• cystic fibrosis
  • The pulmonologist begins the diagnostic process with a general review focusing on: hereditary diseases affecting the lungs (cystic fibrosis, alpha 1-antitrypsin deficiency) exposure to toxins (tobacco smoke, asbestos, exhaust fumes, coal mining fumes) exposure to infectious agents (certain types of birds, malt processing) an autoimmune diathesis that might predispose to certain conditions (pulmonary fibrosis, pulmonary hypertension) Physical diagnostics are as important as in the other fields of medicine. (wikipedia.org)
  • severe
  • More severe degrees of emphysema resulted in a marked increase in total airway resistance due almost entirely to the increase in the peripheral airway component. (ersjournals.com)
  • Severe disease occurs in about 1 in 5,000. (wikipedia.org)
  • The most common cause of severe deficiency is a single base-pair substitution leading to a glutamate to lysine mutation at position 342 (dbSNP: rs28929474), while PiS is caused by a glutamate to valine mutation at position 264 (dbSNP: rs17580). (wikipedia.org)
  • airflow limitation
  • Emphysema, by reducing the elastic recoil of the lung through parenchymal destruction and increase in alveolar size, as well as reducing the elastic load applied to the airways through destruction of alveolar attachments, also contributes to the airflow limitation characteristic of smokers. (ersjournals.com)
  • acute
  • While C1 inhibitor therapy has been used acutely for more than 35 years in Europe in patients with C1 inhibitor deficiency, new methods of treating acute attacks have emerged: a plasma kallikrein inhibitor and the bradykinin receptor antagonist icatibant. (wikipedia.org)
  • resistance
  • This work established the then new, and still prevailing, concept that peripheral airways are the major site of increased resistance and disease in smoke-induced obstructive lung disease, and that significant increases in the resistance of these airways can be present without changes in the total airway resistance of the lung. (ersjournals.com)
  • occurs
  • In its most common form, it presents as marked swelling of the face, mouth and/or airway that occurs spontaneously or to minimal triggers (such as mild trauma), but such swelling can occur in any part of the body. (wikipedia.org)