• catalytic
  • There are two classes of fructose-bisphosphate aldolases with different catalytic mechanisms: class I enzymes [ PMID: 3355497 ] do not require a metal ion, and are characterised by the formation of a Schiff base intermediate between a highly conserved active site lysine and a substrate carbonyl group, while the class II enzymes require an active-site divalent metal ion. (ebi.ac.uk)
  • In mammalian aldolase, the key catalytic amino acid residues involved in the reaction are lysine and tyrosine. (wikipedia.org)