• Furthermore, ATryn, the recently approved recombinant antithrombin by U.S. FDA, is found to have contraindications in patients who have hypersensitivity to goat milk proteins. (openpr.com)
  • While EPO-Fc can be simultaneously detected with other recombinant erythropoietins by routine doping control assays, there are currently no tests for other doping-relevant Fc-fusion proteins such as the myostatin inhibitor ActRIIB-Fc (ACE031) or the cytokine GDF15/Fc, which is a member of the transforming growth factor beta (TGFβ) superfamily. (wada-ama.org)
  • Within this study, a proteomics-based detection assay for emerging Fc-fusion proteins relevant as performance-enhancing agents in sports will be developed. (wada-ama.org)
  • The aim of this research project was to develop detection assays for two emerging Fc-fusion proteins potentially relevant as performance-enhancing agents in sports: The TGF-β cytokine GDF-15/Fc and an ActRIIB-Fc fusion protein related to the TGF-β/myostatin inhibitor ACE-031. (wada-ama.org)
  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. (cusabio.com)
  • These novel sequences of recombinant DNA are used to produce repetitive proteins to create new types of drugs and bioengineered tissues. (bionity.com)
  • Using Dyadic's proprietary filamentous fungal based microbial protein production platforms, the Company has been able to successfully develop stable cell lines to produce animal-free recombinant bovine serum albumin and recombinant human serum albumin at high levels. (itbusinessnet.com)
  • Today, serum albumin can be manufactured without blood plasma through recombinant protein production technology. (itbusinessnet.com)
  • Recombinant serum albumin provides high-quality consistency reducing time and offering high-grade performance for applications where protein contaminants are undesirable. (itbusinessnet.com)
  • It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)
  • Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
  • Fc-fusion based drugs are an emerging class of pharmaceuticals which already found their way into competitive sports: EPO-Fc is an erythropoiesis-stimulating agent where the attachment of two immunoglobulin Fc domains to the protein results in a prolonged therapeutic activity due to an increased plasma half-life and enables administration via inhalation. (wada-ama.org)
  • This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)
  • Results suggest that insulin like growth factor binding protein 6 (IGFBP6) may be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). (cusabio.com)
  • We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like growth factor binding protein-6 (IGFBP6) gene. (cusabio.com)
  • The preferred route of administration for an injected therapeutic agent is subcutaneous (SC), but SC injections are generally limited to no more than 1-2 mL in volume, representing a major challenge, especially for large protein biologics. (pharmtech.com)
  • This multifaceted protein serves as an essential carrier of iron and is crucial for cellular growth, immunity, and various physiological processes. (prospecbio.com)
  • A variety of growth factors (GFs)-including bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), and peptides of the parathyroid hormone (PTH)-have been tested for local bone regeneration. (allenpress.com)
  • There are many protein-polymer based medications in use today, such as human growth hormones, drugs to stimulate blood cell formation in cancer patients and anti-viral agents. (bionity.com)
  • A plethora of biological agents are currently available in the market, including insulins, vaccines, human growth hormone, erythropoietin, interleukins, interferon, clotting factors and monoclonal antibodies 3 4 . (lww.com)
  • Background: Adverse outcomes in breast cancer patients treated with recombinant human erythropoietin (rhEpo) have been linked to the expression of Epo-receptors (EpoR) in cancer cells, although limited data on the clinical significance of these observations are available. (iiarjournals.org)
  • Initial independent analytical testing of the Company's recombinant bovine albumin demonstrated it is structurally equivalent to commercial animal derived product. (itbusinessnet.com)
  • or = 2 years' duration) were treated in a retrospective analysis of the results of vitrectomy, 16% perfluoropropane gas tamponade, and one of three adjunctive agents (bovine transforming growth factor beta-2, recombinant transforming growth factor beta-2, or autologous platelet extract). (nih.gov)
  • One application was recombinant bovine growth hormone (rBGH), which aims to increase the yield of milk. (berkeley.edu)
  • c) increasing access, affordability and effective deployment of vaccines, antiviral agents, diagnostics and other materials for pandemic preparedness and response. (who.int)
  • The antitumor efficacy of the recombinant virus on hepatoma was examined both in cell cultures and in mice. (usda.gov)
  • Clinical trials and studies involving individuals with iron-related disorders, such as iron-deficiency anemia, will be conducted to evaluate the efficacy and safety of recombinant transferrin supplementation. (prospecbio.com)
  • A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency. (qxmd.com)
  • Model mice for allergic airway inflammation were intranasally administered recombinant adenovirus that express SCGB3A2, and the effect of overexpressed SCGB3A2 on antigen-induced airway inflammation was investigated. (biovendor.com)
  • YKL-1, E1B 55 kDa-deleted recombinant adenovirus vector, capable of harboring a transgene casette of up to 4.9 kb, was newly constructed by reintroducing E1A and E1B 19 kDa into E1/E3-deleted adenoviral vector with a homologous recombination in E. coll. (elsevierpure.com)
  • Increasingly, recombinant serum albumin is being used as an alternative to plasma-derived albumin in human therapeutics, cell culture media, diagnostic test kits, and research & development. (itbusinessnet.com)
  • Most fungal plant pathogens, human infectious agents and post-harvest damage caused by pathogens have been a serious threat to the economy and human health. (benthamscience.com)
  • In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
  • Antimicrob Agents types in human airway epithelium. (cdc.gov)
  • Recombinant Human Transferrin produced in CHO cells is a glycosylated, polypeptide chain containing having a molecular mass of 76 kDa. (prospecbio.com)
  • Human recombinant transferrin, a glycoprotein responsible for iron transport in the body, has gained increasing attention in the fields of biomedicine and health sciences. (prospecbio.com)
  • This study aims to provide a comprehensive exploration of human recombinant transferrin, shedding light on its various functions and potential applications in health and biomedicine. (prospecbio.com)
  • The second objective is to assess the clinical relevance of human recombinant transferrin in medical interventions. (prospecbio.com)
  • The third objective is to explore the broader implications of human recombinant transferrin in biomedicine and research. (prospecbio.com)
  • By delving into the diverse functions of human recombinant transferrin, this research aims to expand our understanding of its physiological roles and clinical applications. (prospecbio.com)
  • Therapy with recombinant human insulin-like growth factor-I (rhIGF-I) can bypass the defect in the GH receptor and potentially stimulate growth. (qxmd.com)
  • All projects involving microorganisms, recombinant DNA technologies and human or animal fresh/frozen tissues, blood or body fluids must adhere to the rules below AND, depending on the study, to the additional rules in Section A, B or C. (societyforscience.org)
  • Because the Epo response to cancer anaemia appears to be limited, human recombinant erythropoetin or so called erythropoesis stimulating agents (ESAs) have been introduced for the treatment of patients with cancer-related or chemotherapy-induced anaemia ( 9 ). (iiarjournals.org)
  • In the mouse model, recombinant human SCGB3A2 exhibited anti-fibrotic and growth factor activities comparable to those of recombinant mouse SCGB3A2. (biovendor.com)
  • The recombinant porcine sequence product (Obizur) is less likely to be affected by the antibodies against human FVIII that are present in people with acquired hemophilia A. Recombinant FVIII porcine sequence is specifically indicated for treatment of bleeding episodes in adults with acquired hemophilia. (medscape.com)
  • What does human growth hormone (hgh) therapy cost? (efectownie.pl)
  • Recombinant human growth hormone improves muscle amino acid. (efectownie.pl)
  • This article describes the trends and characteristics of the data associated with restricted experimental requests involving select agents and toxins that have an impact on public health and safety (US Department of Health and Human Services agents only) or both public health and safety and animal health or products (overlap agents). (cdc.gov)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • The TGFβ superfamily includes several growth factors which are promising therapeutic targets for metabolic disorders and muscular dystrophies. (wada-ama.org)
  • Therapeutic agents can be introduced into the body by several routes of administration with each having specific advantages and disadvantages (see Table I). For many drugs, including biologics and anticancer agents, the traditional route of administration is intravenous (IV). (pharmtech.com)
  • Its recombinant form, produced through advanced biotechnological methods, offers several advantages for therapeutic and research purposes. (prospecbio.com)
  • These investigations may provide insights into the use of recombinant transferrin as a therapeutic agent in various clinical settings. (prospecbio.com)
  • These results suggest that SCGB3A2 may have a potential to be used as a therapeutic agent in treating patients suffering from lung diseases or promoting lung development in premature infants in future. (biovendor.com)
  • Somatorelin is a diagnostic agent for determining growth hormone deficiency. (wikipedia.org)
  • It is a recombinant version of growth hormone-releasing hormone (GHRH). (wikipedia.org)
  • Somatorelin has been used to study hormone deficiency (particularly growth hormone deficiency), cognitive impairment, sleep disorders, and aging. (wikipedia.org)
  • Therefore, active, broad-spectrum antimicrobial agents have been dis- we generated recombinant influenza (A/WSN/33) viruses covered since quinolones. (cdc.gov)
  • Analysis of the recombinant influenza exploit a new mechanism of action. (cdc.gov)
  • To stimulate growth hormones led to increased strength in thigh muscles. (efectownie.pl)
  • Erythropoetin (Epo) is a 30.4 kDa glycoprotein that regulates erythropoesis by stimulating growth, preventing apoptosis and inducing differentiation of red blood cell precursors. (iiarjournals.org)
  • In vitro and in vivo experiments will be conducted to investigate how recombinant transferrin interacts with cellular receptors, regulates iron uptake, and influences cellular proliferation. (prospecbio.com)
  • The antigenic analysis demon- tent antimicrobial activity even against multiple drug- strated that the 1918 recombinant viruses most closely resistant strains. (cdc.gov)
  • Among the biological agents re- because species specificity limits the causes lymphoproliferative diseas- viewed in Volume 100B of the IARC feasibility of this approach for most of es in New World monkeys and in Monographs (IARC, 2012) are sever- these viruses. (who.int)
  • Antimicrobial Agents and Chemotherapy. (cdc.gov)
  • antimicrobial agents that can combat the rising tide of microbial resistance. (cdc.gov)
  • Lately, an interest about granulocyte transfusions was renewed, what is a logical approach in the management of patients with prolonged 'reversible' severe neutropenia and severe infection, which is not controlled with appropriate antimicrobial and supportive treatment, including recombinant hematopoietic growth factors. (elis.sk)
  • The recent FDA approval of recombinant antithrombins in major region has increasingly boosted the market. (openpr.com)
  • In spite of the development of growth factors, new broad spectrum antibiotics and antifungal drugs against nearly all known pathogens, severe neutropenia associated with bacterial or invasive fungal infections remains a major cause of morbidity and mortality in patients undergoing aggressive cancer chemotherapy or hematopoietic stem cell transplantation. (elis.sk)
  • In addition, recombinant serum albumin is more homogeneous than plasma-derived serum albumin and lacks immunogenicity and toxicity while offering a distinct and uniform medium. (itbusinessnet.com)
  • the mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with the growth of normal and neoplastic cells. (medscape.com)
  • The molecule, a recombinant Antithrombin, has been manufactured by rEVO Biologics and has been useful in treating patients suffering from hereditary antithrombin (AT) deficiency undergoing surgery or giving birth. (openpr.com)
  • Key companies operating in the antithrombin (recombinant) market include rEVO Biologics Inc., Ovation Pharmaceuticals, and GTC Biotherapeutics Inc. In the coming years, the market is expected to witness several large pharmaceutical companies making a foray in the biotechnology segment. (openpr.com)
  • Using a recombinant DNA-derived hyaluronidase enzyme is an approach for possibly changing dosing regimens and bioavailability of several types of agents, including biologics. (pharmtech.com)
  • When dealing with potentially hazardous biological agents, it is the responsibility of the student and all of the adults involved in a research project to conduct and document a risk assessment on Form (6A) to define the potential level of harm, injury or disease to plants, animals and humans that may occur when working with biological agents. (societyforscience.org)
  • Experiments that involve the deliberate transfer of, or selection for, a drug (or chemical) resistance trait to select agents that are not known to acquire the trait naturally, if such acquisition could compromise the control of disease agents in humans, veterinary medicine, or agriculture (ie, the transfer of drug-resistant traits into select agents). (cdc.gov)
  • Experiments involving the deliberate formation of synthetic or recombinant DNA containing genes for the biosynthesis of select toxins lethal for vertebrates at an LD 50 <100 ng/kg body weight (ie, nucleic acids that encode select toxins). (cdc.gov)
  • Representative examples include, but are not limited to the following known agents: MRSA (Methicillin- Resistant Staphylococcus aureus ), VISA/VRSA (Vancomycin Intermediate or Resistant Staphylococcus aureus ), VRE (Vancomycin-Resistant Enterococci ), CRE (Carbapenem Resistant Enterobacteriacae ), ESBLs (Extended Spectrum Beta-Lactamase producing gram negative organisms), and fungi (yeasts or molds) with known resistance to antifungal agents. (societyforscience.org)
  • Medications used to treat acquired hemophilia include antihemophilic agents, corticosteroids, immunosuppressive agents, and monoclonal antibodies (mAbs). (medscape.com)
  • The improved, modified population of agents is able to grow, compete with other microbial strains and fungi, and provide protection for plants from pathogens. (justia.com)
  • The substantial growth in these regional markets is attributed to the early adoption of recombinant antithrombins in preventing various clinical conditions caused by the prevention of blood clots. (openpr.com)
  • The requirement of high dosage of serum albumin in clinical applications is expected to continue to drive demand for economical large-scale production of animal-free recombinant serum albumin which provides us the opportunity to leverage our microbial expression platforms to potentially develop and commercialize multiple end-market serum albumin products in both pharmaceutical and non-pharmaceutical applications. (itbusinessnet.com)
  • The present invention is useful for enhancing the competitiveness of modified biological agents particularly over other microbial agents which are not herbicide resistant. (justia.com)
  • The US Centers for Disease Control and Prevention Division of Select Agents and Toxins (DSAT) regulates laboratories that possess, use, or transfer select agents and toxins within United States as part of the Federal Select Agent Program. (cdc.gov)
  • Factors driving market growth include increase in the adoption of albumin products, growth in awareness about recombinant albumin products, and increasing use of albumin in other applications such as an excipient and drug formulating agent. (itbusinessnet.com)
  • Scholars@Duke publication: Role of growth factors and thrombopoietic agents in the treatment of chronic hepatitis C. (duke.edu)
  • Advanced liver disease and interferon-based treatment are both associated with varying degrees of cytopenia in patients with chronic hepatitis C. Growth factors to increase hemoglobin and neutrophils are commonly used in clinical practice, despite the absence of data to indicate benefits in terms of sustained viral response. (duke.edu)
  • Skin aging is a complex biological process influenced by a combination of endogenous (ie, chrono-aging) and exogenous (ie, from external agents, such as ultraviolet light, environmental insults, etc.) factors. (dovepress.com)
  • The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. (allenpress.com)
  • PI3K is activated by growth factors resulting in, among others, the activation of Akt and mTOR. (hindawi.com)
  • Recombinant products are recommended to manage bleeding in acquired hemophilia. (medscape.com)
  • Engineered recombinant antithrombin has gained clinical significant in recent years for the prevention of various peri-partum and peri-operative thromboembolic events or blood clots. (openpr.com)
  • Nevertheless, recent advances in clinical studies in evaluating the potential of recombinant antithrombins in prolonging gestation so as to improve maternal and neonatal outcomes have opened up exciting opportunities for market players. (openpr.com)
  • Such modified populations can be added to soils to prevent fungal pathogens and the associated diseases thereby promoting plant growth. (justia.com)
  • The mature chain is composed of three epidermal growth factor (EGF) repeats and two discoidin-I-like domains. (rndsystems.com)
  • Methods for improving the ability of a population of biological agents to compete and survive in a field setting are provided. (justia.com)
  • Modified biological agents and modified populations of such agents that are herbicide tolerant or resistant are selected or engineered. (justia.com)
  • Disclosed compositions include selected or engineered herbicide resistant biological agents and modified populations of biocontrol agents. (justia.com)
  • These modified biological agents can be used as an inoculant or seed coating for plants and seeds. (justia.com)
  • There is a need for biological control agents that are able to compete in field conditions particularly in the presence of herbicides and fungicides that are commonly used in commercial farming and can have antibiotic effects on microorganisms. (justia.com)
  • In addition, modified biological control agents promote plant growth and yield. (justia.com)
  • The modified biological agents are able to grow in the presence at least one herbicide, fungicide, pesticide, or other crop protection chemical that is used in commercial farming. (justia.com)
  • Students are permitted to do research projects with potentially hazardous biological agents meeting the conditions and rules described below which were designed to protect students and to ensure adherence to federal and international biosafety regulations and guidelines. (societyforscience.org)
  • 3. Experimentation involving the culturing of potentially hazardous biological agents, even BSL-1 organisms, is prohibited in a home environment. (societyforscience.org)
  • The US Centers for Disease Control and Prevention Division of Select Agents and Toxins (DSAT) manages the possession, use, and transfer of biological select agents and toxins, which have the potential to pose a severe threat to public health and safety. (cdc.gov)
  • Newcastle disease virus (NDV), an avian disease pathogen, has been proved to be an efficient cancer cells killing, or oncolytic, agent. (usda.gov)
  • NDV Anhinga strain, which could be classified as a lytic strain, is an effective oncolytic agent on hepatoma. (usda.gov)
  • Most importantly, ERRP was found to inhibit pancreatic tumor growth in a severe combined immunodeficient mouse xenograft model. (aacrjournals.org)
  • Furthermore, YKL-1 effectively prohibited both Hep3B and C33A tumor growth in nu/nu mice in a dose-dependent manner. (elsevierpure.com)
  • Using an E. coli strain deficient with ALKB, we found that ALKBH6 complements ALKB deficiency and increases resistance after alkylating agent treatment. (frontiersin.org)
  • Drugs that disturb platelet function, including aspirin and nonsteroidal anti-inflammatory agents (NSAIDs), and any herbal medications that can precipitate bleeding should be avoided until the inhibitor is eradicated. (medscape.com)
  • The primary end users of recombinant serum albumin are biotech and pharmaceutical companies, especially those in vaccine development, hospitals and medical clinics, and research and development organizations. (itbusinessnet.com)
  • Understanding the multifaceted properties of recombinant transferrin may open new avenues for innovative approaches in various medical specialties and scientific research. (prospecbio.com)
  • This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)
  • In the current study, we examined the effects of recombinant ERRP on the growth and ligand-induced activation of multiple members of erbB family in three pancreatic cancer cell lines that express varying levels of EGFR and other member(s) of its family, specifically HER-2. (aacrjournals.org)
  • EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. (rndsystems.com)
  • which under the select agent regulations are experiments that pose heightened biosafety risks. (cdc.gov)
  • The lead investigator in this study, Caroline Thomsen, MD, a medical oncologist at Vejle Hospital in Denmark, believes the effects of delta tocotrienol rely not only on its antiangiogenic activity but also on inhibition of additional mechanisms specific to aberrant cellular growth. (naturalmedicinejournal.com)
  • Discovering a specific agent, which targets multiple members of the erbB family, would be important in pancreatic cancer therapy. (aacrjournals.org)
  • The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
  • Patients are refractory to both endogenous and exogenous GH, resulting in severe growth retardation. (qxmd.com)
  • These factor are expected to catalyze the market growth over the forecast period. (openpr.com)
  • Get accurate market forecast and analysis on the Antithrombin (recombinant) Market. (openpr.com)
  • This is likely to intensify the competition in the global antithrombin (recombinant) market over the forecast period. (openpr.com)
  • A problem with the continued use of pesticides, herbicides, or other crop protection chemicals is the development of resistance to the control agent. (justia.com)
  • Pesticide resistance is the decreased susceptibility of a pest population to a control agent at doses that once killed most individuals of the species. (justia.com)
  • rhIGF-I treatment is effective in stimulating skeletal growth in GH receptor deficiency. (qxmd.com)
  • Due to late-stage diagnoses, ovarian cancer commonly recurs and requires cytotoxic treatment, eventually becoming refractory to all approved agents. (naturalmedicinejournal.com)