• derivatives
  • We demonstrated that microbial fermentation can be used to produce halogenated alkaloid derivatives, which can ultimately serve as potential drug leads, through feeding amino acid derivatives to strains. (pnas.org)
  • Noscapine, and its synthetic derivatives called noscapinoids, are known to interact with microtubules and inhibit cancer cell proliferation The lactone ring is unstable and opens in basic media. (wikipedia.org)
  • latex
  • A latex containing several important alkaloids is obtained from immature seed capsules one to three weeks after flowering. (opioids.com)
  • Commercial poppy farming traditionally involved lancing the seed capsule to release the latex from which medicinal alkaloids, including noscapine, could be extracted. (blogspot.com)
  • compound
  • We have previously described a tubulin-binding, natural compound, noscapine, that was nontoxic and triggered apoptosis in many cancer types albeit at 10 μmol/L or higher concentrations depending on the cell type. (aacrjournals.org)
  • pathway
  • Noscapine titers were improved by 18,000-fold (to low mg/L levels) via a combination of enzyme engineering, pathway and strain engineering, and fermentation optimization. (pnas.org)
  • synthetic
  • We now show that a synthetic analogue of noscapine, 9-bromonoscapine, is ∼10-fold to 15-fold more potent than noscapine in inhibiting cell proliferation and induces apoptosis following G 2 -M arrest in hormone-insensitive human breast cancers (MDA-MB-231). (aacrjournals.org)
  • substances
  • Nausea Vomiting Loss of coordination Hallucinations (auditory and visual) Loss of sexual drive Swelling of prostate Loss of appetite Dilated pupils Increased heart rate Shaking and muscle spasms Chest pains Increased alertness Loss of any sleepiness Loss of stereoscopic vision Noscapine can increase the effects of centrally sedating substances such as alcohol and hypnotics. (wikipedia.org)
  • drug
  • Noscapine is currently being investigated as the preferred drug candidate for the clinical trials based on its effectiveness on Heriditary Spastic Paraplegia (HSP) stem cells, safety data, toxicology data, patent status, availability, and future affordability to HSPers. (wikipedia.org)
  • found
  • Noscapine is metabolised by the body, and is itself rarely found in urine, instead being present as the primary metabolites, cotarnine and meconine. (wikipedia.org)
  • presence
  • medical citation needed] Nausea can be attributed to the presence of noscapine and is more common in first-time or inexperienced users. (wikipedia.org)