Ages experiment age factors. Medical search. Frequent questions

Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
generated positive changes, producing a decrease in pro-inflammatory states, oxidative stress, and aging. (bvsalud.org)

The prevalence of replicating pancreatic β-cells declines dramatically with age in both rodents and humans ( 4 , 5 ). (diabetesjournals.org)
A team of students from various Swiss universities (Academic Space Initiative Switzerland ARIS) wants to investigate how the ageing process in humans changes in space and how cellular senescence influences the development of aging and age-related disorders. (designworldonline.com)
Alternatively, if the kinetic processes influenc- out adjustment for the kinetic differences in particle ing particle disposition in the lungs of humans and ro- clearance and retention, would be inadequate for pre- dents are not related by a standard scaling factor (e.g. (cdc.gov)

Previous studies have shown the involvement of cell-autonomous factors in this phenomenon, particularly the decline of polycomb genes and accumulation of p16/INK4A. (diabetesjournals.org)
This is a phenomenon where cells stop dividing and secrete inflammatory factors. (designworldonline.com)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
However, she cautioned that because biological age estimation is "a very recent concept in addiction research and is influenced by many factors, further studies are required to investigate this phenomenon, with larger sample sizes than were possible here. (medscape.com)
As a worldwide phenomenon, aging causes changes in various contexts of society. (bvsalud.org)
Aging is a phenomenon that is common to all individuals, but it occurs idiosyncratically to each one, being influenced by biopsychosocial surroundings (Neri, 2014). (bvsalud.org)

Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
E2F1 is one of the transcription factors that cells enter the S phase and plays a key role in cell cycle. (hindawi.com)
Interestingly, differential DNA methylation was related to several transcription factors and proteins with DNA binding domains, which implies direct effects of these DNA methylation changes on gene expression. (medscape.com)

In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
Bellegarrigue NA, Velásquez factor, and sirtuin enzyme pathways are considered, generating a neuroprotective effect. (bvsalud.org)

The young researchers are currently designing the construction of a satellite platform for a corresponding biological experiment, which must meet extreme requirements. (designworldonline.com)
In a novel study of postmortem brain tissue, "we detected a trend towards stronger biological aging of the brain in individuals with cocaine use disorder compared to individuals without cocaine use disorder," lead investigator Stephanie Witt, PhD, Central Institute of Mental Health, Mannheim, Germany, said in a news release. (medscape.com)
Using patterns of DNA methylation as a measure of the biological age of cells, a total of 20 differentially methylated regions were significantly associated with CUD status after multiple testing correction. (medscape.com)

Introduction The language ability is known to decline across the life span and it has been shown that aging in healthy speakers compromises language comprehension in three main aspects: processing speed, inhibition of irrelevant information and working memory (Myerson et al. (frontiersin.org)
In the psycholinguistic literature, the decline of language ability with aging has been studied at the syntactic, phonological and semantic level. (frontiersin.org)
We conclude that systemic factors contribute to the replicative decline of old pancreatic β-cells. (diabetesjournals.org)
Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. (karger.com)
The natural aging process is marked by molecular changes that occur during development, maturation, and decline. (karger.com)
During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)

Adult age differences in the ability to read and remember metaphor, Educ Gerontol, 17(4), 297-313. (frontiersin.org)
At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)

In the human body, aging processes take place at the cellular level, which is referred to as senescence. (designworldonline.com)

Some studies indicate that vaccine hesitancy among the Black population is due to a well-founded mistrust of health care institutions predicated on contemporary and historical medical racism (6,11), a form of racism perpetuated by health care practices, teachings, and norms that include US government-sanctioned experiments on members of the Black population (eg, the Tuskegee Syphilis Study) and discriminatory patient-provider encounters. (cdc.gov)

Time-series intervention analyses of monthly aggregations of hospitalization for acute and chronic causes among men and women aged 15-39, 40-49, 50-69 and more than 69 years. (nih.gov)
After the price reduction the chronic hospitalization rate for men increased among those below age 70 years. (nih.gov)
Aging strongly correlates with the development and incidence of chronic respiratory diseases, including cancer and idiopathic pulmonary fibrosis, but is most strongly linked with development of chronic obstructive pulmonary disease. (karger.com)
We will also examine how regenerative failure may contribute to development of aging-related, chronic lung disease. (karger.com)

The study population included 11,985 adults (aged 18 years) diagnosed with active TB from January 1, 2015 through December 31, 2019, and 1,849,820 adults tested for HCV antibodies between January 1, 2015 and September 30, 2020, who were not diagnosed with TB during that time. (cdc.gov)

Much less is known on the effect of aging in pragmatic processing, which has been studied mainly in relation with two typical pragmatic processes: the turn-taking system (Murphy et al. (frontiersin.org)
cal factors influencing these processes. (cdc.gov)

On the other hand, the disturbances in the proper HO-1 level are associated with the pathogenesis of some age-dependent disorders, including neurodegeneration, cancer or macular degeneration. (springer.com)

Cochran, along with collaborators from HudsonAlpha, the University of California, Santa Barbara, University of Miami, Columbia University, Universidad de Antioquia, Icahn School of Medicine at Mt. Sinai, and Washington University in St. Louis analyzed the genomes of 340 individuals from the Antioquia family as well as similar families from other studies to gain insight into the genetic landscape of age of disease onset. (sflorg.com)
One promising hit was a new variant near the gene CLU, previously implicated as a genetic risk factor for late-onset Alzheimer's disease, and two other top candidate variants also might affect CLU-related biology. (sflorg.com)

Welcome to On Aging, a series that highlights industry icons' approach to beauty through the decades. (mindbodygreen.com)
ORH should be integrated into primary health care programmes by building policies suited to each country and based on the common risk factor approach. (who.int)
In most countries, populations of very effectively established an agenda for a pri- young and school-age children receive mary health care approach based on practi- considerable benefit from preventive health cal, scientifically sound and socially measures such as vaccinations and exami- accepted methods and technology. (who.int)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
This effect can be measured by certain proteins and mRNA, which are emitted during cell aging. (designworldonline.com)

In China, the age-standardized incidence of ovarian cancer ranged from 4.75 to 6.05 per 100,000 population from 1999 to 2010, while the overall age-standardized incidence for these years was 5.35 per 100,000 population [ 3 ]. (hindawi.com)

It was largest among those aged 50-69 years: 22%, which implies an increase of 18.0 monthly hospitalizations per 100,000 person-years, and there was an 11% and 16% (11.5 and 4.8 monthly hospitalizations) increase among those aged 40-49 and 15-39, respectively. (nih.gov)
Acute hospitalizations increased by 17% and 20% (6.2 and 7.0 per month) among men aged 40-49 and 50-69 years, respectively, and by 38% among women aged 50-69 years (2.3 per month). (nih.gov)
BACKGROUND: To describe patterns and correlates of tobacco product use other than cigarettes in adolescents 12-17 years of age. (who.int)
Ten gay elder men, at the average age of 65.7 years participated of it (SD = 3.86). (bvsalud.org)
Within the Brazilian context, an IBGE - Brazilian Institute of Geography and Statistics - (2016) research indicated the real aging of the country, which will reach 30.2 million Brazilians aging more than 60 years. (bvsalud.org)

Age differences in prefontal recruitment during verbal working memory maintenance depend on memory load. (frontiersin.org)
After correcting for differences in age, time since death, brain pH, and other conditions such as depressive disorder and alcohol use disorder, the researchers observed that cells in BA9 appeared biologically older in the men who had CUD. (medscape.com)

Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
This regulation is sive loss of neurons and white matter that believed to positively impact these diseases can lead to brain atrophy and different by promoting normal aging and delaying types of disability. (bvsalud.org)

We are delighted to announce the fifth Ending Age-Related Diseases conference on August 11-14, 2022! (fightaging.org)
The enormous growth in the elderly population is posing a socioeconomic challenge to societies worldwide, and necessitates new sweeping interventions for age-associated diseases. (fightaging.org)
It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself. (fightaging.org)

The predictable age of onset and existence of rare outliers provides researchers a valuable opportunity to study genetic variation linked to the age of Alzheimer's onset. (sflorg.com)
Cells in a specific area of the brain thought to be important for inhibitory control appear biologically older in individuals with cocaine use disorder (CUD), suggesting that the cells may age faster when exposed to cocaine, researchers report. (medscape.com)

By around 2050, it is expected that, for the first time, there will be more elderly people than children aged below 15, causing elderly population to reach 2 billion people, or 22% of the world population (Instituto Brasileiro de Geografia Estatística - IBGE, 2016). (bvsalud.org)

Most of the best conferences relating to aging research, and the longevity industry that has emerged from that research, feature an even mix of entrepreneurs, scientists, and investors. (fightaging.org)

According to the United Nations, the proportion of people aged over 65 now outnumber children younger than 5. (fightaging.org)

Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
We disaggregated coded excerpts by race, age, education, and income to examine emerging themes. (cdc.gov)

Drug and alcohol dependency affects people of all genders, ages and walks of life. (drug-rehabs.org)

1991). Apparently, what is still missing is a research line on the effect of age on the processing of presuppositions (PSPs), namely the information implicitly communicated as taken for granted, which are another core level of pragmatic processing. (frontiersin.org)
Welcome to the 9th Aging Research and Drug Discovery (ARDD) Meeting. (fightaging.org)
The Swiss Artificial Gravity Experiment (SAGE) is dedicated to this research task. (designworldonline.com)
Building on research by NASA and many other groups around the world, there is reason to believe that cells age more slowly in microgravity than on Earth. (designworldonline.com)

In the risk factor analysis adjusted for age, sex, and case definition (new versus previously treated), multidrug-resistant (MDR) TB was associated with an increased risk of LTFU after a positive HCV antibody test (adjusted risk ratio [aRR] = 1.41, 95% CI [1.12, 1.76], p = 0.003). (cdc.gov)

In this study, we contribute to understanding how underlying genetics associate with age of onset in individuals with dominant Alzheimer's. (sflorg.com)
Find out how they did it and how their work might contribute to the study of aging. (nyas.org)
It is expected that data can contribute to new investigations and reflections on the aging of homosexual people, bringing life quality to that group. (bvsalud.org)

Here, we demonstrate that a systemic factor found in the circulation of young mice is able to increase the proliferation rate of old pancreatic β-cells. (diabetesjournals.org)

The team identified several gene candidates likely involved in Alzheimer's disease's age of onset. (sflorg.com)

The results of the largest study to date looking at genetic modifiers of the age of onset of dementia were recently published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association . (sflorg.com)
This study aimed at analyzing social representations of Brazilian gay men concerning male aging, homosexuality and homophobia. (bvsalud.org)
The main limitation of this study was that due to the reliance on existing electronic databases, we were unable to account for the impact of all confounding factors in some of the analyses. (cdc.gov)

Aging lowers the replicative potential of most cells and the capacity for tissue regeneration ( 1 , 2 ). (diabetesjournals.org)
In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)

Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)

This year we have an incredibly exciting program with global thought-leaders sharing their latest insights into aging and how we target aging process ensuring everyone lives a healthier and longer life. (fightaging.org)
The social representations of male aging showed negative aspects, such as sadness and loneliness, and positive ones, such as health and life experience, as well as sexuality. (bvsalud.org)

RESULTS: Only 3% of adolescents who never smoked cigarettes experimented with other tobacco products. (who.int)

With the 2×2 binning feature, it is possible, if necessary, to reduce the amount of data to be transmitted by a factor of four and thus increase both the light sensitivity and the frame rate. (designworldonline.com)

Nearly 60% of current cigarette experimenters had tried another tobacco product, but almost 90% of current established smokers had experimented with one. (who.int)

The present work takes a first step towards a psycholinguistic investigation on the potential impact of the aging factor on the processing of PSPs. (frontiersin.org)

she will also experiment with her own beauty looks-she debuted a sleek, blunt bob months before it became the trendiest style of the season-and champion transparency in the industry at large. (mindbodygreen.com)

General slowing in semantic priming and word recognition, Psychology and Aging, 7, 257-270. (frontiersin.org)

Can Cocaine Addiction Lead to Faster Brain Aging? (medscape.com)

Currently, its standard treatment includes surgery and platinum chemotherapy, but most patients will relapse within 16-22 months due to drug resistance and other factors, and the 5-year survival rate of ovarian cancer is only 46% [ 6 ]. (hindawi.com)

Oxidative stress3

Humans3

Phenomenon6

Transcription factors3

Pathways2

Biological3

Decline6

Adult2

Cellular level1

Teachings1

Chronic4

Adults1

Processes2

Disorders1

Disease2

Approach3

Proteins2

Incidence1

Years5

Differences2

Lung2

Regulation2

Diseases3

Researchers2

Elderly1

Scientists1

Younger1

Examine2

Alcohol1

Research4

Risk factor1

Contribute3

Young1

Gene1

Study3

Cells2

Tissue1

Life2

Results1

Increase1

Current1

Impact1

Industry1

Word1

Lead1

Drug1