Affinity glucose transporter type 5. Medical search. Frequent questions

The two ways in which glucose uptake can take place are facilitated diffusion (a passive process) and secondary active transport (an active process which on the ion-gradient which is established through the hydrolysis of ATP, known as primary active transport). (wikipedia.org)
GLUT1 and GLUT3 are located in the plasma membrane of cells throughout the body, as they are responsible for maintaining a basal rate of glucose uptake. (wikipedia.org)
therefore GLUT1 and GLUT3 have a high affinity for glucose and uptake from the bloodstream is constant. (wikipedia.org)
As muscle is a principal storage site for glucose and adipose tissue for triglyceride (into which glucose can be converted for storage), GLUT4 is important in post-prandial uptake of excess glucose from the bloodstream. (wikipedia.org)
Upon reaching the plasmalemma, the vesicles fuse with the membrane, increasing the number of GLUT4 transporters expressed at the cell surface, and hence increasing glucose uptake. (wikipedia.org)
Since the mid-1960s, it has been known that there are energy-dependent, sodium-coupled glucose transporter (SGLT) and energy-independent, facilitative glucose transporter (GLUT) pathways for glucose uptake in the lung [ 1 ], and that glucose can permeate the alveolar epithelial barrier [ 2 ]. (ersjournals.com)
Glucose removal is determined by cellular glucose uptake and metabolism ( fig. 1 ) [ 4 , 12 - 14 ]. (ersjournals.com)
The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. (lbl.gov)
The high affinity nutritional proline uptake porter, PutP. (tcdb.org)
Two weeks after surgery, H + -dependent [ 14 C]glycylsarcosine uptake by the renal brush-border membrane vesicles isolated from 5/6 nephrectomized rats was significantly increased compared with that from sham-operated controls. (elsevierpure.com)
Kinetic analysis revealed that the maximum velocity value for [ 14 C]glycylsarcosine uptake by the high-affinity-type of peptide transporter was increased threefold by 5/6 nephrectomy, without significant changes in the apparent Michaelis-Menten constant value. (elsevierpure.com)
TLK16998 also increased the potency of insulin in stimulating 2-deoxy- d -glucose uptake in 3T3-L1 adipocytes, with a detectable effect at 8 μmol/l and a 10-fold increase at 40 μmol/l. (diabetesjournals.org)
In contrast, only small effects were observed on IGF-1-stimulated 2-deoxy- d -glucose uptake. (diabetesjournals.org)
This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. (cusabio.com)

These have a high affinity for glucose and a low capacity. (wikipedia.org)
High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose. (lbl.gov)
TMS IV of the high-affinity sodium-glucose cotransporter participates in sugar binding ( Liu et al . (tcdb.org)
These findings indicated that the high-affinity-type H + -peptide cotransport activity is upregulated by 5/6 nephrectomy, accompanied by the increased expression of PEPT2. (elsevierpure.com)
The rest of the 10C20% of filtered glucose is normally reabsorbed with the high-affinity, low-capacity SGLT1 transporter in the greater distal part of the proximal tubule. (cell-signaling-pathways.com)

rate of glucose entry is proportional to blood glucose levels. (wikipedia.org)
Fenugreek seeds have been used as an oral insulin substitute, and seed extracts have been reported to lower blood glucose levels. (drugs.com)
In diabetic mice, TLK16998, at a dose of 10 mg/kg, lowered blood glucose levels for up to 6 h. (diabetesjournals.org)
DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)

close to the glomerulus, where glucose levels are high, SGLT2 has a low affinity yet high capacity for glucose transport. (wikipedia.org)
SGLT2 inhibitors are a new class of oral drugs for the treatment of type 2 diabetes mellitus currently in phase III studies. (bjcardio.co.uk)
SGLT2 inhibitors represent a novel 'glucuretic' therapeutic strategy for the treatment of type 2 diabetes, and are currently in phase III trials. (bjcardio.co.uk)
Approximately 10% of renal glucose re-absorption occurs via SGLT1, and the remaining 90% occurs via SGLT2, which is found in the early proximal tubule. (bjcardio.co.uk)
SGLT2, a high-capacity, low-affinity transporter of glucose and sodium is found in high concentration at the brush border membrane of the S1 and S2 segment of the proximal convoluted tubule (PCT). (bjcardio.co.uk)
SGLT2 binds to sodium and glucose in the filtrate and these compounds are translocated across the apical cell membrane, an active process driven by the electrochemical sodium gradient between tubular filtrate and the cell. (bjcardio.co.uk)
Where Does Combination Therapy With an SGLT2 Inhibitor Plus a DPP-4 Inhibitor Fit in the Management of Type 2 Diabetes? (silverchair.com)
In this study, we examined the alterations of H + -peptide cotransporters (PEPT1 and PEPT2) and Na + -D-glucose cotransporters (SGLT1 and SGLT2) in chronic renal failure. (elsevierpure.com)
In animal studies, SGLT2 inhibition reduces plasma glucose levels, resulting in improved β-cell function and enhanced insulin sensitivity in liver and muscle. (uthscsa.edu)
Although the long-term efficacy and safety of SGLT2 inhibitors remain under study, the class represents a novel therapeutic approach with potential for the treatment of both type 2 and 1 diabetes. (uthscsa.edu)
As the majority of blood sugar reabsorption takes place via the SGLT2 transporter, pharmaceutical businesses have centered on the introduction of SGLT2 inhibitors, and multiple SGLT2 inhibitors presently are in individual stage II and III scientific studies (17). (cell-signaling-pathways.com)
Nevertheless, none of the SGLT2 inhibitors have the ability to inhibit PTC124 >30C50% from the filtered blood sugar fill, despite in vitro research indicate that 100% inhibition from the SGLT2 transporter ought to be achieved in the medication concentrations in human beings (22,23). (cell-signaling-pathways.com)

Understanding of mechanisms underlying lung glucose homeostasis could identify new therapeutic targets for control of ASL glucose and prevention and treatment of lung infection. (ersjournals.com)
The maintenance of normal glucose homeostasis requires a complex, highly integrated interaction among the liver, muscle, adipocytes, pancreas and neuroendocrine system. (uthscsa.edu)
Recent studies have showed that the kidneys also play a central role in glucose homeostasis by reabsorbing all the filtered glucose, an adaptive mechanism that ensures sufficient energy is available during fasting periods. (uthscsa.edu)
The combination of these defects results in an inability of the body to maintain glucose homeostasis leading to hyperglycemia and other metabolic disturbances ( 2 ). (diabetesjournals.org)
The adipocyte is the major site of fatty acid storage in the body and plays a critical role in maintaining normal glucose and lipid homeostasis. (jci.org)
An understanding of glucose homeostasis can help narrow the differential diagnosis. (medscape.com)
The kidneys play an important role in glucose homeostasis. (medscape.com)
It helps to maintain glucose homeostasis by at least two mechanisms. (medscape.com)
Glycogen storage disease (GSD) type I, also known as von Gierke disease, is a group of inherited autosomal recessive metabolic disorders of the glucose-6- phosphatase system which helps maintain glucose homeostasis. (medscape.com)

However, much subsequent research in this area was focused on the role of pulmonary SGLT transport as a modifier of lung liquid volume [ 3 , 4 ], and the effects of starvation and diabetes on glucose transport [ 1 , 5 ]. (ersjournals.com)
This mechanism becomes maladaptive in diabetes, however, as hyperglycaemia augments the expression and activity of the sodium-glucose cotransporter (SGLT) 2 in the proximal tubule of the kidney. (uthscsa.edu)
Almost all (80C90%) of filtered plasma glucose is normally reabsorbed in the first proximal tubule with the high-capacity, low-affinity sodium glucose cotransporter (SGLT) 2 (15,16). (cell-signaling-pathways.com)
Secondary active transport occurs in the intestine and the kidney tubules (predominantly proximal tubule) and is mediated by members of the SGLT transporter family. (medscape.com)
i) The apical transporters are SGLT-1 (type 1) and SGLT-2. (medscape.com)

GLUT2 in contrast has a high Km value (15-20mM) and therefore a low affinity for glucose. (wikipedia.org)
Once inside the epithelial cells, glucose reenters the bloodstream through facilitated diffusion through GLUT2 transporters. (wikipedia.org)
Glucose is then transported passively by GLUT2 along its concentration gradient into the interstitium. (bjcardio.co.uk)
The second stage of re-absorption is the transport of glucose through the utilisation of GLUT2 transporters in the basolateral membrane. (bjcardio.co.uk)
The GLUT2 facilitated glucose transporter isoform is a membrane protein present in the pancreatic .beta. (justia.com)
In these cells, GLUT2 catalyzes the transepithelial transport of glucose. (justia.com)
In pancreatic islets, GLUT2 allows a rapid equilibration of glucose between the extracellular space and the interior of the cells and it may play a crucial role in the glucose signaling mechanism leading to insulin secretion (43). (justia.com)
cells, the level of expression of GLUT2 is low and the intracellular glucokinase activity seems to be the rate-limiting step in the glycolytic pathway (5,11). (justia.com)
On the other hand, insulinoma cells that had lost their normal glucose responsiveness have low GLUT2 content, but some glucose sensitivity may be recovered after reintroducing GLUT2 expression through stable transfection of these cells (10,16). (justia.com)
Furthermore, transgenic mice that express GLUT2 antisense RNAs driven by the insulin promoter led to an 80% reduction in GLUT2 which was paralleled by a decreased glucose-induced insulin secretory response and by the onset of diabetes (48). (justia.com)
A fragment of the murine GLUT2 promoter has been cloned and shown to be glucose-responsive when transfected into differentiated insulin-producing cells or into hepatocytes (35,36,52). (justia.com)

GLUT4 transporters are insulin sensitive, and are found in muscle and adipose tissue. (wikipedia.org)
During fasting, some GLUT4 transporters will be expressed at the surface of the cell. (wikipedia.org)
[16] It does this by decreasing the translocation of glucose transporters (especially GLUT4 ) to the cell membrane. (wikipedia.org)

The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). (lbl.gov)
Screen Quest™ assay kits, a set of HTS-ready tools for high throughput screening of biochemical and cellular targets such as protein kinases, proteases, HDAC, cell apoptosis and cytoxicity, GPCR, ion channels, ADME/metabolism and transporters. (stratech.co.uk)
Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N2, H5N1) in three human cell types (A549, NHBE, THP-1), we map 332 IAV-human protein-protein interactions and identify 13 IAV-modulated kinases. (cdc.gov)

Overexpression of LANCL1/2 significantly increased, while silencing conversely reduced the mitochondrial number, OXPHOS complex I, proton gradient, glucose and palmitate-dependent respiration, transcription of uncoupling proteins, expression of proteins involved in cytoskeletal, contractile and electrical functions. (bvsalud.org)
The EcoCyc database describes 532 transport reactions, 480 transporters, and 97 proteins involved in sugar transport. (encyclopedia.pub)
Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. (cusabio.com)

Hence reabsorption of glucose is dependent upon the existing sodium gradient which is generated through the active functioning of the NaKATPase. (wikipedia.org)
Consequently the affinity of the transporters for glucose along the tubule increases to allow for complete reabsorption of glucose from the urine. (medscape.com)
Reabsorption of glucose predominantly occurs on the brush border membrane of the convoluted segment of the proximal tubule. (medscape.com)

They inhibit glucose re-absorption in the proximal renal tubules providing an insulin independent mechanism to lower blood glucose. (bjcardio.co.uk)
Glucose is removed from ASL in proximal airways via facilitative glucose transporters, down a concentration gradient generated by intracellular glucose metabolism. (ersjournals.com)
However, reabsorption of small peptides and D-glucose across the renal proximal tubule in this model remains poorly understood. (elsevierpure.com)
Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction. (medscape.com)
The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)
As the rate of glucose entering the nephron rises above 260-350mg/1.73m 2 /min (14.5-19.5mmol/1.73m 2 /min), the excess glucose exceeds the reabsorptive capacity of proximal tubule and is excreted in the urine (i.e. glucosuria). (medscape.com)
Glucose enters at the luminal side of the proximal tubular cells by an active carrier-mediated transport process that requires energy provided by the sodium gradient between the intra- and extracellular compartments generated by sodium-potassium ATPase. (medscape.com)

The first step in glycolysis (ie, conversion of glucose to glucose-6-phosphate [G6P] by glucokinase) is the rate-limiting step in glucose metabolism. (medscape.com)

solute carrier family 2, facilitated glucose transporter member 8. (lbl.gov)
However, a significant therapeutic strategy for malignant cells may involve the blockage of several glucose transporters, including glut 4 encoded by the solute carrier family-2-member-4-gene (Slc2a4) by certain phytochemicals from Panax ginseng. (ijpsr.com)

The absence of glucose, Na + , a membrane potential in vesicles, or the directionality of water flow did not grossly altered the pf. (tcdb.org)
E. coli nonspecifically transports glucose from the extracellular medium into the periplasmic space through the outer membrane porins. (encyclopedia.pub)
[3] It is hypothesized that increasing cell membrane fluidity by increasing PUFA concentration might result in an enhanced number of insulin receptors, an increased affinity of insulin to its receptors, and reduced insulin resistance. (wikipedia.org)

1995). "Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. (wikipedia.org)
The article "Differential expression of the glucose transporter gene glcH in response to glucose and light in marine picocyanobacterial" by Moreno-Cabezuelo et al. (peerj.com)
Here we chose to use chemostat cultures on D-glucose as a carbon source at two different growth rates (one repressing and one derepressing [ 16 ]) to investigate the genome-wide changes in gene expression in relation to CRE1 function, using a Δcre1 recombinant mutant strain of T. reesei and corresponding control strain. (biomedcentral.com)
Mutations in the sodium-glucose cotransporter 2 gene are responsible for the majority of cases. (medscape.com)
The cdr1B gene, encoding an ABC transporter, plays a role in azole resistance. (cdc.gov)

Two metabolic defects that seem to be central to the pathology of type 2 diabetes are impaired insulin secretion and the reduced ability of insulin to act on the major insulin-sensitive tissues ( 2 - 5 ). (diabetesjournals.org)
Glucose and several amino acids stimulate insulin secretion under physiologic conditions, and the sequence of events leading to insulin secretion is well delineated. (medscape.com)

The rate of glucose entry into the beta cell is facilitated by a glucose transporter, and the entry rate exceeds the oxidation rate of glucose. (medscape.com)

Two means of glucose transport are noted: facilitative and secondary active transport. (medscape.com)
Facilitative transport occurs in essentially all cell types and is driven by the concentration gradient across cellular membranes. (medscape.com)
Glucose enters the cell along with sodium, and sodium exits the cell at the basolateral side of the cell, which is sodium-independent and a facilitative transport requiring no energy. (medscape.com)

Inhibition of renal tubular blood sugar reabsorption, resulting in a decrease in blood glucose focus through improved urinary blood sugar excretion, offers a book insulin-independent therapy (2,12) that in pet types of diabetes provides been proven to invert glucotoxicity and improve insulin awareness and -cell function (13,14). (cell-signaling-pathways.com)
AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. (cusabio.com)

SGLTs transport sodium and glucose into cells using the sodium gradient created by sodium/potassium ATPase pumps at the basolateral cell membranes. (bjcardio.co.uk)
In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)
In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
ii) The glucose carriers expressed in the basolateral domain are GULT-1 and GLUT-2 that do not require energy, sodium, or any other ion. (medscape.com)

Its use as a therapeutic target is limited by side effects from malabsorption of glucose and galactose in the small intestine. (bjcardio.co.uk)
galactose transporter. (lbl.gov)
Galactose, glucose uniporter, Gal2. (lbl.gov)

ASL glucose concentrations are increased in respiratory disease and by hyperglycaemia. (ersjournals.com)

Glycolysis is an anaerobic, sequential, enzymatic and catabolic multi-step process that converts a single glucose molecule into two pyruvates in the cytoplasm coupled with the production of two NADH molecules and a net yield of two molecules of ATP. (kdwis.com)
These results suggest, therefore, that small nonpeptide molecules that directly sensitize the IR may be useful for treating type 2 diabetes. (diabetesjournals.org)
GSD type Id is deficiency in a transporter that translocates free glucose molecules from microsomes into the cytosol. (medscape.com)

5,6 Dipeptidylpeptidase-4 (DPP-4) inhibitors are well tolerated, but are merely weight neutral. (bjcardio.co.uk)
Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining attention for the treatment of different cancer types, but also to contrast neurodegenerative disease, diabetes, and autoimmune syndromes. (bvsalud.org)
Human studies have confirmed the efficacy of SLGT2 inhibitors in improving glucose control and reducing the A1c. (uthscsa.edu)
Some medications are associated with insulin resistance including corticosteroids , protease inhibitors (type of HIV medication), [11] and atypical antipsychotics . (wikipedia.org)

Type 2 diabetes mellitus is a major risk factor for developing both microvascular (retinopathy, nephropathy and neuropathy) and macrovascular complications (coronary heart disease, cerebrovascular disease and peripheral vascular disease). (bjcardio.co.uk)
Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
The risk of cancers appears to be increased in both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) ( 2 ). (frontiersin.org)
Promising findings in randomized controlled studies indicate that supplementation with flavan-3-ols or anthocyanidins may improve glycemic control in subjects at-risk or diagnosed with type 2 diabetes mellitus . (oregonstate.edu)
Type 2 diabetes mellitus (T2DM) is the most common form of diabetes. (biomedcentral.com)

The small intestine converts dietary fructose into glucose and organic acids. (nature.com)
1. Glucose and fructose form similar osazone crystals. (medical-junction.com)

This form of glucose transport is predominantly mediated by members of the GLUT transporter family. (medscape.com)

Gluconeogenesis in the kidneys exceeds renal glucose consumption. (medscape.com)

Under normal physiological conditions, approximately 180 g of glucose is filtered by the kidney daily. (bjcardio.co.uk)
Under normal circumstances, the kidney filters and reabsorbs 100% of glucose, approximately 180 g (1 mole) of glucose, each day. (medscape.com)

Gluconeogenesis and Fasting Blood Sugar Too High Gestational Diabetes glycogenolysis are important for maintenance of the plasma glucose concentration. (2mtravel.ba)
As plasma glucose concentration increases, there is concordant increase in the filtered load of glucose. (medscape.com)

These transporters require energy and are sodium dependent. (medscape.com)

which often does not achieve the required glycemic goal and it is associated with putting on weight and hypoglycemia (5,6). (cell-signaling-pathways.com)
Maternal diet apparently does not have a significant role on neonatal cord blood insulin, C-peptide, or plasma glucose levels although a lower maternal glycemic load appears to be associated with lower adiposity in infants born to these women. (medscape.com)

However, in the kidney, glucose is reabsorbed from the filtrate in the tubule lumen, where it is at a relatively low concentration, passes through the simple cuboidal epithelia lining the kidney tubule, and into the bloodstream where glucose is at a comparatively high concentration. (wikipedia.org)
Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)
This is in contrast to conditions in the gut and kidney, where luminal glucose concentrations regularly exceed plasma glucose concentrations [ 6 , 7 ]. (ersjournals.com)
The prognosis of RCC is poor because approximately 25% of patients present with metastases at the time of diagnosis, and another 30-35% of patients underwent resection for localized or locally invasive kidney cancer will develop potentially fatal metachronous distant metastases [ 5 , 6 ]. (thno.org)

Close to the loop of Henle and in the distal convoluted tubule of the nephron where much glucose has been reabsorbed into the bloodstream, SGLT1 transporters are found. (wikipedia.org)
The progression of renal damage resulting from reduced nephron mass has been extensively studied in the 5/6 nephrectomized rat. (elsevierpure.com)

Here, we deciphered the CRE1 regulatory range in the model cellulose and hemicellulose-degrading fungus Trichoderma reesei (anamorph of Hypocrea jecorina ) by profiling transcription in a wild-type and a delta- cre1 mutant strain on glucose at constant growth rates known to repress and de-repress CCR-affected genes. (biomedcentral.com)
CreA/CRE1 binds to the promoters of the respective target genes via the consensus motif 5'-SYGGRG-3', whose function in vivo has been shown both in Aspergillus nidulans and Trichoderma reesei [ 9 - 12 ]. (biomedcentral.com)
For practical purposes, depending on the enzyme activity and the presence of mutations in the G6Pase and T genes, respectively, GSD type I may be subdivided into 2 major forms. (medscape.com)

Metabolic Syndrome Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal adipose tissue), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (msdmanuals.com)

Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. (lbl.gov)
Problems, such as the different elements that cause it and the fact that these factors do not express themselves in each cause of cancer with a uniform pathway across all cancer types are confronted in the search for a solution to cancer 2 . (ijpsr.com)

For over 50 years, glucose has been recognised to cross the lung epithelial barrier and be transported by lung epithelial cells. (ersjournals.com)

Glucokinase is the rate-limiting step of glycolysis (ATP production), not glucose transport. (medscape.com)

Once in periplasmic space, glucose is transported into the cytoplasm by several systems, including the phosphoenolpyruvate-dependent phosphotransferase system (PTS), the ATP-dependent cassette (ABC) transporters, and the major facilitator (MFS) superfamily proton symporters. (encyclopedia.pub)

Functioning in conjunction, these two secondary active transporters ensure that only negligible amounts of glucose are wasted through excretion in the urine. (wikipedia.org)

Therefore, the concentration gradient of glucose opposes its reabsorption, and energy is required for its transport. (wikipedia.org)
Na+ ions diffuse down their concentration gradient into the columnar epithelia, co-transporting glucose. (wikipedia.org)

Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977. (lbl.gov)

The Journal of Clinical Investigation 96(5): 2489-2495. (wikipedia.org)
Although it continues to be known for 50 years (10,11) that renal blood sugar reabsorption is elevated in type 2 diabetics, just recently have got the clinical healing implications of the observation been regarded (2,12). (cell-signaling-pathways.com)
There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are not often used in clinical practice. (wikipedia.org)

GSD type IV, also known as amylopectinosis, Glycogen Branching enzyme deficiency (GBE) or Andersen disease, is a rare disease that leads to early death. (medscape.com)

The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. (lbl.gov)

E. coli preferentially uses glucose in the presence of sugar mixtures, preventing using other carbon sources. (encyclopedia.pub)
It cannot be overstated that the rate at which cancer uses glucose for proliferation is one of the many variables contributing to the alarmingly high mortality rate of cancer over time. (ijpsr.com)

Additionally, numerous transporters with overlapping sugar specificities for monosaccharides increase the potential capability to transport glucose [ 6 ] , indicating the extraordinary capability and plasticity of transporting and growing glucose as a carbon source. (encyclopedia.pub)

Current model of the mechanisms controlling glucose concentrations in the surface liquid lining the airway and distal lung epithelium. (ersjournals.com)
Several transcriptional and post-transcriptional regulatory mechanisms control the preferential use of glucose over other sugars. (encyclopedia.pub)
This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers. (frontiersin.org)
However, the underlying mechanisms between various types of diabetes and cancers have not yet been summarized. (frontiersin.org)

Glucose diffuses into ASL via paracellular pathways at a rate determined by paracellular permeability and the transepithelial glucose gradient. (ersjournals.com)
Glucose diffusion is determined by epithelial permeability to glucose, the transepithelial glucose gradient and surface area. (ersjournals.com)

Almost all of this is re-absorbed into the circulation via sodium glucose co-transporters (SGLTs). (bjcardio.co.uk)

Anatomy17

Organisms7

Diseases3

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Psychiatry and Psychology1

Phenomena and Processes29

Disciplines and Occupations1

Information Science3

Uptake20

High affinity5

Blood glucose levels4

SGLT212

Homeostasis9

SGLT5

GLUT211

GLUT43

Protein3

Proteins3

Reabsorption of glucose3

Proximal7

Metabolism1

Solute2

Membrane3

Gene5

Secretion2

Rate of glucose entry1

Facilitative3

Inhibition2

Basolateral4

Galactose3

Hyperglycaemia1

Molecules3

Inhibitors4

Diabetes mellitus6

Fructose2

GLUT1

Renal glucose1

Approximately 1802

Plasma glucose concentration2

Sodium-dependent1

Glycemic2

Kidney4

Nephron2

Genes3

Adipose tissue1

Pathway2

Epithelial cells1

Glucokinase1

Superfamily1

Excretion1

Concentration gradient2

Transports glucose1

Clinical3

Enzyme1

Facilitator1

Uses glucose2

Transport glucose1

Mechanisms4

Transepithelial2

SGLTs1