Aggressive gene cancer cell tumor cells cultured. Medical search. Frequent questions

This study investigates the role of YB-1 in mediating metastasis in highly invasive breast cancer cell lines. (biomedcentral.com)
The association between YB-1 and coronin-1C offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated. (biomedcentral.com)
Breast cancer is the leading cancer that affects women around the world, where the majority of deaths due to this dreaded disease could be attributed to metastasis. (biomedcentral.com)
Metastasis involves the invasion of cancer cells from the primary tumour site to the surrounding extracellular matrix and stroma, from wherein the cancer cells intravasate, travel through the vasculature and extravasate to form a secondary tumour at a distant site [ 2 ]. (biomedcentral.com)
It is estimated that approximately 10-15% of breast cancer patients, show evidence of distant metastasis within 3 years from the initial detection of the primary tumour [ 3 ]. (biomedcentral.com)
However, in some breast cancer patients, metastasis occurs after 10 years from the initial presentation of the primary tumour [ 4 ]. (biomedcentral.com)
Furthermore, the heterogeneous nature of breast cancer makes it difficult for identification of patients who are at risk of developing metastasis. (biomedcentral.com)
Recent research has shed light on a potential biomarker for early metastasis, namely Y-box binding protein-1 (YB-1) encoded by the YBX1 gene. (biomedcentral.com)
The Waltz laboratory is interested in the molecular mechanisms by which cell-surface receptor tyrosine kinases and growth factors control human disease processes, with a special emphasis on mechanisms regulating cancer growth and metastasis, and inflammation. (uc.edu)
A polyphenol with known anti-inflammatory, antioxidant and antiviral properties, chlorogenic acid has been reported by previous studies to suppress the invasion and metastasis of hepatocellular carcinoma (HCC) cells. (anticancer.news)
The upregulation of these tumor suppressors, in turn, led to the inhibition of HCC cell proliferation, invasion and metastasis. (anticancer.news)
Because of its role in cancer metastasis, the ERK1/2 pathway has become a viable target of conventional cancer treatments, with several inhibitors already approved by the Food and Drug Administration since 2011. (anticancer.news)
Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues. (oncotarget.com)
Important steps during cancer progression are tumor growth and subsequent metastasis. (umassmed.edu)
Subsequently, normal cell-cell interactions between the tumor and surrounding tissues and immune cells begin to breakdown, leading to invasion and eventual metastasis to distant sites. (umassmed.edu)
MCCB researchers focus on a number of different steps in tumor progression and metastasis, using both disease and developmental models. (umassmed.edu)
Metastasis suppressor genes inhibit one or more steps required for metastasis without affecting primary tumor formation. (umassmed.edu)
Due to the complexity of the metastatic process, the development of experimental approaches for identifying genes involved in metastasis prevention has been challenging. (umassmed.edu)
The Green lab developed a genome-wide RNA interference (RNAi) screening strategy that enables the discovery of new genes that regulate metastasis. (umassmed.edu)
2008) A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene. (umassmed.edu)
Associate Professor Margaret Currie is interested in how the tumour microenvironment affects tumour growth, tumour cell metastasis and tumour response to therapy. (otago.ac.nz)
These cells are thought to sustain the growth of the tumor, promote metastasis and lead to relapses. (medicalxpress.com)
The protein phosphatase SHP2 plays a fundamental role in breast cancer proliferation, invasion and metastasis. (medicalxpress.com)
When the scientists depleted SHP2 from breast cancer cells with a small hairpin RNA, it decreased proliferation and invasiveness in 3D cultures, blocked tumor growth and reduced metastasis. (medicalxpress.com)
In Dr. A.M. Shamsuddin's review of findings in Nutrition and Cancer vol. 55, he states that in addition to its role in cancer prevention and control of experimental tumor growth, progression and metastasis, IP6 possesses other significant benefits, such as the ability to enhance the immune system, function as a natural antioxidant, prevent calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. (naturalnews.com)
The epithelial‑mesenchymal transition (EMT) serves vital roles in the angiogenesis, cell invasion and metastasis of various malignant tumors, including bladder cancer. (spandidos-publications.com)
Therefore, PPE and PPII may have antimetastatic effects and PPII may serve as a potential therapeutic option for inhibiting bladder cancer metastasis. (spandidos-publications.com)
Despite the intensive research of the past decades in oncology, cancer invasion and metastasis still represent the most important problem for treatment and the most common cause of death in cancer patients. (units.it)
Metastasis refers to the spread of malignant cells from a primary tumour to distant sites of the body and the adaptation of these cancer cells to a new and different tissue microenvironment. (units.it)
Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
Increasing evidence suggested EMT was involved in cancer invasion, metastasis ( 16 ) and the malignancy of tumors ( 17 ), often marked by reduction of E-cadherin and induction of N-cadherin ( 18 ). (spandidos-publications.com)
Conclusion: Local recurrence after treatment of breast cancer with mastectomy+radiotherapy+/-systemic therapy is associated with a significantly higher risk of distant metastasis and death. (who.int)

This conundrum brings to question whether cancer ST6GAL1 overexpression is beneficial or ultimately detrimental to long-term patient outcomes and highlights the incomplete mechanistic understanding of how ST6GAL1 is involved in cancer progression. (nature.com)
It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
Recent studies indicate that adipose tissue in obesity promotes breast cancer progression by secreting protumorigenic chemokines, growth factors, and fatty acids. (uni-regensburg.de)
Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)
In head and neck cancer, the histologic progression of severity from hyperplasia, dysplasia, and carcinoma in situ to invasion provides a framework to understand the genetic progression of cancer. (medscape.com)
Future studies will involve the utilization of in vivo gene-targeted murine models to study disease progression as well as the isolation and analysis of primary epithelial and stromal cells from the breast and prostate environments. (uc.edu)
Recent studies suggest that coffee and tea, two of the most consumed beverages in the world after water, also contain an active compound that can disrupt the progression of cancer in various ways. (anticancer.news)
Multiple studies have reported that chlorogenic acid is a promising candidate for achieving this , having shown exceptional anticancer activities which include inhibiting cancer cell cycle progression, inducing apoptosis (programmed cell death) and suppressing cancer cell proliferation. (anticancer.news)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
These CSCs are potential driving force of tumor initiation and progression due to their self-renewal and tumorigenic properties [ 5 , 6 ]. (oncotarget.com)
The lab aims to elucidate advantages these metabolic alterations can play in the growth and progression of tumors, and how these changes can be exploited to selective target cancer cells, such as selectively inducing the accumulation of toxic metabolites to poison cancer cells within the tumor. (umassmed.edu)
The Mercurio group is interested in the initiation and progression of epithelial-derived tumors (carcinomas), especially aggressive, poorly differentiated tumors. (umassmed.edu)
However, since 2009 Associate Professor Currie's interests have expanded to include the contribution to tumour progression made by tumour infiltrating immune cell populations, breast cancer stem cell-like populations, and obesity-related factors. (otago.ac.nz)
2012) Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. (medicalxpress.com)
DTL (Cdc10-dependent transcript 2) is a critical regulator of cell cycle progression and genomic stability. (transhumanist.ru)
A clonogenic assay, immunostaining, double thymidine block, imaging flow cytometry analysis, and a tumor spheroid formation assay were used to analyze the role of DTL in tumor cell growth, cell cycle progression, micronucleation, ploidy, and tumorigenicity. (transhumanist.ru)
The goal of our study was the mechanical characterization of cell lines chosen as model of cancer progression using different biophysical techniques and the correlation of the mechanical properties with possible alterations of the cytoskeleton structure and plasma membrane composition. (units.it)
In recent years, epithelial-mesenchymal transition (EMT) has been suggested to play a key role in the process of embryonic development, differentiation of tissues and organs, chronic inflammation and fibrosis, as well as cancer progression ( 14 ). (spandidos-publications.com)

We extended our investigation in vivo and confirmed that mice injected with USP19 depleted cells display increased tumor-free survival, as well as a delay in the onset of the tumor formation and a significant reduction in the appearance of metastatic foci, indicating that tumor cell invasion and dissemination is impaired. (nature.com)
According to a FierceBiotech article, approximately 30% of men who have a type of prostate cancer thought to be curable eventually develop an aggressive metastatic type of the disease. (darkdaily.com)
In addition, we differentiate for the first time the contributions of ERBB1 and ERBB2 to the key metastatic properties of in vivo tumor cell invasion and intravasation. (aacrjournals.org)
In particular, the laboratory has shown that Ron overexpression specific to the breast epithelium is sufficient to induce aggressive breast cancers that are highly metastatic. (uc.edu)
Because metastatic cancers are hard to stop, one of the main focuses of ongoing cancer research is to find ways to kill or suppress the growth of primary tumors and metastatic cancer cells. (anticancer.news)
Usually, millions of cells can be released by a tumour into the circulation every day, but only a tiny minority of these cells are able to reach and colonize a distant organs: the utter inefficiency of the metastatic process implies that cells might strongly need biomechanical alterations that allow them to invade and colonize different tissues. (units.it)
During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)

p21 and other tumor suppressor genes' inactivation are therefore most likely involved in the first steps of the cancer model, with later stages possibly involving protooncogene activation and inflammation. (medscape.com)
According to a study published in the journal Medical Science Monitor , human cancers consistently show alterations in the methylation patterns of tumor suppressor genes. (anticancer.news)
However, the Bergmann Lab has discovered a novel class of tumor suppressor genes: non-autonomous tumor suppressors. (umassmed.edu)

BRCA mutations have also been implicated in breast, ovarian, and pancreatic cancers, among some other types. (darkdaily.com)
The knowledge that BRCA1 and BRACA2 mutations could indicate a more aggressive cancer is likely to spark investigation into whether poly ADP ribose polymerase (PARP) inhibitors could be used as an effective therapy. (darkdaily.com)
The multihit model postulates that several unique genetic mutations combine to cause cancer. (medscape.com)
In colorectal cancer, multiple mutations are present. (medscape.com)
For example, in the hereditary cancer syndromes familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, mutations have been discovered in the APC gene and DNA mismatch repair genes. (medscape.com)
Although the exact process has not been elucidated, the sum of these mutations is believed to lead to cancer development in this model. (medscape.com)
Our findings provide a mechanistic rationale for exploring the therapeutic use of vitamin C to treat colorectal cancers that carry KRAS or BRAF mutations," said senior author Dr. Lewis Cantley, the Meyer Director of the Sandra and Edward Meyer Cancer Center and the Margaret and Herman Sokol Professor in Oncology Research at Weill Cornell Medicine. (crazzfiles.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
With gene-wise functional analyses, we detected a significant correlation between recurrent NOTCH2 noncoding mutations and clinical response to imatinib. (e-crt.org)
Based on Pan-Cancer Analysis of Whole Genomes data analyses, NOTCH2 mutations affect expression levels particularly in the presence of CTNNB1 missense mutations. (e-crt.org)
During tumor growth, normal cellular pathways that prevent growth and protect genome integrity are often blocked due to mutations. (umassmed.edu)
Chronic inflammation increases the risk of cancer and contributes to tumor development through the induction of oncogenic mutations, enhanced angiogenesis and early tumor promotion ( 7 ). (spandidos-publications.com)
They can lead to mutations or increase the error rate during the doubling of the DNA during each cell division. (invitrojobs.com)
Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options. (medindia.net)

In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
It relieved the inhibitory effect of DNMT3A mutation, promoted the phenotypic recovery of the co-cultured macrophages, eliminated resistance, and regulated the immune microenvironment. (frontiersin.org)
Macrophages are the most abundant white blood cells in the immune microenvironment and have a high degree of heterogeneity. (frontiersin.org)
The local tumour microenvironment is the milieu within which the tumour develops, and includes tumour blood vessels, other cells types (e.g. immune cells, fibroblasts, adipocytes), soluble growth factors and signalling molecules. (otago.ac.nz)
All the various components of the tumour microenvironment can influence tumour growth and spread and, conversely, tumour cells can influence the local tumour microenvironment. (otago.ac.nz)
A further layer of complexity exists because the wider tumour microenvironment (i.e. the body within which the tumour develops) alters with age and health, and is affected by systemic changes in metabolism, hormones and immunity. (otago.ac.nz)
The Mackenzie Cancer Research Group has been investigating the contribution of stromal cells and the tumour microenvironment to human tumour biology since the inception of our research group in 1998. (otago.ac.nz)
However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. (lu.se)
Immunotherapy has so far been of little use at treating highly aggressive pancreatic cancer, due to its immunosuppressive tumor microenvironment and lack of neoantigens," Dr. Gravekamp said. (pancan.org)

Here, we report pathological expression of HML-2 in malignant gliomas in both cerebrospinal fluid and tumor tissue that was associated with a cancer stem cell phenotype and poor outcomes. (bvsalud.org)
Furthermore, ACM-treated TNBC cells displayed a pronounced aggressive cell phenotype, with enhanced wound healing, proliferation, and invasion capabilities. (uni-regensburg.de)
Together, our data suggest that factors released by adipose tissue change PPAR-regulated gene expression and lipid metabolism and induce a more aggressive TNBC cell phenotype. (uni-regensburg.de)
The immediate goals for these projects are to understand the physiological signaling pathways that control the aggressive tumor phenotype downstream of Ron signaling. (uc.edu)
We are culturing human fat cells (adipocytes) and tumour cells together, to find out how adipocytes alter tumour cell phenotype and response to therapy. (otago.ac.nz)

One such study into the genetic pathways of prostate cancer is bringing precision medicine ever-closer to the anatomic pathology laboratory. (darkdaily.com)
The pathways that we discovered to be abnormal in the localized BRCA2-associated cancers are usually only found in general population cancers when they become resistant to hormone therapy and spread through the body," noted Bristow in the ScienceDaily release. (darkdaily.com)
In addition, the laboratory plans to use orthotopic transplantation of gene-modified cell lines into syngeneic models to explore these signaling pathways in detail. (uc.edu)
In addition, the researchers reported that chlorogenic acid inactivated ERK1/2, which has been described as " one of the most commonly dysregulated [signaling] pathways in human cancers. (anticancer.news)
Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Designed to mimic the neural pathways of the brain, the device allows for real-time monitoring of tumor cell adhesion and growth. (sciencedaily.com)
The Kim lab investigates how various metabolic pathways, such as amino acid biosynthesis pathways, in a tumor cell relative to normal tissues. (umassmed.edu)
KEGG enrichment and gene set enrichment analysis (GSEA) showed that a large number of genes were enriched in inflammatory immune-related pathways, such as the toll-like receptor signaling pathway. (frontiersin.org)
Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. (jci.org)
According to Dr. Shamsuddin, when IP6 is administered it is rapidly taken into the cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways. (naturalnews.com)

membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. (cancerindex.org)
Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
This type of cancer is associated with aggressive behavior and an overall poor prognosis 16 . (nature.com)
The epidermal growth factor receptor (ERBB1) and related family member HER-2/ neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. (aacrjournals.org)
The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
A few gene therapy trials now target head and neck cancer, which makes up only 4% of all cancers but has a dismal prognosis in advanced stages. (medscape.com)
Researchers in this group are identifying mechanisms that account for the loss of differentiation and the highly aggressive behavior of these tumors, and exploiting these mechanisms to improve prognosis and therapy. (umassmed.edu)
Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research describe how the protein phosphatase SHP2 promotes breast cancer with poor prognosis. (medicalxpress.com)
These genes are activated in a large subset of primary breast tumors associated with invasive behavior and poor prognosis . (medicalxpress.com)
Cells were chosen according to the nowadays accepted classification of breast cancer based on gene expression pattern and proteomic expression, which divide breast cancers in subtypes that differ in terms of risk factor, distribution, prognosis, therapeutic treatment responsiveness, clinical outcomes and survival. (units.it)
In some cases, the disease can heal and disappear by itself, but aggressive forms of neuroblastoma have a more unfavorable prognosis. (gu.se)
A few gene therapy trials now target head and neck cancer, which comprises only 4% of all cancers but has a dismal prognosis in advanced stages. (medscape.com)

Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. (hindawi.com)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
These CSCs, which were found to overexpress tumor promoter caveolin-1 (Cav-1), displayed aggressive cancer phenotypes of apoptosis resistance and enhanced cell invasion and migration compared with their non-CSC counterpart. (oncotarget.com)
Normally, cells which have lost a classical tumor suppressor gene become highly proliferative and resistant to apoptosis, thus permitting autonomous tumor growth. (umassmed.edu)
The degree of methylation affects the expression of target genes and has a significant impact on cell proliferation, apoptosis, cytokine secretion, and cell activity ( 6 , 7 ). (frontiersin.org)
Apoptosis (necessary programmed cell death) of the adenocarcinoma cells was increased. (naturalnews.com)
Researchers concluded that treatment of pancreatic cancer with IP6 significantly decreased cellular growth and increased apoptosis. (naturalnews.com)
In this investigation, the role of autophagy and apoptosis in Solanum nigrum fruit extract-induced cytotoxicity in MDA-MB-468, a triple negative breast cancer cell line was studied. (ijpsonline.com)
In addition, cell apoptosis was measured by double staining, DNA fragmentation and annexin V-fluorescein isothiocyanate binding assays. (ijpsonline.com)
The expression levels of apoptosis-related genes Bcl2 and Bax were determined by real-time PCR. (ijpsonline.com)
These findings indicated that Solanum nigrum extract induced cell death in MDA-MB-468 cells by two distinct mechanisms, apoptosis and autophagy, and these findings further suggest a possibility that this extract could be used to treat triple negative breast cancer. (ijpsonline.com)
Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)
A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)
Autophagy and apoptosis are two forms of programmed cell death, which are essential for cellular homeostasis. (ijpsonline.com)
In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)

In contrast, overexpression of USP19 increased cell invasiveness both in vitro and in vivo, further validating our findings. (nature.com)
Finally, we showed that USP19 overexpression is a surrogate prognostic marker of distant relapse in patients with early breast cancer. (nature.com)
Overexpression and silencing of YBX1 were performed to assess the expression of CORO1C , one of the differentially regulated genes from the transcriptomic analysis. (biomedcentral.com)
The study further revealed that overexpression of DNMT1 is a common feature of invasive tumors , which suggests that it could be associated with the aggressive behavior of certain cancers. (anticancer.news)
We previously showed that VEGF signaling in primary endothelial cell cultures caused overexpression of VEGFR2 in a positive feed-forward loop, which is at least partly regulated by loss of miRNA-mediated control of VEGF receptor degradation. (plos.org)

We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
Instead, the mutant cells influence the behavior of neighboring wild-type (non-mutant) cells and promote their proliferation and increased apoptotic resistance, causing non-autonomous overgrowth. (umassmed.edu)
Their research projects emphasize molecular cell biology but they derive from the analysis and clinical behavior of carcinomas. (umassmed.edu)
Therefore, understanding the molecular basis of the aggressive behavior of grade 4/5 cancer is of considerable clinical relevance. (biomedcentral.com)

Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. (aacrjournals.org)
Acute myeloid leukemia (AML) is a common, heterogeneous, and aggressive hematopoietic malignancy, characterized by apparent genetic abnormalities ( 1 ). (frontiersin.org)
Pancreatic cancer is an aggressive malignancy with less than 5% of the patients alive at 5 years and 92% of the patients dead at 2 years[ 1 , 2 ]. (wjgnet.com)
The cell lines analyzed derive from breast tissue and represent a model of human epithelial cells towards malignancy. (units.it)

In addition, the Waltz group has found that Ron is an important contributing factor controlling the growth of prostate cancers through the regulation of tumor angiogenesis (blood vessel formation). (uc.edu)
Drs. Kim Vanderlinden and Ivana Vucenik describe what is presently known about how IP6 works to help normalize the rate of cell division, normalize cell physiology, enhance Natural Killer (NK) cells, increase tumor suppressor P53 gene activity, inhibit inflammation, and inhibit angiogenesis. (naturalnews.com)
Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. (plos.org)
Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
Angiogenesis - the formation of new blood vessels - occurs during tissue growth and development, but also during wound healing and cancer [1] , [2] . (plos.org)

Specifically, the study focused on Kupffer cell proinflammatory cytokines IL-6 and TNF-α and activation of NF-κB after chronic ethanol feeding followed by in vitro stimulation with lipopolysaccharide (LPS). (uni-frankfurt.de)
In the paper titled 'Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro,' there was an error in the Acknowledgments. (uni-frankfurt.de)
An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
The DNMT3A-mutated AML cells attenuated M1 macrophage polarization and resisted its killing effect in vitro and in vivo . (frontiersin.org)
To investigate the in vitro effects of suicide gene therapy system of herpes simplex virus thymidine kinase gene (HSV-TK) in combination with the treatment of nucleotide analog-ganciclovir (GCV) on human pancreatic cancer, and to provide a novel clinical therapeutic method for human pancreatic cancer. (wjgnet.com)
They hypothesized that IP6 would inhibit the cell growth rate of Barrett's adenocarcinoma in vitro. (naturalnews.com)
As published in Journal of Surgical Research , June 2006, researchers reported that IP6 had previously been shown to have significant inhibitory effects against pancreatic cancer in vitro. (naturalnews.com)
They hypothesized that IP6 would significantly inhibit cell growth of cutaneous melanoma in vitro. (naturalnews.com)
They hypothesized that IP6 would significantly inhibit cell growth and increase the apoptotic rate of pancreatic cancer in vitro. (naturalnews.com)
The present study aimed to screen the sensitivity of bladder cancer to natural compounds by using six classic anti‑inflammatory and detoxifying herbs, including the ethanol extract of Paris polyphylla (PPE), Scutellaria barbata, Pulsatillae decoction, Dahuang Huanglian Xiexin decoction, Bazhengsan and Hedyotis diffusa combined with S. barbata, were used to treat bladder cancer cells in vitro. (spandidos-publications.com)
In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)

Alteration or exacerbation of malignant tumor cell migration and dissemination is the principal cause of death due to solid tumors 5 . (nature.com)
Evolving research in stem cells and cancer biology have provided strong evidence for the existence of cancer stem cells (CSCs) in various human solid tumors, including brain, breast, bone marrow, prostrate, colon, and lung [ 3 , 4 ]. (oncotarget.com)

Next, they introduced live rodent models with cells that could grow into invasive tumors. (sciencedaily.com)

Cell motility is a complex process that requires post-translational regulation of a wide variety of proteins. (nature.com)
The Chinese researchers found that in both HCC cell cultures and tumor-injected mice, chlorogenic acid treatment suppressed the expression of DNMT1, which significantly enhanced the activities of two tumor suppressor proteins, namely, p53 and p21. (anticancer.news)
To achieve this ordering, many cell cycle-regulatory proteins are expressed exclusively when their functions are needed. (umassmed.edu)
In addition, they are investigating how cell cycle-regulation of chromatin proteins helps to coordinate the condensation of chromosomes with their segregation during mitosis. (umassmed.edu)
Resistin significantly promoted the expression of inflammatory proteins in AML cells. (frontiersin.org)
DTL depletion resulted in the disruption of the mitotic proteins cyclin B, CDK1 , securin, seprase, Aurora A, and Aurora B as well as the upregulation of the cell cycle arrest gene [i]p21[/i]. (transhumanist.ru)
We employed a comprehensive approach for global and dynamic profiling of the surfaceome and endocytosed (endocytome) proteins and their regulation by hypoxia in patient-derived GBM cultures. (lu.se)
We provide a quantitative ranking of more than 600 surface resident and endocytosed proteins, and their regulation by hypoxia, serving as a resource to the cancer research community. (lu.se)
Autophagy, the type II cell death, is a physiological mechanism involving degradation of intracellular damaged proteins and organelles into membrane vacuoles. (ijpsonline.com)
They react i.e. also with proteins or immune cells, as is the case with asbestos. (invitrojobs.com)
Neoantigens are small pieces of proteins on cancer cells that stimulate an immune response - they help the patient's immune system differentiate the cancer cells from healthy cells. (pancan.org)
The Gravekamp lab has solicited the help of Listeria monocytogenes to deliver highly immunogenic tetanus toxoid proteins, as a neoantigen surrogate, into tumor cells," Dr. Gravekamp said. (pancan.org)
Once the provirus is integrated into the host cell DNA, it is transcribed using typical cellular mechanisms to produce viral proteins and genetic material. (msdmanuals.com)

This study shows that we can stifle the growth of invasive brain tumors with a compound that has a substantial clinical advantage, and can aid in the reduction or refinement of mainstream treatments, particularly radiation and/or chemo," said Lohitash Karumbaiah, associate professor of regenerative medicine in UGA's College of Agricultural and Environmental Sciences. (sciencedaily.com)
To explore the surfen molecule further, the team worked with Leidong Mao, associate professor in UGA's College of Engineering and co-developer of a microfluidic device used to examine glycosaminoglycans (GAGs) -- highly negatively charged molecules produced by brain tumors. (sciencedaily.com)
Gliomas, especially glioblastomas (GBMs), are the most malignant primary brain tumors[1]. (123dok.net)

Design and Methods Growth in culture, colony formation and oncogenicity in vivo were assessed in mouse primary B cells exogenously expressing various combinations of Bcl2 , Myc and Ccnd1 . (haematologica.org)
Researchers of the study published in the journal Science Translational Medicine stated that they "demonstrate mutant IDH1 -dependent PARP inhibitor sensitivity in a range of clinically relevant models, including primary patient-derived glioma cells in culture and genetically matched tumor xenografts in vivo . (darkdaily.com)
Our studies were designed to evaluate the effect of ERBB inhibition on tumor cell motility and intravasation in vivo using clinically relevant small-molecule inhibitors. (aacrjournals.org)
Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
In this study, we investigated the systemic and hepatic effect of chronic ethanol feeding on in vivo activation of NF-κB in NF-κB(EGFP) reporter gene mice. (uni-frankfurt.de)
Using a combination of cell culture models, molecular biology approaches, and in vivo modeling, the Lewis lab is characterizing the roles of novel factors involved in tumor dissemination. (umassmed.edu)

Results Primary B cells exogenously expressing Bcl2 , Myc and Ccnd1 showed factor-independent growth ability, enhanced colony-forming capability and aggressive oncogenicity, unlike the cases observed with the expression of any combination of only two of the genes. (haematologica.org)
These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)
Tumor volume (V2) was assessed by MRI (on day 13 after treatment) and the tumor growth ratio (V2/V1) was calculated. (uni-frankfurt.de)
Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)
Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)
[ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
In a recent study published in Science, a team of researchers from Weill Cornell Medicine, Cold Spring Harbor Laboratory, Tufts Medical Center, Harvard Medical School and The Johns Hopkins Kimmel Cancer Center found that high doses of vitamin C - roughly equivalent to the levels found in 300 oranges - impaired the growth of mutant colorectal tumors in cultured cells and mice. (crazzfiles.com)
High doses of vitamin C are preferentially delivered to the areas surrounding the tumour because the vitamin molecule looks similar to a sugar molecule and cancer cells have an increased demand for sugar to fuel their unregulated growth. (crazzfiles.com)
For example, plants naturally produce ascorbic acid - also known as vitamin C - because it plays an important role in photosynthesis and is needed for controlling plant cell growth. (anticancer.news)
Consistently, ablation of VCP markedly retarded growth of cultured PDAC cells and xenograft PDAC tumors. (aacrjournals.org)
The UGA researchers identified that surfen-treated cells were "blocked" from tumor growth, and the spread of tumor cells in the brain. (sciencedaily.com)
In the non-treated image, you see rampant invasive growth, compared to the surfen-models where you see a nicely contained and almost circular-shaped tumor. (sciencedaily.com)
As the tumor grows, hypoxia induces the expression of growth factors that stimulate blood vessel formation into and around the tumor, further promoting growth. (umassmed.edu)
They can inhibit the growth of tumor cells, kill them via phagocytosis, and promote anti-tumor immunity. (frontiersin.org)
We are also studying tumour samples from normal weight and obese breast cancer patients to better understand the role adipocytes play in promoting aggressive tumour growth and spread, and identify patients likely to benefit from additional treatment during cancer therapy. (otago.ac.nz)
This population of cells can not only initiate cancer, it may, in some tumor types, also be the one to promote growth, resist therapy, or cause relapse. (medicalxpress.com)
NewsTarget) Three recent studies have confirmed the role of inositol hexaphosphate (IP6) in cancer prevention and control of experimental tumor growth. (naturalnews.com)
Researchers concluded that IP6 decreased cellular growth of these cells by pro-apoptotic mechanisms. (naturalnews.com)
Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. (transhumanist.ru)
DTL depletion inhibited liver cancer cell growth, increased senescence, and reduced tumorigenesis. (transhumanist.ru)
A rescue assay indicated that DTL should be targeted through TPX2 downregulation for cancer cell growth inhibition. (transhumanist.ru)
Moreover, DTL silencing inhibited the growth of patient-derived primary cultured HCC cells. (transhumanist.ru)
VEGF, produced in large amounts by cancer cells during tumor growth, interacts with its receptors VEGFR1 and VEGFR2 thereby causing endothelial cell survival, proliferation, and sprouting [7] . (plos.org)
A tumor means first and foremost a growth or swelling due to increased cell division of tissue. (invitrojobs.com)
Furthermore, we established a BCa cell model with downregulated LAPTM5, revealing a significantly delayed growth rate in the BCa cells with knockdown of LAPTM5. (spandidos-publications.com)
Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)
Such aggressive and invasive growth is the hallmark feature that gives rise to their high morbidity and mortality. (123dok.net)
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer. (medindia.net)
Through their efforts, we are gaining a better understanding of cancer formation and developing diagnostic tools for early detection, while also exploring ways to prevent tumor growth and much more. (lu.se)

AIM: To evaluate and compare the effect of combined transarterial chemoembolization (TACE) and arterial administration of Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats. (uni-frankfurt.de)
Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)

This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
The combination of the personalized cancer vaccine with ACT led to ovarian cancer control in few patients within a span of three months, stated study results. (medindia.net)

However, ST6GAL1 is also released into the extracellular milieu and extracellularly remodels cell surface and secreted glycans. (nature.com)
We hypothesize that ST6GAL1 action is the combined effect of natively expressed sialyltransferase acting cell-autonomously within the ER-Golgi complex and sialyltransferase from extracellular origins acting extrinsically to remodel cell-surface glycans. (nature.com)
Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
Moreover, we discovered that some glioblastoma cells formed immature retroviral virions, and inhibiting HML-2 expression with antiretroviral drugs reduced reverse transcriptase activity in the extracellular compartment, tumor viability, and pluripotency. (bvsalud.org)
but the extracellular acidity characteristic of many tumors would be expected to reduce the activity of this transporter, which has a mildly alkaline pH optimum. (curehunter.com)

Additionally, we demonstrate that HML-2 critically regulated embryonic stem cell programs in NPC-derived astroglia and altered their 3D cellular morphology by activating the nuclear transcription factor OCT4, which binds to an HML-2-specific long-terminal repeat (LTR5Hs). (bvsalud.org)
Our results suggest that HML-2 fundamentally contributes to the glioblastoma stem cell niche. (bvsalud.org)
Because persistence of glioblastoma stem cells is considered responsible for treatment resistance and recurrence, HML-2 may serve as a unique therapeutic target. (bvsalud.org)
This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
Cancer stem cells (CSCs) may represent targets for carcinogenic initiation by chemical and environmental agents. (oncotarget.com)
Cancer stem cells (CSCs) represent a distinct group of cells within cancerous tissue that possess the ability to initiate tumorigenesis and exhibit potency, self-renewal, and drug resistance. (bmrat.org)
A major focus of this work is to define mechanisms that control the genesis and function of cancer stem cells with an emphasis on the role of integrin and VEGF signaling. (umassmed.edu)
When looking at the molecular signaling events after SHP2 depletion, the scientists realized that SHP2 activates transcription factors that are usually associated with stem cells. (medicalxpress.com)
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)
Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
called either cancer stem cells (CSCs) or tumor-initiat-ing cells[3]. (123dok.net)
At the end of 2023, researchers at Lund Stem Cell Center received funding amounting to SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Childhood Cancer Fund. (lu.se)
At Lund Stem Cell Center, researchers are using innovative approaches to advance the field, offering exciting possibilities for the future. (lu.se)
We hope that this new method will foster a culture of proactive health management and shift the paradigm towards preventive care, in addition to paving the way for more effective treatments," says Sandra Linstedt, research group leader at Lund Stem Cell Center. (lu.se)

In order to identify novel molecular targets of tumor cell migration and invasion we performed a genetic screen with an shRNA library against ubiquitination pathway-related genes. (nature.com)
More importantly, we demonstrated that USP19 catalytic activity is important for the control of tumor cell migration and invasion, and that its molecular mechanism of action involves LRP6, a Wnt co-receptor. (nature.com)
To identify novel molecular targets within the ubiquitination pathway that positively regulate migration we conducted a loss-of-function genetic screen using an epithelial cell line derived from human triple-negative breast cancer (MDAMB231) infected with a pooled shRNA interference library. (nature.com)
We confirmed S. haematobium by using molecular analysis of mitochondrial cytochrome oxidase subunit I gene. (cdc.gov)
1 Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana. (aacrjournals.org)
Furthermore, our results provide insights into molecular mechanisms for targeting DTL in liver cancer cells. (transhumanist.ru)
Despite the accumulating knowledge about the biology of PCa, the molecular machineries that differ between grade 3 and 4/5 cancers and mark a critical change from curable to lethal are largely unknown. (biomedcentral.com)
The present treatment regimes are very hard for children to undergo and side effects can have consequences for the rest of their lives," says Ruth Palmer, Professor of Molecular Cell Biology at the University of Gothenburg, who leads one of the research groups behind the new study. (gu.se)

Biochemical and genetic data suggest a role as a tumor suppressor. (cancerindex.org)
Intense efforts to examine genetic alterations in human cancer have provided a catalogue of cancer-causing genes. (haematologica.org)
Genetic alterations of BCL2 (B-cell CLL/lymphoma 2), MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] and CCND1 (cyclin D1) are the most frequently found alterations in human B-cell lymphomas. (haematologica.org)
Thus, a research study that has identified unique genetic features within prostate cancer that can help determine if the cancer is aggressive or not, and whether certain drugs may be effective, is good news for men, for urologists, and for the clinical laboratories that will be called upon to perform testing. (darkdaily.com)
Researchers from the Princess Margaret Cancer Centre , which is associated with the University of Toronto Faculty of Medicine , have discovered that some tumors in prostate cancer have a genetic fingerprint that may indicate whether or not the disease will become more aggressive and less responsive to treatment. (darkdaily.com)
Published in the journal Nature , the researchers examined the genetic sequences of those tumors, looking for differences between those that responded to surgery or radiation and those that did not. (darkdaily.com)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
To validate the genetic interaction with expression level in desmoid-tumor condition, we utilized large-scale whole-genome sequencing and transcriptome datasets from the Pan-Cancer Analysis of Whole Genomes project. (e-crt.org)
Inhibition of VCP either by genetic depletion or the pharmacologic inhibitor CB-5083 increased ubiquitination and degradation of p53-R273H, leading to cell death. (aacrjournals.org)
5 However, tumors can also be of genetic origin or caused by ionizing radiation, viruses or chemical substances (single substances or mixtures). (invitrojobs.com)
The target is the basic genetic material (genome) of the cell, the deoxyribonucleic acid (DNA). (invitrojobs.com)
Using data generated from patients and mice with genetic mutation for the disorder Usher syndrome, researchers from the University of Maryland School of Medicine, the National Institutes of Health's National Eye Institute, and National Institute on Deafness and Other Communication Disorders, documented the natural history of vision impairment in patients and identified the cell mechanism behind progressive vision loss. (news-medical.net)

To analyze the mechanisms responsible for the Ron-dependent regulation of cytokine/chemokine production, the laboratory utilizes co-culture systems composed of primary tissue macrophages and epithelial cells from select gene knockout animals to dissect the role of macrophages in tissue injury. (uc.edu)
Here, we show that chronic (6-month) exposure of human lung epithelial cells to single-walled (SW) CNTs at the workplace-relevant concentration induced an emergence of lung CSCs, as indicated by the induction of CSC tumor spheres and side population (SP). (oncotarget.com)
We examined the effects of clorgyline on the transcriptional program of epithelial cells cultured from high grade PCa (E-CA). (biomedcentral.com)

Here we show that co-culture with adipose tissue from high-fat diet induced obese C57BL/6 mice alters transcriptome profiles in triple-negative breast cancer (TNBC) cells, leading to upregulation of genes involved in inflammation and lipid metabolism, such as IL1B, PLIN2, and ANGPTL4. (uni-regensburg.de)
For their study, the Chinese researchers examined the effects of chlorogenic acid treatment on cultured human HCC cells and mice injected with the same cancer cells. (anticancer.news)
Harvard Medical School Professor Bruce Spiegelman was among the researchers who demonstrated that symptoms of cachexia in mice with lung tumors improved or were prevented when they were given an antibody that blocked the effects of a protein, PTHrP, secreted by the tumor cells. (harvard.edu)
In the July 13 advanced online edition of Nature, scientists led by Bruce Spiegelman , the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School, reported that symptoms of cachexia in mice with lung tumors improved or were prevented when the mice were given an antibody that blocked the effects of a protein, PTHrP, secreted by the tumor cells. (harvard.edu)
The researchers carried out two experiments using mice that developed lung tumors and cachexia. (harvard.edu)
You would have expected, based on our first experiments in cell culture, that blocking PTHrP in the mice would reduce browning of the fat," said Spiegelman. (harvard.edu)
In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study from University of Gothenburg researchers shows. (gu.se)
In experiments in culture with human cell lines, we see the same RNA and protein expression patterns as we do in mice treated with this new regime, showing we're on the right track," says Jimmy Van den Eynden of the Cancer Research Institute at Ghent University, who led the Belgian part of the work. (gu.se)
This delivery, tested in mice so far, elicits an immune response, partly because of immune memory T-cells that remember their exposure to tetanus through childhood vaccination. (pancan.org)
When combined with low doses of gemcitabine chemotherapy, which further decreases immune suppression, advanced pancreatic cancer tumor burden and metastases were significantly reduced through this investigational treatment combination in mice," Dr. Gravekamp said. (pancan.org)
Researchers describe the Treg-cell-inducing activity of lipid extracts from the feces of specific-pathogen-free mice. (news-medical.net)

Using single-cell RNA-Seq, we identified glioblastoma cellular populations with elevated HML-2 transcripts in neural progenitor-like cells (NPC-like) that drive cellular plasticity. (bvsalud.org)
Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
In addition to being found in plants, IP6 is contained within almost all mammalian cells, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. (naturalnews.com)
Reductions in cellular proliferation were observed in both cell lines. (naturalnews.com)
The hypothesis that cellular biomechanics may play a significant role in tumour genesis and cancer invasion, gains every day more and more support: therefore characterizing these properties in connection with the membrane and cytoskeleton organization could be very important for understanding better the migration mechanisms and to develop new diagnostics and therapeutics tools. (units.it)

Although normally silenced, the most recently integrated provirus HERV-K (HML-2) can be reactivated in certain cancers. (bvsalud.org)
Before trying the anti-PTHrP antibody in human patients, he said, "clinicians would probably first want to find out if the protein is elevated in certain cancers, and determine which patients would be good candidates for a clinical trial. (harvard.edu)

Moreover, we found that glioblastoma cells, notorious for their VEGF production, elicited a similar response when co-cultured with endothelial cells [11] . (plos.org)

Initially, their research focused on tumour blood vessel development and anti-angiogenic therapies. (otago.ac.nz)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
Single-cell RNA sequencing (scRNA-seq) is a technique that measures gene expression in individual cells. (bvsalud.org)
Many of the upregulated genes were activated by PPAR nuclear receptors, as shown by pathway analyses and gene expression experiments using PPAR agonists and antagonists. (uni-regensburg.de)
Furthermore, LPS and TNF-α stimulated the gene expression of different inflammatory mediators, in part, in a NF-κB-dependent manner. (uni-frankfurt.de)
Gene expression profiling using Affymetrix GeneChip® Human Transcriptome 2.0 array was subsequently carried out in YB-1 silenced MDA-MB-231 cells. (biomedcentral.com)
Global gene expression profiling in the YBX1 silenced MDA-MB-231 cells identified differential expression of several genes, including CORO1C (which encodes for an actin binding protein, coronin-1C) as a potential downstream target of YB-1. (biomedcentral.com)
While knockdown of YBX1 gene decreased CORO1C gene expression, the opposite effects were seen in YB-1 overexpressing cells. (biomedcentral.com)
Silencing of YBX1 caused a similar reduction in CORO1C expression , concomitant with a significant decrease in migration in Hs578T cells. (biomedcentral.com)
By analyzing RNA-sequencing with additional desmoid tumor samples, we found that NOTCH2 expression was significantly correlated with HES1 expression. (e-crt.org)
After the co-culture, the increase in pro-inflammatory cytokine expression in the mutant cells was significantly lower than that in the control group, while that in immunosuppressive factors was not significantly different. (frontiersin.org)
In our previous study, the upregulation of DTL expression in aggressive HCC correlated positively with tumor grade and poor patient survival. (transhumanist.ru)
We systematically assessed gene expression changes induced by clorgyline in E-CA cells using high-density oligonucleotide microarrays. (biomedcentral.com)
Expression of genes of interest was validated by quantitative real-time polymerase chain reaction. (biomedcentral.com)
The expression of 156 genes was significantly increased by clorgyline at all time points over the time course of 6 - 96 hr identified by Significance Analysis of Microarrays (SAM). (biomedcentral.com)
Moreover, clorgyline downregulated EZH2, a critical component of the Polycomb Group (PcG) complex that represses the expression of differentiation-related genes. (biomedcentral.com)
We could validate these findings by immunofluorescence analyses in patient tumors and by increased expression in the hypoxic core of GBM spheroids. (lu.se)
The results demonstrated that PPII treatment significantly inhibited cancer cell migration and invasion, increased the expression level of E‑cadherin and decreased the levels of N‑cadherin, snail family transcriptional repressor 2, twist family bHLH transcription factor 1, matrix metallopeptidase (MMP) 2 and MMP9 compared with those in the control group (untreated cells). (spandidos-publications.com)
These results suggested that PPII treatment may suppress bladder cancer cell migration and invasion by regulating the expression of EMT‑associated genes and MMPs. (spandidos-publications.com)
miRNAs comprise a large group of endogenous non-coding RNAs that can block mRNA translation or negatively regulate mRNA stability and thereby play a central role in regulating gene expression [10] , [11] . (plos.org)
Autophagy was detected using acridine orange staining and real-time PCR for Lc3 and Beclin1 genes expression. (ijpsonline.com)
The expression levels of autophagy-related genes, Lc3 and Beclin1 increased in cells treated with 1.5 mg/ml of Solanum nigrum extract. (ijpsonline.com)
A new research perspective was published in Oncotarget's Volume 14 on April 26, 2023, entitled, "Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism. (news-medical.net)
Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19). (news-medical.net)
Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood. (news-medical.net)
Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)

The ubiquitination pathway plays a fundamental role in the maintenance of protein homeostasis both in normal and stressed conditions and its dysregulation has been associated with malignant transformation and invasive potential of tumor cells, thus highlighting its value as a potential therapeutic target. (nature.com)
Altogether, these findings demonstrate that USP19 might represent a novel therapeutic target in breast cancer. (nature.com)
However, Dr. Cantley and his colleagues discovered that the opposite was true in regards to high-dose vitamin C's therapeutic effects for the KRAS and BRAF forms of colorectal cancer - they occur as a result of inducing oxidation in these cancer cells. (crazzfiles.com)
Various therapeutic options, including imatinib, are available to treat desmoid tumor. (e-crt.org)
Our results show that HES1 , regulated by NOTCH2 , as an indicator of sensitivity to imatinib, and an important therapeutic consideration for desmoid tumor. (e-crt.org)
Despite of the development in the three routine therapeutic methods of surgery[ 3 ], chemotherapy, and radiotherapy, the cure rate for pancreatic cancer has improved only minimally, and the overall survival of patients remains dismal. (wjgnet.com)
In recent years, these so-called tumor initiating cells (TICs) have thus moved into the focus of attention because of their promise for therapeutic intervention: TICs seem to be the reason why patients with some cancers do not react to therapy or relapse quickly after remission, and TICs seem to be more abundant in aggressive and refractory cancers. (medicalxpress.com)
By better understanding the signaling events governing tumor initiating cells, we hope to develop new, more efficacious, therapeutic approaches. (medicalxpress.com)
We hypothesize that targeting DTL may provide a novel therapeutic strategy for liver cancer. (transhumanist.ru)

Conclusions Bcl2 , Myc and Ccnd1 or Bcl2 , Myc and CCND3 synergistically transformed mouse primary B cells into aggressive malignant cells. (haematologica.org)
In addition to the arresting of cell proliferation, this process also induces the differentiation of malignant cells. (naturalnews.com)
As previous known, the more differentiated the malignant cells, the less aggressive and dangerous is the cancer. (naturalnews.com)

Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)
One of the hallmarks of breast cancer is resistance of tumor cells to cell death. (ijpsonline.com)
Salamanders have a unique ability to regenerate their limbs and have shown resistance to cancer in previous studies, making them a fascinating animal species for researchers in the field of regenerative medicine. (lu.se)

However, an important part of their hypothesis is that the mouse immune system received signals from the tumor cells that caused the natural immune cells to infiltrate and destroy the tumor cells. (gu.se)
Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
But neoantigens are scarce in pancreatic cancer cells, and the tumor and its surrounding environment fight to keep the immune system out. (pancan.org)
Dr. Gravekamp, Associate Professor in the Department of Microbiology & Immunology at Albert Einstein School of Medicine, received a PanCAN Translational Research Grant in 2016 to determine whether using Listeria bacteria to deliver neoantigens directly to the cancer cells may stimulate an immune response and effectively kill off the pancreatic cancer cells. (pancan.org)

The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. (biomedcentral.com)

RESULTS: The mean tumor volume before (V1) and after (V2) treatment was 0.0355 cm3 and 0.2248 cm3 in group A, 0.0374 cm3 and 0.0573 cm3 in group B, 0.0380 cm3 and 0.3674 cm3 in group C, respectively. (uni-frankfurt.de)
However, a mutation does not (yet) mean tumor formation. (invitrojobs.com)

In recent decades, the biggest challenge for urologists , and for the pathologists who diagnosed the prostate tissue specimens they referred, has been how to accurately differentiate between non-aggressive prostate cancer, which can exist for decades with no apparent symptoms, and aggressive prostate cancer that kills quickly. (darkdaily.com)
However, the detailed mechanisms by which hypertrophic adipose tissue influences breast cancer cells are still not well understood. (uni-regensburg.de)
Similar results were obtained by treating TNBC cells with adipose tissue conditioned media (ACM) generated from fat tissue of obese female patients. (uni-regensburg.de)
Bone marrow mononuclear cells (BMCs) are suitable for bone tissue engineering. (uni-frankfurt.de)
HCC occurs as a malignant tumor that expands into nearby environments , invading surrounding tissue. (anticancer.news)
Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
Glioblastoma, also known as GBM, is a fast-growing, web-like tumor that arises from supportive tissue around the brain and resists surgical treatment. (sciencedaily.com)
Described by some as "sand in grass," GBM cells are hard to remove and tend to reach out in a tentacle-like fashion through surrounding healthy brain tissue. (sciencedaily.com)
Logun is studying how brain cancer takes advantage of highly charged elements in brain tissue to aid in invasion. (sciencedaily.com)
11 With the exception of blood cancers, such tumors grow invasively into the surrounding tissue and destroy it. (invitrojobs.com)

ERBB1 and ERBB2 inhibition rapidly (within 3 h) inhibits both tumor cell motility and intravasation. (aacrjournals.org)
Using gefitinib, ERBB1 inhibition rapidly inhibits tumor cell motility and invasion but not intravasation, whereas ERBB2 inhibition by AG825 rapidly blocks intravasation. (aacrjournals.org)

The scientists said their findings were the first to explain in detail how PTHrP from tumors switches on a thermogenic (heat-producing) process in fatty tissues, resulting in unhealthy weight loss. (harvard.edu)
GSE76211) ( 3 , 4 ), revealing a significantly upregulated gene in BCa tissues, the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5). (spandidos-publications.com)

Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life. (nature.com)
It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
Improved oral health, as indicated by the count of natural teeth and dental appointments preceding the diagnosis, correlated with enhanced head and neck cancer survival rates. (medindia.net)

The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
Background A synergistic effect resulting from a combination of BCL2 and MYC or MYC and CCND1 has been implicated in human B-cell lymphomas. (haematologica.org)
These genes are transcriptionally deregulated as the partner genes of IgH translocation, and are thus thought to perform crucial roles in human B-cell lymphomagenesis. (haematologica.org)
2 A synergistic effect resulting from a combination of two genes from BCL2 , MYC and CCND1 has been implicated in human B-cell lymphomagenesis. (haematologica.org)
7 That multiple genes are involved in human lymphoma formation has also been suggested by experimental mouse models. (haematologica.org)
13 The identification and clarification of the multiple cooperative genes implicated in human lymphoma formation is important, although our present understanding of such genes remains scant. (haematologica.org)
The objective of this study was to identify additional cooperative gene(s) associated with BCL2 and MYC or MYC and CCND1 in human B-cell lymphomagenesis. (haematologica.org)
Importantly, human B-cell lymphoma cases with concurrent multiple translocations including BCL2 , MYC and CCND1 have been reported. (haematologica.org)
This includes postmortem human brains and organoids derived from peripheral cells. (bvsalud.org)
This technologic and biologic revolution continued through the 1960s to today, and the explosion in technology has fueled the current expansion of knowledge into the working of the human cell. (medscape.com)
Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies, including breast cancer. (biomedcentral.com)
They found that cruciferous vegetables, in particular, are a rich source of sulfur-containing chemicals that are transformed by the human body into cancer-fighting agents. (anticancer.news)
Cruciferous vegetables are not the only cancer-fighting foods in the human diet. (anticancer.news)
While carcinogenesis induced by various chemicals and environmental agents including cigarette smoke, air pollution, and heavy metals has been extensively studied [ 7 - 9 ], relatively little has been carried out or known about the cancer risk caused by nanomaterial exposure, notably carbon nanotubes (CNTs) which share similar properties with asbestos fibers, a known human carcinogen [ 10 - 13 ]. (oncotarget.com)
In various human cancers, obesity is linked to invasive tumours that are resistant to therapy and have poor outcome. (otago.ac.nz)
Our data demonstrate that HSV-TK/GCV suicide gene therapy system is effective for treating experimental human pancreatic cancer, which is largely resistant to the common therapies, so the suicide gene therapy system may be a potential treatment approach for pancreatic cancer. (wjgnet.com)
As it is a naturally occurring substance already found in human cells, there are no side effects. (naturalnews.com)
Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). (biomedcentral.com)
Human bladder cancer is a heterogeneous disease that is one of the most common types of cancer worldwide, with ~550,000 new diagnosed cases annually ( 1 ). (spandidos-publications.com)
Human bladder cancer (BCa) is currently one of the most common cancers worldwide ( 1 ). (spandidos-publications.com)
The robots and microtiter plates are kept in a chamber which, through precisely regulated temperature and humidity, provides an environment similar to that of the human body, and which also protects the tumour cells against external influences that can falsify the test results. (medindia.net)
Examples of retroviruses are the human immunodeficiency viruses and the human T-cell leukemia viruses. (msdmanuals.com)

3 - 7 The synergistic effect of BCL2 and MYC has also been implicated in the histological and clinical transformation of indolent follicular lymphoma into a more aggressive lymphoma. (haematologica.org)
Researchers of the study published in the journal Clinical Cancer Research investigated how PARP inhibitors impact DNA repair in gliomas. (darkdaily.com)
Clinical studies have shown that a high intake of these compounds can reduce the risk of different types of cancer. (anticancer.news)
The results also indicate several other starting points for future preclinical and clinical studies on liver cancer treatment. (transhumanist.ru)
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)
In the fight against pancreatic cancer, clinical trials often provide the best treatment options. (pancan.org)

In another study, researchers looked at 15 patients with BRCA2-inheritied prostate cancer and compared the genomic sequences of those tumors to a large group of sequences from tumors in less-aggressive cancer cases. (darkdaily.com)
The researchers found that surfen-treated animals demonstrated smaller tumors and substantially reduced brain hemorrhage volume than control animals. (sciencedaily.com)
As published in Oncology Research , February 2008, researchers reported that IP6 was shown to have significant inhibitory effects against a variety of primary tumors. (naturalnews.com)
As published in Journal of Surgical Research , June 2005, researchers reported that IP6 has been found to have significant inhibitory effects against a variety of primary tumors including breast and colon. (naturalnews.com)
Researchers suspect that there occur 5,000 so-called DNA strand breaks per hour in the cell alone. (invitrojobs.com)
Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss. (news-medical.net)

We report a case of chronic Schistosoma haematobium infection with pseudometastatic pulmonary nodules and high-grade squamous cell carcinoma in a 30-year-old man in Mali. (cdc.gov)
Schistosomiasis-induced squamous cell carcinoma of the bladder with pseudometastatic pulmonary nodules in a 30-year-old man from Mali. (cdc.gov)
Anatomopathology revealed urinary schistosomiasis complicated by a high-grade, well-differentiated, keratinized squamous cell carcinoma (SCC) (Figure, panel B). Within the wall, ovoid structures, sometimes calcified, corresponded to bilharzia eggs. (cdc.gov)
Cutaneous squamous cell carcinomas (cSCC) are common in NZ, and most are simply treated. (otago.ac.nz)

Robert Bristow, MD, PhD , and Paul Boutros, PhD , conducted a study of nearly 500 Canadian men who had prostate cancer. (darkdaily.com)
This information gives us new precision about the treatment response of men with prostate cancer and important clues about how to better treat one set of men versus the other to improve cure rates overall," stated Bristow in a University Health Network (UHN) press release . (darkdaily.com)
According to a ScienceDaily news release , they found that only 2% of men with prostate cancer have the BRCA2-inherited type. (darkdaily.com)
In contrast, each increase of 10% in the percent of the tumor classified as grade 4/5 at the time of surgery leads to a 10% increase in the failure rate as measured by detectable and rising serum prostate specific antigen (PSA), a biomarker of prostate cancer (PCa). (biomedcentral.com)
An international research team co-led by scientists at Roswell Park Comprehensive Cancer Center and The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified an important accelerator of treatment-resistant prostate cancer. (news-medical.net)

It may turn out that the PTHrP mechanism is responsible for cachexia in a subset of cancer patients, but not all, Spiegelman suggested. (harvard.edu)

Cancer Res (2021) 81 (15): 4041-4053. (aacrjournals.org)

We found a heterogeneous surface-endocytome profile and a divergent response to hypoxia across GBM cultures. (lu.se)

Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
Lung cancer is the leading cause of cancer-related death, and environmental and occupational exposure is a major cause of most cases [ 1 , 2 ]. (oncotarget.com)
A collaborator on the study, Vickie E. Baracos at the University of Alberta in Edmonton, Canada, provided blood from 47 patients with lung or colon cancer who were cachexic. (harvard.edu)
Lung cancer is a severe form of cancer and detecting it at an early stage is critical for effective treatment. (lu.se)
Dr. Sandra Lindstedt, a senior consultant in thoracic surgery at Skåne University Hospital and an adjunct professor at Lund University, is leading a team to develop a non-invasive diagnostic tool for lung cancer. (lu.se)
The project funded by Cancerfonden, will focus on using exhaled breath particles as a non-invasive method for diagnosing and monitoring non-small-cell lung cancer. (lu.se)
By continuously analyzing breath particles, we anticipate the ability to detect any signs of lung cancer recurrence at an early phase, facilitating prompt medical attention and tailored treatment strategies," explains Sandra Linstedt. (lu.se)

Colorectal cancer is the third most-common cancer diagnosed in the United States, with about 93,090 new cases each year. (crazzfiles.com)

We identified the deubiquitinase USP19 and demonstrated that its silencing reduces the migratory and invasive potential of highly invasive breast cancer cell lines. (nature.com)
Despite reports of YB-1 and its association with distant spread of breast cancer, the intrinsic mechanism underlying this observation remains elusive. (biomedcentral.com)
Silencing the YBX1 gene (which encodes the YB-1 protein) by small interfering RNA (siRNA) was performed in MDA-MB-231 and Hs578T breast cancer cell lines, followed by phenotypic assays including cell migration and invasion assays. (biomedcentral.com)
Downregulation of the YB-1 protein inhibited cell migration and invasion in MDA-MB-231 breast cancer cells. (biomedcentral.com)
The Shaw lab investigates mechanisms by which carcinoma cells acquire the ability to metastasize, with a focus on breast cancer. (umassmed.edu)
In a breast cancer study, Mohamed Bentires-Alj and scientists from his group at the Friedrich Miescher Institute for Biomedical Research identified now an important player in the signaling cascades governing TICs. (medicalxpress.com)
Breast cancer cells were treated with varying concentrations (1 to 5 mg/ml) of Solanum nigrum extract for 24 and 48 h. (ijpsonline.com)
Breast cancer is the most common cancer in women worldwide [ 1 ]. (ijpsonline.com)
Triple negative breast cancer (TNBC) is an aggressive form of tumor. (ijpsonline.com)
A team of clinicians and scientists from the National Cancer Centre Singapore (NCCS), Singapore General Hospital (SGH) and A*STAR's Genome Institute of Singapore (GIS) has identified a novel method to treat triple-negative breast cancer (TNBC). (news-medical.net)
Management of breast cancer during pregnancy or pregnancy associated breast cancer requires special consideration to avoid harm to the fetus. (medindia.net)
Introduction: In India, almost 150,000 women are diagnosed with breast cancer every year and almost half of patients expected to die of the disease. (who.int)
In India most of patients with breast cancer diagnosed with advanced stage of the disease. (who.int)
As breast cancer treatment is multimodality approach Radiation therapy has significant impact on prevention of local recurrence. (who.int)

siRNA-mediated silencing of CORO1C and down-regulation of YBX1 in CORO1C overexpressing MDA-MB-231 cells were performed to evaluate cell migration and invasion. (biomedcentral.com)
Silencing of CORO1C by siRNA in MDA-MB-231 cells was also observed to reduce cell migration and invasion. (biomedcentral.com)
In coronin-1C overexpressing MDA-MB-231 cells, increased migration and invasion were abrogated by YB-1 knockdown. (biomedcentral.com)
Bladder cancer was more sensitive to PPE compared with the other tested herbs, and PPE significantly suppressed bladder cancer cell migration and invasion. (spandidos-publications.com)

For the functional screening, Bcl2 - and Myc- expressing primary B cells were infected with a retroviral cDNA library. (haematologica.org)
HCC is the most common form of primary liver cancer in adults and is said to be responsible for more than 12,000 deaths in the U.S. per year. (anticancer.news)
But what makes this tumor truly dangerous is the fact that it can metastasize, meaning tumor cells can break away from the primary tumor and migrate to a new location, allowing the cancer to spread. (anticancer.news)

The lipid composition of cells was analysed by MALDI-mass spectroscopy in order to correlate the mechanical alterations of cells with alteration at the cytoskeleton and plasma membrane level. (units.it)

Anatomy15

Organisms6

Diseases84

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Health Care9

Metastasis32

Progression19

Metastatic7

Suppressor genes3

Mutations14

Microenvironment9

Phenotype5

Pathways12

Prognosis12

Apoptosis18

Overexpression5

Behavior5

Malignancy4

Angiogenesis5

Vitro12

Solid tumors2

Invasive tumors1

Proteins13

Brain tumors3

Vivo6

Growth29

Hepatocellular Carcinoma2

Ovarian2

Extracellular5

Stem16

Molecular8

Genetic12

Epithelial cells3

Mice11

Cellular6

Certain cancers2

Endothelial cells1

Blood vessel1

Expression27

Therapeutic9

Malignant cells3

Resistance3

Immune5

Induces2

Mean tumor2

Tissue10

Motility2

Tissues2

Survival3

Human22

Clinical6

Researchers6

Squamous4

Prostate cancer5

Subset1

20211

Hypoxia1

Lung7

Colorectal1

Breast Cancer14

Migration and invasion4

Primary3

Alterations1