunits of hemoglobin actually bind to oxygen cooperatively , the binding of oxygen to one site of the four subunits will increase the likelihood of the remaining sites to bind with oxygen as well. (wikibooks.org)
  • The most common type of hemoglobin in mammals contains four such subunits. (wikipedia.org)
  • oxygen
  • Hemoglobin helps red blood cells spread oxygen through your body. (genesishcs.org)
  • Red blood cells, which contain hemoglobin, deliver oxygen to all parts of the body. (kidshealth.org)
  • This affects hemoglobin and decreases the ability of red blood cells to transport oxygen around the body. (kidshealth.org)
  • Hemoglobin is contained in red blood cells, which efficiently carries oxygen from the lungs to the tissues of the body. (wikibooks.org)
  • As red blood cells passes through the capillary beds of the lungs, gills (in fish), or other respiratory organs, oxygen is diffused into the erythrocytes and hemoglobin binds O 2 and NO. Hemoglobin then unloads its cargo in the capillaries. (wikibooks.org)
  • The iron is the main component that actually binds to oxygen, thus each hemoglobin molecule is able to carry four molecules of O 2 . (wikibooks.org)
  • Hemoglobin has a lower affinity for oxygen the lower the concentration of oxygen gets. (wikibooks.org)
  • The lower affinity and lower concentrations means that when we are working out, our bodies are low on oxygen which means hemoglobin has less affinity for oxygen and can more easily drop the oxygen off at human tissues. (wikibooks.org)
  • On the other hand, when oxygen concentration is high, the hemoglobin has a higher affinity for oxygen and therefore does not drop the oxygen where it is not needed. (wikibooks.org)
  • On the otherhand, the cousin of hemoglobin, myoglobin is used to store oxygen in muscles. (wikibooks.org)
  • This myoglobin has a slighty higher affinity for oxygen than hemoglobin especially at lower levels. (wikibooks.org)
  • This is because myoglobin has an easier job in that it only needs to store oxygen and release it for the muscles, while hemoglobin also has to transport the oxygen and release it in the correct areas. (wikibooks.org)
  • Cooperation refers to the interactions among active sites, in the case of hemoglobin, cooperation allows the binding of oxygen to be increased as one site is filled, the remaining active sites will be more likely to bind to O 2 as well. (wikibooks.org)
  • The interaction that results between iron and oxygen in hemoglobin is a combination of resonance structures, one with (Fe 2+ )and O 2 and another between (Fe 3+ ) and super ion O 2 . (wikibooks.org)
  • Hemoglobin H has a high oxygen affinity which means it does not let go of oxygen as easily as normal hemoglobin, so Hb levels may be misleading. (thalassemiapatientsandfriends.com)
  • These abnormal hemoglobin molecules cannot effectively carry oxygen to the body's tissues. (wikipedia.org)
  • The hemoglobin transports oxygen efficiently in a low oxygen environment. (wikipedia.org)
  • citation needed] Hemoglobin H increases the affinity for oxygen. (wikipedia.org)
  • Hemoglobin in the blood carries oxygen from the respiratory organs (lungs or gills) to the rest of the body (i.e. the tissues). (wikipedia.org)
  • Hemoglobin has an oxygen-binding capacity of 1.34 mL O2 per gram, which increases the total blood oxygen capacity seventy-fold compared to dissolved oxygen in blood. (wikipedia.org)
  • The mammalian hemoglobin molecule can bind (carry) up to four oxygen molecules. (wikipedia.org)
  • In these tissues, hemoglobin has a non-oxygen-carrying function as an antioxidant and a regulator of iron metabolism. (wikipedia.org)
  • In these organisms, hemoglobins may carry oxygen, or they may act to transport and regulate other small molecules and ions such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. (wikipedia.org)