A group of compounds which did control septoria were amides of pyrazole-4-carboxylic acid, with the most successful being derivatives with an N-methyl group and a difluromethyl group in position 3 of the ring. (wikipedia.org)
To increase the antitubercular potency, we synthesized a series of novel pyrazolylpyrazoline derivatives ( 9a - p ) using the one-pot multicomponent reaction of the substituted heteroaryl aldehyde ( 3a , b ), 2-acetyl pyrrole/thiazole ( 4a , b ), and substituted hydrazine hydrates ( 5 - 8 ) in the presence of base NaOH as a catalyst in ethanol as the solvent at room temperature. (nih.gov)
It is also found that the water-solubilization of acCB-1 for aromatic aldehydes can promote their reaction with acylhydrazines to form hydrozone derivatives. (sioc-journal.cn)
In the presence of acetic acid as a catalyst, reactions of acetohydrazide with 2,4-pentanedione and 2,5-hexanedione yielded pyrazole and pyrrole derivatives, respectively. (ktu.lt)
3- Cyano pyridone derivatives were synthesized by treating 1-(4-bromophenyl)-3-(4-(dimethyl amino) phenyl) prop-2-en-1-one with compounds containing active methylene group in the presence of ammonium acetate. (tsijournals.com)
Also some pyrazole derivatives have been synthesized via the interaction of the chalcone with hydrazine hydrate. (tsijournals.com)
4. Investigation of antimicrobial activities of indole-3-aldehyde hydrazide/hydrazone derivatives. (nih.gov)
Glycerol/potassium carbonate is a low cost and environmentally friendly DES that recently its efficiently was proven in the preparation of pyrazole derivatives [ 28 ]. (biomedcentral.com)
In order to develop applications of Gly/K 2 CO 3 to other heterocycles, it was successfully used as catalytic media in the synthesis of novel 5-amino-isoxazole-4-carbonitrile derivatives via multicomponent reaction of malononitrile, hydroxylamine and various aryl aldehydes (Fig. 1 ). (biomedcentral.com)
reported the formation of 1,4-dihydropyridine derivatives (1,4-DHPs) 35 containing substituted pyrazole moiety simply because potent antimicrobial, aswell as, antioxidant agencies [56]. (engineering-gdfsuez.com)
Aromatic9
Chalcones (2a-j) were synthesized from acetanilide and various aromatic aldehydes in presence of ethanol and sodium hydroxide solution. (hindawi.com)
The promotion of two sulfate or carboxylate-bearing acyclic cucurbiturils for the water-solubility of arenes and aromatic aldehydes is described. (sioc-journal.cn)
Water-Solubilization of Acyclic Cucurbiturils for Arenes and Aromatic Aldehydes and the Promotion for the Generation of Two Hydrazine-Based Macrocycles[J]. Chinese Journal of Organic Chemistry , 2020, 40(3): 663-668. (sioc-journal.cn)
Schiff bases resulted from aromatic aldehydes ortho-substituted with a hydroxyl group have initially arouse the researchers interest because of their ability to act as bidentante ligands for transitional metal ions [ 1 ]. (tsijournals.com)
Later, in studies concerning quantitative structure antitumor activity relationship of a series of Schiff bases derived from variously substituted aromatic amines and aldehydes, it has been shown that azomethines from salicylaldehydes gave the best correlation. (tsijournals.com)
In the present investigation, the chalcone intermediates are synthesized by Claisen-Schmidt condensation reaction between acetanilide and appropriate aromatic aldehydes. (ijpsr.com)
Acetanilide (1, 1 mmole), dissolved with appropriate aromatic aldehydes (2, 1 mmole) in 95% of ethanol solvent (10 mL) and 2N sodium hydroxide (3 mL), taken into a 100 ml conical flask. (ijpsr.com)
Within this sense, some curcumin 3,4-dihydropyrimidinones/thiones/imines 7 had been synthesized in 90C96% produce Menadiol Diacetate through a one-pot multicomponent cyclocondensation response between curcumin (5), substituted aromatic aldehydes 1 and urea/thiourea/guanidine 6 in the current presence of chitosamine hydrochloride being a biodegradable and nontoxic catalyst under solvent-free microwave irradiation (MWI) (System 2). (engineering-gdfsuez.com)
Researchers at Astex have systematically cataloged several dozen of these, which include such simple entities as amines, acids, aromatic chlorides, and more abstract concepts such as a 1-bond donor-acceptor (think pyrazole). (blogspot.com)
Amines2
Many commercial inhibitors include aldehydes or amines, but presumably due to the C=N bond the Schiff bases function more efficiently in many cases. (tsijournals.com)
The reaction of amines with aldehydes and ketones has been exploited for over 150 years to produce Schiff bases, one of the most popular classes of compounds in both organic and coordination chemistry. (figshare.com)
Synthesis7
Often, the synthesis of five-membered rings such as isoxazoles, triazoles, pyrazoles, etc. has been performed by using these intermediates through a two-step or even by one pot procedures. (eurekaselect.com)
16. Synthesis and evaluation of antimicrobial and anticancer activities of 3-phenyl-1-phenylsulfonyl pyrazoles containing an aminoguanidine moiety. (nih.gov)
Among Pyrazoles, 2-pyrazolines are widely used as useful synthons in organic synthesis and having various biological activities 7, 8 . (ijpsr.com)
Shishkin, O. V. One-pot synthesis of CF3-substituted pyrazolines / pyrazoles from electron-deficient alkenes / alkynes and in situ generated CF3CHN2. (knu.ua)
It is utilized in solid phase peptide synthesis and in the optical purity determination of alfaamino aldehyde. (sagarlifescience.in)
3Aminobenzonitrile was used in the synthesis of series of 1substituted3(5)(6methylpyridin2yl)4(quinoxalin6yl)pyrazoles. (sagarlifescience.in)
The present invention is directed to a synthesis of a dual-target inhibitor of cannabinoid-1 (CB1R) receptor and inducible nitric oxide synthase, and more specifically, to an improved process for synthesis of (S,1E,NE)-N-(1-aminoethylidene)-3-(4-chlorophenyl)-4-phenyl-N'-((4-(trifluoromethyl)phenyl)sulfonyl)-4,5-dihydro-1H-pyrazole-1-carboximidamide. (nih.gov)
Aryl2
Multicomponent reaction between malononitrile ( 1 ), hydroxylamine hydrochloride ( 2 ) and different aryl or heteroaryl aldehydes 3a - i afforded novel 5-amino-isoxazole-4-carbonitriles 4a - i in good product yields and short reaction times. (biomedcentral.com)
Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases (SBJ-Ia-l). (ajrconline.org)
Intermediates1
Treatment of the appropriate tryptophan methyl ester under Pictet-Spengler conditions in the presence of the appropriate aldehydes provided intermediates 1 . (med-abstracts.com)
Heteroaryl1
Substituted heteroaryl aldehyde ( 3a , b ) was synthesized from 5-chloro-3-methyl-1-phenyl-1 H -pyrazole-4-methyl-carbaldehyde on protection with ethylene glycol followed by treatment with 4-amino triazole/5-amino tetrazole and then deprotection using acid. (nih.gov)
Ketones2
Appropriate enolates, in a number of synthetic approaches, are easily formed in situ from a variety of carbonyl compounds (aldehydes, ketones, amides, etc.) and used for the ring construction of (poly)substituted heterocycles. (eurekaselect.com)
It is known to have a role to play for chemical glycosylation reactions and is required for the protection of ketones or aldehydes. (sagarlifescience.in)
Hydrazide1
also, the reactivity of the hydrazide toward carbon electrophiles (different aldehydes, ethyl acetoacetate, acetyl acetone, cylohexanone, phthalic anhydride, and maleic anhydride) was investigated with the aim of obtaining some interesting heterocyclic compounds. (tsijournals.com)
Triazoles1
This account particulars our efforts in the direction of broadening the unreal utility of the Bestmann-Ohira reagent and related compounds for the preparation of azaheterocycles akin to pyrazoles, spirooxindoles, triazoles, triazolines, and spiropyrazolines, emphasizing on domino multicomponent reactions utilizing out there feedstock reagents. (tissue-cell-culture.com)
Alkynes1
In this context, the Bestmann-Ohira reagent has flip right into a broadly identified reagent for the 1,3-dipolar cycloaddition reactions to provide phosphonylated heterocycles, other than its widespread use as a homologating agent for the conversion of aldehydes to alkynes. (tissue-cell-culture.com)
Cycloaddition1
Kazuaki Ishihara of Nagoya University developed a Cu catalyst that mediated the Diels-Alder cycloaddition of the acyl pyrazole 21 with isoprene 22 , leading to the ester 23 ( Synlett 2022 , 33 , 585. (organic-chemistry.org)
Compounds1
Ten pharmacologically and synthetically important ( E )-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones 4a-j ) were chosen as model compounds for this study. (hindawi.com)
Zhou1
14. Y. Zheng, L. Cui, Y. Wang, Z. Zhou*, Stereocontrolled construction of tetrahydropyrano[2,3-c]pyrazole scaffold via an organocatalyzed formal [3+3] annulation, J. Org. (nankai.edu.cn)
Reactions1
First of all, condensation reactions of acetohydrazide with different aldehydes were carried out, 7 hydrazones were obtained. (ktu.lt)
Ethylene1
The clusters 1-4 catalyse the hydroformylation of ethylene and propylene to give the corresponding aldehydes, 2 showing higher activities than those observed for Ru-3(CO)(12) and Ru-3(CO)(10)(dppc). (unine.ch)
Acid2
The compound is an amide which combines a pyrazole acid with a substituted phenethylamine to give an inhibitor of succinate dehydrogenase. (wikipedia.org)
This, in turn, is reduced with sodium cyanoborohydride to give the amine required for amide formation with the acid chloride of the pyrazole. (wikipedia.org)