• sedative
  • Withdrawal from GABAergic-acting sedative-hypnotic drugs causes acute GABA underactivity as well as glutamate overactivity, which can lead to sensitization and hyper-excitability of the central nervous system, excito-neurotoxicity, and increasingly profound neuroadaptions. (wikipedia.org)
  • intoxication
  • Approximately 3 percent of people who are alcohol dependent experience psychosis during acute intoxication or withdrawal. (wikipedia.org)
  • Repeated acute intoxication followed by acute withdrawal is associated with profound behavioural changes and neurobiological alterations in several brain regions. (wikipedia.org)
  • Short-term effects of alcohol consumption include intoxication and dehydration. (wikipedia.org)
  • This is about six times the level of ordinary intoxication (0.08%), but vomiting or unconsciousness may occur much sooner in people who have a low tolerance for alcohol. (wikipedia.org)
  • detoxification
  • As such, the term "detoxification" may be somewhat of a misnomer since the process need not refer exclusively to the removal of toxic substances from the body. (wikipedia.org)
  • Detoxification may or may not be indicated depending upon an individual's age, medical status, and history of alcohol intake. (wikipedia.org)
  • onset
  • Patients should never try to tackle the task of discontinuing barbiturates without consulting a doctor due to the high lethality and relatively sudden onset of the withdrawal, attempting to quit "cold turkey" may result in serious neurological damage, severe physical injuries received during convulsions, and even death via glutamatergic excitotoxicity. (wikipedia.org)
  • Psychosocial
  • The effects of an alcohol-related psychosis include an increased risk of depression and suicide as well as psychosocial impairments. (wikipedia.org)
  • acutely
  • Stress, hangovers, and the oral contraceptive pill may increase the desire for alcohol because these things will lower the level of testosterone and alcohol will acutely elevate it. (wikipedia.org)
  • impairments
  • This progressively lowers the threshold needed to cause alcohol-related brain damage and cognitive impairments, leading to altered neurological function. (wikipedia.org)
  • addiction
  • Definitions of substance use can vary from substance use once in past month or year, life time use or use characterised by the fully developed syndrome of addiction. (wikibooks.org)
  • As described earlier, drug addiction refers to a behavioral syndrome where the procurement and use of a drug seem to dominate the individual's motivation and where the normal constraints on the individual's behavior seem largely ineffective. (addictionscience.net)
  • Addiction to drugs and alcohol in expecting mothers does not only cause NAS but also an array of other issues which can continually affect the infant throughout his/her lifetime. (wikipedia.org)
  • consumption
  • An abstainer may be subconsciously motivated to resume alcohol consumption, but for a variety of reasons, abstains (e.g. a medical or legal concern precluding use). (wikipedia.org)
  • The Seventh-day Adventist Church encourages the consumption of only clean meats as specified in Leviticus and strongly discourages the consumption of alcohol, smoking, and the use of narcotics. (wikipedia.org)
  • Although even moderate alcohol consumption increased the risk of death in younger people, it has been shown to decrease the risk of death for individuals ages 55+ (due to decreased risk of ischemic heart disease). (wikipedia.org)