• peptides
  • This is a significant decrease and is almost certainly a result of the abnormally efficient binding of HLA-A*02 to peptides originating from EBV. (wikipedia.org)
  • This high affinity increases the probability of CD8+ t-cell recognition of EBV peptides held by HLA-A*02 complexes. (wikipedia.org)
  • Only considering CD8 + T cells that recognize peptide epitopes typically 8 to 10 amino acids long, and occasionally 11 amino acids long, each mutation could generate 38 different peptides that could potentially bind to an HLA class I molecule. (aacrjournals.org)
  • Because only peptides that can bind to HLA class I or II provide eligible T-cell targets, one possible strategy for selecting vaccine targets is to choose candidate neoepitopes based on their predicted affinities for the HLA molecules expressed by the patient, determined using HLA-binding affinity prediction algorithms ( 6-8 ). (aacrjournals.org)
  • The main function of MHC molecules is to present processed peptides for the recognition of antigen-specific T cells. (frontiersin.org)
  • HLA genes encode cell surface molecules specialized to present antigenic peptides to T-cell receptors. (biomedcentral.com)
  • gene
  • However, B51 tends not to be found in ABD when a certain SUMO4 gene variant is involved, and symptoms appear to be milder when HLA-B27 is present. (wikipedia.org)
  • Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
  • In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
  • Vogel R, Al-Daccak R, Drews O, Alonzeau J, Mester G, Charron D, Stevanovic S, Mallet J (2013) Mass spectrometry reveals changes in MHC I antigen presentation after lentivector expression of a gene regulation system. (immunology-tuebingen.de)
  • proteins
  • as of December 2013 there are 456 different HLA-A*02 proteins. (wikipedia.org)
  • In essence, every individual's immune system is tuned to the specific set of HLA and self proteins produced by that individual. (wikipedia.org)
  • HLA research didn't heat up until the 1980s when a group of researchers finally elucidated the shape of the HLA-A*02 protein (just one of many specific HLA proteins). (wikipedia.org)
  • Even more recently, in 2010, the WHO committee responsible for naming all HLA proteins revised their standards for naming to introduce more clarity and specificity in the naming system. (wikipedia.org)
  • clinical
  • HLA typing might be a useful clinical method for screening patients with high risk of progression to ESRD. (biomedcentral.com)
  • HLA-B58 can help the clinical decision on starting allopurinol in Korea and 4Department of Internal Medicine, Hi gang, Tried porting over to XP11 today. (nvision08.com)
  • HLA-B58 can help the clinical decision on starting allopurinol in Korea and 4Department of Internal Medicine, SimCoders - Reality Expansion Pack for Carenado Beechcraft Baron B58 A custom flight dynamics engine is replacing part of the internal X-Plane engine in order to In this section, you will learn about some of the basic internal inputs for strategy formulation-starting with the organization's strengths and weaknesses. (nvision08.com)
  • designation
  • In order to standardize the HLA designation of prior low-resolution typings with the more advanced DNA based typings, all HLA-A, −B and -DR were analyzed using a low resolution serologic equivalent. (biomedcentral.com)
  • epitopes
  • Furthermore, regardless of the total number, only a fraction of mutations are expected to generate HLA-binding (known as MHC in mice) epitopes capable of serving as relevant vaccine targets, and it is possible that attempting to target all possible mutant neoepitopes may drown out the relevant targets and reduce efficacy. (aacrjournals.org)
  • At a minimum, it will be necessary to choose (or at least enrich for) vaccine targets that are actually processed and presented by antigen-presenting cells and presented on HLA by the tumor to activate the T cells that can recognize these epitopes and mediate tumor lysis. (aacrjournals.org)
  • CD4 + T-cell epitopes are longer and are processed differently, but also must be exposed and not destroyed, and they must have affinity for HLA class II molecules instead of HLA class I. (aacrjournals.org)
  • frequency
  • B58 baron manuals katzenstore, internal dynamic shadows on vc, volumetric normal mapping, specular mapping and bloom lights polygon optimized The HLA-B58 allele was present in all patients with allopurinol-induced SCARs, while the frequency of HLA-B58 was only 9. (nvision08.com)
  • novel
  • Each of these mutations has the potential to generate one or more novel T-cell antigens (termed "neoepitopes") uniquely specific to each individual patient's tumor. (aacrjournals.org)
  • group
  • There are a number of alleles within the B*52 allele group. (wikipedia.org)
  • There are a large number of alleles within the B*51 allele group. (wikipedia.org)
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
  • The polymorphisms of HLA class I and II antigens in ESRD patients and a healthy control group were retrospectively analyzed. (biomedcentral.com)
  • The information of 141 ESRD patients was obtained from the medical record of the Keelung branch of Chang Gung Memorial Hospital and was compared to the HLA type of a control group comprized of 190 healthy unrelated Taiwanese from one of our previous studies. (biomedcentral.com)
  • In this study, HLA class I and II polymorphisms of ESRD patients were compared to a healthy control group in an effort to provide a better understanding of the etiology of this disease. (biomedcentral.com)
  • The positive rate of HLA-B58 was significantly higher in patients with SCARs than in the allopurinol-tolerant group [odds ratio (OR) = 179. (nvision08.com)
  • patients
  • In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower viral loads in HIV patients. (wikipedia.org)
  • peripheral
  • HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)
  • system
  • The HLA system belongs to the major histocompatibility complex (MHC) in humans and it is located on chromosome 6p21.3. (biomedcentral.com)
  • cells
  • Mechanisms include the following: regulatory T cells (Tregs), direct inactivation of effector T (Teff) cells by induction of anergy or apoptosis and activities mediated by tolerogenic antigen-presenting cells (APCs). (frontiersin.org)
  • immune
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • large
  • As of December 2013, there are 456 alleles identified (mostly by sequence homology) as being A2, of those 27 are nulls, and a large majority have unknown serotypes, although it is highly probable that they will all return A2 serotypes. (wikipedia.org)
  • study
  • The aim of this study is to investigate detailed HLA subtypes in a case-control study of Taiwanese individuals. (biomedcentral.com)
  • disease
  • Takayasu's arteritis appears to have an independent link to B52 associated disease. (wikipedia.org)
  • Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, is expressed as, respectively, increased susceptibility to disease or decreased susceptibility to disease. (wikipedia.org)
  • risk
  • HLA-A*02 has been linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL). (wikipedia.org)
  • The current work suggests that HLA-DR3 (odds ratio = 1.91, 95 % CI = 1.098-3.324, P = 0.024, Pc = 0.312) and HLA-DR11 (odds ratio = 2.06, 95 % CI = 1.133-3.761, P = 0.021, P c = 0.273) may represent susceptibility risk factors for the development of ESRD in Taiwanese individuals. (biomedcentral.com)
  • appears
  • In summation, HLA-A*02 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. (wikipedia.org)
  • shown
  • HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)