• Blockade
  • Blockade of the 5-HT2A receptor may also play a role in its effectiveness against positive symptoms, though the significance of this property in antipsychotic drugs is still debated among researchers. (wikipedia.org)
  • In mildly asthmatic subjects, cetirizine hydrochloride at 5 to 20 mg blocked bronchoconstriction due to nebulized histamine, with virtually total blockade after a 20 mg dose. (imen.info)
  • There is increasing interest in antipsychotics intended to manage positive symptoms via D 2 receptor blockade and improve negative symptoms and cognitive deficits via 5-HT 1A activation. (springer.com)
  • e.g., parkinsonism, dystonia, akathisia, and tardive dyskinesia) that are thought to reflect blockade of D 2 receptors in the basal ganglia ( Casey, 1996 ). (aspetjournals.org)
  • Blockade of the histamine 1 (H1) receptors is believed to play a crucial role in olanzapine induced weight gain, whereas the therapeutic effects of this drug are mainly attributed to its favourable serotoninergic 2A and dopamine 2 (5HT2A/D2) receptor binding affinity ratios. (edu.au)
  • pharmacological
  • This study aims to review pharmacological literature on compounds interacting at both 5-HT 1A and D 2 receptors (as well as at other receptors), including aripiprazole, perospirone, ziprasidone, bifeprunox, lurasidone and cariprazine, PF-217830, adoprazine, SSR181507, and F15063. (springer.com)
  • vivo
  • Amargos-Bosch M, Bortolozzi A, Puig MV, Serrats J, Adell A, Celada P, Toth M, Mengod G, Artigas F (2004) Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex. (springer.com)
  • In vivo experimentation confirmed the antihistaminic and antiallergic activity, which was at least comparable to that of other second-generation H1-antihistamines such as cetirizine. (wikipedia.org)
  • neurotransmitter
  • Acetylcholine (often abbreviated ACh) is a neurotransmitter whose receptor is a protein found in synapses and other cell membranes. (wikipedia.org)
  • Besides responding to their primary neurochemical, neurotransmitter receptors can be sensitive to a variety of other molecules. (wikipedia.org)
  • cetirizine
  • The effects of intradermal injection of various other mediators or histamine releasers were also inhibited by cetirizine, as was response to a cold challenge in patients with cold-induced urticaria. (imen.info)
  • In different murine models, bilastine by oral route, antagonizes the effects of histamine in a dose-dependent manner, with potency similar to that of cetirizine and between 5.5 and 10 times greater than that of fexofenadine. (wikipedia.org)
  • Clinical studies using different dosages were done on histamine-induced wheal and flare reaction over a 24-h period, compared with a single 10-mg oral dose of cetirizine. (wikipedia.org)
  • The results of this research indicated that bilastine was at least as efficient as cetirizine in reducing histamine-mediated effects in healthy volunteers. (wikipedia.org)
  • compounds
  • Nevertheless, further investigations are necessary to evaluate recent compounds, notably in view of their differing levels of 5-HT 1A affinity and efficacy, which can markedly influence activity and side-effect profiles. (springer.com)