Jia He et al, Zika virus NS2A protein induces the degradation of KPNA2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy, Autophagy (2020). (philosophicalmisadventures.com)
Protein10
First, it binds importin alpha, a form of karyopherin that binds the cargo protein in the cytoplasm, before the cargo protein is imported into the nucleus through the nuclear pore driven by energy from the Ran gradient. (prospecbio.com)
Without the aid of the importin alpha adapter protein, Importin beta can transport proteins into the nucleus. (prospecbio.com)
The exchange involves the active transport by a carrier protein called karyopherins. (wikipedia.org)
In order to explore the factors that regulate the nuclear import of TDP-43, we used a small interfering RNA library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopherin-beta1 and cellular apoptosis susceptibility protein resulted in marked cytoplasmic accumulation of TDP-43. (crick.ac.uk)
KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. (antibodies-online.cn)
Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. (utsouthwestern.edu)
Dive into the research topics of 'Hantaan virus nucleocapsid protein binds to importin α proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B'. Together they form a unique fingerprint. (mssm.edu)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human GA Binding Protein Transcription Factor Alpha (GABPa) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (therabio.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human GA Binding Protein Transcription Factor Alpha (GABPa) in samples from serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (therabio.org)
Proteins5
Karyopherins are proteins that help eukaryotic cells transport molecules between their cytoplasm and nucleus. (prospecbio.com)
Karyopherins may act as imports (helping proteins enter the nucleus) or exports (helping proteins leave the nucleus) (i.e., helping proteins get out of the nucleus). (prospecbio.com)
Importin beta is a form of karyopherin that helps cargo proteins get into the nucleus. (prospecbio.com)
The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. (utsouthwestern.edu)
Binds3
Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. (utsouthwestern.edu)
It binds to importin-beta and causes a significant change in shape, leading to the release of importin-alpha and the cargo. (rcsb.org)
It binds to importin-alpha and Ran and carries them out of the nucleus. (rcsb.org)
Molecules1
Huge tube-shaped nuclear pores act as the highway connecting the nucleus and the cytoplasm, and importins and exportins (collectively known as karyopherins) ferry molecules back and forth through the pore. (rcsb.org)
Importins1
Once the importin-beta/importin-alpha/cargo complex gets inside the nucleus, the cargo must be released and the importins must be recycled back to the cytoplasm. (rcsb.org)
Receptors1
Small RNAs are exported using Ran-GTP for directionality by karyopherin transport receptors, but mRNA is exported using a different mechanism that involves various quality controls. (prospecbio.com)
Localization1
Notice how the extended nuclear localization signal of this cargo is gripped by importin-alpha. (rcsb.org)
Bound1
In glutathione S-transferase pull-down assays, TDP-43 bound to karyopherin-alphas, thereby confirming the classical nuclear import pathway for the import of TDP-43. (crick.ac.uk)
Cytoplasm1
Several karyopherins are sequestered in stress granules, cytoplasmic aggregates of ribonucleoprotein complexes, as they avoid shuttling between the nucleus and the cytoplasm. (prospecbio.com)
Nucleus2
In most cases, karyopherin-mediated transport occurs through nuclear pores, which serve as a portal into and out of the nucleus. (prospecbio.com)
For example, the biological unit of hemoglobin includes two alpha chains and two beta chains, making it a tetrameric α 2 β 2 structure. (proteopedia.org)
Complex of importin-beta (blue), importin-alpha (green), and the cargo nucleoplasmin (yellow). (rcsb.org)
Importin-alpha is an adapter molecule that connects importin-beta with the cargo. (rcsb.org)
Actin3
Due to the loss of CREB3L1, ATC cells were unable to activate alpha - smooth muscle actin (α - SMA) - positive cancer - associated fibroblasts (CAFs). (biomedcentral.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Actin Alpha 1, Skeletal Muscle (ACTa1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (myelisakit.com)
Description: Quantitative sandwich ELISA for measuring Human Actin, alpha skeletal muscle (ACTA1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (myelisakit.com)
Proinflammatory1
For both, disease pathogenesis is thought to be immunologically mediated and there have been numerous reports of patients with elevated levels of proinflammatory and inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), in their sera. (mssm.edu)
Transport2
Then, a similar cleavage of the GTP in Ran releases importin-alpha for another round of transport. (rcsb.org)
E. Conti, C. W. Muller and M. Stewart (2006) Karyopherin flexibility in nucleocytoplasmic transport. (rcsb.org)
Subset1
When it is very large, it will be simplified to alpha carbon atoms (or a subset thereof) automatically by FirstGlance. (proteopedia.org)
Domain1
The SRP1 domain is Karyopherin(importin) alpha. (wikipedia.org)
Chain2
For example, 1bk5 (karyopherin alpha) is a truncated part of the natural chain, and forms a dimer that would be prevented by the full-length chain. (proteopedia.org)
BACKGROUND: Karyopherin α2 (KPNA2) is involved in the nucleocytoplasmic transport system and is functionally involved in the pathogenesis of various solid tumors by the translocation of cancer associated cargo proteins. (medscape.com)
13. Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma. (nih.gov)
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Inside the CELL NUCLEUSalpha karyopherins dissociate from beta karypherins and their cargo. (bvsalud.org)
Gene2
The protein encoded by this gene is a member of the importin alpha family. (nih.gov)
Among the genes containing nonsense mutations were the zinc finger protein-coding gene ZNF480, the karyopherin alpha 1 gene KPNA1, the low-density lipoprotein receptor-related gene LRP1, and the ALS-like protein-coding gene ALS2CL. (genomeweb.com)
Importins2
Both far-western analyses and immuno-pull-down assays indicate interaction of APE1 with karyopherin alpha 1 and 2, which requires the 20 N-terminal residues and implicates nuclear importins in APE1's nuclear translocation. (nih.gov)
Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX . (online-medical-dictionary.org)
Bind2
In plakoglobin arm repeats bind alpha-catenin and N-cadherin. (embl.de)
Karyopherin Alpha 2 Is an Adverse Prognostic Factor in Clear-Cell and Papillary Renal-Cell Carcinoma. (medscape.com)
Description2
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Hemoglobin Alpha 1 (HBa1) in samples from serum, plasma, erythrocyte lysates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (therabio.org)
Description: A sandwich ELISA kit for detection of Hemoglobin Alpha 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)