DomperidoneAkathisiaAbsorptionNauseaPregnancyPatientsIncreaseProblemsTardive DyskinesiaThrombocytopenic purpuraIntravenousHydrochlorideDopamineNeutropeniaPheochromocytomaLeukopeniaNeurolepticSevereSymptomsMotilityLevodopaOccurDisordersPeripheralExposureTabletsDrugsReactionsGastricDosesStomachDurationTreatmentSide effectsMedicationsWeeksStudiesPeopleVomiting associated
Domperidone2
- Accelerated absorption with metoclopramide and domperidone. (addinpharma.com)
- The absorption of paracetamol is increased by metoclopramide and domperidone. (ibnhayyanpharma.com)
Akathisia1
- Common adverse drug reactions (ADRs) associated with metoclopramide therapy include restlessness (akathisia), and focal dystonia. (wikipedia.org)
Absorption1
- With the simultaneous use of metoclopramide may increase absorption of Coritab (Acetaminophen) and its increased concentration in blood plasma. (sdrugs.com)
Nausea1
- Metoclopramide is commonly used to treat nausea and vomiting associated with conditions such as uremia, radiation sickness, cancer and the effects of chemotherapy, labor, infection, and emetogenic drugs. (wikipedia.org)
Pregnancy2
- Metoclopramide has long been used in all stages of pregnancy with no evidence of harm to the mother or foetus. (wikipedia.org)
- A large cohort study of babies born to Israeli women exposed to metoclopramide during pregnancy found no evidence that the drug increases the risk of congenital malformations, low birth weight, preterm birth, or perinatal mortality. (wikipedia.org)
Patients1
- Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
Increase1
- While metoclopramide is used to try to increase breast milk production, evidence for its effectiveness for this is poor. (wikipedia.org)
Problems1
- Metoclopramide is a medication used for stomach and esophageal problems. (wikipedia.org)
Tardive Dyskinesia5
- Metoclopramide can cause tardive dyskinesia (TD), a serious movement disorder that is often irreversible. (nih.gov)
- The majority of reports of tardive dyskinesia occur in people who have used metoclopramide for more than three months. (wikipedia.org)
- Metoclopramide therapy should be discontinued in patients who develop signs or symptoms of tardive dyskinesia. (nih.gov)
- Treatment with metoclopramide for longer than 12 weeks should be avoided in all but rare cases where therapeutic benefit is thought to outweigh the risk of developing tardive dyskinesia. (nih.gov)
- There is no known treatment for tardive dyskinesia, although symptoms may lessen or resolve after metoclopramide discontinuation. (drugs.com)
Thrombocytopenic purpura1
- Hematologic: Agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic purpura. (genesight.com)
Intravenous2
- Intravenous metoclopramide is used in small-bowel follow-through, small-bowel enema, and radionuclide gastric-emptying studies to reduce the time taken for barium to go through the intestines, thus reducing the total time needed for the procedures. (wikipedia.org)
- Relative to an intravenous dose of 20 mg, the absolute oral bioavailability of metoclopramide is 80% ± 15.5% as demonstrated in a crossover study of 18 subjects. (nih.gov)
Hydrochloride4
- Metoclopramide hydrochloride is a white or practically white, crystalline, odorless or practically odorless powder. (nih.gov)
- Each tablet for oral administration contains 5 mg or 10 mg metoclopramide (present as the hydrochloride). (nih.gov)
- Metoclopramide has active ingredients of metoclopramide hydrochloride . (ehealthme.com)
- It is based on metoclopramide hydrochloride (the active ingredients of Metoclopramide) and Metoclopramide (the brand name). (ehealthme.com)
Dopamine2
- The antiemetic properties of metoclopramide appear to be a result of its antagonism of central and peripheral dopamine receptors. (nih.gov)
- Dopamine produces nausea and vomiting by stimulation of the medullary chemoreceptor trigger zone (CTZ), and metoclopramide blocks stimulation of the CTZ by agents like l-dopa or apomorphine which are known to increase dopamine levels or to possess dopamine-like effects. (nih.gov)
Neutropenia1
- Blood disorders including thrombocytopenia, leukopenia, pancytopenia, neutropenia and agranulocytosis, skin rash or other allergic reactions, tissue necrosis of liver or kidney in the case of taking too much acetaminophen, pancreatitis. (daanapharma.com)
Pheochromocytoma1
- Metoclopramide is contraindicated in pheochromocytoma. (wikipedia.org)
Leukopenia1
- Leukopenia and agranulocytosis have occurred. (medicinenet.com)
Neuroleptic1
- [ 1 ] More than 20 different parenteral medications and combinations of medications are used to treat migraine in US EDs, including migraine-specific medications such as sumatriptan and dihydroergotamine (DHE), anti-dopaminergics, such as metoclopramide and the neuroleptic prochlorperazine, opioids, corticosteroids, nonsteroidal anti-inflammatory drugs, and anti-histamines such as diphenhydramine and promethazine. (medscape.com)
Severe1
- However, if severe symptoms are present, therapy should begin with metoclopramide injection (IM or IV). (pfizermedicalinformation.com)
Symptoms3
- If symptoms occur, discontinue metoclopramide and seek immediate medical attention. (nih.gov)
- Metoclopramide is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis. (pfizermedicalinformation.com)
- Administration of Metoclopramide Injection, USP up to 10 days may be required before symptoms subside, at which time oral administration of metoclopramide may be instituted. (pfizermedicalinformation.com)
Motility3
- Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. (nih.gov)
- The effect of metoclopramide on motility is not dependent on intact vagal innervation, but it can be abolished by anticholinergic drugs. (nih.gov)
- Metoclopramide should not be used whenever stimulation of gastrointestinal motility might be dangerous, e.g., in the presence of gastrointestinal hemorrhage, mechanical obstruction or perforation. (pfizermedicalinformation.com)
Levodopa1
- Nitrophenolic herbicides dinitrophenol (dnp) and substituted bromocriptine fluvoxamine benzamides levodopa levodopa pergolide clebopride antipsychotics metoclopramide carbon monoxide has a strong urge to pass through the process of human chorionic gonadotropin (hcg) is a reection of the body. (reflectionsbodysolutions.com)
Occur1
- Some side effects of metoclopramide may occur that usually do not need medical attention . (drugs.com)
Disorders1
- Metoclopramide may be the most common cause of drug-induced movement disorders. (wikipedia.org)
Peripheral1
- Metoclopramide inhibits the central and peripheral effects of apomorphine, induces release of prolactin and causes a transient increase in circulating aldosterone levels, which may be associated with transient fluid retention. (nih.gov)
Exposure1
- A large cohort study in Denmark found, in addition, no association between metoclopramide exposure and miscarriage. (wikipedia.org)
Tablets2
- These highlights do not include all the information needed to use METOCLOPRAMIDE TABLETS safely and effectively. (nih.gov)
- See full prescribing information for METOCLOPRAMIDE TABLETS. (nih.gov)
Drugs1
- There may be a drug interaction between Trimetazidine and other drugs such as Metoclopramide, isocarboxazid, phenelzine, selegiline, tranylcypromine. (canadapharmacyonline.com)
Reactions1
- Common adverse drug reactions (ADRs) associated with metoclopramide therapy include restlessness (akathisia), and focal dystonia. (wikipedia.org)
Gastric4
- Metoclopramide increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. (nih.gov)
- Metoclopramide also abolishes the slowing of gastric emptying caused by apomorphine. (nih.gov)
- Metoclopramide Injection, USP may be used to stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and/or small intestine. (pfizermedicalinformation.com)
- If only the earliest manifestations of diabetic gastric stasis are present, oral administration of metoclopramide may be initiated. (pfizermedicalinformation.com)
Doses1
- For doses in excess of 10 mg, Metoclopramide Injection, USP should be diluted in 50 mL of a parenteral solution. (pfizermedicalinformation.com)
Stomach1
- Metoclopramide is a medication used for stomach and esophageal problems. (wikipedia.org)
Duration1
- The incidence of side effects correlates with dose and duration of metoclopramide (the active ingredient contained in Reglan) therapy. (drugs.com)
Treatment2
- The physician should make a thorough assessment of the risks and benefits prior to prescribing further metoclopramide treatment. (pfizermedicalinformation.com)
- Prolonged treatment with metoclopramide (greater than 12 weeks) should be avoided in all but rare cases where therapeutic benefit outweighs the risks. (drugs.com)
Side effects3
- We study 76,991 people who have side effects when taking Metoclopramide. (ehealthme.com)
- 76,991 people reported to have side effects when taking Metoclopramide. (ehealthme.com)
- Metoclopramide may increase the side effects of antipsychotic agents. (medicinenet.com)
Medications1
- In 2012, metoclopramide was one of the top 100 most prescribed medications in the United States. (wikipedia.org)
Weeks1
- The preferred parenteral solution is Sodium Chloride Injection (normal saline), which when combined with Metoclopramide Injection, USP, can be stored frozen for up to 4 weeks. (pfizermedicalinformation.com)
Studies1
- Metoclopramide, prochlorperazine, and sumatriptan each had multiple class 1 studies supporting acute efficacy, as did dexamethasone for prevention of headache recurrence. (medscape.com)
People1
- The phase IV clinical study analyzes which people take Metoclopramide and have Monoclonal gammopathy. (ehealthme.com)
Vomiting associated1
- Metoclopramide Injection, USP is indicated for the prophylaxis of vomiting associated with emetogenic cancer chemotherapy. (pfizermedicalinformation.com)