• cyclic
  • Secondary messenger systems can be synthesized and activated by enzymes, for example, the cyclases that synthesize cyclic nucleotides, or by opening of ion channels to allow influx of metal ions, for example Ca2+ signaling. (wikipedia.org)
  • The activated Gs alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the conversion of ATP into cyclic adenosine monophosphate (cAMP), directly increasing the cAMP level. (wikipedia.org)
  • In a cAMP-dependent pathway, the activated Gs alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the conversion of ATP into cyclic adenosine monophosphate (cAMP). (wikipedia.org)
  • mammalian
  • The sequence identity between different fungal alpha subunits is relatively low and is equivalent to the level of similarity observed between mammalian alpha subtypes. (ebi.ac.uk)
  • The diversity of mammalian PKA subunits was realized after Dr. Stan Knight and others identified possible four subunit C genes and presence of four R subunit genes. (wikipedia.org)
  • Some proteins known to contain a GoLoco motif are listed below: Mammalian regulators of G-protein signaling 12 and 14 (RGS12 and RGS14), multifaceted signal transduction regulators. (wikipedia.org)
  • Mammalian Purkinje-cell protein-2 (Pcp2). (wikipedia.org)
  • Drosophila protein Rapsynoid (also known as Partner of Inscuteable, Pins) and its mammalian homologues, AGS3 and LGN. (wikipedia.org)
  • catalytic
  • The classical PKA holoenzyme structure consists of two regulatory subunits and two catalytic subunits. (wikipedia.org)
  • The catalytic subunit contains the active site, a series of canonical residues found in protein kinases that bind and hydrolyse ATP and a domain to bind the regulatory subunit. (wikipedia.org)
  • However, recent studies evaluating the intact holoenzyme complexes, including regulatory AKAP-bound signalling complexes, have suggested that the local sub cellular activation of the catalytic activity of PKA might proceed without physical separation of the regulatory and catalytic components, especially at physiological concentrations of cAMP. (wikipedia.org)
  • In contrast, experimentally induced supra physiological concentrations of cAMP are able to cause separation of the holoenzymes, and release of the catalytic subunits. (wikipedia.org)
  • The liberated catalytic subunits can then catalyze the transfer of ATP terminal phosphates to protein substrates at serine, or threonine residues. (wikipedia.org)
  • signal transducer
  • GO annotations related to this gene include GTP binding and signal transducer activity . (genecards.org)
  • This study describes the immunohistochemical distribution of RGS7 throughout the adult rat brain and its cellular colocalization with Gαq/11, an important G protein‐coupled receptor signal transducer for phospholipase Cβ‐mediated activity. (deepdyve.com)
  • regulate
  • The 1992 Nobel Prize in Physiology or Medicine to Edwin G. Krebs and Edmond H. Fischer for describing how reversible phosphorylation works as a switch to activate proteins , and to regulate various cellular processes including glycogenolysis . (wikipedia.org)
  • RGS14
  • Recombinant protein encompassing a sequence within the N-terminus region of human RGS14. (genetex.com)
  • RGS14 antibody [N1Ndetects RGS14 protein at cytosol on mouse fore brain by immunohistochemical analysis. (genetex.com)
  • RGS14 antibody [N1Ndetects RGS14 protein at cytosol on mouse testis by immunohistochemical analysis. (genetex.com)
  • RGS14 is a member of the regulator of G protein signalling family. (wikipedia.org)
  • Increasing the expression of the RGS14 protein in the V2 secondary visual cortex of mice promotes the conversion of short-term to long-term object-recognition memory. (wikipedia.org)
  • glucagon
  • When dissolved in a fluid state, glucagon can form amyloid fibrils, or tightly woven chains of proteins made up of the individual glucagon peptides, and once glucagon begins to fibrilize, it becomes useless when injected, as the glucagon cannot be absorbed and used by the body. (wikipedia.org)
  • Promotes
  • Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). (genecards.org)