Agonists receptors adrenergic. Medical search. Frequent questions

Beta-adrenergic receptor agonists delay while antagonists acce. (mysciencework.com)
Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epithelium. (mysciencework.com)
Conversely, beta-adrenergic receptor antagonists accelerate CEC migration, enhance electric field-mediated directional migration, and promote corneal wound repair. (mysciencework.com)
The H2 antagonists are highly selective, do not affect the H1 receptors, and are not anticholinergic agents. (medscape.com)
Signaling is regulated by the interactions between receptors and their ligands, it can be stimulated by agonists, or inhibited by antagonists or inverse agonists. (biomedcentral.com)
Machine learning well suits this purpose by extracting complex relationship from experimental data and classification algorithms are typically adapted to distinguish agonists from antagonists [ 4 , 5 ]. (biomedcentral.com)
However, their application is limited to well-studied protein targets with many known agonists and antagonists. (biomedcentral.com)
While agonist ligands are known to have a higher binding affinity for the active state, and antagonists for the inactive state[ 12 ], the structures of the binding pocket in both states tend to be very similar [ 11 ]. (biomedcentral.com)
Methods Using an extensive range of pharmacological tools, the relaxant potential of PGE 2 and selective agonists for the EP 1-4 receptors in the presence and absence of selective antagonists in guinea pig, murine, monkey, rat and human isolated airways was investigated. (bmj.com)
This especially applies to the use of ß or a adrenergic receptors agonists/antagonists (e.g., ß-blockers). (who.int)

Most agonists of the beta receptors are selective for one or more beta-adrenoreceptors. (wikipedia.org)
For example, patients with low heart rate are given beta agonist treatments that are more "cardio-selective" such as dobutamine, which increases the force of contraction of the heart muscle. (wikipedia.org)
Selected examples are: Arformoterol Buphenine Clenbuterol Dopexamine (β1 and β2) Epinephrine (non-selective) Fenoterol Formoterol Isoetarine Isoprenaline (INN), isoproterenol (USAN) (β1 and β2) Levosalbutamol (INN), levalbuterol (USAN) Orciprenaline (INN), metaproterenol (USAN) Pirbuterol Procaterol Ritodrine Salbutamol (INN), albuterol (USAN) Salmeterol Terbutaline These agents are also listed as agonists by MeSH. (wikipedia.org)
Synthesis and in vitro characterisation of N -[5-(4,5-dihydro-1 H -imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α 1A receptor agonist. (rndsystems.com)
A-61603, a potent α 1 -adrenergic receptor agonist, selective for the α 1A receptor subtype. (rndsystems.com)
Previously, descriptions of pharmacological effects associated with 'non-selective' β-adrenergic receptor agonists used to manage pulmonary diseases such as asthma or COPD necessarily include unwanted side effects often due to β 1 adrenergic receptor activation. (pharmacology2000.com)
Other medications, which are relatively selective for β 2 -adrenergic receptors, retain the benefits in management of asthma and COPD, while limiting adverse effects mediated by β 1 -adrenergic receptor activation. (pharmacology2000.com)
At higher doses β 2 -selective adrenergic agonists are still able to activate β 1 -receptors, again emphasizing the role of drug concentration in drug specificity. (pharmacology2000.com)
The premise of β 2 -agonist-mediated receptor activation (applying also to 'non-selective' β-receptor agonists) is based on both smooth muscle relaxation and reduced airway resistance. (pharmacology2000.com)
is a commonly used selective β 2 -adrenergic receptor agonist that may be administered either orally or by inhalation. (pharmacology2000.com)
When comparing the non-selective adrenergic agonist isoproterenol to albuterol, at doses that produce comparable bronchodilation, albuterol will exhibit substantially less cardiac stimulation. (pharmacology2000.com)
These data explain the lack of bronchodilator activity observed with selective EP 2 receptor agonists in clinical studies. (bmj.com)

The best models applied to post-process raw data from retrospective virtual screening obtained by docking of test libraries effectively filtered out irrelevant poses, discarding inactive and non-agonist ligands while identifying agonists. (biomedcentral.com)
Assessing the binding of 17 ligands of varying efficacy to the β2AR in the absence and presence of Nb60 or Nb80 reveals large ligand-specific effects that can only be explained using an allosteric model which assumes equilibrium amongst at least three receptor states. (nih.gov)
These data demonstrate that ligands can initiate a wide range of cellular responses by differentially stabilizing multiple receptor states. (nih.gov)

The interaction of isoproterenol with β‐adrenergic receptor (βAR) binding sites was measured in membranes prepared from rat brain cerebral cortical slices previously incubated in the presence or absence of γ‐aminobutyric acid (GABA) receptor agonists. (johnshopkins.edu)
The results suggest that GABA B , but not GABA A , receptor activation modifies the coupling between βAR and stimulatory guanine nucleotide‐binding protein, which may in part explain the ability of baclofen to augment isoproterenol‐stim‐ulated cyclic AMP accumulation in brain slices. (johnshopkins.edu)
Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. (rndsystems.com)

We propose that the mechanism for the pro-motogenic effect of the beta-adrenergic antagonist is blockade of the beta2-adrenergic receptor preventing autocrine catecholamine binding. (mysciencework.com)
agonist triggers signaling, unlike antagonist and inverse agonist (henceforth referred to as antagonist too, for simplicity). (biomedcentral.com)
Although much is known about the characteristics of DA D2 receptor antagonism on effort-related choice behavior, less is known about the effects of D1 antagonism, and agonist/antagonist interactions. (nih.gov)
Cirazoline is a full agonist at the α 1A adrenergic receptor , a partial agonist at both the α 1B and α 1D adrenergic receptors, [1] and a nonselective antagonist to the α 2 adrenergic receptor . (wikipedia.org)
Avoid use of amisulpride, a dopamine receptor antagonist, with dopamine agonists. (medscape.com)

However, how agonists with varying efficacy modulate these receptor states to initiate cellular responses is not well understood. (nih.gov)
Agonists generally exert efficacy by stabilizing the active Nb80-stabilized receptor state (R80). (nih.gov)
Recent research has revealed that β 2 - Adrenergic receptor (β 2 -AR) agonists lose bronchodilatory efficacy because the receptor-mediated molecular pathways responsible for their beneficial actions are desensitized by infection. (monash.edu)
Although GABA activates synaptic (αβγ) GABA A receptors with high efficacy, partial agonist activation of αβγ isoforms and GABA activation of the primary extrasynaptic (αβδ) GABA A receptors are limited to low-efficacy activity, characterized by minimal desensitization and brief openings. (jneurosci.org)
The unusual sensitivity of αβδ receptor channels to neurosteroid modulation prompted investigation of whether this high sensitivity was dependent on the δ subunit or the low-efficacy channel function that it confers. (jneurosci.org)
αβγ) of neurosteroid modulation could be reversed by conditions that reversed isoform-specific activity modes, including the use of β-alanine to achieve increased efficacy with αβδ receptors and taurine to render αβγ receptors low efficacy. (jneurosci.org)
We suggest that neurosteroids preferentially enhance low-efficacy GABA A receptor activity independent of subunit composition. (jneurosci.org)
Allosteric conversion of partial to full agonism may be a general mechanism for reversibly scaling the efficacy of GABA A receptors to endogenous partial agonists. (jneurosci.org)
Although the physiological relevance of endogenous partial agonists remains poorly understood, the possibility of reversible augmentation of partial agonist efficacy by endogenous modulators raises the interesting possibility of plasticity at the level of agonist-dependent gating. (jneurosci.org)

Terbutaline sulfate injection, USP is a beta-adrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. (rxlist.com)
Conclusion Identification of the receptor mediating PGE 2 -induced relaxation represents a key step in developing a novel bronchodilator therapy. (bmj.com)
New bronchodilator therapies are needed, given that currently approved bronchodilators such as long-acting β 2 adrenoceptor agonists often fail to relieve symptoms of COPD and severe asthma and safety concerns have been raised over long-term use. (bmj.com)

studies have shown that the R- and S-enantiomers of racemic albuterol, a β 2 -adrenergic receptor agonist used in asthma treatment, have differential effects on the contractile properties of airway smooth muscle. (scirp.org)
This observation illustrates the relatively weaker albuterol β 1 -receptor activating property compared to its effect at β 2 receptor sites. (pharmacology2000.com)

To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)

Different conditions were tested: low to high affinity agonists, varying simulation duration, considering or ignoring hydrophobic contacts, and tuning of the classifier parametrization. (biomedcentral.com)
Scholars@Duke publication: A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. (duke.edu)
Activation of guanyl nucleotide regulatory proteins (G proteins) by hormones and neurotransmitters appears to require the formation of high affinity agonist-receptor-G protein ternary complexes. (duke.edu)
Nevertheless, D267-273 exhibited high affinity agonist binding identical to that of the wild-type receptor. (duke.edu)
These findings indicate that the formation of high affinity agonist-receptor-Gs complexes is not sufficient to fully activate Gs. (duke.edu)
We show that Nb60 stabilizes a previously unappreciated low-affinity receptor state which corresponds to one of two inactive receptor conformations as delineated by X-ray crystallography and NMR spectroscopy. (nih.gov)
We find that the agonist isoprenaline has a 15,000-fold higher affinity for β2AR in the presence of Nb80 compared to the affinity of isoprenaline for β2AR in the presence of Nb60, highlighting the full allosteric range of a GPCR. (nih.gov)
Both GABA and baclofen, but not isoguvacine, altered βAR agonist binding by increasing the affinity of both the low‐ and high‐affinity binding sites and by increasing the proportion of low‐affinity receptors. (johnshopkins.edu)
Pharmacological activity is mediated by the R-form, which exhibits about 100 times more affinity for the β-receptor compared to the S-form. (pharmacology2000.com)

In contrast, for a number of partial agonists, both stabilization of R80 and destabilization of the inactive, Nb60-bound state (R60) contribute to their ability to modulate receptor activation. (nih.gov)

When tested with beta-adrenergic agonists, the maximal adenylyl cyclase response mediated by this mutant receptor was less than one-half of that seen with the wild-type receptor. (duke.edu)

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. (jci.org)
Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. (jci.org)
report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. (jci.org)

Coincidently we used a disease model to mirror the treatment of acetylcholine receptor deficiency, and demonstrate improved muscle fatigue, improved neuromuscular transmission and improved synaptic structure resulting from the addition of the β2-adrenergic agonist salbutamol to the anticholinesterase medication pyridostigmine. (ox.ac.uk)
In conclusion, we demonstrate for the first time how the improvement seen in patients from adding salbutamol to their medication can be explained in an experimental model of acetylcholine receptor deficiency, the most common form of congenital myasthenic syndrome. (ox.ac.uk)
Importantly, PGE 2 causes heterologous β 2 -AR desensitization and reduces cAMP production in response to short-Acting (salbutamol) and long-Acting (formoterol) β 2 -Agonists. (monash.edu)

Carazolol occupies a similar position as the rhodopsin inverse agonist, retinal. (proteopedia.org)

By binding to specific receptor-sites these agents appear to potentiate the effects of gamma-aminobutyric acid (GABA) and facilitate inhibitory GABA neurotransmission and other inhibitory transmitters. (medscape.com)
Activation of these receptors enhances the effects of GABA. (medscape.com)
Many GABA A receptor modulators exhibit clear subunit selectivity ( Olsen and Macdonald, 2002 ). (jneurosci.org)
It is even more intriguing to consider the potential plasticity of allosteric modulation given the observation of agonist-dependent functional properties of GABA A receptors. (jneurosci.org)

Receptor subtype involved in α 1A -adrenergic receptor-mediated Ca 2+ signaling in cardiomyocytes. (rndsystems.com)

Thus, glucocorticoids and beta-agonists can participate in the programming of development of postsynaptic reactivity by exerting actions upon post-receptor coupling mechanisms. (rti.org)
Ethanol binds to postsynaptic GABAA receptors (inhibitory neurons). (medscape.com)

These agents are reversible competitive blockers of histamine at the H2 receptors, particularly those in the gastric parietal cells where they inhibit acid secretion. (medscape.com)
Adrenergic blockers include alpha-blockers, beta-blockers, alpha-beta blockers, and peripherally acting adrenergic blockers. (msdmanuals.com)

Proin is the brand name for the alpha-adrenergic agonists medication that veterinarians prescribe most often to treat canine urinary incontinence. (vetinfo.com)

G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins in humans. (biomedcentral.com)
G-protein-coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. (nih.gov)

They express a high level of beta2-adrenergic receptors but their function is unknown. (mysciencework.com)
This study aims to investigate the association between prenatal exposure to terbutaline and other beta2 adrenergic receptor (B2AR) agonists and autism spectrum disorders (ASDs). (kaiserpermanente.org)
In this model, Beta2-Adrenergic Receptor (B2AR) - T4 Lysozyme fusion was developed to allow for structure solution. (proteopedia.org)

Adrenergic alpha-2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Adrenergic+beta-Agonists at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Delbruck, Max. (wikipedia.org)

Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (ebi.ac.uk)

Interactions patterns between a reference agonist and the receptor, here exemplified on the β2 adrenergic receptor, were extracted from molecular dynamics simulations of the agonist/receptor complex and encoded in graphs used to train a one-class machine learning classifier. (biomedcentral.com)
Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. (duke.edu)
Our data thereby suggest that the molecular determinants of the beta 2-adrenergic receptor involved in formation of the ternary complex are not identical to those that transmit the agonist-induced stimulatory signal to Gs. (duke.edu)

Glucorticoids and adrenergic stimulation are both thought to control the development of beta-adrenergic receptors/responses. (rti.org)
In contrast to previous publications, a role for the EP 4 receptor in relaxant responses in human airways in vitro was found. (bmj.com)
A number of clinical studies have reported beneficial effects of inhaled PGE 2 on airway calibre in normal subjects and patients with asthma and COPD, and we have identified a role for the EP 4 receptor in these relaxant responses. (bmj.com)

Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)
The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)

An agent that selectively binds to and activates alpha -adrenergic receptors. (ebi.ac.uk)

Opioid withdrawal is treated with a long-acting opioid agonist, such as methadone 20-35 mg/d or buprenorphine 4-16 mg/d, and then tapered over days to weeks. (medscape.com)
Differences in µ-opioid receptors in the human brain [Time Frame: The 11C-carfentanil binding potential (BP) will be analyzed 45 minutes after the consumption of the two meals (high or low-hedonic reward). (who.int)

Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)
Usage information: Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)
Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis. (jci.org)

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
To date, however, mutagenesis studies with the beta 2-adrenergic receptor have not clarified this question since mutant receptors with impaired abilities to activate Gs have generally possessed a diminished capacity to form the ternary complex as assessed in binding assays. (duke.edu)

In the current study, rats were exposed to dexamethasone or terbutaline during late gestation and the development of beta-receptor binding capabilities and adenylate cyclase activity evaluated in membrane preparations from kidney and lung. (rti.org)
Although dexamethasone and terbutaline also caused significant changes in development of beta-receptor binding capabilities, in neither tissue could these effects account for the direction or magnitude of the changes in adenylate cyclase reactivity. (rti.org)
Exposure to B2AR agonists other than terbutaline was not associated with an increased risk for ASDs. (kaiserpermanente.org)
Terbutaline Sulfate Injection is a beta-adrenergic receptor agonist used for the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema . (rxlist.com)

We demonstrate that CECs express key enzymes required for epinephrine (beta-adrenergic receptor agonist) synthesis in the cytoplasm and can detect epinephrine in cell extracts. (mysciencework.com)
Indications of administration for β agonists include: Bradycardia (slow heart rate) Asthma Chronic obstructive pulmonary disease (COPD) Heart failure Allergic reactions Hyperkalemia Beta blocker poisoning Premature labor (this is an off-label use and could be detrimental) Although minor compared to those of epinephrine, beta agonists usually have mild to moderate adverse effects, which include anxiety, hypertension, increased heart rate, and insomnia. (wikipedia.org)
Epinephrine belongs to a class of drugs called alpha-adrenergic and beta-adrenergic receptor agonists. (medicalnewstoday.com)

Exposure to B2AR agonists during 30 days prior to conception and each trimester of pregnancy was ascertained from prenatal medical records and health plan databases. (kaiserpermanente.org)
The frequency of exposure to any B2AR agonist during pregnancy was similar for mothers of children with ASD and mothers of controls (18.9% vs. 14.8%, P = 0.19). (kaiserpermanente.org)
of B2AR, reducing the basal activity of the receptor. (proteopedia.org)

These data have been confirmed in murine airways from EP 2 receptor-deficient mice ( Ptger2 ). (bmj.com)

Patients with acetylcholine receptor deficiency can also benefit from the addition of a β2-adrenergic receptor agonist to their medication. (ox.ac.uk)
Here, we report the long-term follow-up for the addition of β2-adrenergic agonists for a cohort of patients with acetylcholine receptor deficiency on anticholinesterase medication that demonstrates a sustained quantitative improvement. (ox.ac.uk)

The causes of weak bladder sphincter are age, obesity, reduced sensitivity or neurologic receptors in the sphincter. (vetinfo.com)

A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. (ebi.ac.uk)
ozanimod increases toxicity of fenoldopam by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. (medscape.com)

Therefore, spinal AMPA receptor phosphorylation contributes to the mechanisms underlying stress-induced pain transition. (jneurosci.org)

The D1 agonists SKF38393, SKF81297 and A77636 were assessed for their ability to reverse the effects of ecopipam, and in each case the D1 agonist significantly attenuated the effects of ecopipam, typically with an inverted-u shaped dose/response curve. (nih.gov)
In summary, the present results implicate DA D1 receptors in the regulation of behavioral activation and effort-related functions, and demonstrate the utility of using tests of effort-related choice behavior for assessing the effects of D1 agonists. (nih.gov)
receptors may cause respiratory depression and other undesired effects (e.g. nausea, vomiting, pruritus). (druglibrary.org)

Thus, bacterial infectious stimuli act in a PGE 2 -dependent manner to severely curtail the beneficial actions of β 2 -Agonists. (monash.edu)
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. (rndsystems.com)

This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)
The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries. (rndsystems.com)
Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. (rndsystems.com)

Ligand binding to an extracellular orthosteric pocket propagates conformational change to the receptor cytosolic region to promote binding and activation of downstream signalling effectors such as G proteins and β-arrestins. (nih.gov)
Furthermore, increasing biophysical evidence, primarily using the β2-adrenergic receptor (β2AR) as a model system, supports the existence of multiple active and inactive conformational states. (nih.gov)

This graph shows the total number of publications written about "Adrenergic alpha-2 Receptor Agonists" by people in this website by year, and whether "Adrenergic alpha-2 Receptor Agonists" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Adrenergic alpha-2 Receptor Agonists" by people in Profiles. (rush.edu)
Arbutamine Befunolol Bromoacetylalprenololmenthane Broxaterol Cimaterol Cirazoline Etilefrine Hexoprenaline Higenamine Isoxsuprine Mabuterol Methoxyphenamine Oxyfedrine Ractopamine Reproterol Rimiterol Tretoquinol Tulobuterol Zilpaterol Zinterol Alpha-adrenergic agonist "WHAT ARE BETA-AGONISTS? (wikipedia.org)
It is in a class of medications called centrally acting alpha 2A -adrenergic receptor agonists. (medlineplus.gov)
Other dogs require medications called alpha-adrenergic agonists. (vetinfo.com)
Alpha-adrenergic agonists work by enhancing the release of the neurotransmitter chemicals that increase the sensitivity of the sphincter. (vetinfo.com)
An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. (rndsystems.com)
A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. (rndsystems.com)
Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. (rndsystems.com)
Stuckey et al19 evaluated whether an 8-week and central alpha 2-1 and beta-adrenergic receptors. (bvsalud.org)

Activation of β1 receptors induces positive inotropic, chronotropic output of the cardiac muscle, leading to increased heart rate and blood pressure, secretion of ghrelin from the stomach, and renin release from the kidneys. (wikipedia.org)
Activation of β2 receptors induces smooth muscle relaxation in the lungs, gastrointestinal tract, uterus, and various blood vessels. (wikipedia.org)
Activation of the β3 receptors induces the metabolism of lipids. (wikipedia.org)
Hypoglycemia was also reported due to increased secretion of insulin in the body from activation of β2 receptors. (wikipedia.org)
This finding raises the possibility that discrete regions of the receptor mediate ternary complex formation, whereas different loci may be involved in other aspects of G protein activation. (duke.edu)
[3] Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats. (wikipedia.org)
Salivary seromucous glands are regulated predominantly by parasympathetic activation of muscarinic receptors, resulting in exocrine secretion of mucins and macroglobulin responsible by lubrication and protection of oral mucosa 3-4 . (bvsalud.org)

We have expressed in a mammalian cell line a mutant beta 2-adrenergic receptor comprising a seven-amino acid deletion in the carboxyl-terminal region of its third cytoplasmic loop (D267-273), a region proposed to be critically involved in coupling to Gs. (duke.edu)

2-adrenergic agonists (e.g. clonidine) or with somatostatin. (druglibrary.org)

Short-acting β 2 -adrenergic agonists administered by inhalation represent drugs of choice for management of acute asthma presentations and for prevention of exercise-induced bronchospastic reactions. (pharmacology2000.com)

Anatomy9

Organisms8

Diseases1

Chemicals and Drugs206

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Psychiatry and Psychology2

Phenomena and Processes21

Disciplines and Occupations1

Information Science2

Antagonists10

Selective12

Ligands3

Isoproterenol3

Antagonist5

Efficacy9

Bronchodilator3

Albuterol2

Dopamine1

Affinity9

Partial agonists1

Adenylyl cyclase1

Mirabegron3

Salbutamol3

Inverse agonist1

GABA4

Signaling in cardiomyocytes1

Postsynaptic2

Blockers2

Urinary incontinence1

GPCRs2

Beta23

MeSH2

Stimulate1

Molecular3

Responses3

Pharmacological2

Activates1

Opioid2

Disorders of glucose homeostasis3

Activate2

Terbutaline4

Epinephrine3

B2AR3

Mice1

Medication2

Obesity1

Sympathetic2

Mechanisms1

Effects3

Stimuli2

Subtype3

Conformational2

Alpha10

Activation7

Mammalian1

Clonidine1

Drugs1