Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
Strains of mice2
Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
The suppressive effect of Toxoplasma infection on initiation of memory cells to dinitrophenylated keyhole limpet hemocyanin (DNP-KLH) was drastically different among inbred strains of mice. (uky.edu)
C57BL2
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
C57BL/6 (B6), C57BL/10 (B10), and SJL mice showed markedly suppressed secondary anti-DNP responses when infected. (uky.edu)
Strain3
Together they generated the DBA (Dilute, Brown and non-Agouti) inbred mouse strain and initiated the systematic generation of inbred strains. (wikipedia.org)
Clarence Cook Little begins to develop the first inbred strain, designated DBA for dilute, brown, and non-agouti. (jax.org)
The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
Transgenic1
There are hundreds of established inbred, outbred, and transgenic strains. (wikipedia.org)
Humans3
Mice belong to the Euarchontoglires clade, which includes humans. (wikipedia.org)
This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
Mice are mammals of the clade (a group consisting of an ancestor and all its descendants) Euarchontoglires, which means they are amongst the closest non-primate relatives of humans along with lagomorphs, treeshrews, and flying lemurs. (wikipedia.org)
Clarence Cook L1
In the early part of the 20th century, Harvard undergraduate Clarence Cook Little was conducting studies on mouse genetics in the laboratory of William Ernest Castle. (wikipedia.org)
Rats2
Little and Castle collaborated closely with Abbie Lathrop who was a breeder of fancy mice and rats which she marketed to rodent hobbyists and keepers of exotic pets, and later began selling in large numbers to scientific researchers. (wikipedia.org)
[4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
Lathrop1
Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
Genome Informatics1
The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. (wikipedia.org)
Nomenclature1
1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)
Experiments1
In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
Survival1
for example, it has been suggested that albino alligators have an average survival span of only 24 hours due to the lack of protection from UV radiation and their lack of camouflage to avoid predators. (wikipedia.org)
Genetic3
Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)
These mice have both BALB/c inbred and NIH(S) outbred stock in their genetic background. (vivobio.com)
Note to the Reader Please cite this work as: Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. (nervenet.org)
Genes2
The laboratory mouse genome has been sequenced and many mouse genes have human homologues. (wikipedia.org)
Both H-2-linked and -nonlinked genes appeared to be responsible for the regulation of the immunosuppression, since the suppressive effect of infection in B10.D2 mice, which have the B10 background and the same H-2 haplotype as BALB/c, was weaker than that of B10 mice, but stronger than in BALB/c mice. (uky.edu)
Biomedical research2
Mice have been used in biomedical research since the 17th century (from May 30, 1678) when William Harvey used them for his studies on reproduction and blood circulation and Robert Hooke used them to investigate the biological consequences of an increase in air pressure. (wikipedia.org)
The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
Laboratory4
The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets. (wikipedia.org)
Laboratory mice are usually of the species Mus musculus. (wikipedia.org)
Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse (Peromyscus leucopus) and the North American deer mouse (Peromyscus maniculatus). (wikipedia.org)
The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. (wikipedia.org)
Model2
The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
Abstract The study was aimed to assess impact of high fat diet (HFD) and synthetic human gut microbiota (GM) combined with HFD and chow diet (CD) in inducing type-2 diabetes (T2D) using mice model. (bvsalud.org)
20022
The mice were derived by embryo transfer in 2002 by Taconic US. (vivobio.com)
2002. Cytogenitic studies on the effect of feeding mice with stored wheat grains treated with malathion. (cdc.gov)
Drug1
The same methodology was applied to MEL mice treated with the clinically approved anti-fibrotic drug nintedanib. (ibecbarcelona.eu)
Injection1
In B6 mice, an injection with 1 × 10 2 organisms of T. gondii induced a suppressed elicitation of the memory cells to DNP-KLH. (uky.edu)
Transplantation1
To our knowledge, this is the first study using selected human GM transplantation via culture based method coupled dietary modulation in mice for in vivo establishment of inflammation leading to T2D and gut dysbiosis. (bvsalud.org)
Stomach1
Stomach absorption of intubated insecticides in fasted mice. (cdc.gov)
Study4
During the 18th century Joseph Priestley and Antoine Lavoisier both used mice to study respiration. (wikipedia.org)
Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice. (ac.ir)
This interventional study was conducted on 120 mice in 12 groups. (ac.ir)
1997. Genotoxicity of malathion- a sub-chronic study in mice. (cdc.gov)
Introduction1
The mice were derived by hysterectomy to achieve Germfree status prior to introduction into Restricted Flora™ IBU colonies. (vivobio.com)
Harvard1
William Castle opens Harvard 's Bussey Institution , where many early mouse geneticists get their start. (jax.org)
Groups1
Inbred strains of albino mice were divided into four groups and were fed with CD, HFD, GM+HFD and GM+CD. (bvsalud.org)
Important1
Initially sought as pets, the Granby mice become important in research. (jax.org)
Wide range1
Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
Research1
Dive into the research topics of 'Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice. (uky.edu)
Pets1
Lab mice sold at pet stores for snake food can also be kept as pets. (wikipedia.org)
Effect1
The difference in the suppressive effect of infection between B6 and BALB/c mice was also observed in the primary anti-DNP antibody responses to DNP-KLH. (uky.edu)