Aged function age factors. Medical search. Frequent questions

Cognitive function declines with age, reflecting a complex and interrelated set of changes in neurons, neural stem cells, glia and vascular cells. (simonsfoundation.org)
Aging causes declines in cognitive functions. (biomedcentral.com)
The other piece of good news is that some age related declines in mental functioning can be prevented or even reversed. (healthy.net)
However, it is unclear to what extent age-related declines in NE functioning in humans affect reward-based decision-making. (jneurosci.org)
SIGNIFICANCE STATEMENT Age-related impairments in value representation and updating during reward-based learning are associated with declines in the catecholamine modulation with age. (jneurosci.org)
However, it is unclear how age-related declines in the LC-NE system may affect reward-based learning. (jneurosci.org)

We have discovered that blood contains proteins that can restore some age-related cognitive decline. (simonsfoundation.org)
The purpose of this longitudinal study was to assess the factors in childhood that determine the level of FEV 1 in early adulthood in asthmatic individuals, and to examine factors associated with decline in FEV 1 during adulthood. (atsjournals.org)
A smaller decline in FEV 1 after ages 22 to 32 yr occurs in asthmatics who quit smoking and who continue to use inhaled corticosteroids. (atsjournals.org)
Many published epidemiologic studies on age-related growth and decline of lung function have as their primary aim the natural history of FEV 1 and FVC throughout childhood and adulthood in healthy subjects ( 1-9 ). (atsjournals.org)
These studies generally show that a growth in FEV 1 during childhood is followed by a stable phase from adolescence through early adulthood and a decline in FEV 1 after the age of 32 yr ( 4 , 5 ). (atsjournals.org)
Both the obtained maximal level of FEV 1 and the rate of decline of FEV 1 determine the severity of lung function impairment at older age in symptomatic persons. (atsjournals.org)
Therefore, it is important to know which factors are associated with the level of FEV 1 in early adulthood and which factors are associated with an accelerated decline of FEV 1 throughout adulthood. (atsjournals.org)
Studies of risk factors for accelerated decline in FEV 1 have generally focused on the effect of smoking on lung function, and have involved subjects with chronic obstructive pulmonary disease (COPD) or subjects from the general population. (atsjournals.org)
Two longitudinal studies, one of middle-aged and older men with no history of asthma, the other of subjects aged 65 yr or older, found that bronchial hyperresponsiveness (BHR) and atopy were both independent predictors of decline of lung function ( 15 , 16 ). (atsjournals.org)
The findings raise the question of whether it might be possible to shield the brain from aging by eliminating or mitigating the effects of these apparently detrimental blood-borne substances, or perhaps by identifying other blood-borne substances that exert rejuvenating effects on the brain but whose levels decline with age, said associate professor of neurology and neurological sciences Tony Wyss-Coray, PhD, the study's senior author. (sciencedaily.com)
In another study, participants who reported higher levels of PIL exhibited better cognitive function, and further, PIL protected those with already existing pathological conditions, thus slowing their decline. (sciencedaily.com)
Executive dysfunction may play a major role in cognitive decline with aging because frontal lobe structures are particularly vulnerable to advancing age. (biomedcentral.com)
The main objective of our research is to examine the role of diet (inflammatory diet) and nutrition (protein intake) with age-related cognitive decline, and brain age using large population-based longitudinal studies. (ki.se)
Aging is an important determinant of a decline in metabolic rate, with an estimated reduction of around 150 kcal per decade of adult life. (drsharma.ca)
Factors that result in the age‐related decline in energy requirements include changes in neuroendocrine factors (e.g. sympathetic activity, thyroid function, etc.) as well as a reduction in skeletal muscle quantity and quality (resulting from reduced physical activity, reduced protein intake and other less‐well‐understood factors). (drsharma.ca)
In humans, aging is characterized by the progressive decline in biological, physiological, and psychological functions, and is a major risk factor in the development of chronic diseases. (frontiersin.org)
Furthermore, TWK10 attenuated the aging-associated decline in learning and memory abilities, as well as bone mass. (frontiersin.org)
Aging-associated decline in the functions of tissues and organs represents a major risk factor in the development of chronic disease ( 1 ). (frontiersin.org)
Meanwhile, learning and memory start to gradually decline as early as in the 20s and 30s, with the decline becoming more prominent after reaching 60 years of age. (frontiersin.org)
Our evidence with the LC-MRI contrast further showed the age-related decline of the LC structure in modulating value representations during reward-based learning. (jneurosci.org)

Based on our findings, the occurrence of cancer is much higher in adults over 75 years of age compared with the proportion of patients in this age group who enroll in clinical trials," said lead study author Bindu Kanapuru, MD, medical officer in the Division of Hematology Products, Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. (prnewswire.com)
Finally, the lack of longitudinal studies with neuropsychological data collected before the pandemic made it impossible to detect potential changes in cognitive functioning and/or mood, limiting the resulting findings to short-term effects and neglecting the crucial role of "baseline" performance. (nature.com)
Depending on the findings from the history, detailed examination of other body functions may also be warranted. (medscape.com)
The experimental findings of the current study suggest that the activation of growth and metabolism in juvenile mice preprograms the subsequent loss of function of hematopoietic stem cells and inscribes this into the cell's memory. (idw-online.de)
These findings suggest that task-related pupillary responses can reflect age-related deficits in value estimation and updating during reward-based decision-making. (jneurosci.org)
Our findings may demonstrate a pioneering model to unravel the role of the LC-NE system in reward-based learning in aging. (jneurosci.org)
Epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. (who.int)
Moreover, the findings of a small preliminary 2016 study suggest ginseng may help improve frontal lobe function. (medicalnewstoday.com)
These findings suggest that youth who have lost a caregiver, many of whom are not attending school, are experiencing a significant ongoing burden in terms of their daily functioning and psychological health in the post-war period and should be the focus of further study and intervention targeting substance use and community reintegration. (who.int)

Irrespective of the pathogenesis, it can lead to significant impairment of motor, sensory, or autonomic function. (medscape.com)

This shuts down the frontal lobe which is responsible for our executive function, including impulse control, perspective, attention and decision making. (officer.com)

Approximately 40% of people aged 60 years or older have memory impairments, and each year ~1% of them will go on to develop dementia ( 7 , 8 ). (frontiersin.org)
Burden due to impaired kidney function was estimated in people aged 15 and over. (aihw.gov.au)
In people aged 65 years and over, the most burden due to impaired kidney function was from chronic kidney disease followed by coronary heart disease. (aihw.gov.au)

For example, giving old mice factors found in young blood can enhance the birth of new neurons, which typically slows with age. (simonsfoundation.org)
The "old-blood" mice seemed to learn the desirable location as easily as the "youngbloods" did -- but they forgot it more quickly, a sign of impaired hippocampal function. (sciencedaily.com)
Young (4 months, n = 16) and aged (23 months, n = 18) C57BL/6N mice performed an attentional set-shifting task (ASST) that evaluates simple discrimination (SD), compound discrimination (CD), IDS, EDS, and reversal learning. (biomedcentral.com)
The performance data were subjected to an exploratory factor analysis to extract the latent structures of ASST performance in young and aged mice. (biomedcentral.com)
In the two-factor model, the factor associated with SD and CD was clearly separated from the factor associated with the rest of the ASST stages in the young mice only. (biomedcentral.com)
The separation of performance factors in aged mice was less clear than in young mice, which suggests that aged mice utilize neuronal networks more broadly for specific cognitive functions. (biomedcentral.com)
In this study, the effect of TWK10 on the progression of age-related impairments was investigated in mice. (frontiersin.org)
We found that TWK10 not only enhanced muscle strength in young mice, but also prevented the aging-related loss of muscle strength in aged mice, which was accompanied by elevated muscle glycogen levels. (frontiersin.org)
Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena have been able to demonstrate that in mice, the growth factor Igf2bp2 controls hematopoietic stem cell function in young adulthood by activating stem cell metabolism and growth. (idw-online.de)
Surprisingly, mice in which the gene is mutated show a reduction in the age-associated loss of function of the blood stem cells in late life, even though the gene is no longer active. (idw-online.de)
LT-HSCs from young and aged mice have differential responses to acute inflammatory challenge. (biorxiv.org)
One of the LT-HSC subsets is more prevalent in young and the other in aged mice. (biorxiv.org)
Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)

Th1 cells that produce IL-2, IFN- γ , TNF- α, and TNF- β evoke cell-mediated immunity and phagocyte-dependent inflammation while Th2 cells that produce IL-5, IL-4, IL-6, IL-10, and IL-13 induce a strong antibody response that comprises the IgE class and eosinophil accumulation, but it inhibits several functions of phagocytic cells [ 7 ]. (hindawi.com)
These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)
Klf5 , Ikzf1 and Stat3 regulate age‐ and inflammation-related LT-HSC myeloid-bias. (biorxiv.org)
The criteria include an individual aged less than 21 years presenting with fever, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization with multisystem, that's two or more, organ involvement, including cardiac renal, respiratory hematologic, GI, derm, or neuro. (cdc.gov)

This is the latest in a recent surge of investment in ventures seeking to build anti-aging interventions on the back of basic research into epigenetic reprogramming (modifying chemical marks on DNA to turn genes on or off). (scientificamerican.com)
Several groups, including those headed by Stanford University's Vittorio Sebastiano, the Salk Institute's Juan Carlos Izpisúa Belmonte and Harvard Medical School's David Sinclair (See Table), have shown that partial reprogramming can dramatically reverse age-related characteristics in the eye, muscle and other tissues in cultured mammalian cells and even rodent models by countering epigenetic changes associated with aging. (scientificamerican.com)

We study how cardiovascular/metabolic disorders, organ function, and nutrition relate to brain pathologies and dementia risk, explore compensatory factors that may support healthier cognitive aging, and examine care utilization among people with dementia. (ki.se)
Because heritable factors appear to be responsible for 45-75% of the inter‐individual variation in body mass index (BMI), the potential impact of genetic determinants of metabolic rate upon the predisposition to obesity must be considered. (drsharma.ca)
Additional factors that can affect metabolic rate will be discussed in subsequent posts. (drsharma.ca)
Aging is a progressive process associated with negative changes in the physical performance, body composition, learning and memory, social and psychological responses, joints, and metabolic regulation. (frontiersin.org)
However, as the organism ages, increased metabolic activity can also lead to functional exhaustion of hematopoietic stem cells. (idw-online.de)
Whether the metabolic and dividing activity of hematopoietic stem cells during embryonic development or in adolescence already predetermines later aging of the cells had not been previously been reported and was therefore the subject of the current study. (idw-online.de)
The Igf2bp2-gene drives growth and metabolic activity at a young age but these activities contribute to the age-associated loss of hematopoietic stem cell function in later life. (idw-online.de)

The number of stem cells in adult brains diminishes with increasing age, as do certain cognitive capacities, such as spatial memory: An example in humans is remembering where you parked the car -- or, if you are a mouse, recalling the whereabouts of an underwater platform you can perch on so you won't have to keep swimming in order to keep your nose above water. (sciencedaily.com)
The Wisconsin Card Sorting Test (WCST) has been widely used to assess executive function in humans [ 8 ]. (biomedcentral.com)

Just as vitamins are needed for normal nervous system development in children, they are required for normal neurological functioning in adults-young and old. (healthy.net)

In the Finnish studies, a clearly identifiable middle-aged subgroup declined rapidly in subsequent years, whereas a group maintaining high function through the sixth decade was also recognizable. (cdc.gov)
At the population level, we will foster research to understand the pathways to disability and the causes of change in mobility and function over time as well as subgroup disparities. (nih.gov)

MAIN OUTCOME MEASURES: Postoperative outcomes were compared among younger, middle-aged, and older adults before surgery and at 3 and 6 months after surgery using analysis of variance modeling. (duke.edu)
IPF is the most common interstitial lung disease among middle-aged and older adults . (medscape.com)

St. β = 0.231, P = .004), despite no age group differences in outcome. (duke.edu)
The purpose of this paper was to assess sex differences in the intellectual function of early school-aged children in rural China. (biomedcentral.com)
Multilevel analyses were used to assess sex differences in intellectual functioning in 7-10-year-old children in rural China. (biomedcentral.com)
There is no evidence to suggest sex differences in the general intelligence of early school-aged children in rural China. (biomedcentral.com)
Therefore, in this paper, we aim to assess sex differences in the intellectual functioning of early school-aged children in rural China, where sons are preferred. (biomedcentral.com)

Other genes that have been studied in people with age-related hearing loss play roles in aging and other age-related diseases. (medlineplus.gov)
Age and Health-Chronic diseases affecting the cardiovascular and musculoskeletal systems inevitably rise as the workforce ages. (cdc.gov)
Lifestyle choices and habits can reduce the risk of age-related diseases. (healthnews.com)
Aging gracefully often means that someone would like to age "well" and live a long, healthy life without diseases. (healthnews.com)
Impaired kidney function was causally linked to 6 diseases-chronic kidney disease, coronary heart disease, dementia, stroke, gout and peripheral vascular disease (see ABDS 2018 Risk factor estimates data table ). (aihw.gov.au)
The majority of the total burden due to impaired kidney diseases occurred in older Australians- over the age of 65. (aihw.gov.au)
This study aimed to characterize the common chronic respiratory diseases, along with their lung function and possible determinants in symptomatic patients attending clinics at Bishoftu General Hospital, Ethiopia. (who.int)
Chronic respiratory diseases (CRDs) are diseases of such as age above 50years, being a smoker, being the respiratory airways and lung parenchyma. (who.int)
The zeal is shared by Joan Mannick, head of R&D at Life Biosciences, who says partial reprogramming could be potentially "transformative" when it comes to treating or even preventing age-related diseases. (scientificamerican.com)
While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. (hindawi.com)
Hence, endothelial dysfunction, a predictor of several cardiovascular diseases (CVDs), is caused by imbalance between vasodilating and vasoconstricting agents, including NO, endothelium-derived hyperpolarizing factor, prostacyclin, or vasoconstrictive factors such as thromboxane (TXA 2 ) and endothelin-1 (ET-1) [ 8 ]. (hindawi.com)
Although it was regarded as a rare disease when it was first described, Alzheimer disease has become one of the most common diseases in the aging population, ranking as the fourth most common cause of death. (medscape.com)

In conclusion, bronchial hyperresponsiveness and a low level of lung function in childhood are independent risk factors for a low level of FEV 1 in early adulthood. (atsjournals.org)
A growing body of evidence finds that targeting lifestyle and vascular risk factors have a beneficial effect on overall cognitive performance. (sciencedaily.com)
A new review examines research that finds spiritual fitness, a new concept in medicine that centers on psychological and spiritual wellbeing, and Kirtan Kriya, a simple 12-minute meditative practice, may reduce multiple risk factors for AD. (sciencedaily.com)
A new review in the Journal of Alzheimer's Disease , published by IOS Press, examines research that finds spiritual fitness, a new concept in medicine that centers on psychological and spiritual wellbeing, and Kirtan Kriya, a simple 12-minute meditative practice, may reduce multiple risk factors for AD. (sciencedaily.com)
In general the age effect is larger, but for some conditions, for example knee disease in plumbers, work is the dominant risk factor. (cdc.gov)
By investigating diet in conjunction with genetic and cardiometabolic risk factors, we aim to clarify how diet can be harnessed to promote healthy aging. (ki.se)
This is due to the fact that aging causes physical changes that lead to increased sensitivity to many medications and consequently an increased risk of medication side effects, especially if the use of medication is extensive. (ki.se)
Protecting our cellular DNA from damage increases cellular health and decreases the risk of age-related illness. (healthnews.com)
Although there is no way to prevent dementia, modifying the risk factors of high blood pressure , high cholesterol , alcohol intake, and keeping diabetes as well-controlled as possible, as well as exercising regularly can help. (medicinenet.com)
Currently, a careful clinical assessment of family history of obesity and related risk factors remains the best measure of genetic risk for obesity. (drsharma.ca)
Each is actually a separate disease with its own risk factors, but both are essentially a result of damage caused by acid in the stomach. (thehorse.com)
Australian Institute of Health and Welfare (2021) Australian Burden of Disease Study 2018: Interactive data on risk factor burden , AIHW, Australian Government, accessed 29 September 2023. (aihw.gov.au)
Questionnaires were used to collect data on demographics, symptoms, diagnoses, and potential risk factors. (who.int)
We calculated prevalence, standard errors (SEs), and 95% confidence intervals (CIs) and ranked states according to the prevalence of each risk factor indicator. (cdc.gov)
Some evidence suggests that ginseng may be a natural sexual enhancer, help improve cardiovascular risk factors, and help relax muscles necessary for erection. (medicalnewstoday.com)
Although the cause of IPF is unknown, risk factors include a history of smoking, family history, and genetic predispositions. (medscape.com)
And on May 14th, CDC issued a health advisory recommending that healthcare professionals report patients meeting the MIS-C case definition to local, state, or territorial health departments in order to enhance knowledge of the risk factors, pathogenesis, clinical course and treatment of this syndrome. (cdc.gov)

An interaction among muscle function, physical demand, and cardiovascular stress has been observed, meaning that physical fitness is important but does not explain away the effect of working conditions. (cdc.gov)
NO is a gas which plays an important role in blood pressure modulation due to its signaling action on renal, cardiovascular, and central nervous system functions [ 9 ]. (hindawi.com)

Blood proteins from younger animals can also restore declining blood vessel function in older animals, improving blood flow and the delivery of key nutrients to brain cells. (simonsfoundation.org)
Task-related pupil dilations and locus coeruleus (LC) magnetic resonance imaging (MRI) contrast, which served as a potential window of the LC-NE functions, were assessed in younger and older adults. (jneurosci.org)
Here, we show that compared with younger adults, older adults exhibited reduced uncertainty-induced pupil dilations, suggesting age-related deficits in value estimation and updating. (jneurosci.org)
Older adults showed a lower structural MRI of the LC contrast than younger adults, indicating age-related degeneration of the LC structure. (jneurosci.org)
Other countries have larger proportions of their populations at older ages than the U.S., and some of those with currently younger populations are aging at a much more rapid rate. (nih.gov)

Finally, we will use molecular and behavioral assays to determine how selected factors exert their effects on neural function and improve cognitive performance. (simonsfoundation.org)
The HANDLS study investigates whether race and SES influence health status and age-related health disparities separately or synergistically as co-factors of behavioral, psychosocial, and environmental conditions. (nih.gov)

With so few patients aged 75 or older enrolled in clinical trials, critical information on the safety and effectiveness of new therapies in this age group is greatly lacking. (prnewswire.com)
The magnitude of the disparity is particularly concerning given that the number of adults aged 75 and older who are diagnosed with blood cancers is only expected to rise as the population ages. (prnewswire.com)
By contrast, patients aged 75 and older account for approximately 29 percent of CML diagnoses, yet this age group made up less than 4 percent of those enrolled in clinical trials to evaluate new treatments for the disease. (prnewswire.com)
We weren't surprised to see that, overall, adults aged 75 years and older were under-represented in clinical trials, as this is common across cancer trials," said Dr. Kanapuru. (prnewswire.com)
But Dr. Kanapuru points to multiple barriers to enrolling patients aged 75 and older in clinical trials. (prnewswire.com)
Age-related hearing loss is one of the most common health conditions affecting older adults. (medlineplus.gov)
For reasons that are not fully understood, some health conditions that are common in older people, including heart disease and diabetes, also influence age-related hearing loss. (medlineplus.gov)
Even as awareness about aging rises, most major magazines and television stations still fail to display vital, older people. (healthy.net)
By paying a little attention to lifestyle, most older individuals can live active, healthy lives and we can all shatter those old age myths. (healthy.net)
Introduction: The primary objective of researchers in the biology of aging is to gain a comprehensive understanding of the aging process while developing practical solutions that can enhance the quality of life for older individuals. (mdpi.com)
Scholars@Duke publication: Older Age as a Prognostic Factor of Attenuated Pain Recovery After Shoulder Arthroscopy. (duke.edu)
However, the extent to which older age affects recovery after shoulder surgery is not well understood. (duke.edu)
OBJECTIVE: To assess influence of older age on postoperative recovery factors 3 and 6 months after shoulder arthroscopy. (duke.edu)
The influence of older age on 3- and 6-month pain outcomes were determined via multivariate regression analyses after accounting for preoperative, intraoperative, and postoperative prognostic factors. (duke.edu)
RESULTS: Older adults had higher movement-evoked pain intensity (F2,108 = 5.18, P = .007) and experimental pain response (F2,111 = 7.24, P = .001) at 3 months compared with young and middle-aged adults. (duke.edu)
Older age was found to be the strongest predictor of 3- and 6-month movement-evoked pain. (duke.edu)
Erectile dysfunction (ED), formerly called impotence, can affect men of all ages, although it is much more common among older men. (limamemorial.org)
Uncertainty-evoked pupil dilations in older adults ( N = 41, 27 males) were smaller, indicating age-related impairments in value estimation and updating. (jneurosci.org)
While the increased longevity and improved health at older ages seen in many parts of the world represent one of the crowning achievements of the 20th century, these trends also present significant challenges. (nih.gov)
Societal aging can affect economic growth, patterns of work and retirement, the way that families function, the ability of governments and communities to provide adequate resources for older adults, and the prevalence of chronic disease and disability. (nih.gov)
E-1: Understand how population aging and changes in the social, economic, and demographic characteristics of cohorts reaching old age affect the health and well-being of older adults in the U.S. and other countries. (nih.gov)
For example, educational attainment is one of the strongest correlates of physical health and cognitive functioning at older ages. (nih.gov)
Older adults may hold negative attitudes about their own aging or be the target of inaccurate and negative stereotypes and discrimination. (nih.gov)
Although only few studies were identified among the older population, smart home technologies hold bright prospects in assisting and aiding older people to age in place and function independently, especially in Western countries, where there are shortages of long-term care workers. (jmir.org)
It was designed to provide national estimates of the health and nutritional status of the United States' civilian, noninstitutionalized population aged two months and older. (cdc.gov)
The prevalence of smoking among US adults aged 65 years or older was 9.6% ( Table 1 ). (cdc.gov)
Patients are primarily older than age 60 years. (medscape.com)

Research shows positive relationships are the strongest protective factor. (officer.com)
The analysis showed that distance from the health service, education of the mother and her age were the strongest determinants of the choice of maternal child health service used. (who.int)

In 2018, 1.9% of the total disease burden in Australia was due to impaired kidney function (including chronic kidney disease). (aihw.gov.au)
In 2018, the prevalence rate of people with a disability of all ages in the United States was 12.6%, or 40,585,700 people. (medscape.com)

Does work add to or interact with the physiologic changes of 'normal aging? (cdc.gov)

Our data stress the importance of studying intervention strategies for asthma in young childhood and early adulthood in order to prevent or postpone further lung function deficits. (atsjournals.org)

Age-related hearing loss first affects the ability to hear high-frequency sounds, such as speech. (medlineplus.gov)
Before we look at how stress affects us differently as we age, here's a reminder of what stress does to our bodies. (officer.com)
This research has been extended to include how aging affects retinal and photoreceptor function. (nih.gov)

Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) have now found a gene mechanism that is responsible for the aging of hematopoietic stem cells. (idw-online.de)
The eventual aging of hematopoietic stem cells is apparently already preprogrammed by their gene-driven growth in youth. (idw-online.de)
One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)

But when our joints become stiff, or our muscles lose their range of motion, it could be a sign of age-related illnesses and frailty. (healthnews.com)
Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. (hindawi.com)

Dissecting the interaction of race, socioeconomic status, behavior, environmental exposure, genetics, and social environment provides insight into how these interactions may result in disparate rates of age-related disease and disability. (nih.gov)
Genetics is just one factor in determining how well we age. (healthnews.com)

Furthermore, superoxide anions can modify endothelial function by reducing nitric oxide (NO) biosynthesis and bioavailability [ 7 ]. (hindawi.com)

691 adolescents from the city of Montes Claros participated: 52% men and 48% women, aged 11 and 19 years old (M = 14.64, SD = 1.79, Mo = 15). (bvsalud.org)
By comparison, adults under 65 years tend to be overly represented in these trials, despite the fact that a majority of blood cancers are most frequently diagnosed in those over 65 years of age. (prnewswire.com)
Patients under 65 years of age were over-represented in trials for lymphomas, CLL, CML, and multiple myeloma compared with the incidence of those cancers in this age group. (prnewswire.com)
Our baseline cohort is representative of working-age African Americans and whites between 30-64 years old recruited as a fixed cohort of participants by household screenings from an area probability sample of thirteen neighborhoods (contiguous census tracts) in Baltimore City beginning in 2004. (nih.gov)
A Swedish construction worker 55-59 years old was more than twice as likely to have shoulder problems as a similarly aged office worker, but 25% less likely to be symptomatic when both were 25-29 years old. (cdc.gov)
PATIENTS: A convenience sample of 139 persons between 20 and 79 years of age who experienced shoulder pain, had musculoskeletal dysfunction based on imaging and physician assessment, and were scheduled for an arthroscopic shoulder procedure. (duke.edu)
In the U.S., one in 10 people over 65 years of age have dementia according to a 2016 study. (medicinenet.com)
The mean age was 49 years (SD=16). (who.int)
But in recent years, Yamanaka factors have also become the focus for another burgeoning area: to set back the clock on aging. (scientificamerican.com)
A house-to-house survey of all households in this village was carried out, and all women of child-bearing age who had a child less than five years old were interviewed. (who.int)
and that from the age of 15 to 16 years, boys develop a small IQ advantage of approximately 1 IQ point, which increases in later adolescence and reaches approximately 4 IQ points in adulthood [ 3 , 4 ]. (biomedcentral.com)

Second, we will use RNA sequencing and high-resolution imaging to determine how factors that don't enter the brain restore blood vessel function. (simonsfoundation.org)
We're investing in this area [because] it is one of the few interventions we know of that can restore youthful function in a diverse set of cell types," explains Jacob Kimmel, a principal investigator at Alphabet subsidiary Calico Life Sciences in South San Francisco, California. (scientificamerican.com)
Aim of the Female Anti-Aging Program is to restore exhausted pools of stem cells by introduction of the fetal stem cells. (placidway.com)
This strategy addresses the need to improve these age factors, to restore circulatory system function. (wikipedia.org)
This strategy addresses the need to restore the sensory organs, sight, taste, smell, touch, and hearing, while eliminating the aches and pains associated with advancing age. (wikipedia.org)

The Health Disparities Research Section (HDRS) conducts interdisciplinary clinical and basic science research focused on examining the underlying cause of the disproportionate incidence, morbidity, and mortality of age-related disease among minority and low socioeconomic status (SES) Americans. (nih.gov)
We have accomplished this by establishing a clinical component, The Healthy Aging in Neighborhoods of Diversity across the Life Span Study (HANDLS) https://handls.nih.gov/ and a basic science laboratory component, The DNA Repair Unit, that are interdependent and pursuing related hypotheses. (nih.gov)
Future age-related research should consider use of movement-evoked pain intensity and experimental pain response as pain outcomes, as well as the utility of such measures in clinical care. (duke.edu)

Methods: We conducted a literature search using PubMed, Embase, PLOS, Digital Commons Network, Google Scholar and Cochrane Library from 2000 to 2023, analyzing studies dealing with the relationship between hormetic, cognitive, and reproductive aspects of human aging. (mdpi.com)
METHODS: Seventy-five young people (age 13-18) in the capital city of Monrovia, Liberia were recruited in 2012. (who.int)

Age-related impairments in value representations and updating during decision-making and reward-based learning are often related to age-related attenuation in the catecholamine system such as dopamine (DA) and norepinephrine (NE). (jneurosci.org)

Most studies of the growth of FEV 1 in childhood have shown that lower respiratory tract infections and passive and active smoking by healthy children and adolescents are associated with smaller growth of lung function and a lower maximally attained level of lung function ( 10-14 ). (atsjournals.org)
Lung function was measured by spirometry. (who.int)
Classification of lung function revealed 23 (15%) normal, 29 (19%) obstructive, 36(23.5%) restrictive and 61(39.9%) mixed obstructive/ restrictive patterns. (who.int)
Conclusion: This study demonstrated a high burden of abnormal lung function in patients attending clinics due to chronic respiratory symptoms. (who.int)
Increasing age, exertional breathlessness, prior diagnosis of asthma, BMI, and clinically diagnosed COPD and asthma were independently associated with obstructed lung function. (who.int)
Progressive deterioration in lung function results in increasing dyspnea, chronic cough, and frequent hospitalizations. (medscape.com)

The discovery of the ' Yamanaka factors '-four transcription factors (Oct3/4, Sox2, c-Myc and Klf4), ), proteins that can reprogram a fully mature cell into an embryonic-like state-earned Kyoto University researcher Shinya Yamanaka a share of the Nobel prize in 2012. (scientificamerican.com)
We predict several transcription factors to regulate differentially expressed genes between mLT-HSCs and other LT-HSC subsets. (biorxiv.org)
We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)

Resilience was defined as evidence of adaptive functioning and psychological health. (who.int)

Research reveals that religious and spiritual involvement can preserve cognitive function as we age. (sciencedaily.com)
The authors discuss the research on how these factors affect brain function and cognition. (sciencedaily.com)
After that, the gene is silenced and loses its function, it shows hardly any activity in the stem cells in advanced age," explains Prof. K. Lenhard Rudolph, research group leader at the FLI and professor of molecular medicine at FSU Jena. (idw-online.de)
NIA will continue to support research on the social, economic, and demographic consequences of the aging population in the U.S. and other countries. (nih.gov)
We will support research to better understand the impact of the changing age composition of the population and economic factors across the lifespan that affect health and well-being. (nih.gov)
This review aims to map published studies on smart home technologies aimed at promoting physical activity among the general and aging populations to unveil the state of the art, its potential, and the research gaps and opportunities. (jmir.org)
The Yamanaka factors that can reprogram cells into their embryonic-like state are at the heart of longevity research. (scientificamerican.com)
On January 19, co-founders Rick Klausner and Hans Bishop publicly launched an aging research initiative called Altos Labs, with $3 billion in initial financing from backers including tech investor Yuri Milner and Amazon founder Jeff Bezos. (scientificamerican.com)
[9] Today, anti-aging or longevity research exists in the scientific mainstream and represents a $7 trillion dollar marketplace. (wikipedia.org)
The goal of this research was to identify factors contributing to resilience among youth in post-conflict Liberia. (who.int)

A longitudinal study first examined the role of neuropsychogeriatric factors in lockdown fatigue, by comparing data collected in healthy, cognitively aging, individuals before and during the pandemic. (nature.com)

The objective of this study was to evaluate the cytokine profiles of IL-4, IL-2, IL-10, IL-5, IFN- γ, and TNF in serum samples of infected school-aged children by using flow cytometry before and after treatment. (hindawi.com)
One thousand seven hundred forty four early school-aged offspring of women who had participated in a prenatal supplementation trial with different combinations of micronutrients and continued to reside in two rural counties in China were followed. (biomedcentral.com)
The intelligence difference between early school-aged boys and girls in rural China is less clear. (biomedcentral.com)
This study focused on follow-up assessments of early school-aged children's mental and psychomotor development. (biomedcentral.com)

The good news, she adds, is that among patients aged 65 to 74, data show the proportion enrolled in lymphoma (excluding CLL) and CML trials essentially mirrored the reported incidence of blood cancers in this age group. (prnewswire.com)
Consecutive adult patients aged 18 and above with chronic respiratory symptoms (lasting more than 8 weeks) and no evidence of active tuberculosis were recruited. (who.int)

the relationship between aging and increasing musculoskeletal symptom prevalence was persistent across all trades. (cdc.gov)

It's no wonder we fear and even deny our own inevitable aging. (healthy.net)
Some people believe that senility or senile dementia is an inevitable result of aging , and never seek evaluation for family members who show signs of memory loss. (medicinenet.com)

This suggests that Igf2bp2 gene function in early life leads to the aging of the stem cells. (idw-online.de)
How does aging and environment affect gene function? (nih.gov)

The results evidenced the existence of the hypothetized trifactor model, revealing a positive Phi (φ) association between the factors. (bvsalud.org)
MANOVA showed significant results only for the main effect at school level and gender and for interaction effect at school level versus age, all in relation to play habits. (bvsalud.org)
This condition results from a combination of genetic, environmental, and lifestyle factors, many of which have not been identified. (medlineplus.gov)
The result that the factors associated with SD and CD were separated in the three-factor model may suggest that the introduction of an irrelevant or distracting dimension results in the use of a new/orthogonal strategy for better discrimination. (biomedcentral.com)
Results showed that scores before and during the pandemic were the same in memory and attention, whereas global cognitive, executive, and language functions improved. (nature.com)
These results have spurred interest in translating insights from animal models into anti-aging interventions. (scientificamerican.com)
It is important to start early to gain better results out of the anti-aging procedures. (placidway.com)

Furthermore, TWK10 administration to some extent reversed the aging-associated accumulation of pathogenic bacterial taxa. (frontiersin.org)

With age, however, they produce a myeloid-biased output that may lead to poor immune responses to infectious challenge and the development of myeloid leukemias. (biorxiv.org)

But if we were able to understand it sufficiently well, new therapies could be developed to improve health in old age. (idw-online.de)

However, another gene variant, APOE3, is associated with longevity and does not affect cognitive function. (healthnews.com)

Depending on the situation, a person can be sexually aroused by a variety of factors, both physical and mental. (wikipedia.org)
Age-related decreases in physical capacity, particularly in peak performance, vary greatly. (cdc.gov)

These factors include long-term exposure to loud noise (particularly through earphones at high volume), smoking, and exposure to heavy metals such as mercury or lead. (medlineplus.gov)

By 2020, 41% of all men and 32% of all women between the ages of 65-69 will be working, a 22% proportional increase in men and 35% proportional increase in women compared with average participation rates from the last decade. (cdc.gov)

Some of these genes are important for the normal structure or function of the inner ear. (medlineplus.gov)
Both age and type of work are important predictors of musculoskeletal disorders. (cdc.gov)
Consuming a balanced, nutritious diet is important for maintaining health, especially as individuals age. (ki.se)
The gene Igf2bp2 is important in youth for the full function of these cells, as it activates their growth and metabolism. (idw-online.de)
For instance, in spite of the equitable distribution of primary health care and MCH services in Saudi Arabia, place of residence has been an important factor in their utilization [2,3]. (who.int)
One important caveat not on this slide is that some individuals may fulfill full or partial criteria for Kawasaki disease, but should be reported if they meet the case definition for MIS-C. And I also just wanted to comment on the age criteria, because we have been asked about this. (cdc.gov)

However, reports have shown that health service utilization is determined not only by its availability but by a number of other factors [1,8,9]. (who.int)

Other factors may act on vascular cells, boosting neural function via better blood flow or by increasing the vascular system's secretion of neuroactive factors. (simonsfoundation.org)
Impaired kidney function was responsible for the entire burden of chronic kidney disease, 12% of gout burden, 10% of peripheral vascular disease burden, 8% of dementia burden, and 6% of coronary heart disease and stroke burden. (aihw.gov.au)
In that event, NOS is turned into a peroxynitrite generator, leading to detrimental effects on vascular function, due to lipidic peroxidation [ 6 ]. (hindawi.com)

Female Anti-Aging Program is a powerful approach for rejuvenation created in joint effort of our doctors and scientists in order to increase quality of life of the patients of Infinity Clinic. (placidway.com)

These situations are considered normal, but depend on the maturity, age, culture and other factors influencing the person. (wikipedia.org)
Once the brain senses safety, body function returns to normal. (officer.com)

Memo to mature, health-minded vampires: You might want to consider limiting your treats to victims under age 30. (sciencedaily.com)
Let's look at the science underlying aging and lifestyle decisions that could delay aging and improve our health. (healthnews.com)
Let's take a look at the strategies to maintain health and age gracefully. (healthnews.com)
No matter your age, it is never too late to change lifestyle habits that support an increase in your health span as you age gracefully. (healthnews.com)
In conclusion, TWK10 could be viewed as a potential therapeutic agent that attenuates aging-related disorders and provides health benefits by modulating the imbalance of gut microbiota. (frontiersin.org)
It also compares the characteristics of users and nonusers of the private and government health services and elucidates factors that determine the choice of service. (who.int)

This way, we could examine the effects of old mice's blood on young mice's brains, and vice versa," said Saul Villeda, PhD, a postdoctoral researcher in Wyss-Coray's laboratory, who led the study en route to his doctoral thesis. (sciencedaily.com)
Neurotheological studies can help understanding of how a practice such as KK can lead to more permanent effects in brain function that support spiritual fitness, according to Dr. Khalsa and Dr. Newberg. (sciencedaily.com)
The authors of a 2017 review note that due to its antioxidant properties, ginseng may reduce the effects of aging. (medicalnewstoday.com)

So-called partial reprogramming consists of applying Yamanaka factors to cells for long enough to roll back cellular aging and repair tissues but without returning to pluripotency in which a cell can specialize into other cell types. (scientificamerican.com)
Treatment with fetal stem cell stimulate self-renewal of the organism of the patient due to enhanced functional substitution of senescent and dying cells and release of trophic factors that are involved in regeneration of the tissues. (placidway.com)

The patient begins to have some difficulty but can still function independently. (medicinenet.com)
patients are unable to function independently. (medicinenet.com)

You erase all of these signatures that look like aging or any abnormal signatures, and [cells are] being reset essentially to the baseline 'perfect' epigenome," Meissner says. (scientificamerican.com)

We also wish to elucidate how photoreceptor function is maintained throughout life. (nih.gov)

Anatomy2

Organisms3

Diseases13

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Psychiatry and Psychology18

Phenomena and Processes23

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena15

Technology, Industry, Agriculture2

Humanities1

Information Science8

Named Groups10

Health Care81

Geographicals25

Declines6

Decline20

Findings9

Impairment1

Frontal lobe1

People Aged3

Mice13

Inflammation4

Epigenetic2

Metabolic7

Humans2

Neurological1

Subgroup2

Middle-aged and older2

Differences5

Diseases12

Risk17

Cardiovascular2

Younger5

Behavioral2

Older27

Strongest2

20182

Physiologic1

Deficits1

Affects3

Hematopoietic stem3

Frailty2

Genetics2

Nitric Oxide1

Years11

Restore5

Clinical3

Methods2

Impairments1

Lung function6

Transcription factors3

Psychological1

Research10

Longitudinal study1

School-aged4

Patients aged2

Prevalence1

Inevitable2

Gene function2

RESULTS7

Extent1

Responses1

Therapies1

Longevity1

Physical2

Include1

20201

Important6

Utilization1

Vascular3

Scientists1

Normal2

Health6

Effects3

Tissues2

Independently2

Abnormal1

Elucidate1