• PMID
  • Vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transfer [ PMID: 15261670 ]. (ebi.ac.uk)
  • While clathrin mediates endocytic protein transport, and transport from ER to Golgi, coatomers primarily mediate intra-Golgi transport, as well as the reverse Golgi to ER transport of dilysine-tagged proteins [ PMID: 14690497 ]. (ebi.ac.uk)
  • For example, the coatomer COP1 (coat protein complex 1) is responsible for reverse transport of recycled proteins from Golgi and pre-Golgi compartments back to the ER, while COPII buds vesicles from the ER to the Golgi [ PMID: 11208122 ]. (ebi.ac.uk)
  • Coatomers reversibly associate with Golgi (non-clathrin-coated) vesicles to mediate protein transport and for budding from Golgi membranes [ PMID: 17041781 ]. (ebi.ac.uk)
  • Coatomer protein complex I (COPI)-coated vesicles are involved in transport between the endoplasmic reticulum and the Golgi but also participate in transport from early to late endosomes within the endocytic pathway [ PMID: 12893528 ]. (ebi.ac.uk)
  • Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha ( IPR001019 ), beta ( IPR001632 ) and gamma ( IPR001770 ) [ PMID: 14762218 ]. (ebi.ac.uk)
  • G proteins and their receptors (GPCRs) form one of the most prevalent signalling systems in mammalian cells, regulating systems as diverse as sensory perception, cell growth and hormonal regulation [ PMID: 15294442 ]. (ebi.ac.uk)
  • The length of the G protein signal is controlled by the duration of the GTP-bound alpha subunit, which can be regulated by RGS (regulator of G protein signalling) proteins or by covalent modifications [ PMID: 11313912 ]. (ebi.ac.uk)
  • These fall into 4 main groups on the basis of both sequence similarity and function: alpha-S ( IPR000367 ), alpha-Q ( IPR000654 ), alpha-I ( IPR001408 )and alpha-12( IPR000469 ) [ PMID: 1902986 ]. (ebi.ac.uk)
  • sequence
  • Binding of SRP to the signal sequence as it emerges from the ribosome creates a cytosolic targeting complex containing the nascent polypeptide chain, the translating ribosome, and SRP. (ucsf.edu)
  • PKA phosphorylates two physiologically important sites in the ChREBP , which is located near nuclear localization signal sequence (NLS), and within the basic helix-loop-helix site, resulting in inactivation of nuclear translocation of ChREBP and of the DNA-binding activity, respectively [ 1 ]. (bio-rad.com)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Farnesyltransferase (FTase) adds a 15-carbon isoprenoid called a farnesyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminus of a protein. (wikipedia.org)
  • putative
  • The N-terminal domain of the 54K subunit contains a putative GTP-binding site, whereas the C-terminal domain binds signal sequences and SRP RNA. (ucsf.edu)
  • Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. (uniprot.org)
  • pathways
  • In eukaryotic cells, K+ channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes. (wikipedia.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • whereas
  • All of them are activated by activated G-alpha (s) subunits, whereas G-alpha (i) is capable to inhibite some forms Adenylyl cyclases , including Adenylyl cyclases I [ 2 ]. (bio-rad.com)
  • Farnesyltransferase catalyzes the chemical reaction farnesyl diphosphate + protein-cysteine ⇌ {\displaystyle \rightleftharpoons } S-farnesyl protein + diphosphate Thus, the two substrates of this enzyme are farnesyl diphosphate and protein-cysteine, whereas its two products are S-farnesyl protein and diphosphate. (wikipedia.org)
  • ribosome
  • Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (ebi.ac.uk)
  • First the ribosome, freely floating in the cytosol, begins to synthesize a protein. (enotes.com)
  • and the ribosome/nascent protein/SRP complex is targeted to the SR on the endoplasmic reticulum. (enotes.com)
  • Both subunits act as anchor for the ribosome/nascent chain/SRP complex. (enotes.com)
  • Once GTP is hydrolyzed, the SRP of the ribosome/nascent chain/SRP complex is free from that trio and also free from the SR located on the endoplasmic reticulum. (enotes.com)
  • encodes
  • The human genome encodes roughly 800 G protein-coupled receptors, which detect photons of light, hormones, growth factors, drugs, and other endogenous ligands. (wikipedia.org)
  • This gene encodes the alpha subunit in cones. (wikipedia.org)
  • The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated potassium channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. (wikipedia.org)
  • amino acids
  • G protein alpha subunits are 350-400 amino acids in length and have molecular weights in the range 40-45 kDa. (ebi.ac.uk)
  • There are four binding pockets in FTase, which accommodate the last four amino acids on the carboxyl-terminus of a protein. (wikipedia.org)
  • The carboxyl-terminal amino acid (X) discriminates FTase's targets from those of the other prenyltransferases, allowing only six different amino acids to bind with any affinity. (wikipedia.org)
  • transducin
  • The subunit composition of transducin differs between different photoreceptor cells. (abcam.com)
  • Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells. (abcam.com)
  • The transducin alpha subunits in rods and cones are encoded by separate genes. (wikipedia.org)