• The water-immiscible solvents methyl tert-butyl ether and acetonitrile are used to simplify the workup procedure, which involved stirring with 1 M aqueous ammonium sulfate. (wikipedia.org)
  • Allyl-CONH-PEG6-COOH is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs. (bocsci.com)
  • PLA-PEG-MAL is an amphiphilic AB diblock copolymer composed of hydrophilic block polyethylene glycol (PEG) and hydrophobic block polylactic acid or polyllactide (PLA). (bocsci.com)
  • Using the inexpensive Lewis acid magnesium bromide diethyl etherate (commonly prepared fresh by the addition of magnesium turnings to 1,2-dibromoethane in benzene:diethyl ether), the epoxide is opened with allyl amine to yield the corresponding 1,2-amino alcohol. (wikipedia.org)
  • The final product is obtained in high purity (99.7%) and an overall yield of 17-22% from (−)-shikimic acid. (wikipedia.org)
  • Sodium Alginate is the sodium salt form of alginic acid and gum mainly extracted from the cell walls of brown algae, with chelating activity. (kuwaityellowpagesonline.com)
  • citation needed] The current production method is based on the first scalable synthesis developed by Gilead Sciences starting from naturally occurring quinic acid or shikimic acid. (wikipedia.org)
  • A reported azide-free Roche synthesis of tamiflu is summarised graphically below: The synthesis commences from naturally available (−)-shikimic acid. (wikipedia.org)
  • If there is another functional group at a carbon, it may be named with the Greek letter, e.g., the gamma-amine in gamma-aminobutyric acid is on the third carbon of the carbon chain attached to the carboxylic acid group. (wikipedia.org)
  • The aminoalcohol was converted directly to the corresponding allyl-diamine in an interesting cascade sequence that commences with the unselective imination of benzaldehyde with azeotropic water removal in methyl tert-butyl ether. (wikipedia.org)
  • The water-immiscible solvents methyl tert-butyl ether and acetonitrile are used to simplify the workup procedure, which involved stirring with 1 M aqueous ammonium sulfate. (wikipedia.org)
  • The aminoalcohol was converted directly to the corresponding allyl-diamine in an interesting cascade sequence that commences with the unselective imination of benzaldehyde with azeotropic water removal in methyl tert-butyl ether. (wikipedia.org)
  • Roche has other routes to oseltamivir that do not involve the use of (−)-shikimic acid as a chiral pool starting material, such as a Diels-Alder route involving furan and ethyl acrylate or an isophthalic acid route, which involves catalytic hydrogenation and enzymatic desymmetrization. (wikipedia.org)
  • 90 to 5% by weight of at least one polyester which contains carboxyl and amino groups, has an acid number of 10 to 160 mg of KOH/g and an amine number of 0 to 90, and contains tertiary amino groups. (everypatent.com)
  • The t-butyl-protected carboxyl group can be deprotected under acidic conditions. (bocsci.com)
  • Finally, deallylation as above, yielded the freebase of oseltamivir, which was converted to the desired oseltamivir phosphate by treatment with phosphoric acid. (wikipedia.org)
  • With the librated methanesulfonic acid, the aziridine opens cleanly to yield a diamine that immediately undergoes a second transimination. (wikipedia.org)
  • Hydroxy-PEG9-t-butyl ester is a PEG linker containing a hydroxyl group and a t-butyl ester. (bocsci.com)
  • Due to lower yields and the extra steps required (because of the additional dehydration), the quinic acid route was dropped in favour of the one based on shikimic acid, which received further improvements by Hoffmann-La Roche. (wikipedia.org)
  • Selective acylation with acetic anhydride (under buffered conditions, the 5-amino group is protonated owing to a considerable difference in pKa, 4.2 vs 7.9, preventing acetylation) yields the desired N-acetylated product in crystalline form upon extractive workup. (wikipedia.org)