• AlkP
  • Sigma-Aldrich offers a broad range of alkaline phosphatase (ALP/ALKP) preparations optimized for conjugation to antibodies and other proteins for ELISA, Western blotting, and histochemical detection. (sigmaaldrich.com)
  • gene
  • In addition, this gene is polymorphic and three common alleles (type 1, type 2, and type 3) for this form of alkaline phosphatase have been well-characterized. (wikipedia.org)
  • Raynaud's phenomenon Anemia Hypertension Normocytic anemia Normochromic anemia Gastrointestinal bleeding or telangiectasias Elevated alkaline phosphatase The official name of the TREX1 gene is "three prime repair exonuclease 1. (wikipedia.org)
  • coli
  • In Gram-negative bacteria, such as Escherichia coli (E. coli), alkaline phosphatase is located in the periplasmic space, external to the inner cell membrane and within the peptidoglycan portion of the cell wall. (wikipedia.org)
  • Alkaline phosphatase in E. coli is uncommonly soluble and active within elevated temperature conditions such as 80 °C. Due to the kinetic energy induced by this temperature the weak hydrogen bonds and hydrophobic interactions of common proteins become degraded and therefore coalesce and precipitate. (wikipedia.org)
  • cysteine
  • Each monomer contains five cysteine residues, two zinc atoms, and one magnesium atom crucial to its catalytic function, and it is optimally active at alkaline pH environments. (wikipedia.org)
  • Hodgkin's
  • Breast carcinoma Colon cancer Leukemia - cancer of the bone marrow Lymphoma Pancreatic cancer Lung cancer Hodgkin's lymphoma - cancer of the white blood cells An alkaline phosphatase isoenzyme test can be done to check for elevated ALP levels. (wikipedia.org)
  • substrate
  • The mechanism of action of alkaline phosphatase involves the geometric coordination of the substrate between the Zn ions in the active sites, whereas the Mg site doesn't appear to be close enough to directly partake in the hydrolysis mechanism, however, it may contribute to the shape of the electrostatic potential around the active center. (wikipedia.org)
  • cell
  • The alkaline phosphatase blood test may be used to monitor the health of people with alcoholism, renal cell carcinoma, pancreatitis and gallstones. (reference.com)
  • Since the periplasmic gap is more prone to environmental variation than the inner cell, alkaline phosphatase is suitably resistant to inactivation, denaturation, or degradation. (wikipedia.org)