PropulsidErythromycinMetoclopramide and cisaprideGastroprokinetic agentDomperidoneDrugsIntestinalEfficacyMosaprideCardiac arrhythmiasGERDConstipation2023DosingVeterinaryPlaceboMedicationDrugTabletStomachMegacolonOsmotic agentClinicalDietaryPregnancyDisordersHumansAnticholinergicSideClassPatientsModerateEffectiveLongerEffectively
Propulsid5
- Propulsid (cisapride) is a "prokinetic" agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn . (rxlist.com)
- Our Propulsid (cisapride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
- Generic name: cisapride [ SISS-a-pride ] Brand name: Propulsid Drug class: GI stimulants. (urlbacklinks.com)
- Cisapride is available under the following different brand names: Propulsid What Are Dosages of Cisapride? (urlbacklinks.com)
- Cisapride (Propulsid) causes less diarrhea and extra-pyramidal side effects than Metoclopropamide (Reglan). (web-gerd.com)
Erythromycin3
- Other molecules, including macrolides such as mitemcinal and erythromycin , have affinity for the motilin receptor where they act as agonists resulting in prokinetic properties. (wikipedia.org)
- Cisapride is the drug of choice for treating delayed gastric emptying followed by erythromycin and ranitidine or nizatidine. (oregonstate.edu)
- However, Cisapride can cause life threatening cardiac arrhythmias, especially in patients with cardiac or renal diseases, those with prolonged QT interval on their EKG, patients who are on anti-fungal, anti-viral and Mycin types of antibiotics like erythromycin and clarithromycin. (web-gerd.com)
Metoclopramide and cisapride2
- Present management involves the empirical use of prokinetic drugs such as domperidone, metoclopramide, and cisapride. (bmj.com)
- Prokinetic drugs like metoclopramide and cisapride are used in conjunction with other measures in patients who are suffering from nausea or bloating in addition to heartburn. (web-gerd.com)
Gastroprokinetic agent3
- A prokinetic agent (also gastroprokinetic agent , gastrokinetic agent or propulsive ) is a type of drug which enhances gastrointestinal motility by increasing the frequency or strength of contractions , but without disrupting their rhythm. (wikipedia.org)
- WebCisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. (urlbacklinks.com)
- Mosapride is a serotonin 5HT₄-receptor agonist and serotonin 5HT₃-receptor antagonist that is a gastroprokinetic agent. (affinityacupuncture.com)
Domperidone3
- The most widely studied agents include bethanechol, metoclopramide, domperidone and cisapride. (nih.gov)
- AEPIO DSR CAPSULE is a combination of Domperidone and Esomeprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. (netmeds.com)
- Domperidone is a prokinetic medicine with anti-emetic properties. (netmeds.com)
Drugs9
- Many of these patients also took drugs expected to increase cisapride blood levels by inhibiting the cytochrome P450 3A4 enzymes that metabolize cisapride. (rxlist.com)
- Cisapride is contraindicated in patients taking any of these drugs. (rxlist.com)
- QT prolongation, torsades de pointes (cisapride removed from us market) (sometimes with syncope), cardiac arrest, and sudden death have been reported in patients taking cisapride without the above-mentioned contraindicated drugs. (rxlist.com)
- Prokinetic agents are drugs that increase contractile force and accelerate intraluminal transit. (nih.gov)
- Activation of a wide range of serotonin receptors by serotonin itself or by certain prokinetic drugs results in enhanced gastrointestinal motility. (wikipedia.org)
- Other prokinetic drugs may increase acetylcholine concentrations by stimulating the M 1 receptor which causes acetylcholine release, or by inhibiting the enzyme acetylcholinesterase which metabolizes acetylcholine. (wikipedia.org)
- Researchers are examining ways to improve reflux control by developing better acid suppressors with more rapid onsets and longer durations, by testing prokinetic drugs, and by searching for ways to reduce esophageal sensitivity. (pharmacytimes.com)
- While it was originally developed for use in humans, cisapride has since been withdrawn from the human market in many countries due to the risk of reactions with other drugs causing heart arrhythmias and death. (wagwalking.com)
- Antimicrobial drugs include: antibiotics, chemotherapeutic agents. (gpatindia.com)
Intestinal3
- if necessary, these can be followed by intestinal secretagogues and/or prokinetic agents. (medscape.com)
- Cisapride for intestinal constipation. (dergipark.org.tr)
- Do not give cisapride for dogs to pets who are allergic to the drug or have an intestinal obstruction or perforation. (wagwalking.com)
Efficacy2
- With the exception of cisapride, the clinical efficacy of the various prokinetic agents in treating GERD has not been confirmed consistently. (nih.gov)
- Keep reading for more information on the dosage, efficacy, and drug interactions of cisapride for dogs. (wagwalking.com)
Mosapride1
- Some of these prokinetic agents, such as mosapride and cisapride , classic benzamides , have only moderate affinity for 5HT 4 receptors. (wikipedia.org)
Cardiac arrhythmias2
- Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and QT prolongation have been reported in patients taking cisapride. (rxlist.com)
- As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K + ] channels) contributes to its potential to cause cardiac arrhythmias . (wikipedia.org)
GERD4
- On the other hand, cisapride is thus far the most effective prokinetic agent studied for the treatment of GERD. (nih.gov)
- Its most important role may be in the maintenance treatment of GERD either as a single agent or in combination therapy with an H2-antagonist after oesophagitis healing. (nih.gov)
- CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal reflux disease (GERD). (urlbacklinks.com)
- Prilosec, Nexium and Prevacid are the agents of choice in achieving symptom relief, improving quality of life, healing, and prevention of mucosal injury in GERD patients. (web-gerd.com)
Constipation12
- Anorectal tests should be used to evaluate for defecatory disorders if over-the-counter agents do not relieve the constipation. (medscape.com)
- The key to treating most patients with constipation is correction of dietary deficiencies, which generally involves increasing intake of fiber and fluid and decreasing the use of constipating agents (eg, milk products, coffee, tea, alcohol). (medscape.com)
- 1,8,10,11 Other common risk factors of constipation include reduced caloric intake, sedentary lifestyle, decreased fiber intake, and usage of anti-inflammatory agents. (ajmc.com)
- Treatment of chronic constipation with cisapride and placebo. (dergipark.org.tr)
- Staiano A, Cucchiara S, Andreotti MR, Minella R, Manzi G. Effect of cisapride on chronic idiopathic constipation in children. (dergipark.org.tr)
- Cisapride in management of chronic pediatric constipation. (dergipark.org.tr)
- Odeka EB, Sagher F, Miller V, Doig C. Use of cisapride in treatment of constipation in children. (dergipark.org.tr)
- Nurko S, Garcia-Aranda JA, Worona LB, Zlochisty O. Cisapride for the treatment of constipation in children: A double-blind study. (dergipark.org.tr)
- Various studies have evaluated the effect of prokinetic agents such as cisapride in management of chronic constipation, however due to the possible lethal side effects, its consumption has been limited. (dergipark.org.tr)
- In this study we assessed the effect of metoclopramide a drug with similar prokinetic effects and less side effects in management of chronic constipation. (dergipark.org.tr)
- Conclusion: In this study we achieved no significant response from consumption of metoclopramide as a prokinetic agent in the treatment of chronic constipation of children. (dergipark.org.tr)
- Cisapride Capsules Information extract from Plumb's, fifth edition: Oral GI prokinetic agent used for GI stasis, reflux eosophagitis and megacolon/constipation in cats Contraindicated in GI perforation/obstruction, haemorrhage and hypersensitivity Caution in pregnancy. (stenlake.com.au)
20231
- WebAug 26, 2023 · Uses of Cisapride Tablets: It is used to treat heartburn. (urlbacklinks.com)
Dosing1
- PPIs are potent agents, offer ease of dosing with favorable drug interaction and extreme safety profile. (web-gerd.com)
Veterinary1
- However, according to the Merck Veterinary Manual , there haven't been reports of similar adverse reactions to the clinical use of cisapride in veterinary medicine. (wagwalking.com)
Placebo3
- 1 CDSR ( Carroll W, 2021 ) was performed in order to evaluate trials comparing laxative therapy for preventing DIOS (including osmotic agents, stimulants, mucolytics and substances with more than one action) at any dose to placebo, no treatment or an alternative laxative therapy, in people of any age with sufficient or insufficient exocrine pancreas and any stage of lung disease. (cfdb.eu)
- Only 1 cross‐over trial with a duration of 12 months, including 17 patients, was selected in which participants were randomly allocated to either cisapride (a gastro‐prokinetic agent) or placebo for 6 months each. (cfdb.eu)
- No significant differences were registered at 6 months between cisapride and placebo for abdominal distension, MD ‐0.90 (95% CI ‐2.39 to 0.59) or abdominal pain, MD ‐0.4 (95% CI ‐2.05 to 1.25). (cfdb.eu)
Medication1
- Cisapride is a prescription medication used for treating gastrointestinal dysmotility. (urlbacklinks.com)
Drug4
- Most prokinetic agents are grouped under the Anatomical Therapeutic Chemical Classification System (a World Health Organization drug classification system), as ATC code A03F . (wikipedia.org)
- Cisapride for dogs is a prokinetic drug that supports the proper functioning of the digestive tract. (wagwalking.com)
- If your dog has been prescribed cisapride, it's important to know how the drug works and what potential side effects it could have on your dog. (wagwalking.com)
- A prokinetic drug, cisapride speeds up the passage of food through the digestive tract. (wagwalking.com)
Tablet3
- The starting dose of cisapride is one 10 mg tablet or 10 ml of the suspension 4 times daily at least 15 minutes before meals and at bedtime. (rxlist.com)
- Cisapride comes as a tablet and liquid to take by mouth. (urlbacklinks.com)
- Cisapride is available as a compounded tablet, capsule, or liquid . (wagwalking.com)
Stomach2
- Cisapride increases the rate at which your esophagus, stomach, and intestines move during digestion. (urlbacklinks.com)
- As a result, cisapride treats vomiting caused by megaesophagus, as well as a range of other conditions associated with the stomach emptying too slowly. (wagwalking.com)
Megacolon1
- This page is a mishmash - hodgepodge of information on Megacolon and the En spotting breeds. (vgr1.com)
Osmotic agent1
- If this is not effective, laxatives of the bulk-forming agent, osmotic agent, stool softener, or lubricant type may be recommended. (wikipedia.org)
Clinical1
- In terms of dosage amount and cisapride toxicosis, severe clinical signs have been reported in acute exposures as low as 18 mg per kg . (wagwalking.com)
Dietary1
- Treatment consists of dietary management and gastric prokinetic agents. (oregonstate.edu)
Pregnancy1
- During pregnancy, cisapride should be taken only if prescribed. (rxlist.com)
Disorders2
- Most patients had disorders that may have predisposed them to arrhythmias with cisapride. (rxlist.com)
- metoclopramide has been associated with extrapyramidal side effects and movement disorders, and cisapride with serious cardiac events. (pharmacytimes.com)
Humans1
- Research into the prokinetic effects of probiotics on the gastrointestinal tract has also been conducted in humans. (wikipedia.org)
Anticholinergic2
- Benztropine is a centrally acting anticholinergic agent with antihistaminic properties resulting from the combination of the tropine portion of the atropine molecule and the benzohydryl portion of diphenhydramine. (sgpharma.com)
- BENZTROPINE MESYLATE TABLETS USP is a powerful anticholinergic agent which is mainly effective in relieving tremor and rigidity. (sgpharma.com)
Side4
- These agents have variable effects on oesophageal and gastric motor function and are fraught with side-effects. (nih.gov)
- This agent also has an odd side effect: It causes a rise in body temperature, yet 50% of study subjects report feeling cold. (pharmacytimes.com)
- Beacause of this side-effect, Cisapride is no longer availabe in the US. (web-gerd.com)
- Consult your veterinarian if you're concerned about any of the side effects of cisapride. (wagwalking.com)
Class2
- In recent years, it has become clear that the selectivity profile is a major determinant of the risk-benefit profile of this class of agent. (wikipedia.org)
- We propose that analogues of ghrelin may represent a new class of prokinetic agents. (bmj.com)
Patients2
- BENZTROPINE MESYLATE TABLETS USP often is helpful in patients who have become unresponsive to other agents. (sgpharma.com)
- Patients with parthenium dermatitis are often unresponsive to topical steroids, and immunosuppressive agents may be necessary to reduce their need for systemic corticosteroids. (academicconcepts.net)
Moderate1
- Paracetamol ( acetaminophen or para -hydroxyacetanilide ) is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. (worldsbest.rehab)
Effective1
- Studies show that cisapride is more effective than metoclopramide hydrochloride at increasing lower esophageal sphincter resting pressure . (wagwalking.com)
Longer1
Effectively1
- Several investigational agents may reduce TLESR more effectively. (pharmacytimes.com)