• Her hospital course was complicated by spinal headache and transient acetaminophen-induced liver injury, but she was eventually discharged to her home in good condition. (cdc.gov)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
  • In large clinical trials, abnormalities in routine liver tests were common in patients treated with pazopanib, with serum aminotransferase elevations occurring in up to half of patients and total serum bilirubin in approximately one-third. (nih.gov)
  • Liver test abnormalities are frequent during pazopanib therapy and routine monitoring is recommended at 3 to 4 week intervals. (nih.gov)
  • Many mechanisms of ethanol-induced fatty liver have been proposed. (medscape.com)
  • The role of the early growth response-1 (EGr-1) transcription factor is thought to be essential for ethanol-induced fatty liver injury in mice. (medscape.com)
  • This may be related to mitochondrial proteins that regulate apoptosis and necrosis and that are shown to be induced in mouse fatty liver models. (medscape.com)
  • Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
  • The term drug-induced liver injury (DILI) may be used to mean clinically significant liver injury or all (including asymptomatic) liver injury. (msdmanuals.com)
  • Despite various documented roles of PGJ, there are no studies on antifibrotic potential in NDEA-induced mammalian liver fibrotic model. (nature.com)
  • These findings point towards pomegranate as a potential and efficacious therapeutic agent against liver fibrosis. (nature.com)
  • Drug-induced liver injury has occurred. (aol.com)
  • In early 1961 doctors noticed an extraordinary increase in documented cases of children with a verity of birth defects, and they soon hypothesized that maternal exposure to Thalidomide during pregnancy caused these often-severe congenital abnormalities. (asu.edu)
  • A 1962 study titled "Thalidomide and Congenital Abnormalities," by Victor Knapp, George Christie, and Mary Seller, all working in the UK, looked at the teratogenic effects of Thalidomide on rats, mice, and rabbits, and the study reported no abnormalities in the offspring of these animals after researchers had exposed the pregnant females to the drug. (asu.edu)
  • Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. (wakehealth.edu)
  • In addition to this, the rising incidence of several associated risk factors, such as drug abuse, traumatic brain injury, arteriovenous malformations, vascular abnormalities, use of blood-thinning medications, etc., is also propelling the market growth. (imarcgroup.com)
  • Recent advances in the understanding of the cellular mechanisms responsible for these vascular abnormalities may ultimately lead to new therapeutic approaches for the treatment of asthma. (ersjournals.com)
  • In contrast, nongenomic actions are mediated by rapid cellular mechanisms, and induce transient vasoconstriction in the airway, thereby reversing inflammatory hyperperfusion. (ersjournals.com)
  • Both topical and systemic monotherapy may induce resistance among Cutibacterium acnes (C. acnes) and other organisms that comprise the commensal and transient flora. (skintherapyletter.com)
  • It has been established by recent studies that pomegranate derived products abrogate chemically induced tumors of lung, skin, breast and colon and it also abates the metastasis of xenografted lung and prostrate tumors in rodents 13 . (nature.com)
  • Many of the medical complications that arise are the direct consequence of the need to administer potent immunosuppressive agents, with their attendant risks of infection, malignancy and drug toxicity. (ersjournals.com)
  • conversely, food or one of its components may affect bioavailability and half-life, circulating plasma concentrations of drugs resulting in an increased risk of toxicity and its adverse effects, or therapeutic failure. (mdpi.com)
  • Coadministration with these agents may cause increases in simvastatin levels and potentiate its hepatic or muscle toxicity. (nih.gov)
  • However, pediatric drug toxicity cannot be predicted based on observation of adult patients. (ajmc.com)
  • Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system pathology. (druglib.com)
  • The failure of rodent models to inform scientists of Thalidomide's teratogenicity in humans ignited debate about the proper use of cross-species testing during drug development. (asu.edu)
  • In humans limb truncation in offspring is a common congenital abnormality arising from Thalidomide use by pregnant women. (asu.edu)
  • Similar to Knapp, Christie, and Seller's statement from three years prior, McColl and colleagues stated that the factors involved in embryogenesis and drug interaction are so complex that straightforward predictions from animal models to humans were not possible. (asu.edu)
  • Pazopanib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A4 activity. (nih.gov)
  • Загальні джерела літератури Many drugs (eg, statins) commonly cause asymptomatic elevation of hepatic enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase). (msdmanuals.com)
  • Hepatic fibrosis in rats was induced by the intra-peritoneal injection of NDEA (10 mlkg −1 b.wt. (nature.com)
  • Although cases have been reported even in the absence of predisposing factors, particular caution is advised in treating patients with other QT-prolonging conditions (including electrolyte imbalance [particularly hypokalemia and hypomagnesemia], drugs known to prolong QT, underlying cardiac abnormalities, hypothyroidism, and familial long QT-syndrome). (nih.gov)
  • It is subclassified into idiopathic, malignancy associated, and drug induced. (medindiajournal.com)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)
  • A ripiprazole, a partial agonist at central D 2 receptors, is a widely prescribed atypical antipsychotic drug. (psychiatrist.com)
  • Drug-induced urinary symptoms such as urinary retention, urgency, or incontinence or nocturnal enuresis have been reported rarely with various typical and atypical antipsychotic agents. (psychiatrist.com)
  • Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)
  • Therefore, the present study proposes a strategy for drug safety monitoring using the available biomarkers of SKM injury. (degruyter.com)
  • Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. (degruyter.com)
  • This can be incredibly useful in both clinical practice and for de-challenge/re-challenge investigational trials where the risk of drug-induced SKM injury is present. (degruyter.com)
  • The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)
  • These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
  • In clinical practice, as well as during drug development and in clinical trials, the diagnosis of SKM injury can be challenging due to the variable symptomology, reliance on patient-self reporting, and lack of highly specific biomarkers, such as those available for cardiac myocyte injury (i.e., cardiac troponins) [ 3 ]. (degruyter.com)
  • The use of checkpoint inhibitors in combination therapy further complicates the safety monitoring of SKM injury due to the potential for drug-drug interactions. (degruyter.com)
  • Adverse drug reactions (ADRs) due to antineoplastic agents are a common form of iatrogenic injury, and the lungs are a frequent target, as they process the entire cardiac output. (medicalnotes.info)
  • Apoptosis can be induced via two main pathways: interference with mitochondrial function, also called the intrinsic pathway, or triggering of cell surface death receptors, also called the extrinsic pathway (2,3). (eotp.org)
  • Nonspecific cytotoxic drugs such as alkylating agents or purine analogs have commonly been used to induce apoptosis via the intrinsic pathway. (eotp.org)
  • HDAC-Is exert pleiotropic antitumor effects by inducing growth arrest, differentiation, and apoptosis, both in vitro and in vivo (12). (eotp.org)
  • In malignant cells, HDACIs induce apoptosis SMIP004 by upregulation of proapoptotic and repression of antiapoptotic genes (14C16). (eotp.org)
  • These abnormalities are usually asymptomatic and self-limited even if therapy is continued. (nih.gov)
  • 2 Some patients may be asymptomatic and VBDS is initially identified based on laboratory abnormalities. (medsafe.govt.nz)
  • Many animals with compensated and asymptomatic chronic renal insufficiency sustain subtle insults (e.g., fever, concomitant disease, vomiting, diarrhea, congestive heart failure, drug administration), which precipitate a seemingly acute uremic crisis (designated A acute-on-chronic@ renal failure). (vin.com)
  • At birth, NADH-dependent methemoglobin reductase (also called cytochrome-b5 reductase), the major enzyme responsible for reduction of induced methemoglobin back to normal hemoglobin, has only about half the activity it has in adults [Hjelt et al. (cdc.gov)
  • It may be inherited, due either to a deficiency of methemoglobin reductase or to a structural abnormality of hemoglobin, or it may be acquired, usually secondary to exposure to drugs or chemicals that oxidize hemoglobin Nearly 90 compounds have been implicated in the production of Methemoglobinemia, nitrates and aniline derivatives are among the most common agents. (longdom.org)
  • Drugs rarely produce clinically significant Methemoglobinemia when given to a normal adult in therapeutic doses, while individuals with methemoglobin reductase deficiency or abnormal hemoglobin may exhibit severe effects as well as overdose. (longdom.org)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • A syndrome of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs. (druglib.com)
  • Drug-induced myopathies may result from various mechanisms. (degruyter.com)
  • The mechanisms of NAFLD and in particular fructose-induced lipid accumulation remain unclear, although there is evidence for a role for endoplasmic reticulum (ER) stress and oxidative stress. (aurorakinaseb.com)
  • Chemotherapeutic agents may cause adverse cardiac effects either directly, by compromising myocardial structure and function, or indirectly, by impairing vascular hemodynamics or other organ systems such as the endocrine glands, which may result in endocrinopathies. (ajmc.com)
  • If SCLE is drug-induced, withdrawal of the culprit medication in conjunction with medical therapy is often necessary for disease control. (medscape.com)
  • Valproic acid (VPA) is a short-chain fatty acid that belongs to a relatively new class of agents used for anticancer therapy, the histone deacetylase inhibitors (HDAC-I). VPA has been used as an anticonvulsant and mood-stabilizing drug for decades. (eotp.org)
  • 3. Patients with documented evidence of metastatic CRPC who have had at least one line of systemic therapy for metastatic CRPC (either chemotherapy or an novel hormonal agents [NHA]) or for whom no alternative approved therapy is available. (astrazenecaclinicaltrials.com)
  • Any other chemotherapy, immunotherapy, immunosuppressant medication (other than corticosteroids) or anti-cancer agents within 3 weeks of the first dose of study treatment, except hormonal therapy with luteinising hormone-releasing hormone (LHRH) analogues for medical castration in patients with prostate cancer, which are permitted. (astrazenecaclinicaltrials.com)
  • 5 Although ovarian cancer in advanced stages initially appears to be chemotherapy sensitive as response rates to platinum-based therapy exceed 80%, long-term survival remains poor as a result of recurrence and emergence of drug resistance. (nature.com)
  • During the course of initial treatment some patients may never respond, may develop drug-resistant disease or may not be able to tolerate their therapy. (aol.com)
  • If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. (druglib.com)
  • Furthermore, the inflating adoption of effective drugs, including diuretics, antihypertensive agents, antiepileptics, etc., for reducing the disease symptoms is acting as another significant growth-inducing factor. (imarcgroup.com)
  • SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome , deficiency of the second component of complement (C2d), or it may be drug-induced. (medscape.com)
  • however, some patients require additional agents to control their cutaneous disease. (medscape.com)
  • In perhaps as many as 30% of patients with SCLE, drugs may exacerbate or induce their disease. (medscape.com)
  • however, other antihypertensive agents, along with a list of over 100 different agents, have been reported in relation to the induction or exacerbation in individual patients. (medscape.com)
  • In a large case series of pregnant women with listeriosis, most patients were given a β-lactam antimicrobial drug, with or without gentamicin ( 6 ). (cdc.gov)
  • 19 published his findings on cortisone causing dramatic improvements in patients with rheumatoid arthritis, corticosteroids have become established as the most potent anti-inflammatory agents in the pharmacotherapy of various chronic inflammatory diseases, including asthma 20 . (ersjournals.com)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • SAN DIEGO, March 23 /PRNewswire-FirstCall/ - ACADIA Pharmaceuticals Inc. (Nasdaq: ACAD) today reported results from its Phase II clinical trial of ACP-103 in patients with Parkinson's disease suffering from treatment-induced psychosis. (acadia.com)
  • The Phase II clinical trial was a multi-center, double-blind, placebo-controlled study designed to evaluate the motoric tolerability, antipsychotic efficacy, and safety of ACP-103 in patients with Parkinson's disease suffering from treatment-induced psychosis. (acadia.com)
  • Occasionally neutrophilia may be absent in patients who are neutropenic secondary to malignancy, drugs, and congenital neutropenia. (medindiajournal.com)
  • The use of chemotherapy in CLL is limited, however, because of rapidly developing resistance and partial unresponsiveness of patients with p53 abnormalities (9,10). (eotp.org)
  • In view of this case report, amisulpride can be an alternative in patients with antipsychotic-induced urinary incontinence. (psychiatrist.com)
  • [ 1 ] In addition, drugs normally excreted by the kidney can accumulate to toxic levels in patients with chronic kidney disease (CKD). (medscape.com)
  • Therefore, adjusting dosages or avoiding such drugs, including iodinated contrast in high-risk patients, is a key management principle in patients with CKD. (medscape.com)
  • The administration of general anesthesia may induce a reduction in renal blood flow in up to 50% of patients, resulting in the impaired excretion of nephrotoxic drugs. (medscape.com)
  • For use of antiretroviral agents for post-exposure prophylaxis consult the most recent official guidelines, e.g. those of the WHO. (who.int)
  • This abnormality is caused by exposure to the drug in a short time period in early human embryonic development. (asu.edu)
  • The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (wakehealth.edu)
  • Additional implicated agents include calcium channel blockers, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, antifungal agents (particularly terbinafine), chemotherapy agents, immunotherapies, proton pump inhibitors, and tumor necrosis factor (TNF) antagonists. (medscape.com)
  • The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplatin, across the blood-brain tumor barrier. (biomedcentral.com)
  • Metabolically stable bradykinin B2 receptor agonists, methionine-lysine-bradykinin and labradimil, enhance the transvascular delivery of small chemotherapy drugs across the BBTB of malignant gliomas by increasing the blood half-life of the co-infused drug. (biomedcentral.com)
  • This permits the selective entry of small conventional chemotherapy drugs or contrast agents into malignant glioma tumor tissue[ 5 ]. (biomedcentral.com)
  • Even though the inherent leakiness of the BBTB does allow for the selective transvascular passage of small conventional chemotherapy drugs, such as carboplatin, these drugs do not achieve sufficiently high concentrations within tumor tissue after systemic infusion[ 9 ]. (biomedcentral.com)
  • Sweet syndrome (SS) is defined as an acute febrile neutrophilic dermatosis, which can be subclassified as classical, drug induced, and malignancy associated. (medindiajournal.com)
  • There is a large unmet medical need for new therapies that will effectively treat the psychosis and other dysfunctions that result from the use of dopamine replacement drugs without causing excess sedation, orthostatic hypotension or impairing motor function. (acadia.com)
  • Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
  • Corticosteroids are the most effective drugs to suppress airway inflammation, mainly by downregulation of pro-inflammatory proteins 22 , 23 . (ersjournals.com)
  • In addition, corticosteroids seem to reverse components of the asthma-induced structural changes (airway remodelling), including the increased vascularity of the bronchial wall 24 . (ersjournals.com)
  • The concomitant adverse effects resulting from the employment of synthetic drugs and chemicals have led to the discovery and implementation of efficacious nutraceuticals against diverse diseases. (nature.com)
  • Using dynamic contrast-enhanced MRI, the pharmacokinetics of gadolinium-diethyltriaminepentaacetic acid (Gd-DTPA), a small MRI contrast agent, were imaged in rodents bearing orthotopic RG-2 malignant gliomas. (biomedcentral.com)
  • The selectivity of the increase in drug delivery into the malignant glioma tissue, but not into normal brain tissue or skeletal muscle tissue, is due to the inherent porous nature of the BBTB of malignant glioma microvasculature. (biomedcentral.com)
  • A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. (druglib.com)
  • Abnormalities, Drug-Induced" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (who.int)
  • 6 Following the initial demonstration of the important role for miR in human cancer, such as downregulation of miR-15a-miR-16-1 in chronic lymphocytic leukemia, 7 a number of cancers have been shown to exhibit distinct miR expression patterns related to various phenotypes with remarkable cytogenetic abnormalities. (nature.com)
  • Donald L. Gilbert, MD, MS, with the division of neurology at Cincinnati Children's Hospital, and colleagues noted that all Food and Drug Administration-approved medications for Tourette syndrome are antipsychotics. (medscape.com)
  • Conversely, however, there are multiple reports 5 , 6 highlighting the benefits of aripiprazole in the treatment of enuresis induced by other antipsychotics, especially clozapine. (psychiatrist.com)
  • Such factors make the prediction of SKM-related adverse events challenging to predict for both new investigational agents and establishing approved therapeutics. (degruyter.com)
  • Any investigational agents or study drugs from a previous clinical study within 30 days of the first dose of study treatment. (astrazenecaclinicaltrials.com)
  • Sulfur mustard (SM) is a chemical warfare agent which is cytotoxic in nature, and at the molecular level, SM acts as DNA alkylating agent leading to genotoxic and reproductive effects. (nih.gov)
  • Bleomycin, busulphan, and methotrexate are by far the commonest cytotoxic drugs to cause interstitial pneumonitis. (medicalnotes.info)
  • However, many other cytotoxic drugs have been reported to produce similar lung damage. (medicalnotes.info)
  • Pulmonary abnormalities are a known side effect of several cytotoxic drugs. (medicalnotes.info)
  • Of the many cytotoxics, which of the following cytotoxic drugs is most likely to lead to a pleural friction rub? (medicalnotes.info)
  • 1). C H Collis: Lung damage from cytotoxic drugs. (medicalnotes.info)
  • Some commonly used cancer drugs, such as the anthracyclines, are known to be cardiotoxic. (ajmc.com)
  • In contrast, macrocytic anemias most commonly originate from abnormalities that impair erythroid precursors' maturation in the bone marrow. (eistria.com)
  • Thus chloramphenicol can cause pancytopenia, while granulocytopenia is more commonly seen with sulfonamides or antithyroid drugs. (eistria.com)
  • Commonly, this stems from unclear instructions on self-administration of antibiotics, use of sub-antimicrobial dosing, prescription of antibiotics for minor bacterial infections, use of antibacterial drugs for non-bacterial infections, and use of broad-spectrum antibiotics for narrow-spectrum indications. (skintherapyletter.com)
  • Unearthing and employment of healthy substitutes is now in demand to tackle a number of diseases due to the excessive repercussions of synthetic drugs. (nature.com)
  • However, the complete etiology of drug-induced myopathies remains unclear. (degruyter.com)
  • The grain weevil, an insect (pest) that infects grain, is a frequent contaminant of processed wheat, and its presence may contribute to respiratory abnormalities in grain workers. (cdc.gov)
  • In addition, the function of cholinesterase, an enzyme responsible for breaking down certain anesthetic agents, may be impaired, resulting in prolonged respiratory muscle paralysis if neuromuscular blocking agents are used. (medscape.com)
  • Drugs and pregnancy : human teratogenesis and related problems / edited by D. F. Hawkins. (who.int)
  • Women who are infected with L. monocytogenes in the third trimester of pregnancy are typically treated with antimicrobial drugs until the child's delivery ( 3 ). (cdc.gov)
  • Blood cultures taken after discontinuation of antimicrobial agents were sterile, and the remainder of her pregnancy was unremarkable. (cdc.gov)
  • The extrinsic or receptor-dependent pathway is usually induced by members of the tumor necrosis factor (TNF) family of proteins, where a ligand binds to one of the death receptors that subsequently recruit the death-inducing signaling complex (DISC) and the apical caspase 8 (4,5). (eotp.org)
  • A peripheral venous cannula is generally inserted to allow medication to be given such as sedatives, anesthesia, or drugs. (wikipedia.org)
  • Our Pacerone (Amiodarone HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • However, ovarian cancers often acquire chemotherapeutic resistance to this agent. (nature.com)
  • Any man exposed to a sufficient dose of inorganic arsenic, benzene, radiation, or conventional chemotherapeutic agents develops bone marrow suppression with pancytopenia. (eistria.com)
  • The authors noted that the study provided no grounds to think that drugs containing Thalidomide were safe for human use, and they argued that the only method guaranteed to safely deal with drugs of unknown teratogenicity would be to completely refrain from using them unless absolutely necessary. (asu.edu)
  • Pelvic ultrasound showed no abnormalities of the fetus, gestational sac, or uterus. (cdc.gov)
  • In their study titled "Effect of Some Therapeutic Agents on the Developing Rat Fetus," McColl and colleagues observed in rats an increase in resorption rate but no incidences of phocomelia, the absence or abnormal development of the limbs. (asu.edu)
  • Pharmacists can assist by identifying QT-prolonging medications and other drug-related considerations to help clinicians balance prescribing decisions with other patient-specific risk factors. (enclarapharmacia.com)
  • That outrage motivated a scientific debate over the efficacy of using model organisms, like mice and rats, in drug development. (asu.edu)
  • Last, the electrophysiologist may administer various drugs (proarrhythmic agents) to induce arrhythmia (inducibility of VT/VF). (wikipedia.org)
  • Antibiotics are most frequently associated with VBDS, although several drug classes and medicines have been implicated. (medsafe.govt.nz)
  • To provide rapid relief for Anaphylaxis or Acute Allergy (Angioedema) both to drugs and other allergens. (medicines.org.uk)
  • What Drugs, Substances, or Supplements Interact with Pacerone? (rxlist.com)
  • 5 The American Academy of Dermatology (AAD) guidelines recommend coadministration of benzoyl peroxide, a topical bactericidal agent not reported to cause resistance, together with both topical and oral antibiotics. (skintherapyletter.com)
  • Generalized spasms occur, frequently induced by sensory stimuli. (cdc.gov)
  • In contrast, only occasionally does a reaction occur among idiosyncratic agents that result in the suppression of one or more cell lines (1 in 100 to 1 in a million). (eistria.com)
  • Pharmacologic studies included in vitro challenge of guinea pig trachea with GWE, in parallel organ baths, pretreated with mediator-modifying agents or a control solution. (cdc.gov)
  • In addition, checkpoint inhibitors are more frequently being employed in combination with other agents (including with other checkpoint inhibitors) in clinical practice, as well in hundreds of combination drug trials with other novel biological, targeted, and immunotherapies. (degruyter.com)
  • Serologic abnormalities are common. (medscape.com)
  • The drug treatment of Parkinson's disease produces a high incidence of hallucinations and paranoid delusions, which in turn are the most common causes for nursing home placement. (acadia.com)
  • Drug-induced LQTS is the most common cause of acquired LQTS and will be the focus of this resource. (enclarapharmacia.com)
  • It "may be a safe and effective treatment of Tourette syndrome with advantages over other currently approved therapeutic agents," the authors wrote. (medscape.com)
  • This includes treatment practices, in-market, and pipeline drugs, share of individual therapies, market performance across the seven major markets, market performance of key companies and their drugs, etc. (imarcgroup.com)
  • HA521 trade name] is indicated in combination with another antiretroviral agent for the treatment of human immunodeficiency virus (HIV) infection in adults, adolescents and children weighing over 25 kg. (who.int)
  • Pacerone (amiodarone HCl) is an antiarrhythmic drug indicated for treatment of recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia only when these conditions have not responded to documented adequate doses of other available antiarrhythmics or when alternative agents could not be tolerated. (rxlist.com)
  • 8. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. (astrazenecaclinicaltrials.com)
  • The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. (druglib.com)
  • Haloperidol is contraindicated in severe toxic central nervous system depression or comatose states from any cause and in individuals who are hypersensitive to this drug or have Parkinson's disease. (nih.gov)
  • Nervous system abnormalities, as well as a variety of complications related to severe spasm and prolonged hospitalization, can accompany generalized tetanus. (cdc.gov)
  • The kidneys may be subclinical for disease but they do not tolerate additional insults such as anesthetic induced hypotension. (vin.com)
  • In most cases this doesn't mean that the anesthetic protocol (i.e., drugs) needs to be radically changed but appropriate monitoring and support is very important. (vin.com)
  • It is vital to ensure that dehydration is not present prior to administering the anesthetic agent. (vin.com)
  • However, drug-induced myopathy is among the most frequent causes of muscle disease. (degruyter.com)