• When p75NTR initiates apoptosis, NGF binding to Tropomyosin receptor kinase A (TrkA) can negate p75NTR apoptotic effects. (wikipedia.org)
  • The human TRKA gene encodes a high-affinity tyrosine kinase receptor for nerve growth factor. (nih.gov)
  • Indo Y. Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (medlineplus.gov)
  • 2. Type I interferons up-regulate the expression and signalling of p75 NTR/TrkA receptor complex in differentiated human SH-SY5Y neuroblastoma cells. (nih.gov)
  • 7. [Expression ratio of the nerve growth factor receptor TrkA to p75NTR correlates with the clinical stage and pathological grade of prostate cancer]. (nih.gov)
  • 14. Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75. (nih.gov)
  • 17. Effect of GnRH analogs on the expression of TrkA and p75 neurotrophin receptors in primary cell cultures from human prostate adenocarcinoma. (nih.gov)
  • 19. Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. (nih.gov)
  • Mice lacking the gene for TrkA, a receptor tyrosine kinase for NGF, share dramatic phenotypic features of CIPA, including loss of responses to painful stimuli, although anhidrosis is not apparent in these animals. (nih.gov)
  • Nerve growth factor is an endogenous protein involved in the differentiation and maintenance of neurons, which acts through specific high-affinity (ie, TrkA) and low-affinity (ie, p75NTR) nerve growth factor receptors in the anterior segment of the eye to support corneal innervation and integrity. (medscape.com)
  • Nerve growth factor signals via preexisting TrkA receptor oligomers. (xenbase.org)
  • Nerve growth factor ( NGF ) promotes neuronal survival and differentiation by activating TrkA receptors. (xenbase.org)
  • Similar to other receptor tyrosine kinases, ligand-induced dimerization is thought to be required for TrkA receptor activation. (xenbase.org)
  • To study this process, we expressed TrkA receptors in Xenopus laevis oocytes and analyzed their response to NGF by using a combination of functional, biochemical, and structural approaches. (xenbase.org)
  • TrkA receptor protein was detected in the membrane fraction of oocytes injected with TrkA receptor cRNA, but not in uninjected or mock-injected oocytes. (xenbase.org)
  • Application of NGF to TrkA receptor-expressing oocytes promoted tyrosine phosphorylation and activated an oscillating transmembrane inward current, indicating that the TrkA receptors were functional. (xenbase.org)
  • The appearance of these particles in the plasma membrane correlated with responsiveness to NGF as detected by electrophysiological analysis and receptor phosphorylation, indicating that these novel P-face particles were TrkA receptors. (xenbase.org)
  • The dimensions of these particles (8.6 x 10 nm) were too large to be accounted for by TrkA monomers, suggesting the formation of TrkA receptor oligomers. (xenbase.org)
  • Application of NGF did not lead to a discernible change in the size or shape of these TrkA receptor particles during an active response. (xenbase.org)
  • These results indicate that in Xenopus oocytes, NGF activates signaling via pre-formed TrkA receptor oligomers. (xenbase.org)
  • TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor. (xenbase.org)
  • TrkA cross-linking mimics neuronal responses to nerve growth factor. (xenbase.org)
  • Nuclear overexpression of p75NTR was detected by immunohistochemistry in tumor tissue as compared to normal tissue, whereas neither NGF nor its high-affinity TrkA receptor was detected. (preprints.org)
  • Background: Nerve growth factor (NGF) and its high-affinity recep- tor, tyrosine kinase A (TrkA), are members of the neurotrophin family. (sohag-univ.edu.eg)
  • The activation of tropomyosin-related kinase A (TRKA) receptor signaling by the nerve growth factor (NGF) or the neurosteroid dehydroepiandrosterone (DHEA) may combat neurodegeneration and regulate microglial function. (euroneurotrophin.eu)
  • Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic p75NTR receptors. (euroneurotrophin.eu)
  • We show that ENT-A013 selectively activates the TrkA receptor and its downstream kinases Akt and Erk1/2 in PC12 cells, protecting these cells from serum deprivation-induced cell death. (euroneurotrophin.eu)
  • However, most LRR mRNA in the forebrain and brainstem was coexpressed with that of trkA, a high affinity receptor for nerve growth factor. (nii.ac.jp)
  • Possible future therapies include tocilizumab, denosumab and drugs targeting nerve growth factor and its receptor TrkA. (biomedcentral.com)
  • The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. (wikipedia.org)
  • p75NTR is a neurotrophic factor receptor. (wikipedia.org)
  • Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. (wikipedia.org)
  • p75NTR is a member of the tumor necrosis factor receptor superfamily. (wikipedia.org)
  • p75NTR/LNGFR was the first member of this large family of receptors to be characterized, that now contains about 25 receptors, including tumor necrosis factor 1 (TNFR1) and TNFR2, Fas, RANK, and CD40. (wikipedia.org)
  • p75NTR is an unusual member of this family due to its propensity to dimerize rather than trimerize, because of its ability to act as a tyrosine kinase co-receptor, and because the neurotrophins are structurally unrelated to the ligands, which typically bind TNFR family members. (wikipedia.org)
  • Sortilin is required for many apoptosis-promoting p75NTR reactions, functioning as a co-receptor for the binding of neurotrophins such as BDNF. (wikipedia.org)
  • 3. Nerve growth factor (NGF) exerts its pro-apoptotic effect via the P75NTR receptor in a cell cycle-dependent manner. (nih.gov)
  • 6. Expression of p75NTR in a human prostate epithelial tumor cell line reduces nerve growth factor-induced cell growth by activation of programmed cell death. (nih.gov)
  • Several studies have demonstrated that the p75NTR low-affinity receptor of Nerve Growth Factor (NGF), is produced in abnormally large amounts in several human cancer types. (preprints.org)
  • However, the role of p75NTR varies substantially depending on cell context, so that a dual role of this receptor protein in tumor cell survival and invasion, as well as cell death, has been supported in recent studies. (preprints.org)
  • CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. (exbio.cz)
  • Growing evidence has shown that the p75 neurotrophin receptor (p75NTR) may play important roles in controlling neuronal survival or cell apoptosis within the central nervous system in development, and in pathological or neural injury. (edu.hk)
  • First, pro-nerve growth factor (proNGF) triggers cell apoptosis by its high affinity binding to p75NTR, while NGF induces neuronal survival with low-affinity binding. (edu.hk)
  • Second, p75NTR mediates cell death by combining with co-receptor sortilin, whereas it promotes neuronal survival through combination with proNGF. (edu.hk)
  • each member has an affinity for a specific receptor to stimulate cell survival, while the interaction with p75NTR initiates cell apoptosis pathway by forming a complex with sortilin and neurotrophin precursors. (edgehill.ac.uk)
  • Miranda C, Di Virgilio M, Selleri S, Zanotti G, Pagliardini S, Pierotti MA, Greco A. Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurotrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations. (medlineplus.gov)
  • Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface. (xenbase.org)
  • A stereochemical model for tyrosine kinase receptor activation. (xenbase.org)
  • GM 1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF) by directly and tightly associating with Trk, the high-affinity tyrosine kinase-type receptor for NGF. (matreya.com)
  • Role of Nerve Growth Factor (NGF) and Its Receptor Tyrosine Kinase A (TrK A) in Egyptian Cirrhotic Patients with Pruritus. (sohag-univ.edu.eg)
  • Expression of nerve growth factor and its high-affinity receptor, tyrosine kinase A proteins, in the human scalp skin. (sohag-univ.edu.eg)
  • The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. (cellgs.com)
  • NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR). (cellgs.com)
  • Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. (jxsgjy.com)
  • Neurotrophic tyrosine kinase ( NTRK) is the name of the family of three genes encoding tropmomyosin receptor kinases ( Trk) A, B, and C. Tropomyosin receptor kinases belong to a larger group of receptor tyrosine kinases. (firebaseapp.com)
  • Structural and functional properties of the TRK family of neurotrophin receptors. (xenbase.org)
  • Mirjana Antonijević (ESR6) had her PhD Defence on November 30th, 2021 on her research project on In silico screening and Hit to lead development of small molecules neurotrophin receptors ligands. (euroneurotrophin.eu)
  • Over the course of the project Mirjana's project focused on in silico screening of UNICAEN chemical library to identify hit molecules as ligands for neurotrophin receptors. (euroneurotrophin.eu)
  • The NTRK1 protein is turned on (activated) when another protein called nerve growth factor beta (NGFβ) attaches (binds) to it and signals the NTRK1 protein to phosphorylate itself (autophosphorylation). (medlineplus.gov)
  • Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors. (nih.gov)
  • The identification of a novel protein from Drosophila melanogaster that binds both mammalian epidermal growth factor (EGF) and insulin has been reported (Thompson, K. L., S. J. Decker, and M. R. Rosner, 1985, Proc. (nih.gov)
  • Our results indicate that dp100 binds to other insulin-like and EGF-like growth factors with dissociation constants ranging from 10(-6) to 10(-9) M, and these ligands compete with each other for binding to dp100. (nih.gov)
  • It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). (jxsgjy.com)
  • In vivo, it is targeted to peripheral nerve segments where endogenous soluble NRG1 binds to and efficiently blocks the activity of NRG1 as a Schwann cell survival factor, leading to significant cell apoptosis in both motor and sensory axon area dose-dependently. (wayne.edu)
  • The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons). (medlineplus.gov)
  • Many of the NTRK1 gene mutations lead to a protein that cannot be activated by phosphorylation, which means the mutated NTRK1 protein cannot transmit cell growth and survival signals to neurons. (medlineplus.gov)
  • This 100-kD protein (designated dp100) is also recognized by an antiserum against the human EGF receptor. (nih.gov)
  • Further, dp100 is the sole transforming growth factor-alpha-binding protein detected by affinity labeling in Drosophila Kc cells. (nih.gov)
  • To elucidate the physiological roles of IRR, an orphan receptor, in the brain, we examined its expression at mRNA and protein levels in the brain by in situ hybridization and immunohistochemistry, respectively. (nii.ac.jp)
  • Biochemical and genetic characterization of Wnt-1 protein as a secretory glycoprotein (11,12) that can function in autocrine or paracrine modes, presumably by interaction with membrane receptor(s). (nih.gov)
  • Molecular analysis of injured nerves showed no difference in expression of ciliary neurotrophic factor, myelin basic protein, or low-affinity neurotrophin receptor messenger RNA among the three groups. (elsevierpure.com)
  • Neurotensin receptor-3 or sortilin is a vacuolar protein sorting 10 protein domain (Vps10p) has been firstly discovered in the human brain, it acts as receptor or co-receptor of the cell and traffics different proteins within the cell. (edgehill.ac.uk)
  • This fusion protein retains high affinity for heparin binding and to specific cell surface that express heparan sulfates resulting in a much more potent NRG1 antagonist than any other inhibitors for this molecule. (wayne.edu)
  • GH-secreting tumors are largely sporadic, but genetic abnormalities in the X chromosome (X-linked acrogigantism), overexpression of the pituitary tumor transforming gene ( PTTG ), and mutations in the aryl hydrocarbon receptor-interacting protein (AIP) have been discovered. (msdmanuals.com)
  • Cells with the mutant form of Gs protein secrete GH even in the absence of growth hormone-releasing hormone (GHRH). (msdmanuals.com)
  • The ligands for these receptors are expressed during liver injury, and indeed, candidate ligands may be expressed by stellate cells in an autocrine manner. (medscape.com)
  • All other ligands tested, including platelet-derived growth factor, transforming growth factor-beta, nerve growth factor, and glucagon, either did not bind or bound with a Kd greater than 10(-6) M. Unlike the Drosophila insulin receptor, dp100 does not bind to wheat germ agglutinin and is present in a cytoplasmic as well as a membrane-bound form that cannot be differentiated by two-dimensional PAGE. (nih.gov)
  • Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells. (exbio.cz)
  • Receptor tyrosine kinases exist as monomers in the absence of extracellular ligands, usually growth factors. (firebaseapp.com)
  • The regeneration of peripheral nerves comprises complicated steps involving a set of cellular and molecular events in distal nerve stumps with axonal sprouting and remyelination. (wjgnet.com)
  • Stem cell isolation and expansion for peripheral nerve repair (PNR) can be achieved using a wide diversity of prenatal and adult tissues, such as bone marrow or brain tissues. (wjgnet.com)
  • Abnormal nerve conduction across the brachial plexus and delayed late potentials were found on electrodiagnostic testing, and diffuse subclinical involvement of other regions of the peripheral nervous system was confirmed on the basis of abnormal electromyographic findings for the masticatory muscles and conduction block of the peroneal nerve. (avma.org)
  • Conclusions and Clinical Relevance -Findings suggested that brachial plexus neuropathy can be a multifocal disease in cats, even if clinically apparent neurologic deficits are initially subtle or absent, and that electrodiagnostic techniques can be used to identify subclinical involvement of the peripheral nerves. (avma.org)
  • The purpose of the present study was analyzed the participation of the noradrenergic nervous system in the development of polycystic ovary syndrome using guanethidine as a pharmacological tool that destroys peripheral noradrenergic nerve fibers. (biomedcentral.com)
  • NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. (cellgs.com)
  • Nerve growth factor (NGF) is a neurotrophin, which shows neurotrophic activity on central and peripheral neuronal cells, and exerts variable effects on non-neuronal cells [ 1 ]. (biomedcentral.com)
  • All the results demonstrated this collagen/PCL nerve conduit with tailored degradation rate fabricated by electrospinning could be an efficient alternative to autograft for peripheral nerve regeneration research. (biomedcentral.com)
  • For peripheral nerve repair, nerve autografts have always been considered as the "gold standard" for the restoration of structural and functional nerve regeneration. (biomedcentral.com)
  • Conclusion: These data suggest that ciliary neurotrophic factor may serve as an important neurocytokine for axonal regrowth during peripheral nerve regeneration. (elsevierpure.com)
  • Three types of alternatively-spliced proteins belonging to the neuregulin1 (NRG1) gene family of growth and differentiation factors are essential for Schwann cell survival and peripheral nerve development. (wayne.edu)
  • However, soft-tissue swelling occurs, and the peripheral nerves are enlarged. (msdmanuals.com)
  • Furthermore, exogenous BDNF also promotes Schwann cell survival through promoting the local release of axonal NRG1 by binding axonal trkB or p75 receptor. (wayne.edu)
  • 8. NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling. (nih.gov)
  • This provides an elegant mechanism for the control of neuronal development: a surplus of neurons is produced, and only those that form the correct connections with the target tissue receive adequate survival factors. (bmj.com)
  • Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. (euroneurotrophin.eu)
  • These nerve fibers may express the high affinity nerve growth factor (NGF) receptor, Trk A, which mediates the multiple effects of NGF, including neuronal differentiation and survival. (biomedcentral.com)
  • abstract = "Several recently reported investigations have shown that a member of the neurotrophin family of neuronal growth factors, brain‐derived neurotrophic factor (BDNF), supports motoneurons in vitro and rescues motoneurons from naturally occurring and axotomy‐induced cell death (Oppenheim et al. (elsevierpure.com)
  • this process is needed to transmit signals for cell growth and survival. (medlineplus.gov)
  • Activated stellate cells are susceptible to the withdrawal of specific survival factors, and there is now evidence that these may be soluble factors released during inflammation and liver injury, such as IGF-1. (medscape.com)
  • In addition, critical survival signals may be provided by the ECM, including collagen-I. Finally, there is evidence that stellate cells express at least two transmembrane receptors linked to death domains, stimulation of which elicits an apoptotic response. (medscape.com)
  • 15. Nerve Growth Factor (NGF)-Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma. (nih.gov)
  • All cells will undergo apoptosis in the absence of survival signals, usually peptide growth factors secreted by other cells. (bmj.com)
  • Nerve growth factor (NGF) induces neurite outgrowth and promotes survival of embryonic sensory and sympathetic neurons. (nih.gov)
  • Chronic inflammation increases the risk of cancer occurrence and can also drive inflammatory mediators into the tumor microenvironment enhancing tumor growth and survival. (bvsalud.org)
  • BDNF promotes the survival, growth and differentiation of neurons. (jxsgjy.com)
  • Few components of cellular systems and environment such as chemokines, nerve growth factor cytokines, and transforming growth factor-β (TGF-β) controlled mast cell physiology and survival. (jscimedcentral.com)
  • The role of interleukin-7 receptor (IL-7R) signaling in Igh recombination has been difficult to partition from its role in B cell survival and proliferation. (babraham.ac.uk)
  • Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. (jxsgjy.com)
  • Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. (exbio.cz)
  • Neurotrophin-3 (NT-3) is an important member of the Nerve Growth Factor (NGF) family of proteins. (cellgs.com)
  • T-cells can be genetically modified to express chimeric antigen receptors (CARs), which are fusion proteins comprised of an antigen recognition moiety and T-cell activation domains (see, e.g. (justia.com)
  • Cloning of the chicken and quail genes encoding the putative receptor for RSV, subgroup A. Although the sequencing of genes encoding this long-sought receptor is not yet complete, it will undoubtedly offer a new perspective on viral-host interactions, the mechanism of early events in the virus life cycle, and the nature of the presumptively polymorphic avian proteins that recognize the several subgroups of RSV. (nih.gov)
  • Glycine rich proteins were also detected among growth related genes that whose transcripts increased in abundance Inhibitors,Modulators,Libraries in ABR17 transgenic plants. (statpathway.com)
  • Adipose-derived stem cells(ADSCs) are promising in supporting skin repair because of their significant antioxidant capacity and strong proliferation, differentiation, and migration ability, as well as their enriched secretome containing various growth factors and cytokines. (biomedcentral.com)
  • This work has placed the Wnr-1 proto- oncogene and other members of the Wnt family among genes that affect differentiation and cell growth by cell-cell signalling and has focused attention upon the War receptor(s). (nih.gov)
  • This leads to deregulated neural development - neuron growth, differentiation, proliferation, and apoptosis all fall into disarray, and important synaptic pathways are compromised. (firebaseapp.com)
  • Another step of our research, by using specific receptor targeted monoclonal antibodies, was to point out that cell toxicity of the most toxic pre-aggregated peptides was mediated by the receptor for advanced glycation end-products (RAGE) and the low-affinity nerve growth factor receptor (p75-NGFR). (carusogiuseppe.net)
  • 12. Downmodulation of dimethyl transferase activity enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in prostate cancer cells. (nih.gov)
  • Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent. (xenbase.org)
  • Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. (xenbase.org)
  • We harness this natural targeting ability of soluble NRG1 to develop a novel antagonist by fusing its heparing-binding domain (HBD) to the soluble human epidermal growth factor receptor 4 (HER4). (wayne.edu)
  • The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). (justia.com)
  • Two distinct subpopulations of Olfactory ensheathing glia have been identified with high or low cell surface expression of low-affinity nerve growth factor receptor (p75). (wikipedia.org)
  • A role for the high affinity receptor site. (nih.gov)
  • The process of activation of these cells depended on i.e. high-affinity IgE receptor and independent manner. (jscimedcentral.com)
  • 3] Apart from the activities induced by high-affinity IgE receptor, the β2-integrin, serotonin receptor, and intracellular adhesion molecule-1, the surface markers are other components of mast cells that support these cells for responding toward diverse stimuli. (jscimedcentral.com)
  • Due to its advantage of high surface area for cell attachment, it is believed that this electrospun nerve conduit could find more application in cell therapy for nerve regeneration in future, to further improve functional regeneration outcome especially for longer nerve defect restoration. (biomedcentral.com)
  • Asymmetric distribution of sites with high affinity for antithrombin III in rat skin heparin proteoglycans. (mcmaster.ca)
  • In this study, we identified two peptides (QKRKRKKSRKKH and RKRKRKKSRYIVLS) derived from VEGF125-136 that displayed high binding affinities to VEGFR and strong inhibition of A549 cell growth. (phoenixpeptide.com)
  • Structure and expression of the nerve growth factor gene in Xenopus oocytes and embryos. (xenbase.org)
  • Analysis of the conditioned media and mRNA of the V2R gene silenced and control Caki1 cells showed that V2R regulates the production of CAF-activating factors. (bvsalud.org)
  • Recombinant Human Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding His129-Arg247 is expressed. (jxsgjy.com)
  • Outcome Measures: Functional nerve recovery, muscle mass, and gene expression in the three experimental groups were evaluated. (elsevierpure.com)
  • Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states. (babraham.ac.uk)
  • These results indicate that dp100 shares properties in common with, but distinct from, the Drosophila homologues of the insulin and EGF receptors. (nih.gov)
  • Insulin receptor-related receptor (IRR) is a member of the insulin receptor family. (nii.ac.jp)
  • The pattern of IRR immunoreactivity was similar to that of IRR mRNA.Its restricted pattern indicates that IRR plays unique roles in the brain, in contrast to insulin and insulin-like growth factor-I receptors, other members of the insulin receptor family, which are widely expressed in the brain. (nii.ac.jp)
  • Publications] N.Itoh: 'Expression of insulin receptor-related receptor in the rat brain examined by in situ hybridization and immunohistochemistry' Mol.Brain.Res.41. (nii.ac.jp)
  • Publications] K.Ozaki: 'Localization of insulin receptor-related receptor in the rat kidney' Kidney Int.52. (nii.ac.jp)
  • Diagnosis is clinical, by skull and hand x-rays, and by measurement of levels of growth hormone and insulin -like growth factor 1. (msdmanuals.com)
  • GH controls synthesis of insulin -like growth factor 1 (IGF-1, also called somatomedin-C), which largely controls growth. (msdmanuals.com)
  • All three immunoglobulin loci also participate in a highly specific, developmentally regulated network of interchromosomal interactions with genes encoding B cell-lineage factors. (babraham.ac.uk)
  • Since previous studies have shown that these three neurotrophins bind to the low‐affinity NGF receptor, p75NGFR, with similar affinity, our data suggest that the retrograde transport of neurotrophins by motoneurons may be mediated by additional components, such as the trk family of proto‐oncogenes. (elsevierpure.com)
  • We first examined whether spinal motoneurons in newborn animals could retrogradely transport iodinated neurotrophins from their targets in a specific, receptor‐mediated manner. (elsevierpure.com)
  • Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (nih.gov)
  • Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M: Expression of NGF receptor in the developing and adult primate central nervous system. (exbio.cz)
  • Nerve growth factor (NGF) is a neurotrophin and has been suggested to induce heme oxygenase-1 (HO1) expression. (biomedcentral.com)
  • Publications] N.Itoh: 'Spatially restricted expression of fibroblast growth fastor-10 mRNA in the rat brain' Mol.Brain.Res.47. (nii.ac.jp)
  • Publications] N.Itoh: 'Structure and expression of a novel fibroblast growth factor, FGF-17' Biochem.Biophys.Res.Commun.244. (nii.ac.jp)
  • Publications] N.Itoh: 'Structure and expression of the mRNA encoding a novel fibrablast growth factor, FGF-18' J.Biol.Chem.273. (nii.ac.jp)
  • Transcriptome and accessibility analyses suggest reduced expression of B lineage transcription factors (TFs) and targets and loss of D and V antisense transcription in IL-7Rα B cells. (babraham.ac.uk)
  • These results indicate that FGF-l 7, FGF-18 and FHF-4 are expected to be potential neurotrophic factors. (nii.ac.jp)
  • These forms are rapidly released from axons in vitro by Schwann cell-secreted neurotrophic factors, and, unlike membrane-bound forms, have a unique ability to diffuse and adhere to heparan sulfate-rich cell surfaces. (wayne.edu)
  • These results suggest that V2R plays an important role in secreting pro-fibrotic factors that stimulate fibroblast activation by a YAP-dependent mechanism in ccRCC tumors. (bvsalud.org)
  • We isolated the cDNA encoding members, FGF-7, FGF-18 and FHF-4 of the fibroblast growth factor (FGF) family from rat embryos. (nii.ac.jp)
  • Although regenerated nerve fibers were still in a pre-mature stage 4 months postoperatively, the implanted collagen/PCL nerve conduits facilitated more axons regenerating through the conduit lumen and gradually degraded which well matched the nerve regeneration rate. (biomedcentral.com)
  • The mechanism of bone pain in FD remains uncertain, but by analogy with bone tumors one may consider that ectopic sprouting and formation of neuroma-like structures by sensory and sympathetic nerve fibers also occur in the dysplastic skeleton. (biomedcentral.com)
  • Recent research has suggested a number of roles for the LNGFR, including in development of the eyes and sensory neurons, and in repair of muscle and nerve damage in adults. (wikipedia.org)
  • Killer cell inhibitory receptors. (embl.de)
  • The capacity for production of migration inhibitory factor was assessed by the agarose droplet cell migration inhibition assay, using peritoneal exudate cells and a CVB3(m) cell lysate or KCl extracted antigens from heart tissues of CVB3(m)-inoculated mice. (nih.gov)
  • Migration inhibitory factor activity was not detected in cultures of splenic leukocytes from ts 1 survivors of CVB3(m)-inoculated ts 1 survivors, but it was readily detected in cultures of splenic leukocytes from CVB3(m)-inoculated normal adolescent mice. (nih.gov)
  • In vivo test showed electrospun collagen/PCL porous nerve conduits successfully supported nerve regeneration through an 8 mm sciatic nerve gap in adult rats, achieving similar electrophysiological and muscle reinnervation results as autografts. (biomedcentral.com)
  • Background: Adjunctive measures to enhance nerve repair have focused on a variety of trophic factors that alter the physiologic response to nerve injury through Schwann cell-axonal interactions. (elsevierpure.com)
  • Objective: To evaluate the effects of two trophic factors, ciliary neurotrophic factor and nerve growth factor, on axonal response to injury. (elsevierpure.com)
  • The first recombinant nerve growth factor, cenegermin, was approved by the FDA in August 2018 for treatment of neurotrophic keratitis. (medscape.com)
  • The first recombinant form of human nerve growth factor was approved by the FDA in August 2018. (medscape.com)
  • Studies on recombinant rat GABA A receptors confirm these data ( K i , α 1 β 2 γ 2 = 17, α 2 β 2 γ 2 = 73, α 5 β 3 γ 2 = 215 nM) and indicate intermediate affinity for the α 3 β 2 γ 2 subtype ( K i = 80 nM). (aspetjournals.org)
  • SL651498 behaves as a full agonist at recombinant rat GABA A receptors containing α 2 and α 3 subunits and as a partial agonist at recombinant GABA A receptors expressing α 1 and α 5 subunits. (aspetjournals.org)
  • The inhibition of MK2 has shown promise in combination with both chemotherapy and radiotherapy as a method for controlling cancer growth and metastasis in a variety of cancers. (bvsalud.org)
  • 4) Attachment of gastric cancer cells to the ECM factors secreted by PMCs (integrin). (spandidos-publications.com)
  • Vasopressin type-2 receptor (V2R) is ectopically expressed and plays a pathogenic role in clear cell renal cell carcinoma (ccRCC) tumor cells. (bvsalud.org)
  • Some of these factors were also found to be regulated by YAP in these Caki1 cells. (bvsalud.org)
  • Moreover, DNAJA1 knockdown in HNSCC cells carrying unfolded mutp53 inhibited primary tumor growth and metastases to the lymph nodes and lungs. (bvsalud.org)
  • Numerous factors such as environmental, physiological, and genetic factors have a deep association with mast cells. (jscimedcentral.com)
  • These cells recognized pathogens via the involvement of adhesion and immune receptors. (jscimedcentral.com)
  • other members are brain-derived growth factor, neurotrophin-3 and neurotrophin-4. (edgehill.ac.uk)
  • Nerve growth factor and brain-derived growth factor are the common neurotrophins that have a role in cancer. (edgehill.ac.uk)
  • Cell surface receptors containing an immunoglobin domain. (embl.de)
  • It is the specific cell surface receptor for cholera toxin. (matreya.com)
  • These phenomena initiate more biochemical transformations such as intracellular calcium influx, and activation of certain transcription factors, including cytokine production, mast cell degranulation. (jscimedcentral.com)