• It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. (wikipedia.org)
  • It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. It was also produced in 1986 in recombinant human form, in the Center for Genetic Engineering and Biotechnology of Havana, Cuba, under the name Heberon Alfa R. It has been used for a wide range of indications, including viral infections and cancers. (wikipedia.org)
  • Intron A (Interferon alfa-2b, recombinant) is a recombinant version of a naturally occurring alpha interferon, with both antiviral and immunomodulatory effects. (centerwatch.com)
  • Commercially available interferons are human interferons manufactured using recombinant DNA technology. (medicinenet.com)
  • Roferon-A (Interferon alfa-2a, recombinant) is a sterile protein product for use by injection. (drugs.com)
  • Interferon alfa-2a, recombinant is a highly purified protein containing 165 amino acids, and it has an approximate molecular weight of 19,000 daltons. (drugs.com)
  • 3 million IU (11.1 mcg/0.5 mL) Roferon-A per syringe - The solution is colorless and each 0.5 mL contains 3 MIU of Interferon alfa-2a, recombinant, 3.605 mg sodium chloride, 0.1 mg polysorbate 80, 5 mg benzyl alcohol as a preservative and 0.385 mg ammonium acetate. (drugs.com)
  • The mechanism by which Interferon alfa-2a, recombinant, or any other interferon, exerts antitumor or antiviral activity is not clearly understood. (drugs.com)
  • The biological activities of Interferon alfa-2a, recombinant are species-restricted, i.e., they are expressed in a very limited number of species other than humans. (drugs.com)
  • As a consequence, preclinical evaluation of Interferon alfa-2a, recombinant has involved in vitro experiments with human cells and some in vivo experiments. (drugs.com)
  • 1 Using human cells in culture, Interferon alfa-2a, recombinant has been shown to have antiproliferative and immunomodulatory activities that are very similar to those of the mixture of interferon alfa subtypes produced by human leukocytes. (drugs.com)
  • In vivo, Interferon alfa-2a, recombinant has been shown to inhibit the growth of several human tumors growing in immunocompromised (nude) mice. (drugs.com)
  • The metabolism of Interferon alfa-2a, recombinant is consistent with that of alpha-interferons in general. (drugs.com)
  • Small amounts of radiolabeled Interferon alfa-2a, recombinant appear in the urine of isolated rat kidneys, suggesting near complete reabsorption of Interferon alfa-2a, recombinant catabolites. (drugs.com)
  • The serum concentrations of Interferon alfa-2a, recombinant reflected a large intersubject variation in both healthy volunteers and patients with disseminated cancer. (drugs.com)
  • Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. (qxmd.com)
  • We studied the effects of recombinant human interferon alfa in a prospective, randomized, double-blind, placebo-controlled trial in patients with well-documented chronic hepatitis C. Forty-one patients were enrolled in the trial, 37 of whom were later found to have antibody to hepatitis C virus. (qxmd.com)
  • complete response or partial response) to zidovudine, recombinant interferon alfa-2b, and PEG-interferon alfa-2b therapy in patients with human T-cell lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma (ATLL). (druglib.com)
  • recombinant interferon alfa-2b IV twice daily on days 3-14. (druglib.com)
  • patients achieving partial response (PR) receive another 7 days of zidovudine and recombinant interferon alfa-2b and then proceed to part 1 maintenance therapy. (druglib.com)
  • Interferon alfa-2b is a protein product manufactured by recombinant DNA technology. (medscape.com)
  • Peginterferon alfa-2a is also FDA approved for treatment of chronic hepatitis C, alone or in combination with ribavirin, in patients not previously treated with interferon alfa, and with compensated liver disease. (medscape.com)
  • Interferon alfa-2b comes as a powder in a vial to mix with liquid and as a solution to inject either subcutaneously (just under the skin), intramuscularly (into a muscle), intravenous (into the vein), or intralesionally (into a lesion). (epnet.com)
  • Patients were treated with pegylated interferon alfa-2b 1.5 μg/kg per week subcutaneously plus oral ribavirin 800 mg/d for patients with genotypes 2 and 3 for 24 wk. (wjgnet.com)
  • Patients receive SU5416 IV over 30-60 minutes twice weekly and interferon alfa-2b subcutaneously every 12 hours daily. (knowcancer.com)
  • Twenty-one patients received interferon alfa (2 million units) subcutaneously three times weekly for six months, and 20 received placebo. (qxmd.com)
  • PEG-interferon alfa-2b subcutaneously (SC) once weekly, beginning on day 14 or 21 and continue to day 60. (druglib.com)
  • Methods: This prospective, international, multicenter, open-label study evaluated efficacy and safety of peginterferon alfa-2b (1.5 μg/kg/wk) plus weight-based ribavirin (800-1400 mg/day) in 2333 chronic HCV-infected patients with significant fibrosis/cirrhosis whose previous interferon alfa/ribavirin therapy failed. (psu.edu)
  • Conclusions: Peginterferon alfa-2b plus weight-based ribavirin is effective and safe in patients who failed interferon alfa/ribavirin therapy. (psu.edu)
  • The objectives of this work were twofold: 1) to evaluate the effectiveness and safety of treatment with classic dual interferon pegylated alpha-2a (IFN) and ribavirin therapy in Benin, and 2) to present problems related to financial accessibility to this treatment. (scirp.org)
  • Although treatment for viral hepatitis C (VHC) has been around for many years and is widely used in developed countries, the high cost of pharmaceuticals (pegylated interferon and ribavirin) and pre-, per-, and post-treatment assessment has long been a brake on its implementation in developing countries, including Benin. (scirp.org)
  • The immunomodulatory effects of interferon alfa-2b include enhancement of cytolytic T-cell activity, stimulation of natural killer cell activity, amplification of human leukocyte antigen (HLA) class I protein on infected cells, and suppression of tumor cell proliferation. (medscape.com)
  • 6 to 12 months after the discontinuation of interferon therapy, only two patients (10 percent) still had normal values. (qxmd.com)
  • Discontinue lamivudine and zidovudine tablet as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (nih.gov)
  • Background & Aims: Treatment with peginterferon alfa and ribavirin produces a sustained virologic response (SVR) in approximately 60% of hepatitis C virus (HCV)-infected patients. (psu.edu)
  • To study the safety and efficacy of pegylated interferon alfa-2b, indigenously developed in India, plus ribavirin in treatment of hepatitis C virus (HCV). (wjgnet.com)
  • OBJECTIVES: I. Determine the efficacy and toxicity of SU5416 combined with interferon alfa-2b in patients with unresectable or metastatic renal cell carcinoma. (knowcancer.com)
  • The objective of this multi-institutional phase 2 trial was to evaluate the efficacy and toxicity of paclitaxel and bcl-2 modulators (13-cis retinoic acid and interferon alfa-2b) in patients with advanced-stage or recurrent cervical cancer. (bmj.com)
  • The direct antiviral activity of interferon alfa-2b activates viral ribonucleases and inhibits viral entry into cells and viral replication. (medscape.com)
  • Interferon alfa-2b injection is used to treat a number of conditions. (epnet.com)
  • Tissue damage at the site of injection occurs with all of the interferons but more commonly with interferon beta-1b and pegylated interferon alfa-2b. (medicinenet.com)
  • Our product range includes a wide range of human interferon alfa 2b injection. (orbissgpharma.in)
  • An intralesional injection of interferon alfa resulted in the rapid development of psoriatic lesions on the warts located on the dorsal aspect of the hand, as they were before therapy was started. (jamanetwork.com)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/431591/all/Antiangiogenic_therapy_with_interferon_alfa_for_neovascular_age‐related_macular_degeneration. (unboundmedicine.com)
  • Results: The mean number of days of continuous 5-FU therapy for patients receiving 150, 200, 250, and 300 mg/m 2 /d of 5-FU plus IFN alfa-2a (IFN-α2a) was 75, 54, 37, and 22 days, respectively. (elsevierpure.com)
  • Interferon alfa-2b (IFN-α) therapy has been shown to be effective in the treatment of viral hepatitis B (HBV) or viral hepatitis C (HCV) in patients who did not undergo transplantation. (elsevierpure.com)
  • Conclusions Combination therapy with paclitaxel, 13-cis retinoic acid, and interferon alfa-2b is feasible and safe in treating patients with advanced and recurrent cervical cancer. (bmj.com)
  • PEG-IFN alfa-2b treatment for chronic hepatitis C was maintained and no therapy was given for PR. (balkanmedicaljournal.org)
  • Hepatic decompensation, some fatal, has occurred in HIV-1/HCV co-infected patients receiving combination antiretroviral therapy and interferon alfa with/without ribavirin. (nih.gov)
  • The study aimed to assess results of response guided therapy with pegylated interferon α (PegINFα) and ribavirin in HCV infected patients in different genotypes. (helsinki.fi)
  • Two treatment regimens are available: traditional dual therapy (interferon + ribavirin) used since 2010 and direct-acting antivirals (DAAs) since the end of 2015. (scirp.org)
  • Twenty-two patients received 135 &mgr;g peglyated-interferon α-2a weekly for 48 wk (group A). The remaining patients were left untreated, eleven refused therapy, and three were not candidates for kidney transplantation and were allocated to the control group (group B). At the end of the treatment biochemical and virological response was evaluated, and 24 wk after completion of therapy sustained virological response (SVR) was assessed. (wjgnet.com)
  • Before initiation of therapy with interferon alfa-2b, perform tests to quantitate peripheral blood hemoglobin, platelets, granulocytes, hairy cells, and bone marrow hairy cells. (medscape.com)
  • However, such antitumor activity has been repeatedly demonstrated with, for example, mouse interferon-alfa in transplantable mouse tumor systems. (drugs.com)
  • Interferons are naturally produced proteins with antiviral, antitumor, and immunomodulatory actions. (medscape.com)
  • Background: Several randomized clinical trials in chronic myeloid leukemia (CML) have reported better patient survival with interferon alfa (IFN α) than with standard chemotherapeutic agents, such as busulfan or hydroxyurea. (ox.ac.uk)
  • In conclusion, sustained virological response in genotype 4 Egyptian patients treated with PEG-IFN alfa-2a and ribavirin was estimated around 60%, intermediate between sustained virological response observed in genotype 1 and genotype 2-3 patients in Western countries. (citationimpact.com)
  • Our case is the first case of PR, emerged in a patient with chronic hepatitis C while receiving PEG-IFN alfa 2b and ribavirin. (balkanmedicaljournal.org)
  • SVR could be achieved in 64.7% of patients on hemodialysis with chronic hepatitis C by a treatment with peglyated-interferon α-2a. (wjgnet.com)
  • Peginterferon alfa-2a is indicated for adults with hepatitis B e antigen (HBeAg)-positive and HBeAg-negative chronic hepatitis B disease with compensated liver disease and evidence of viral replication and liver inflammation. (medscape.com)
  • Purpose: To determine the maximum-tolerable dose (MTD) of fluorouracil (5- FU) administered as a low-dose, prolonged continuous intravenous infusion (PCI) plus interferon-alfa (IFN-α) that would permit treatment for at least 28 consecutive days, and to determine the effect of IFN-α on 5-FU pharmacokinetics. (elsevierpure.com)
  • Interferon alfa-2b works to treat hepatitis C virus (HCV) and hepatitis B virus (HBV) by decreasing the amount virus in the body. (epnet.com)
  • Interferon alfa-2b is an antiviral or antineoplastic drug. (wikipedia.org)
  • Currently, pegylated interferon alfa (PEG-IFN-a), entecavir (ETV), and tenofovir disoproxil fumarate (TDF) are the first-line agents in the treatment of hepatitis B disease. (medscape.com)
  • Interferon Beta 1a, specifically, activates macrophages that engulf antigens and natural killer cells (NK cells), a type of immune T-Cell. (medicinenet.com)
  • The mechanism of action of interferon is complex and is not well understood. (medicinenet.com)
  • One study at the University of Texas Medical Branch, Galveston, showed evidence of a direct anti-viral effect of Interferon alpha against novel Coronavirus in vitro. (wikipedia.org)
  • This is why interferon therapies for viral infections are typically a last resort -- the potential for dire side effects. (medicinenet.com)
  • Interferons interact with cells through high affinity cell surface receptors. (syrianclinic.com)
  • Peginterferon alfa-2a binds to cell surface receptors in a cascade of protein interactions, resulting in gene transcription. (medscape.com)
  • Interferons are a family of naturally-occurring proteins that are made and secreted by cells of the immune system (for example, white blood cells, natural killer cells, fibroblasts, and epithelial cells). (medicinenet.com)
  • interferon naturally occurring in the body is responsible for all flu-like symptoms to begin with, whether you have the coronavirus or a common cold . (medicinenet.com)
  • Giving zidovudine, interferon alfa-2b, and PEG-interferon alfa-2b together may stimulate the immune system and slow down or keep the cancer cell from growing. (druglib.com)
  • The treatment consisted of oral 13-cis retinoic acid, 1 mg/kg, and subcutaneous interferon alfa-2b, 6 mU/m 2 , days 1 to 4, and intravenous paclitaxel, 175 mg/m 2 , day 4 until disease progression or adverse events prohibited treatment. (bmj.com)
  • Studies around the world, including a huge WHO study, are looking at different interferons to treat COVID-19 coronavirus, but no existing COVID-19 drug trials in the U.S. included interferons as of April 7, 2020. (medicinenet.com)
  • Can interferons treat COVID-19 coronavirus disease? (medicinenet.com)
  • Interferon beta-1a, currently in use to treat multiple sclerosis , and interferon alfa-2b are both under investigation as potential treatments for people with COVID-19 coronavirus disease, the deadly respiratory pandemic caused by the SARS -nCoV-2 virus. (medicinenet.com)
  • Interferon may exacerbate autoimmune liver disease as well as other autoimmune diseases such as thyroid disease). (pharmac.govt.nz)
  • Evidence Central , evidence.unboundmedicine.com/evidence/view/EBMG/456385/all/Interferon_alfa_for_neovascular_age_related_macular_degeneration. (unboundmedicine.com)
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with interferon alfa-2b and each time you refill your prescription. (epnet.com)
  • Nur ein Patient (Nr. 42) wechselte nach 3 Monaten von Interferon zu Azathioprin aufgrund mangelnder Wirksamkeit von Interferon alfa-2a. (uni-tuebingen.de)
  • The mean serum aminotransferase levels and the histologic features of the liver improved significantly in the patients treated with interferon but not in the patients given placebo. (qxmd.com)
  • So, if someone is already on a ventilator and symptoms are about to overwhelm them, giving them an interferon-based medicine could be catastrophic. (medicinenet.com)
  • Your doctor will order certain tests to check your body's response to interferon alfa-2b. (epnet.com)
  • The patient's response to interferon treatment should be reviewed at either three or four months. (pharmac.govt.nz)
  • Interferons modulate the response of the immune system to viruses , bacteria, cancer , and other foreign substances that invade the body. (medicinenet.com)
  • However, while high-dose interferon alfa-2b and pegylated interferon have been shown to improve relapse-free survival, neither improves overall survival. (medscape.com)