Alpha-agonist hypotensive agentHypertensionOral AntihypertensiveAgonistsCatapres TTSHypersensitivityClinicalReceiving concomitantKAPVAYHydrochloride tabletsSystemicDosesHypertensive ratsTherapeuticDrugsConcurrentlyTransdermal patchBisoprololMedicationsCardiac2021OrallyThiazidesOutcomesBeta-BlockersDerivativesPharmacologicStimulating receptorsTabletsSympatheticSedativesDosageChildren and adultsEffectMagnesiumTherapyDrugHemodynamicBloodImidazolineAlcohol
Alpha-agonist hypotensive agent3
- Clonidine hydrochloride USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. (prescriptiondrugs.com)
- Clonidine is a centrally acting alpha‑agonist hypotensive agent. (nih.gov)
- Clonidine is an alpha-agonist hypotensive agent to decrease blood pressure employed alone or in combination with other antihypertensive drugs. (buyviagraonliney.com)
Hypertension15
- Clonidine hydrochloride USP tablets are indicated in the treatment of hypertension. (prescriptiondrugs.com)
- Clonidine also has peripheral alpha1-agonist activity, which may produce transient vasoconstriction and hypertension early in overdose when peripheral drug levels may be transiently higher than levels in the CNS. (medscape.com)
- Thus, agmatine-like compound has the potential to develop as a new therapeutic agent for hypertension in the future. (hindawi.com)
- Thus, development of the better agent to handle hypertension is urgent [ 1 ]. (hindawi.com)
- Thus, development of new agent for management of hypertension is essential. (hindawi.com)
- Then, this may help the development of new agent(s) for hypertension in the future. (hindawi.com)
- Antihypertensive agents are medications used to lower blood pressure and treat hypertension. (pharmacologymentor.com)
- β-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. (com.bd)
- Clonidine is used to treat hypertension ( high blood pressure ). (online98.org)
- Clonidine is a central alpha-2 adrenergic agonist that is FDA approved for the treatment of hypertension . (wikidoc.org)
- Hypertension treatment with clonidine can be administered orally (tablets) or by transdermal patches. (wikidoc.org)
- Antihypertensives are a class of drugs that are used in medicine and pharmacology to treat hypertension (high blood pressure). (wikidoc.org)
- [8] In particular, atenolol seems to be less useful in hypertension than several other agents. (wikidoc.org)
- Despite lowering blood pressure, alpha blockers have significantly poorer endpoint outcomes than other antihypertensives, and are no longer recommended as a first-line choice in the treatment of hypertension. (wikidoc.org)
- In hypertension, it is used as an adjunct to prolonged therapy with thiazides and similar agents to prevent potassium depletion. (janusinfo.se)
Oral Antihypertensive1
- High blood pressure levels that produce no signs or symptoms of target organ damage may be treated without hospitalization through an increase in or reestablishment of previously prescribed oral antihypertensive medication. (nursingcenter.com)
Agonists1
- Centrally-acting sympatholytic agent/agents (alpha2 adrenergic receptor agonists). (pharmacology2000.com)
Catapres TTS5
- Catapres‑TTS ® (clonidine transdermal system) is a transdermal system providing continuous systemic delivery of clonidine for 7 days at an approximately constant rate. (nih.gov)
- Catapres‑TTS ® is a multi-layered film, 0.2 mm thick, containing clonidine as the active agent. (nih.gov)
- Catapres‑TTS ® (clonidine transdermal system) is programmed to release clonidine at an approximately constant rate for 7 days. (nih.gov)
- If the Catapres‑TTS ® is removed and not replaced with a new system, therapeutic plasma clonidine levels will persist for about 8 hours and then decline slowly over several days. (nih.gov)
- Before you take clonidine, tell your doctor if you have heart disease or severe coronary artery disease, a heart rhythm disorder, slow heartbeats, low blood pressure, a history of heart attack or stroke, kidney disease, or if you have ever had an allergic reaction to a Catapres TTS transdermal skin patch. (online98.org)
Hypersensitivity3
- Clonidine hydrochloride USP tablets should not be used in patients with known hypersensitivity to clonidine (see PRECAUTIONS ). (prescriptiondrugs.com)
- KAPVAY is contraindicated in patients with a history of a hypersensitivity reaction to clonidine. (pillintrip.com)
- Hypersensitivity to Clonidine or any component of the formulation. (buyviagraonliney.com)
Clinical4
- The clinical used antihypertensive agent rilmenidine may reduce blood pressure via an activation of imidazoline I 1 -receptors in brain to lower sympathetic tone [ 8 , 9 ]. (hindawi.com)
- Several systematic reviews of clinical trials support the introduction of spironolactone (compared with other antihy-pertensive agents) as a fourth agent for reducing BP.83-86 However, none of the trials report on cardiovascular out-comes or mortality. (hypertension.ca)
- A number of other agents have been shown to be effective in smoking cessation but are not commonly used in clinical practice. (copdx.org.au)
- Due to the lack of controlled clinical trial data and differing pharmacokinetic profiles, substitution of KAPVAY for other clonidine products on a mg-per-mg basis is not recommended. (pillintrip.com)
Receiving concomitant1
- The following less frequent adverse experiences have also been reported in patients receiving clonidine hydrochloride tablets, but in many cases patients were receiving concomitant medication and a causal relationship has not been established. (prescriptiondrugs.com)
KAPVAY1
- KAPVAY® (clonidine hydrochloride) extended-release is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications. (pillintrip.com)
Hydrochloride tablets2
- Clonidine hydrochloride tablets contain the following inactive ingredients: lactose, magnesium stearate, microcrystalline cellulose, pregelatinized starch, and sodium starch glycolate. (prescriptiondrugs.com)
- Clonidine hydrochloride tablets must be adjusted according to the patient's individual blood pressure response. (wikidoc.org)
Systemic2
- Clonidine from the drug reservoir then begins to flow through the rate‑controlling membrane and the adhesive layer of the system into the systemic circulation via the capillaries beneath the skin. (nih.gov)
- Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine. (nih.gov)
Doses4
- At therapeutic doses (0.2-0.9 mg/d), clonidine is commonly associated with adverse effects such as dry mouth, sedation, dizziness, and constipation. (medscape.com)
- While generally safe, at toxic doses clonidine can cause serious cardiopulmonary instability and central nervous system (CNS) depression in children and adults. (medscape.com)
- Children may be easily affected by relatively small doses of clonidine. (medscape.com)
- Many antihypertensives can be obtained or prepared as oral suspensions for children who cannot take pills or capsules and when nonstandard doses are needed. (msdmanuals.com)
Hypertensive rats1
- Recently, an activation of peripheral imidazoline I 2 -receptor (I-2R) was documented to produce antihypertensive actions in spontaneous hypertensive rats (SHRs) [ 10 ]. (hindawi.com)
Therapeutic1
Drugs4
- Educating patients about the importance of keeping clonidine and all drugs out of children's reach is critical. (medscape.com)
- Thus, peripheral I-2R seems a potential target in development of antihypertensive drugs without side effects of sympathetic inhibition. (hindawi.com)
- If the two drugs are coadministered, the β-blocker should be withdrawn several days before discontinuing clonidine. (com.bd)
- Insomnia inducing drugs include caffeine, nicotine, weight loss preparations, and activating agents of both prescription and abuse. (springer.com)
Concurrently3
- Bisoprolol fumarate should be used with care when myocardial depressants or inhibitors of A-V conduction, such as certain calcium antagonists (particularly of the phenyl alkylamine (verapamil) and benzothiazepine (diltiazem) classes), or antiarrhythmic agents, such as disopyramide, are used concurrently. (com.bd)
- Kidney damage maybe caused by increased concentration of Cyclosporine when Clonidine is administered concurrently. (buyviagraonliney.com)
- Usually half 'Amiloride' tablet (2.5mg) given once a day together with the usual antihypertensive dosage of the thiazide concurrently employed. (janusinfo.se)
Transdermal patch1
- Clonidine is also available as a transdermal patch worn on the skin. (online98.org)
Bisoprolol1
- Bisoprolol fumarate should not be combined with other β-blocking agents. (com.bd)
Medications5
- In this brief overview, medications used to treat insomnia such as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome are discussed. (springer.com)
- These are the agents that should be exclusively classified as hypnotics and utilized to induce sleep when medications are required to treat the complaint of insomnia. (springer.com)
- Medications for treating insomnia are classified as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome (RLS) (Curry et al. (springer.com)
- Concomitant prescription of Clonidine with medications which lower heart rate (beta-blockers) should be done with cautiousness. (buyviagraonliney.com)
- Clonidine is sometimes given with other medications. (online98.org)
Cardiac2
- Acute studies with clonidine hydrochloride in humans have demonstrated a moderate reduction (15% to 20%) of cardiac output in the supine position with no change in the peripheral resistance: at a 45° tilt there is a smaller reduction in cardiac output and a decrease of peripheral resistance. (prescriptiondrugs.com)
- Antihypertensives/cardiac glycosides may lower blood pressure. (nih.gov)
20212
- In the 2021 Annual Report of the American Association of Poison Control Centers' National Poison Data System, 5512 single exposures to clonidine were reported. (medscape.com)
- Of the 5512 reported toxic exposures to clonidine in 2021, 3751 were treated in a health care facility. (medscape.com)
Orally1
- Clonidine maybe used orally or as patches applied to your skin, it treats high blood pressure. (buyviagraonliney.com)
Thiazides2
- Long-term antihypertensive effects of thiazides appear due to reduce vascular resistance. (pharmacology2000.com)
- In congestive heart failure, Amiloride Hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents. (janusinfo.se)
Outcomes1
- For this procedure, outcomes have been improved by intraoperative application of 5-FU (5-fluorouracil) or mitomycin, agents that reduce postoperative fibrosis which may result in channel closure. (pharmacology2000.com)
Beta-Blockers1
- Although beta blockers lower blood pressure, they do not have as positive a benefit on endpoints as some other antihypertensives. (wikidoc.org)
Derivatives1
- Thus, it is of special interest to characterize the I-2R using guanidinium derivatives in blood vessels for development of antihypertensive agent(s). (hindawi.com)
Pharmacologic1
- The exact relationship of these pharmacologic actions to the antihypertensive effect of clonidine has not been fully elucidated. (prescriptiondrugs.com)
Stimulating receptors1
- Clonidine acts primarily as a presynaptic CNS alpha2-agonist, stimulating receptors in the nucleus tractus solitarii of the medulla oblongata. (medscape.com)
Tablets3
- Clonidine hydrochloride USP tablets act relatively rapidly. (prescriptiondrugs.com)
- Clonidine hydrochloride USP tablets may be employed alone or concomitantly with other antihypertensive agents. (prescriptiondrugs.com)
- Do not crush, chew, or break tablets because this will increase the rate of clonidine release. (pillintrip.com)
Sympathetic1
- characterization of substances, such as epinephrine and norepinephrine, that exert their effect in the sympathetic autonomic nervous system and agents that are chemically similar to these substances. (ashp.org)
Sedatives1
- Other pharmacological agents producing sedation (sedatives and agents used off-label for sedative side-effects) should be used cautiously for the treatment of insomnia due to the increased risk of next day sleepiness as well as for known toxicities and adverse side effects. (springer.com)
Dosage3
- Usually Clonidine is taken twice daily, dosage depends on individual blood pressure response of a patient. (buyviagraonliney.com)
- Treatment should be started with a low dose of Amiloride, i.e. 5mg (1 tablet), plus a low dosage of the other diuretic agent. (janusinfo.se)
- If necessary, dosage of both agents may be increased gradually until there is effective diuresis. (janusinfo.se)
Children and adults1
- Clonidine acutely stimulates growth hormone release in both children and adults, but does not produce a chronic elevation of growth hormone with long-term use. (prescriptiondrugs.com)
Effect6
- Tolerance to the antihypertensive effect may develop in some patients, necessitating a reevaluation of therapy. (prescriptiondrugs.com)
- It is concluded that the antihypertensive effect of Abana might be due to its alteration of cation transport into the cell. (ijp-online.com)
- Angiotensin converting enzyme, anti-hypertensive effect, hipotensive agents. (scielo.br)
- Some agents may impair antihypertensive effect. (medicscientist.com)
- Clonidine causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. (buyviagraonliney.com)
- Certain antidepressants may diminish pharmaceutical effect of Clonidine. (buyviagraonliney.com)
Magnesium1
- Magnesium sulfate is not recommended as an antihypertensive agent, but magnesium sulfate remains the drug of choice for seizure prophylaxis in severe preeclampsia and for controlling seizures in eclampsia. (medscape.com)
Therapy1
Drug2
- Slowing of the pulse rate has been observed in most patients given clonidine, but the drug does not alter normal hemodynamic response to exercise. (prescriptiondrugs.com)
- Clonidine flows in the direction of the lower concentration at a constant rate, limited by the rate‑controlling membrane, so long as a saturated solution is maintained in the drug reservoir. (nih.gov)
Hemodynamic1
- The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. (wikidoc.org)
Blood3
- If you suspect that you took too much of Clonidine and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention. (buyviagraonliney.com)
- Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. (online98.org)
- There are many classes of antihypertensives, which-by varying means-act by lowering blood pressure. (wikidoc.org)
Imidazoline1
- Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. (prescriptiondrugs.com)
Alcohol1
- Clonidine hydrochloride is an odorless, bitter, white, crystalline substance soluble in water and alcohol. (prescriptiondrugs.com)