• Malignant tumors are aggressive, grow quickly, and often spread. (medlineplus.gov)
  • otherwise known as Askin tumors) are generally treated with en-bloc resection. (medscape.com)
  • Despite current treatment regimens that include multimodal cytotoxic therapies and aggressive surgery, the survival rate of high-risk NB patients remains below 50%, while patients with refractory or relapsed tumors have no cure [ 6 ]. (jcancer.org)
  • One of the most aggressive brain tumors are astrocyte-derived glioblastoma multiforme, of which the U-87 MG glioblastoma cell line ( 89081402 ) was derived. (sigmaaldrich.com)
  • In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study from University of Gothenburg researchers shows. (gu.se)
  • Neuroblastomas are tumors of the nervous system. (medicalxpress.com)
  • The clinical behavior of neuroblastoma is highly variable, with some tumors being easily treatable, but the majority being very aggressive. (acco.org)
  • Dosimetry in molecular radiotherapy for personalized treatment is assuming a central role in clinical management of aggressive/relapsed tumors. (researchsquare.com)
  • Neuroblastoma remains one of the most puzzling of childhood cancers - ranging from cases of widespread but benign tumors in infants that spontaneously and completely disappear, to high-risk subtypes in older children that are relentlessly aggressive. (scienceblog.com)
  • The results of this study are exciting for patients with high-risk neuroblastoma whose tumors have a genetic alteration in the ALK gene and who have lacked effective targeted treatment options for this often lethal cancer," said senior study author Yael P. Mossé, MD , Professor of Pediatrics in the Cancer Center at Children's Hospital of Philadelphia (CHOP). (emory.edu)
  • Washington, DC - A method to cure neuroblastoma tumors in mice has been discovered by Children's National researchers, opening the door for future clinical studies for a therapeutic patient-specific vaccine to cure one of the most common childhood cancers. (childrensnational.org)
  • The study revealed that "knockdown'" of a DNA-protein inhibitor, known as ID-2, in aggressive high-risk solid tumors resulted in activation of T-cells, which are white blood cells that have figured significantly in immunity research. (childrensnational.org)
  • On the clinical side, I have developed expertise in the management of patients with neuroblastoma, germ cell tumors, and histiocytic diseases (such as Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, or LCH and HLH). (chop.edu)
  • First, we are studying how MYC genes regulate polyamines, and how amplification of the MYCN gene (which is found in about 25 percent of tumors and is associated with a very aggressive tumor) causes a tumor to be dependent on polyamines. (chop.edu)
  • We've discovered that numerous medications that interfere with steps in the pathway of making polyamines can disrupt neuroblastomas -- either blocking them before they form, or making tumors regress or respond more fully to standard therapies. (chop.edu)
  • Neuroblastoma is one of the most common solid tumors of childhood, arising from immature sympathetic nervous system cells. (biomedcentral.com)
  • The clinical heterogeneity of neuroblastoma mirrors the biological and genetic heterogeneity of these tumors. (biomedcentral.com)
  • The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)
  • Knockdown of HIF-2alpha in neuroblastoma and glioma tumor stem/initiating cells leads to reduced levels of VEGF and poorly vascularized, highly necrotic tumors. (lu.se)
  • These PDXs retain the genotype, phenotype, tumorigenic, and metastatic properties of the tumors from which they were derived, making them authentic models for studying and targeting neuroblastoma metastasis and resistance. (lu.se)
  • Discovery of novel strategies to inhibit treatment-resistant metastatic tumors can increase survival and decrease side effects for high-risk neuroblastoma patients. (lu.se)
  • In addition, expression of IGF-II and HIF-2α correlates in neuroblastoma cell lines, tumors and in sympathetic neuroblasts during embryonic week 6.5, but not later, suggesting that these IGF-II and HIF-2α expressing neuroblastomas originate from sympathetic pre-ganglia at developmental week 6.5 or earlier. (lu.se)
  • Embryonal tumors were described over the years as a collection of histologic entities that includes medulloblastoma and also included medulloepithelioma, CNS neuroblastoma, CNS ganglioneuroblastoma and atypical teratoid/rhabdoid tumor (ATRT) as well as primitive neuroectodermal tumors (PNET). (medscape.com)
  • For the study, researchers enrolled 355 children (median age, approximately 3 years) who were newly diagnosed with high-risk neuroblastoma. (oncologynurseadvisor.com)
  • Based on the CCG data, a child diagnosed with high-risk neuroblastoma when treated with the above approaches, can expect an estimated 40% probability of disease- free survival four years from diagnosis. (acco.org)
  • Alice was diagnosed with high-risk neuroblastoma a week before her second birthday. (childrenwithcancer.org.uk)
  • It's remarkable that a two-week protocol that combines these two precision medicines can lead to complete tumor regression in two separate mouse models of neuroblastoma," says the other first author, Joanna Szydzik, a PhD student in the group when the work was done. (gu.se)
  • These novel approaches have been validated in complementary models of neuroblastoma in mice and will also be studied in children with relapsed high-risk disease. (chop.edu)
  • With further testing, they learned it was neuroblastoma , a type of cancer most commonly found in young children. (dana-farber.org)
  • Fortunately, the cancer had not yet spread, and Dr. DuBois thought very aggressive chemotherapy would work," says Fiorella. (dana-farber.org)
  • The outlook depends on how far the tumor has spread, and whether some areas of the tumor contain more aggressive cancer cells. (medlineplus.gov)
  • Holsworth suffers from a rather aggressive form of childhood cancer known as neuroblast. (webpronews.com)
  • The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. (nature.com)
  • These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer. (nature.com)
  • Daya was then diagnosed with an aggressive stage 4 metastatic cancer, neuroblastoma. (ndcs.org.uk)
  • Aided by charity Families Against Neuroblastoma, an appeal was made to raise tens of thousands of pounds to send Olivia to the Hope 4 Cancer clinic to undego their Sono Photo Dynamic Therapy. (quackometer.net)
  • Tighter controls on charities that promote these overseas cancer clinics and raise money, such as Families Against Neuroblastoma, is also desperately needed. (quackometer.net)
  • Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, accounting for 7-10% of pediatric cancers and 15% of all pediatric cancer deaths [ 1 , 2 ]. (jcancer.org)
  • These involve cellular and molecular biological experiments aimed at investigating the role of members of the multidrug transporter gene family in determining clinical outcome of the childhood cancer neuroblastoma and other malignancies. (edu.au)
  • Pediatric Cancer Volume 1 Diagnosis, Therapy and Prognosis: Neuroblastoma , edn. (edu.au)
  • Neuroblastoma is one of the most aggressive childhood cancers contributing to 15% of cancer related childhood deaths. (hrb.ie)
  • Neuroblastoma is a form of childhood cancer that affects the peripheral nervous system (PNS) - that is, the system excluding the brain and spinal cord. (gu.se)
  • Neuroblastoma is an aggressive pediatric cancer that develops from early nerve cells and accounts for up to 10% of childhood cancer deaths. (medicalxpress.com)
  • Researchers at Lund University in Sweden have identified one of the reasons why the childhood cancer neuroblastoma becomes resistant to chemotherapy. (medicalxpress.com)
  • Children who suffer a relapse of the aggressive cancer known as neuroblastoma have small chances of survival. (medicalxpress.com)
  • Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy, with an annual incidence of about 650 new cases per year in the US. (medicalxpress.com)
  • However, the regimen we use for high-risk neuroblastoma is also the most aggressive and toxic regimen we give to children with cancer. (oncologynurseadvisor.com)
  • For neuroblastoma pediatric cancer research. (rochester.edu)
  • Named for Crosby Wilmot, the Fund has been established, in close partnership with the Medical Center, to fund pediatric cancer research with a focus on neuroblastoma. (rochester.edu)
  • This form of childhood cancer, which affects approximately 700 children a year, is particularly aggressive and unpredictable in nature. (rochester.edu)
  • Crosby was just 13 months old when he was diagnosed with neuroblastoma, a cancer of the sympathetic nervous system. (rochester.edu)
  • This rare and aggressive form of childhood cancer affects approximately 7 to 10 children a year in Ireland. (gofundme.com)
  • Pediatric oncologist John M. Maris, M.D., describes the current state of the science in combating neuroblastoma, the most common solid cancer of early childhood. (scienceblog.com)
  • A cancer of the sympathetic nervous system, neuroblastoma most commonly occurs as a solid tumor arising from the adrenal gland in the abdomen. (scienceblog.com)
  • To that end, the Cancer Center at CHOP is currently leading a clinical trial of an ALK inhibitor for children who have relapsed after neuroblastoma treatments. (scienceblog.com)
  • In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children's Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma. (emory.edu)
  • Neuroblastoma is an aggressive pediatric cancer that develops from early nerve cells, often appearing as a solid tumor in the chest or abdomen. (emory.edu)
  • Based on Dr. Mossé's discovery, in 2009 COG launched a clinical trial for children with neuroblastoma that repurposed crizotinib, an ALK inhibitor that was already approved by the FDA to treat adults with a subtype of lung cancer caused by abnormalities in the ALK gene. (emory.edu)
  • Scientists have discovered gene mutations that are the main cause of the inherited version of the childhood cancer neuroblastoma. (clpmag.com)
  • Neuroblastoma is the most common solid cancer of early childhood. (clpmag.com)
  • It accounts for 7 percent of all childhood cancers, but due to its often aggressive nature, causes 15 percent of all childhood cancer deaths. (clpmag.com)
  • John M Maris, MD, senior author of the current study and director of the Center for Childhood Cancer Research at Children's Hospital, leads a laboratory with the world's largest collection of neuroblastoma tissue samples, gathered through the multicenter Children's Oncology Group in the US and through multiple international collaborations. (clpmag.com)
  • Last year saw many successes for the Help Fight Childhood Cancer (HFCC) project in particular and the effort to overcome neuroblastoma in general. (worldcommunitygrid.org)
  • The study is particularly significant because neuroblastoma , most commonly centered in the adrenal glands, is the third most common tumor in childhood, and the most common cancer in babies younger than one year old. (childrensnational.org)
  • A benefit gig to help a toddler suffering from an aggressive cancer is to be held at a special London Jazz Festival on Sunday. (leightonbuzzardonline.co.uk)
  • Robin Samuel, who is 21 months old, suffers from neuroblastoma, an extremely rare and aggressive form of cancer. (leightonbuzzardonline.co.uk)
  • Isla was diagnosed with neuroblastoma - a rare and aggressive form of cancer when she was 2, fighting the battle for almost 5 years. (96fm.ie)
  • Neuroblastoma is an aggressive form of pediatric cancer. (npmlaw.com)
  • Surprisingly, many of the genetic changes that occur in cancer cells to make them very aggressive also provide certain vulnerabilities that can be exploited once they are understood. (chop.edu)
  • Neuroblastoma is a type of children's cancer that affects specialised nerve cells, usually in the abdomen. (childrenwithcancer.org.uk)
  • We'll also learn more about how neuroblastoma cells are cancerous and how cancer genes affect the way in which DNA is repaired. (childrenwithcancer.org.uk)
  • Although the outcome for children with cancer has improved considerably during the past decades, the prognosis of children with aggressive neuroblastoma remains dismal. (biomedcentral.com)
  • As in other cancer entities, altered microRNA expression is also being recognized as an important player in neuroblastoma. (biomedcentral.com)
  • Our overall aims are to unravel mechanisms leading to metastasis and treatment resistance of childhood cancer neuroblastoma, and to test compounds targeting aggressive neuroblastoma. (lu.se)
  • Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. (lu.se)
  • La présente étude transversale a été menée auprès de 138 enfants atteints de cancer et traités dans l'Unité d'oncologie pédiatrique du Centre d'oncologie de l'Université de Mansoura, en Égypte. (who.int)
  • En revanche, les patients de moins de cinq ans et ceux avec un diagnostic de cancer provisoire posé initialement bénéficiaient du délai total médian le plus court. (who.int)
  • Nous suggérons de mettre en place des programmes de formation médicale continue, d'améliorer l'accès aux services de diagnostic, et de faciliter l'orientation-recours de façon à donner la priorité aux patients suspects de cancer et ainsi raccourcir le délai de diagnostic. (who.int)
  • Throughout the diagnosis and treatment process of childhood cancer, both the child and the parents are confronted with multiple stressors ranging from hospitalization and aggressive treatments with side effects to the threat of death, while undergoing considerable changes in daily routines and alterations in family and social roles. (bvsalud.org)
  • Given the aggressiveness of the tumor type, it is accepted practice to treat high-risk neuroblastoma patients with intensive therapy, to increase the probability of cure. (acco.org)
  • NB are classified into risk groups based on the International Neuroblastoma Risk Group (INRG) classification system. (jcancer.org)
  • This involves leadership roles within the Children's Oncology Group (COG), the International Neuroblastoma Risk Group (INRG), and the International Histiocyte Society. (chop.edu)
  • The major focus is on research projects directed at understanding the aggressive nature of childhood cancers such as neuroblastoma and leukaemia. (edu.au)
  • Brain cancers of the the central nervous system include neuroblastomas, gliomas, meningiomas and pituitary adenomas. (sigmaaldrich.com)
  • Furthermore, because there already are drugs in development that target the same gene in adult cancers, we can soon begin testing those drugs in children with neuroblastoma. (clpmag.com)
  • Its improper development is linked to a wide range of pathologies, from craniofacial malformations such as palate clefts to aggressive cancers such as melanoma and neuroblastoma. (phys.org)
  • In some cases, the disease can heal and disappear by itself, but aggressive forms of neuroblastoma have a more unfavorable prognosis. (gu.se)
  • High-Risk relapsed/refractory metastatic Neuroblastoma (HRrrm-NBL) has a poor prognosis and high-activity 131 I-mIBG therapy could represent a promising strategy. (researchsquare.com)
  • The prognosis for infants with neuroblastoma is good, while only 30% of children diagnosed after 12-15 months of age survive despite aggressive multimodal therapies. (aacrjournals.org)
  • Neuroblastomas with poor prognosis are often characterized by 1p36 deletion, containing the kinesin gene KIF1B. (nus.edu.sg)
  • In stage 4 disease, the neuroblastoma tumor cells have already spread (or metastasized) to other sites in the body, such as the bone or bone marrow. (acco.org)
  • Then, if the compounds we identified had the ability to kill the neuroblastoma tumor cells both in vitro and in vivo, the second goal was to develop new drugs to treat the patients with aggressive neuroblastoma using the structural information of the chemical compounds we identified. (worldcommunitygrid.org)
  • Close collaborating between COG (Children's Oncology Group) and SIOPEN (International Society of Paediatric Oncology Europe Neuroblastoma) will allow for the design of complementary studies to define the most effective risk-tailored intensified strategies. (oncologynurseadvisor.com)
  • Maris directs a laboratory at CHOP in collaboration with the multicenter Children's Oncology Group (COG) using tissue samples from 5,000 patients - the world's largest sample collection for neuroblastoma. (scienceblog.com)
  • The findings, published today in Nature Medicine , have led to a major amendment in a phase 3 Children's Oncology Group (COG) clinical trial, which has incorporated lorlatinib for newly diagnosed ALK-driven high-risk neuroblastoma, as well as a planned amendment to the European phase 3 trial in collaboration with the International Society of Paediatric Oncology European Neuroblastoma (SIOPEN). (emory.edu)
  • Myeloablative Busulfan/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children's Oncology Group Trial ANBL12P1. (uc.edu)
  • Because only about 600 new cases of all forms of neuroblastoma occur annually in the US, familial (inherited) neuroblastoma is a very rare subset of a relatively uncommon disease. (clpmag.com)
  • Despite advances in available therapies, children with drug-resistant and relapsed neuroblastoma have a dismal outlook with. (hrb.ie)
  • In his review, Maris describes other innovative therapies, such as a national immunotherapy trial by the COG, using monoclonal antibodies and cytokines to selectively target neuroblastoma cells. (scienceblog.com)
  • A notoriously challenging disease to cure, neuroblastoma is characterized by a variety of types and subtypes caused by separate and interacting gene mutations, which only adds to the complexity in devising rational and effective therapies. (emory.edu)
  • Since the mutations discovered by Mossé trigger an "on" signal for neuroblastoma cells, the abnormality is an outstanding target for therapies that inhibit the ALK protein's activity. (clpmag.com)
  • One of the things that makes our neuroblastoma program at Children's Hospital unique is the depth and breadth of our team - from basic research to the translation of novel discoveries to new therapies that improve outcomes. (chop.edu)
  • The recent successes in unraveling the genetic basis of neuroblastoma are now opening opportunities for development of targeted therapies. (biomedcentral.com)
  • A ganglioneuroblastoma may be only in one area or it may be widespread, but it is usually less aggressive than a neuroblastoma. (medlineplus.gov)
  • Whereas ganglioneuroma, neuroblastoma, and ganglioneuroblastoma identified at an early stage may be treated with primary resection, advanced stages are treated primarily with chemotherapy, and surgical resection is rarely indicated. (medscape.com)
  • described 7 cases of large cell neuroblastoma characterized by larger nuclei with thick nuclear membranes and prominent nucleoli suggesting they might represent a distinct phenotype of neuroblastoma with aggressive clinical behavior. (wikipedia.org)
  • A distinctive phenotype of neuroblastoma with aggressive clinical behavior. (wikipedia.org)
  • My laboratory studies the behavior of such neuroblastoma cells, what distinguishes them from their normal counterparts, and what facets of their behavior might be exploited by novel treatments. (chop.edu)
  • As Children's researchers examined the impact of the knockdown of ID-2 protein on a tumor, they implanted N2a, a fast growing mouse neuroblastoma cell line, in the mice. (childrensnational.org)
  • Scientists at Children's Hospital have studied familial neuroblastoma for the past 15 years, and the current study drew on family data collected from throughout the world. (clpmag.com)
  • Further sequencing of that region identified mutations in the anaplastic lymphoma kinase (ALK) gene in eight families with familial neuroblastoma. (clpmag.com)
  • After detecting ALK mutations in familial neuroblastoma, the researchers then focused on the more common sporadic (non-familial) cases of neuroblastoma, and found that ALK mutations occurred in 12 percent of 194 tumor samples from the aggressive, high-risk form of the disease. (clpmag.com)
  • Phase 1 study shows lorlatinib holds significant promise in the treatment of newly diagnosed ALK-driven high-risk neuroblastoma and has led to a major amendment in a phase 3 pediatric neuroblastoma trial. (emory.edu)
  • series of 7 children with anaplastic large cell neuroblastoma showed a better survival than previously reported cases. (wikipedia.org)
  • Thus, it is reasonable to expect the potential for a higher disease- free survival for high-risk neuroblastoma in ongoing and future clinical trials. (acco.org)
  • Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of high-risk children. (lu.se)
  • During the last part of the 20th century, clinical trials have shown that the basis for treating high-risk neuroblastoma should consist of induction chemotherapy, consolidation with high dose chemotherapy + stem cell transplant. (acco.org)
  • We also are studying the process by which neuroblastoma cells become resistant to the body's protective mechanisms to prevent them from becoming cancerous, and ultimately how these cells become resistant to the chemotherapy and radiation therapy used to kill them. (chop.edu)
  • Some studies have used myeloablative chemotherapy or whole-body irradiation followed by autologous bone marrow transplant, but, to date, benefits of this aggressive therapy have not been identified. (medscape.com)
  • Neuroblastoma tumor initiating cells are immature with a neural crest-like phenotype and. (lu.se)
  • Neuroblastoma tumor initiating cells are immature with a neural crest-like phenotype and downregulation of HIF-2alpha in these cells results in neuronal sympathetic differentiation and the cells become phenotypically similar to the bulk of neuroblastoma cells found in clinical specimens. (lu.se)
  • As high HIF-2alpha expression further correlates with disseminated disease as demonstrated in neuroblastoma, glioma, and breast carcinoma, we propose that targeting HIF-2alpha and/or the pseudo-hypoxic phenotype induced by HIF-2 under normoxic conditions has great clinical potential. (lu.se)
  • Neuroblastoma is a solid tumor of childhood that arises in the nervous system, outside of the brain. (acco.org)
  • Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood. (biomedcentral.com)
  • Neuroblastoma Patient-Derived Orthotopic Xenografts Retain Metastatic Patterns and Geno- and Phenotypes of Patient Tumours. (lu.se)
  • We have recently established and characterized several neuroblastoma orthotopic patient-derived xenografts (PDXs). (lu.se)
  • The researchers will be working toward potential clinical trials to make further progress in neuroblastoma research, with immunotherapy playing a key role, Dr. Sandler says. (childrensnational.org)
  • Due to the aggressive nature of high-rish neuroblastoma, Robin needs a course of cutting-edge immunotherapy to help boost his immune system and train it to recognise cancerous cells in the future, see story here . (leightonbuzzardonline.co.uk)
  • A disease exhibiting extreme heterogeneity, neuroblastoma is stratified into three risk categories: low, intermediate, and high risk. (medicalxpress.com)
  • Because pilot studies of tandem autologous HCT demonstrated tolerable toxicity and potential efficacy and because prior trials have demonstrated that dose intensification improves outcomes, researchers decided to explore tandem transplantation in patients with high-risk neuroblastoma. (oncologynurseadvisor.com)
  • This trial will truly change the paradigm of clinical care and improve outcomes for our neuroblastoma patients. (emory.edu)
  • Subsequent research has showed that abnormal ALK changes drive approximately 20% of newly diagnosed high-risk neuroblastoma and that this frequency is substantially higher among relapsed patients. (emory.edu)
  • This finding means that it is possible to offer simple, non-invasive screening for patients with a family history of neuroblastoma," said Mossé. (clpmag.com)
  • As we increase our knowledge of ALK mutations, we will also offer specialized diagnostic testing for all newly diagnosed patients with neuroblastoma, to eventually allow oncologists to better customize treatment to a child's genetic profile. (clpmag.com)
  • There are currently few treatment options from which pediatric oncologists can select with any degree of confidence to improve the management of multiply recurrent neuroblastoma patients. (aacrjournals.org)
  • The clinical course of patients with neuroblastoma is highly variable, ranging from spontaneous regression to widespread metastatic disease. (biomedcentral.com)
  • Appearance of focal or diffuse presence of pleomorphic and anaplastic cells is the hallmark of this neuroblastoma variant. (wikipedia.org)
  • Another experimental treatment, developed at CHOP and other centers, uses MIBG, a radioactive isotope that zeroes in on neuroblastoma cells. (scienceblog.com)
  • Those chemicals showed very low IC 50 values ( low values indicate a measurement of more effectiveness ) killing neuroblastoma cells in vitro. (worldcommunitygrid.org)
  • Calculations done on World Community Grid successfully identified several compounds for the two binding sites which kill neuroblastoma cells in vitro with low IC 50 values. (worldcommunitygrid.org)
  • cSTAR methodology used for separation of proliferation and differentiation signalling patterns in neuroblastoma cells. (ed.ac.uk)
  • When these cells fail to mature properly, they may instead become cancerous -- giving rise to neuroblastoma. (chop.edu)
  • The team want to analyse the effects of Olaparib and other drugs in neuroblastoma cells in the laboratory, to work out how it kills them. (childrenwithcancer.org.uk)
  • In recent years, high tumor cell levels of HIF-2 and the oxygen sensitive subunit HIF-2alpha have been associated with unfavorable disease and shown to be highly expressed in tumor stem/initiating cells originating from neuroblastoma and glioma, respectively. (lu.se)
  • In a subset of peri-vascularly located immature neural crest-like neuroblastoma cells, aggressiveness and growth promoting charasteristics have been reported to be instigated by HIF-2α, a key element of the oxygen-sensing machinery. (lu.se)
  • Neuroblastoma (NB) is a neural crest-derived malignancy mainly occurring in children. (jcancer.org)
  • Neuroblastoma is a tumor of neural crest origin that arises in tissue of sympathetic nervous system and occurs in young children," said lead investigator Julie R. Park, MD, professor of medicine at Seattle Children's Hospital and the University of Washington. (oncologynurseadvisor.com)
  • The study shows that a treatment combining two different precision medicines, an ATR inhibitor and an ALK inhibitor, eliminates neuroblastoma growth in mice. (gu.se)
  • The difficulties we experienced in targeting ALK with crizotinib in neuroblastoma motivated us to find a more potent ALK inhibitor. (emory.edu)
  • A neuroblastoma may arise from sympathetic nervous tissue anywhere in the body, but this tumor most often develops in the abdomen. (aafp.org)
  • However, since it is not a sympathetic nervous system malignancy it is a distinct clinical entity and is not to be confused with neuroblastoma. (medicalxpress.com)
  • Neuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system. (nus.edu.sg)
  • Later that year, Yael Mosse, M.D., collaborating at CHOP with Maris, reported that mutations in the ALK gene were the main cause of inherited neuroblastoma, and also played a role in many cases of non-inherited neuroblastoma. (scienceblog.com)
  • In 2009, Maris published two more gene studies, identifying common variants in the gene BARD1 and copy number variants on chromosome 1 that raised the risk of neuroblastoma. (scienceblog.com)
  • In 2008, Dr. Mossé and colleagues discovered that the anaplastic lymphoma kinase (ALK) gene causes most cases of rare, inherited neuroblastoma. (emory.edu)
  • Since then, she and colleagues from around the world have investigated how mutations in the ALK gene lead to different types of nonhereditary neuroblastoma. (emory.edu)
  • At the age of two, he was diagnosed with a very aggressive stage IV, high-risk neuroblastoma, which was in his abdomen, hip and bone marrow. (gon.com)
  • Neuroblastoma has long been a puzzling disease, partly because of its broad range in outcomes. (clpmag.com)
  • Overexpression of XAF1 impairs tumor progression whereas knockdown of XAF1 promotes tumor growth, suggesting that XAF1 may be a candidate tumor suppressor in neuroblastoma and its associated pathway may be important for developing future interventions. (nus.edu.sg)
  • For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. (biomedcentral.com)
  • A neuroblastoma (occurring in children over 1 year old) is usually malignant. (medlineplus.gov)
  • One study recruits children as young as one year old with a particularly aggressive form of neuroblastoma. (fda.gov)
  • For example, neuroblastoma, retinoblastoma and Wilms' tumor most commonly occur in children between birth and four years of age, whereas osteosarcoma, Ewing's sarcoma and Hodgkin's disease tend to occur in children more than 10 years of age. (aafp.org)
  • Close to 50 percent of neuroblastoma cases occur in children younger than two years old. (medicalxpress.com)
  • Less than 50% of children with high-risk neuroblastoma will survive following current multi-agent, aggressive therapy. (oncologynurseadvisor.com)
  • This finding will change the way we treat children with high-risk neuroblastoma in North America, which still claims many young lives and is in urgent need of better treatments," said Dr Park. (oncologynurseadvisor.com)
  • The goal of this article is to provide a guide to the initial treatment options available for children with high-risk neuroblastoma. (acco.org)
  • Most pediatric oncologists agree that even with optimal current intensive therapy, the aggressive nature of this disease warrants entering as many of these children as possible on clinical trials that may identify improved forms of treatment. (acco.org)
  • There is a clinical trial for a vaccine that helps prevent relapse in Neuroblastoma children in the Slone Kettering Memorial Hospital in New York. (gofundme.com)
  • She explained that ultrasound or a urine test could assist surveillance of children with an ALK mutation, so that if neuroblastoma appears, it can be detected at an early stage. (clpmag.com)
  • Now Mossé and her colleagues at Children's Hospital are planning pediatric clinical trials of ALK inhibitors in children with high-risk neuroblastoma. (clpmag.com)
  • Some types of the disease strike infants but spontaneously disappear with minimal treatment, while other subtypes in older children may be relentlessly aggressive. (clpmag.com)
  • I help coordinate the care of children with these diseases at Children's Hospital, and have roles in the international community in developing clinical and translational programs for neuroblastoma and histiocytic diseases. (chop.edu)
  • We anticipate that drugs in both of these classes will soon be tested in clinical trials to see if they improve the outcome of children with advanced neuroblastoma. (chop.edu)
  • Neuroblastoma has a 'high-risk' form which, despite using every treatment available, means that some children can't be cured. (childrenwithcancer.org.uk)
  • Nearly half of all children diagnosed with neuroblastoma have 'high-risk' disease. (childrenwithcancer.org.uk)
  • This project could really help children with neuroblastoma. (childrenwithcancer.org.uk)
  • If they can show that these drugs kills neuroblastoma, we should be able to test them on children with the disease quite quickly. (childrenwithcancer.org.uk)
  • Neuroblastoma occurs much less frequently in adults than in children and infants but is a much more aggressive disease. (medscape.com)
  • We present an interesting case of an unrelenting cervical neuroblastoma associated with HD, which posed a therapeutic challenge. (ssohospitals.com)
  • This study is the culmination of decades of work that began at CHOP with our initial discovery of ALK mutations in neuroblastoma in 2008. (emory.edu)
  • In addition, the researchers found that the same mutations play a significant role in high-risk forms of non-inherited neuroblastoma, the more common form of the disease. (clpmag.com)
  • Even though he has endured so much, Stage 4 Neuroblastoma has an extremely high relapse rate, and very little treatment options if relapse occurs. (gofundme.com)
  • Method: The primary objective of this pilot study was to evaluate the feasibility of using predictive modeling based on genome-wide mRNA expression profiles of neuroblastoma tumor biopsies to make real-time treatment decisions. (aacrjournals.org)
  • He's since continued to do work with the Still Strong Foundation, helping families raise money to pay for treatment of the aggressive (and expensive) disease. (sbnation.com)
  • Treatment of mediastinal neuroblastoma is based on the evaluation of a number of risk factors that are used to assign a stage to the disease according the INSS. (medscape.com)
  • Maris also cites federally sponsored collaborative programs designed to identify new drugs that will interrupt the key cell signaling pathways that drive neuroblastoma. (scienceblog.com)
  • These are chemical compounds with much lower IC 50 value to kill the neuroblastoma cell, and are based on the structure of those identified by World Community Grid. (worldcommunitygrid.org)