GeneticLociMutationGenotypeHuntington'sPolymorphismsHaplotypesPopulationsPutativeSTRsMotifsCandidate genesSegregationHeterozygosityDiseasesMendelianGenome-wideMarkersImperfectChromosomesTandemChromosomeLocusCholesterol levelsOccur in the regionProteinCopiesCitationAllelicLargeFoundContextMultipleIndividualVariationPresent studySingleStudyShowBlackHighExpressionAnalysisTotalLengthTypes
Genetic12
- In cases of co-dominance, the genetic traits of both different alleles of the same gene-locus are clearly expressed in the phenotype. (wikipedia.org)
- citation needed] When genes are located on the same chromosome and no crossing over took place before the segregation of the chromosomes into the gametes, the genetic traits will be inherited in connection, because of the genetic linkage. (wikipedia.org)
- citation needed] In Mendelian inheritance, genes have only two alleles, such as a and A. Mendel consciously chose pairs of genetic traits, represented by two alleles for his inheritance experiments. (wikipedia.org)
- citation needed] If one or more genes cannot be expressed because of another genetic factor hindering their expression, this epistasis can make it impossible even for dominant alleles on certain other gene-loci to have an effect on the phenotype. (wikipedia.org)
- Diversity and genetic stability in banana genotypes in a breeding program using inter simple sequence repeats (ISSR) markers. (geneticsmr.com)
- The natural populations from China with specific genetic characteristics enriched the gene pools of global A. thaliana collections. (biomedcentral.com)
- The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)
- The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
- Large changes in allele frequencies after 2003 resulted in a substantial increase in genetic differentiation among valleys within one to two years (1-2 generations) driven primarily by drift and immigration. (biomedcentral.com)
- Further studies are needed to determine if recovery from this perturbation through gradual mixing of diverged populations by migration and gene flow leads to the pre-climate event state, or whether the observed changes represent a new genetic equilibrium. (biomedcentral.com)
- Bottlenecks can cause a rapid loss of genetic variation, fixing mildly deleterious alleles and increasing the degree of inbreeding, thereby reducing the adaptive potential of the population [ 6 - 9 ]. (biomedcentral.com)
- genetic analysis of cinnamyl alcohol dehydrogenase in loblolly pine: single gene inheritance, molecular characterization and evolution. (liverpool.ac.uk)
Loci4
- Short tandem repeats (STRs) compose approximately 3% of the genome, and mutations at STR loci have been linked to dozens of human diseases including amyotrophic lateral sclerosis, Friedreich ataxia, Huntington disease, and fragile X syndrome. (biomedcentral.com)
- Some of these tools are designed to detect STR expansions at disease-related loci, while others detect expansions and contractions of STRs genome-wide but are constrained by sequencing read length and the STR motif size. (biomedcentral.com)
- These highly individual-specific number of repeats and the abundance of motifs have contributed to the polymorphism of STR loci. (researchsquare.com)
- The final consensus maps are based on 1578 microsatellite loci and these maps have a cumulative length of approximately 1400 cM after adjustment for recombination frequencies of RI strains. (nervenet.org)
Mutation8
- Indeed, mutation detection enhancement gel electrophoresis of mixed PCR products from cloned haplotypes revealed 24 distinct heteroduplex patterns for the six possible trinucleotide heterozygotes. (scite.ai)
- YBM12-A and YBM12-B). This mutation in leaf color is controlled by a single dominant nuclear gene. (geneticsmr.com)
- Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by a dynamic mutation due to the expansion of CAG repeats in the HTT gene (4p16.3). (geneticsmr.com)
- METHOD: Mutation screening of positional candidate genes was performed in two stages. (neurotransmitter.net)
- 2005) identified a mutation in the APP gene (104760.0019). (findzebra.com)
- This subtype is due to a mutation in the APP gene (21q21.2), encoding the beta-amyloid precursor protein. (findzebra.com)
- For instance, if you've got a mutation caused by triplet repeat expansion, for instance in the Huntington's gene, where the trinucleotide repeats a CAG, you might have 17 CAGs in a normal chromosome. (hstalks.com)
- Some occur in the coding region of the gene, others occur in the five prime region and others occur in the three prime region, and these have different consequences on the function of the gene and the results of the mutation. (hstalks.com)
Genotype2
- The objective of the present study was to assess ApoE allele and genotype distribution in a large elderly community-based sample and its association with age, sex and skin color. (scite.ai)
- No association between number of ApoE4 alleles and age was found, suggesting the absence of association of ApoE genotype with mortality in this population. (scite.ai)
Huntington's1
- REVIEW-ARTICLE Intermediate alleles of Huntington's disease HTT gene in different populations worldwide: a systematic review. (geneticsmr.com)
Polymorphisms3
- The observation of heteroduplex patterns in non-denaturing polyacrylamide gel electrophoresis (instead of the more commonly used denaturing gels) can thus be utilized to increase the informativeness of microsatellite polymorphisms by unraveling otherwise cryptic sequence variation. (scite.ai)
- The number of repeat units differs between individuals, resulting in highly complex allele polymorphisms. (researchsquare.com)
- Two single nucleotide polymorphisms (SNPs) that showed evidence for divergent distribution between autistic and nonautistic subjects were identified, both within SLC25A12, a gene encoding the mitochondrial aspartate/glutamate carrier (AGC1). (neurotransmitter.net)
Haplotypes1
- Sequencing of their polymerase chain reaction (PCR) products revealed a G-->A transition immediately preceding the trinucleotide repeats, hence defining 8 distinct haplotypes and 36 possible genotypes. (scite.ai)
Populations4
- These populations originated from a common ancestor, and a rapid demographic expansion began approximately 90,000 years ago. (biomedcentral.com)
- In contrast, interactions between genes and the environment cannot usually be studied using conventional mapping populations in which each animal is unique. (nervenet.org)
- We hypothesize that there might be at least three types of autism susceptibility genes/mutations that can be (i) specific to an individual patient or family, (ii) in a genetically isolated sub-population and (iii) a common factor shared amongst different populations. (neurotransmitter.net)
- Slatkin [ 4 ] argued that local extinction and re-colonisation dynamics imply ongoing gene flow, which will prevent local populations from becoming differentiated. (biomedcentral.com)
Putative2
- A putative function has been assigned, using the gene ontology approach, to the set of genes harboring at least one SSR. (researchgate.net)
- in contrast to simple family structures reported for a variety of angiosperm nsltp genes, the putative pine nsltp gene is a member of a complex family. (liverpool.ac.uk)
STRs3
- Short tandem repeats (STRs), or microsatellites, are 1-6 base pair (bp) motifs of repeating units of DNA. (biomedcentral.com)
- Short tandem repeats (STRs) are widely present in the human genome. (researchsquare.com)
- Short tandem repeats (STRs), also known as microsatellites, are repetitive DNA sequences consisting of 1-6-bp motifs present in a genome. (researchsquare.com)
Motifs1
- A total of 4,761 perfect and 6,583 imperfect SSRs were present in 3,781 genes (14.11% of the total), corresponding to an overall density across the gene space of 32,5 and 44,9 SSRs/Mbp for perfect and imperfect motifs, respectively. (researchgate.net)
Candidate genes1
- Next-generation sequencing of the whole exome is useful for testing for multiple candidate genes simultaneously or for discovering new, rare disorders. (medlink.com)
Segregation2
- Mendel's principle of segregation of genes applies too, as in the F2-generation homozygous individuals with the phenotypes of the P-generation appear. (wikipedia.org)
- Only a small number of genomic regions in the BXN set deviate significantly from the expected 50:50 segregation ratio of alleles. (nervenet.org)
Heterozygosity1
- We found that population turnover after 2003 led to a loss of allelic richness and gene diversity but not to significant changes in observed heterozygosity. (biomedcentral.com)
Diseases3
- Long expansions of transcribed trinucleotide microsatellites have been etiologically associated with some neurological diseases. (scite.ai)
- Today I'm going to tell you about microsatellites, and trinucleotide repeat expansions diseases. (hstalks.com)
- These diseases are all caused by microsatellite mutations, where a microsatellite either has three bases, four bases, five bases, or six bases, and these mutations result in excess numbers of copy of these particular units. (hstalks.com)
Mendelian2
- In Mendelian inheritance, each parent contributes one of two possible alleles for a trait. (wikipedia.org)
- As many of the alleles are dominant or recessive, a true understanding of the principles of Mendelian inheritance is an important requirement to also understand the more complicated inheritance patterns of sex-linked inheritances. (wikipedia.org)
Genome-wide1
- Our genome-wide comparisons demonstrated that although these polyploidization-derived SVs have evolved at distinct evolutionary stages, a large number of SV-intersecting genes showed enrichment in functionally important pathways related to secondary metabolites, photosynthesis and basic cellular activities. (bvsalud.org)
Markers3
- Pseudomolecules as well as unmapped scaffolds were used for the bulk mining of SSR markers and for the construction of the first globe artichoke microsatellite marker database. (researchgate.net)
- scolymus) has been used to catalog the genome's content of simple sequence repeat (SSR) markers. (researchgate.net)
- In this study we have increased the density of microsatellite markers 2- to 5-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH, and CXB). (nervenet.org)
Imperfect1
- Perfect repeats mutate about 2 × more often than imperfect repeats. (biomedcentral.com)
Chromosomes1
- These laws describe the inheritance of traits linked to single genes on chromosomes in the nucleus. (wikipedia.org)
Tandem1
- We searched the expressed sequence tag databank for reiterated trinucleotides and selected EST00493 (D2S196E) with 14 tandem ACA triplets as a potentially polymorphic locus. (scite.ai)
Chromosome2
- Domestic cats have a gene with a similar effect on the X-chromosome. (wikipedia.org)
- But in a diseased chromosome, you might have 40 successive copies of CAG trinucleotides in the gene. (hstalks.com)
Locus3
- In the genes for the dog coat colours there are four alleles on the Agouti-locus. (wikipedia.org)
- An example in dog coat genetics is the homozygosity with the allele "e e" on the Extension-locus making it impossible to produce any other pigment than pheomelanin. (wikipedia.org)
- Although the allele "e" is a recessive allele on the extension-locus itself, the presence of two copies leverages the dominance of other coat colour genes. (wikipedia.org)
Cholesterol levels3
- Many human genes, including one for a protein that controls cholesterol levels in the blood, show co-dominance too. (wikipedia.org)
- People with the heterozygous form of this gene produce two different forms of the protein, each with a different effect on cholesterol levels. (wikipedia.org)
- On the other hand, the ε2 allele carriers had lower LDL cholesterol levels (P (scite.ai)
Occur in the region1
- These guarantee onset of early-onset familial Alzheimer disease and all occur in the region of the APP gene that encodes the Aβ domain. (findzebra.com)
Protein1
- lipid transfer protein genes of loblolly pine are members of a complex gene family. (liverpool.ac.uk)
Copies1
- An individual usually has only two copies of each gene, but many different alleles are often found within a population. (wikipedia.org)
Citation1
- citation needed] Many other genes have multiple alleles, including the human genes for ABO blood type. (wikipedia.org)
Allelic1
- 21 allelic mutations have been discovered in the APP gene. (findzebra.com)
Large1
- Whole exome sequencing is not suitable for detecting polynucleotide repeat disorders or large insertion/deletions. (medlink.com)
Found1
- Negative association findings and research involving the serotonin transporter gene, FMR1, RELN, WNT2, HOXA1, and HOXB1 genes may be found elsewhere on this site . (neurotransmitter.net)
Context1
- Apolipoprotein E (ApoE) is one of the most extensively studied genes in the context of aging, but there are few population-based studies on ApoE polymorphism in the elderly in developing countries. (scite.ai)
Multiple1
- multiple alleles at qtl allow the examination of interaction among alleles at qtl (deviation from additive gene action). (liverpool.ac.uk)
Individual1
Variation1
Present study1
- In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region. (neurotransmitter.net)
Single1
- control of cad gene expression could involve either differential regulation of more than one cad gene or, alternatively combinatorial regulation of a single cad gene. (liverpool.ac.uk)
Study2
- Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). (scite.ai)
- In this study, we identified abundant genomic SVs in the Panax genus that are hypothesized to have occurred through during the repeated polyploidizations/(re)diploidizations. (bvsalud.org)
Show1
- Intermediate alleles (IAs) show 27 to 35 CAG repeats and expanded alleles have more than 35 repeats. (geneticsmr.com)
Black1
- For example, in certain varieties of chicken, the allele for black feathers is co-dominant with the allele for white feathers. (wikipedia.org)
High1
- 93-28.25), showing that the African-Brazilian elderly have a high prevalence of the ε4 allele, as observed in blacks from Africa. (scite.ai)
Expression1
- xylem-specific gene expression in loblolly pine. (liverpool.ac.uk)
Analysis1
- And 28 core target genes were then obtained from a PPI network analysis. (bvsalud.org)
Total1
- RESULTS: In total, 487 no-repeat targets corresponding to the bioactive components of ZGW were screened, and 175 target genes in the intersection of ZGW and osteogenesis were obtained. (bvsalud.org)
Length1
- The SSRs were categorized for the numbers of repeats present, their overall length and were allocated to their linkage group. (researchgate.net)
Types1
- What this slide shows is that these types of mutations can occur in various parts of the gene. (hstalks.com)