ReceptorsBeta-adrenergicSympathomimeticsImidazolineSelectiveBrimonidineAntagonistsTherapeuticGuanfacinePhenylephrineIsoproterenolDrugsReducing cardiacMechanismMeSHMedications calledReceptor-mediatedMethoxaminePotentAdrenoreceptorMammalianSubtypeInterventionMyocardialSpecificallyEffectsChemicalsProteinWithdrawalActivityResponseHeartStudy
Receptors19
- Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. (wikipedia.org)
- Alpha 2 receptors are associated with sympatholytic properties. (wikipedia.org)
- Nonspecific agonists act as agonists at both alpha-1 and alpha-2 receptors. (wikipedia.org)
- ergotamine etilefrine indanidine mephentermine metaraminol methoxamine mivazerol naphazoline norfenefrine octopamine phenylpropanolamine propylhexedrine rilmenidine romifidine synephrine talipexole Alpha-adrenergic agonists, more specifically the auto receptors of alpha 2 neurons, are used in the treatment of glaucoma by decreasing the production of aqueous fluid by the ciliary bodies of the eye and also by increasing uveoscleral outflow. (wikipedia.org)
- In previous studies we investigated the role of beta- and alpha 2-adrenergic receptors through local microinjections of various drugs into the dorsal pontine tegmentum (DPT) of the cat. (nih.gov)
- In this study we examined the role of alpha 1-adrenergic receptors. (nih.gov)
- Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
- Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. (pharmacycode.com)
- Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (ebi.ac.uk)
- An agent that selectively binds to and activates alpha -adrenergic receptors. (ebi.ac.uk)
- Cirazoline is a full agonist at the α 1A adrenergic receptor , a partial agonist at both the α 1B and α 1D adrenergic receptors, [1] and a nonselective antagonist to the α 2 adrenergic receptor . (wikipedia.org)
- Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. (rndsystems.com)
- Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)
- The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)
- Other medications, which are relatively selective for β 2 -adrenergic receptors, retain the benefits in management of asthma and COPD, while limiting adverse effects mediated by β 1 -adrenergic receptor activation. (pharmacology2000.com)
- At higher doses β 2 -selective adrenergic agonists are still able to activate β 1 -receptors, again emphasizing the role of drug concentration in drug specificity. (pharmacology2000.com)
- Approaches to targeting β 2 -pulmonary adrenergic receptors involves not only drug design but also drug delivery. (pharmacology2000.com)
- Agmatine acts as an agonist at imidazoline and alpha-2-adrenergic receptors, also modulating NMDA receptor activity. (psicothema.com)
- Stuckey et al19 evaluated whether an 8-week and central alpha 2-1 and beta-adrenergic receptors. (bvsalud.org)
Beta-adrenergic4
- Alpha blocker Adrenergic agonist Beta-adrenergic agonist Declerck I, Himpens B, Droogmans G, Casteels R (September 1990). (wikipedia.org)
- Epinephrine belongs to a class of drugs called alpha-adrenergic and beta-adrenergic receptor agonists. (medicalnewstoday.com)
- Epinephrine oral inhalation is in a class of medications called alpha- and beta-adrenergic agonists (sympathomimetic agents). (safemedication.com)
- Aim 2: Determine how agents that augment PKA, especially therapeutic beta-adrenergic agonists, dampen dust extract-induced PKC isoform activation and attenuate lung inflammation in vitro and in vivo. (cdc.gov)
Sympathomimetics1
- Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)
Imidazoline1
- It is classified as a centrally acting alpha 2 adrenergic agonist and imidazoline receptor agonist and has been in clinical use since 1966. (uspharmacist.com)
Selective7
- Mirvaso (brimonidine) is a relatively selective alpha-2 adrenergic agonist. (centerwatch.com)
- Synthesis and in vitro characterisation of N -[5-(4,5-dihydro-1 H -imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α 1A receptor agonist. (rndsystems.com)
- A-61603, a potent α 1 -adrenergic receptor agonist, selective for the α 1A receptor subtype. (rndsystems.com)
- Previously, descriptions of pharmacological effects associated with 'non-selective' β-adrenergic receptor agonists used to manage pulmonary diseases such as asthma or COPD necessarily include unwanted side effects often due to β 1 adrenergic receptor activation. (pharmacology2000.com)
- The premise of β 2 -agonist-mediated receptor activation (applying also to 'non-selective' β-receptor agonists) is based on both smooth muscle relaxation and reduced airway resistance. (pharmacology2000.com)
- is a commonly used selective β 2 -adrenergic receptor agonist that may be administered either orally or by inhalation. (pharmacology2000.com)
- When comparing the non-selective adrenergic agonist isoproterenol to albuterol, at doses that produce comparable bronchodilation, albuterol will exhibit substantially less cardiac stimulation. (pharmacology2000.com)
Brimonidine2
- Brimonidine is in a class of drugs called alpha adrenergic agonists. (medlineplus.gov)
- Mirvaso is a once daily topical gel formulation of brimonidine, an alpha-2 adrenergic agonist with potent vasoconstrictive activity. (centerwatch.com)
Antagonists1
- Many of the ergot alkaloids act as alpha-adrenergic antagonists. (bvsalud.org)
Therapeutic2
- Additional therapeutic benefits associated with β-adrenergic receptor agonists likely include reduced pulmonary mast cell leukotriene and histamine release, reduced microvascular permeability, phospholipase A 2 inhibition and increased mucociliary activity. (pharmacology2000.com)
- Combination of long-acting β-adrenergic receptor agonists with anti-inflammatory agents represents a strongly endorsed therapeutic approach. (pharmacology2000.com)
Guanfacine1
- Guanfacine extended-release tablets are a central alpha 2A -adrenergic receptor agonist indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications (1, 14). (nih.gov)
Phenylephrine2
- Background The α1-adrenergic receptor (α1AR) agonist phenylephrine (PE), acts via ERK1/2 to phosphorylate (i.e. activate) p90 ribosomal S6 kinases (RSKs). (bmj.com)
- Pretreatment with chlorethylclonidine, which selectively alkylates the alpha-1B subtype, did not affect the Emax value of phenylephrine-induced contractions, but significantly shifted the curve to the right. (aspetjournals.org)
Isoproterenol1
- Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. (rndsystems.com)
Drugs1
- Short-acting β 2 -adrenergic agonists administered by inhalation represent drugs of choice for management of acute asthma presentations and for prevention of exercise-induced bronchospastic reactions. (pharmacology2000.com)
Reducing cardiac1
- The reduction of the stress response caused by alpha 2 agonists were theorised to be beneficial peri operatively by reducing cardiac complications, however this has shown not to be clinically effective as there was no reduction in cardiac events or mortality but there was an increased incidence of hypotension and bradycardia. (wikipedia.org)
Mechanism1
- Increased inositol polyphosphate turnover may be involved in the mechanism(s) whereby alpha 1-adrenoceptor stimulation produces an increase in myocardial force of contraction. (aspetjournals.org)
MeSH2
- Xylometazoline Oxymetazoline Apraclonidine[citation needed] Cirazoline Epinephrine The following agents are also listed as agonists by MeSH. (wikipedia.org)
- Adrenergic alpha-2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Medications called1
- Other dogs require medications called alpha-adrenergic agonists. (vetinfo.com)
Receptor-mediated2
- Receptor subtype involved in α 1A -adrenergic receptor-mediated Ca 2+ signaling in cardiomyocytes. (rndsystems.com)
- All effects were antagonized by the alpha 1-adrenoceptor antagonist prazosin (0.1 microM), indicating receptor-mediated effects. (aspetjournals.org)
Methoxamine1
- The alpha 1-agonist methoxamine and the alpha 1-antagonist prazosin were injected into the DPT of freely moving, unanaesthetized cats. (nih.gov)
Potent1
- A 61603 hydrobromide is a potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. (rndsystems.com)
Adrenoreceptor1
- Alpha adrenoreceptor ligands mimic the action of epinephrine and norepinephrine signaling in the heart, smooth muscle and central nervous system, with norepinephrine being the highest affinity. (wikipedia.org)
Mammalian1
- Existence and alpha 1-adrenergic stimulation of inositol polyphosphates in mammalian heart. (aspetjournals.org)
Subtype2
- The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries. (rndsystems.com)
- Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. (rndsystems.com)
Intervention1
- treatment may include Comprehensive Behavioral Intervention for Tics and alpha-adrenergic agonists or antipsychotics. (msdmanuals.com)
Myocardial1
- A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. (rndsystems.com)
Specifically1
- We will test this hypothesis via three specific aims: Aim 1: Establish how agents that specifically target TNF-alpha, IL-6, and IL-8 modulate dust extract-induced lung inflammation in vivo. (cdc.gov)
Effects2
- A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. (ebi.ac.uk)
- For comparison, the effects of the beta-adrenoceptor agonist isoprenaline were studied. (aspetjournals.org)
Chemicals1
- Alpha-adrenergic agonists work by enhancing the release of the neurotransmitter chemicals that increase the sensitivity of the sphincter. (vetinfo.com)
Protein1
- p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. (rndsystems.com)
Withdrawal1
- Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/435680/all/Alpha_2__adrenergic_agonists_for_the_management_of_opioid_withdrawal:_Cochrane_systematic_review. (unboundmedicine.com)
Activity1
- α1 agonist: stimulates phospholipase C activity. (wikipedia.org)
Response1
- There were no other age-dependent differences in the response to agonists. (aspetjournals.org)
Heart1
- The α-1A Adrenergic Receptor in the Rabbit Heart. (rndsystems.com)
Study1
- The present study focuses on tizanidine, an α 2 noradrenergic (NE) agonist, which is incompletely studied, but is thought to act to depress dorsal horn interneuron excitability [ 14 ]. (biomedcentral.com)