Affinity 1999 binds to transferrin receptors transferrin. Medical search. Frequent questions

However several essential AMG-925 nutrients and carrier proteins are thought to mix the BBB via receptors indicated on mind endothelial cells through a process known as receptor-mediated transcytosis (Rubin and Staddon 1999 Predescu et al. (biotech-angels.com)
Wild-type mice received an individual i.v. shot at among three dosages (5 25 and 50 mg/kg) of high-affinity anti-TfRA/BACE1 or low-affinity anti-TfRD/BACE1 and TfR proteins amounts in the cortex had been evaluated at 1 and 4 d after shot by Traditional western blot from human brain homogenates. (biotech-angels.com)
CDKs are cyclin-dependent serine-/threonine-specific proteins kinases, the experience of which depends upon cyclin binding. (niepokorny.org)
To differentiate specific and nonspecific binding of lactoferrin, lactoferrin affinity chromatography and Western blotting was used to identify metabolically or surface-labeled T. foetus lactoferrin-binding proteins. (bvsalud.org)
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of surface biotinylated proteins affinity-purified on lactoferrin-Sepharose showed biotinylated bands at Mr values of 22, 49, 55, 72, and 155 kDa. (bvsalud.org)
In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)
We demonstrate that recombinant LHCGR proteins which include the hormone-binding domain are secreted from transfected cells and that natural LHCGR is also secreted from human placental explants. (biomedcentral.com)
The plasma membrane is not only the first point of encounter for many types of environmental stress, but given the diversity of receptor proteins and their associated molecules also represents the site at which many cellular signal cascades originate. (cell-stress.com)
The plasma membrane can be envisioned as a central compartment in the cellular adaptation to diverse stress conditions as it shapes the interactions between cells and their environment by harboring an elaborate complement of transmembrane proteins, e.g. transporters, channels, receptors, or adhesion proteins. (cell-stress.com)
Two of them: FrpB1 and FrpB2 were purified as recombinant proteins and their haem- or haemoglobin-binding capability was demonstrated. (walshmedicalmedia.com)
This bacterium synthesizes three membrane proteins of 48, 50 and 77 kDa capable of binding haem, unfortunately their identities remains undetermined [ 17 ]. (walshmedicalmedia.com)
The plasma protein inhibitors are factor H and C4-binding protein, and the regulatory membrane proteins located on cell surfaces are complement receptors 1 (CR1), decay-accelerating factor (DAF), and membrane cofactor protein (MCP). (justia.com)
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). (bvsalud.org)

The earliest biochemical evidence on the existence of cell-free soluble LH receptor was the purification of an hCG-binding protein, relative molecular mass of 65K (M r , 65K) from porcine follicular fluid and was based on gel filtration followed by affinity chromatography [ 9 ]. (biomedcentral.com)
Partial purification of the toad PRL receptor could be achieved by affinity chromatography. (eurekamag.com)
In this work FrpB3 was purified by haem-affinity chromatography and its capacity of haem-binding was analyzed. (walshmedicalmedia.com)

This protein is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1. (wikipedia.org)
This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. (wikipedia.org)
2013 We suggested that lower affinity enhances uptake into human brain by facilitating dissociation from TfR (Yu et al. (biotech-angels.com)
2013 Right here we hypothesized that TfR antibody affinity determines TfR trafficking destiny and sought to review the cellular systems root the robust distinctions between high and low anti-TfR affinity variations and TfR trafficking aswell as the influence of the strategies on human brain uptake of biotherapeutics. (biotech-angels.com)
Upon Fe3+ uptake, transferrins undergo a large scale conformational transition: the apo structure with an opening of the interdomain cleft is transformed into the closed holo structure, implying initial Fe3+ binding in the open form. (lookformedical.com)
3H]Thymidine uptake is clearly stimulated on KB cells by nanomolar concentrations of EGF and transferrin, whereas in Ara-C-treated cells [3H]thymidine uptake is not increased by EGF and transferrin under conditions where maximal EGFR and TrfR up-regulation occurs. (cnr.it)
High affinity zinc-regulated zinc uptake transporter, Zrt1 of 376 aas and 8 TMSs. (tcdb.org)
Low affinity zinc-regulated zinc uptake transporter, Zrt2 of 422 aas and 7 TMSs. (tcdb.org)

In RMT, a ligand (or antibody) binds a receptor on the luminal surface of a brain endothelial cell, after which it undergoes internalization via endocytosis and is trafficked to the abluminal side, where it can be released and gain access to the brain parenchyma. (biomedcentral.com)
The hormonal activation occurs through specific ligand-receptor interactions on the surface of the target cells. (biomedcentral.com)
A different experimental approach by West and Cooke [ 10 ] demonstrated the secretion of M r 80-90K hCG-LH receptor complex into the culture media from ligand-induced rat and mouse leydig cells. (biomedcentral.com)
instead, a specific intra-cellular role of truncated receptor in regulating the cell surface expression of a full-length ligand-binding Lhcgr has been proposed [ 15 ]. (biomedcentral.com)
An in vitro binding kinetic analysis revealed that these phosphorylation-dependent events were attributable to a decrease in the affinity of phosphorylated Homer3 for its ligand. (jneurosci.org)
C3 is unique in that it possesses a rich architecture that provides a multiplicity of diverse ligand binding sites that are important in immune surveillance and immune response pathways. (justia.com)

Therefore high-affinity anti-TfR alters TfR trafficking which dramatically effects the capacity for TfR to mediate AMG-925 BBB transcytosis. (biotech-angels.com)
2013 Yu and Watts 2013 though many limitations have also surfaced including evidence that high-affinity TfR antibodies remain trapped within mind vasculature (Moos and Morgan 2001 Gosk et al. (biotech-angels.com)
Outcomes High-affinity binding to TfR drives cortical TfR degradation in vivo To comprehend how anti-TfR affinity inversely AMG-925 influences human brain contact with antibody we initial determined whether degrees of TfR are influenced by dosing of high- versus low-affinity TfR bispecific antibodies. (biotech-angels.com)

Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody-antigen immune complexes and immunoproteins or Fc receptor expressing immune effector cells. (frontiersin.org)
These Fc receptor-dependent antibody functions provide a direct link between the innate and adaptive immune systems by combining the potent antiviral activity of innate effector cells with the diversity and specificity of the adaptive humoral response. (frontiersin.org)
The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. (frontiersin.org)
Fc receptor-dependent antibody functions are important components of the immune response that provide mechanisms for clearance of infected host cells, immune complexes, or opsonized pathogens. (frontiersin.org)
Fc receptor-dependent antibody functions are also involved in activation of downstream adaptive immune responses by facilitating antigen presentation or by stimulating the secretion of inflammatory mediators ( 12 , 13 ). (frontiersin.org)
To test antibody transcytosis, the lumen of the model's endothelial vessel was perfused with an anti-transferrin receptor antibody or with a control antibody. (biomedcentral.com)
Penetration of the antibody targeting the human transferrin receptor (MEM-189) was markedly higher than penetration of the control antibody (apparent permeability of 2.9 × 10 −5 versus 1.6 × 10 −5 cm/min, respectively). (biomedcentral.com)
To date, there are no inhibitors of complement activation used in the clinic, though certain candidates for clinical use exist, specifically, a recombinant form of complement receptor 1 known as soluble complement receptor 1 (sCR1) and a humanized monoclonal anti-C5 antibody (5G1.1-scFv). (justia.com)
[2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)
These epitopes bind with their antibody in a highly specific interaction, called induced fit , that allows antibodies to identify and bind only their unique antigen in the midst of the millions of different molecules that make up an organism . (wikidoc.org)
The large and diverse population of antibodies is generated by random combinations of a set of gene segments that encode different antigen binding sites (or paratopes ), followed by random mutations in this area of the antibody gene, which create further diversity. (wikidoc.org)

2001). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE" (PDF). (wikipedia.org)

2011 We also lately reported that affinity and effector function determine the basic safety profile of TfR healing antibodies in vivo hence further helping low-affinity strategies and the necessity to better understand the root cell biology (Sofa et al. (biotech-angels.com)
In this review, we discuss the properties of Fc receptors, antibodies, and effector cells that influence ADCP. (frontiersin.org)
We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
Antibodies can also neutralize targets directly by, for example, binding to a part of a pathogen that it needs to cause an infection. (wikidoc.org)
Antibodies occur in two forms: a soluble form secreted into the blood and tissue fluids, and a membrane-bound form attached to the surface of a B cell that is called the B cell receptor (BCR). (wikidoc.org)

Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene. (wikipedia.org)
This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. (wikipedia.org)
2007 Transferrin (Tf) receptor (TfR) a type II transmembrane protein highly indicated on mind endothelial cells (Jefferies et al. (biotech-angels.com)
Esmaeili R, Zhang M, Sternberg MR, Mapango C, Pfeiffer CM . A new multiplex immunoassay for serum ferritin, soluble transferrin receptor, C-reactive protein, α-1-glycoprotein, and retinol-binding protein showed variable comparability with traditional reference assays external icon . (cdc.gov)
However, specific lactoferrin-binding protein receptors have not yet been identified in T. foetus. (bvsalud.org)
The results of recently conducted clinical trials suggest that lactoferrin, an iron-binding protein that is abundant in mammalian colostrum and milk, may be an effective agent in preventing sepsis in newborns. (springer.com)
Lead also binds to metallothionein, a sulfhydryl-rich protein, but does not appear to displace cadmium or zinc. (cdc.gov)
Therefore, how a complex LHCGR protein, embedded within the membrane lipid bilayer, could be secreted as soluble receptor remained unexplained. (biomedcentral.com)
ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)
In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. (justia.com)
In particular, this invention provides peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation. (justia.com)
The binding site in Pra1 is in the C-terminal region of this 299 aa protein ( Łoboda and Rowińska-Żyrek 2017 ). (tcdb.org)

Interestingly, there exists a subset of viruses with natural affinity for receptors on tumor cells that could be exploited for nanotechnology applications. (biomedcentral.com)

1999). "Molecular cloning of transferrin receptor 2. (wikipedia.org)
A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
The molecular characteristics of the Triton X-100 solubilized renal and mammary PRL receptors were assessed by gel filtration and by migration analysis on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) after affinity labeling of the binding sites with 125I-human growth hormone. (eurekamag.com)
The molecular weight of this purified receptor could be determined by analysis on SDS-PAGE. (eurekamag.com)
Ras is a small GTPase that operates as a binary molecular switch between a GDP-bound inactive and GTP-bound active state. (rupress.org)

The bispecific variations share the same non-Tf-TfR preventing epitope and affinities had been previously driven as ～20 nM for anti-TfRA/BACE1 and ～600 nM for anti-TfRD/BACE1 (Sofa et al. (biotech-angels.com)
With the use of a polyclonal antiserum raised against a purified preparation of rabbit mammary PRL receptor, one or several antigenic epitope(s) could be identified on the core of the toad renal PRL receptor. (eurekamag.com)

1998 has been proposed to undergo transcytosis in the BBB to allow access of iron-bound Tf by constitutive endocytosis (Fishman et al. (biotech-angels.com)
The membrane-bound matrix metalloproteinase MT1-MMP (MMP14) is internalized by endocytosis and recycled in endosomal compartments. (nature.com)

Furthermore, both robust phosphorylation of Homer3 and its dissociation from metabotropic glutamate receptor 1α (mGluR1α) were triggered by depolarization in primary cultured Purkinje cells, and these events were inhibited by CaMKII inhibitor. (jneurosci.org)

Lactoferrin (Lf) is an 80-kDa glycoprotein that belongs to the transferrin family and is abundant in the colostrum and milk of mammals. (springer.com)
A glycoprotein albumin from hen's egg white with strong iron-binding affinity. (lookformedical.com)

An increase in the number of epidermal growth factor and transferrin receptors (EGFR, TrfR) is induced by Ara-C on these cells. (cnr.it)

The axonal transmembrane decreases in the bind negatively from modification class, and acts named the proteasome-mediated signal. (erik-mill.de)

In summary, the data showed that binding of lactoferrin to T. foetus may be regulated by an interplay of specific receptor interactions as well as by hydrophobic and charge-related interactions. (bvsalud.org)

anti-TfR dosing induced reductions in mind TfR levels which significantly decreased mind exposure to a second dose of low-affinity anti-TfR bispecific. (biotech-angels.com)
2013 We have previously demonstrated that in the framework of both anti-TfR and bispecific anti-TfR/BACE1 (β-amyloid cleaving enzyme-1) better human brain exposure is attained as the affinity for TfR is normally decreased (Yu et al. (biotech-angels.com)

Receptor-mediated transcytosis is one of the major routes for drug delivery of large molecules into the brain. (biomedcentral.com)

The enhanced EGF and transferrin binding is paralleled by a twofold increase of in vitro targeting of Ara-C-treated KB and A549 cells with anti-EGFR 108.1 mAb and anti-TrfR OKT9 mAb. (cnr.it)

A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states. (lookformedical.com)

2007 the exact route of receptor-mediated transcytosis of Tf-TfR is not well understood in the BBB. (biotech-angels.com)
The transport system that is most attractive to deliver large-molecule drugs into the brain is receptor-mediated transcytosis (RMT). (biomedcentral.com)

11 ] first reported the production and secretion of soluble LH receptor following transient transfection of a naturally truncated variant of the receptor in COS cells. (biomedcentral.com)
Moreover, the lack of a secreted form of the receptor was overcome by co-expression of hCG with the extra-cellular domain of porcine LH receptor leading to the secretion of a mixture of free as well as hCG-receptor complex [ 13 ]. (biomedcentral.com)
The localization of Lcn2-R in the inner medulla is intriguing considering local bacterial infections trigger toll-like receptor-4 (TLR-4)-mediated secretion of the bacteriostatic Fe 3+ -free (apo-)Lcn2. (biomedcentral.com)

Lactoferrin that was not bound to its cognate receptor was able to bind and neutralize lipopolysaccharide. (springer.com)

Complexes of Vps34, the sole class III PI3K member, produce PI 3-phosphate (PI(3)P) in the endolysosomal system and during autophagy to regulate vesicle-mediated sorting en route to lysosomes 1 . (nature.com)

Neutrophil gelatinase-associated lipocalin (NGAL in humans, siderocalin/24p3 in rodents) or lipocalin-2 (Lcn2) is secreted by cells [ 6 ] in an Fe 3+ -free apo form, which binds Fe 3+ through association with bacterial siderophores (forming holo-Lcn2). (biomedcentral.com)

Three of the L. amylovorus strains studied adhered to IPEC-1 cells, while four strains inhibited the adherence of E. coli , indicating additional mechanisms other than competition for binding sites being involved in the inhibition. (biomedcentral.com)

Predicated on series evaluation and a 3D style of pUL97, the viral kinase displays structural similarity to CDK2 in the catalytic middle and in functionally essential residues from the ATP binding site [16]. (niepokorny.org)
Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)

There is, however, no clear interaction between the nitrilotriacetate anion and the synergistic anion binding site, Arg121. (lookformedical.com)
Moreover, we identify a distinct, N-terminal, higher affinity interaction interface between LRRK2 phosphorylated Rab8 and Rab10 termed 'Site #2', that can retain LRRK2 on membranes in cells to catalyze multiple, subsequent phosphorylation events. (stanford.edu)

These effects occur without changes in the affinity of EGFR and TrfR for their ligands. (cnr.it)

For example, the canine parvovirus (CPV) utilizes transferrin receptors (TfRs) for binding and cell entry into canine as well as human cells. (biomedcentral.com)
Attachment of fluorescent dyes neither impaired binding to the TfRs nor affected internalization of the 26 nm-sized VLPs into several human tumor cell lines. (biomedcentral.com)
An antagonist at the opioid mu receptors, it is useful for moderate-to-severe pain in sickle cell disease. (medscape.com)
Additionally, the truncated Lhcgr, misrouted the full-length Lhcgr in ER, thereby decreasing the cell surface expression of the mature functional receptor. (biomedcentral.com)
receptors and dileucine-: TLR1 photosynthesis cell in New Zealand 1945 -1960: family understood in bovine RELB of the Associations for the peptidyl of Master of Arts. (evakoch.com)
Cell surface receptors, unlike enzymes, do not chemically alter their ligands. (bvsalud.org)
for hormone receptors in general coord HORMONES (IM) and RECEPTORS, CELL SURFACE (IM) or RECEPTORS, CYTOPLASMIC AND NUCLEAR (IM), for receptors of specific hormones, coord specific hormone or hormone group (IM) and precoord hormone receptor (e.g. (bvsalud.org)

The RPA gene is the structural excretion loss-of-function, However Binding it from the corresponding growth( De Laat et al. (evakoch.com)

Alternative structural state of transferrin. (lookformedical.com)
In conclusion, although the structure and the biological role(s) of PRL have substantially changed during evolution, the receptor for this hormone has retained many of its structural features as could be assessed between an amphibian and a mammalian species on functionally different target tissues. (eurekamag.com)

In its binding with sulfhydryl groups, lead may interfere with the activity of zinc metalloenzymes, as zinc binds to a sulfhydryl group at the active site. (cdc.gov)

None of the strains bound to porcine mucus. (biomedcentral.com)

An opioid agonist/antagonist, nalbuphine stimulates kappa opioid receptor in the CNS, which causes inhibition of ascending pain pathways. (medscape.com)
Codeine binds to opiate receptors in the CNS, causing inhibition of ascending pain pathways, altering perception and response to pain. (medscape.com)

Structurally, LHCGR is similar to thyroid and follicle stimulating hormone receptors (TSHR and FSHR respectively). (biomedcentral.com)
RECEPTORS, ALDOSTERONE) (IM) or precoord hormone-group receptor (e.g. (bvsalud.org)

As adhesion to host tissues is essential for many gastro-intestinal pathogens, the paradigm of competitive exclusion through competition for binding sites has evolved. (biomedcentral.com)

Bovine lactoferrin was shown to bind more efficiently than human lactoferrin, and each of these bound much better than bovine transferrin. (bvsalud.org)
In the presence of bovine cervical mucus, binding of lactoferrin to T. foetus was diminished, suggesting that mucus has an effect on lactoferrin binding. (bvsalud.org)

Both 3D models showed that they are structurally conserved because they have the typical barrel structure, which is inserted in membrane, also, the motifs necessary for Hb-binding were identified in all the structures. (walshmedicalmedia.com)

WDFY2 localizes to endosomal tubules by binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns3P). (nature.com)
We unravel a coincident mechanism of lipid-induced activation of PI3KC2α at membranes that involves large-scale repositioning of its Ras-binding and lipid-binding distal Phox-homology and C-C2 domains, and can serve as a model for the entire class II PI3K family. (nature.com)

Each of these variants can bind to a different target, known as an antigen . (wikidoc.org)

5 gastric to clear contrast of gamma receptors, diverse nucleases and photovoltaic adipocytes( Shalaby et al. (erik-mill.de)
In animals, lead has been shown to alter a number of neurotransmitter systems including dopamine, norepinephrine, serotonin, and gamma- aminobutyric acid systems (ATSDR 1999). (cdc.gov)

Initially, lead is distributed to the blood plasma and soft tissues, but under steady state conditions 99% of the lead in blood is found in the erythrocyte, where much of it is bound to hemoglobin. (cdc.gov)
Placental hCG and pitutary LH transduce signals in target tissues through a common receptor (LHCGR). (biomedcentral.com)

describes the use of a phage-displayed combinatorial random peptide library to identify a 27-residue peptide that binds to C3 and inhibits complement activation. (justia.com)

This is relevant because T. foetus is both species-specific and only infects the mucosal surface of the reproductive tract, which has little transferrin. (bvsalud.org)
The 3' replication has freely activated by RNase Z surface, a mature binding in receptors( reviewed in Maraia and Lamichhane 2011). (evakoch.com)

Anatomy18

Organisms7

Diseases7

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes28

Information Science3

Proteins13

Chromatography3

Uptake8

Ligand6

High-affinity3

Antibody16

20011

Antibodies7

Protein13

Tumor cells1

Molecular5

Epitope2

Endocytosis2

Inhibitor1

Glycoprotein2

Epidermal1

Transmembrane1

Interactions1

Bispecific2

Molecules1

Vitro1

Isoforms1

Transcytosis2

Secretion3

Cognate1

Complexes1

Humans1

Mechanisms1

Residues2

Interaction2

EGFR1

Cell7

Gene1

Structural2

Zinc1

Porcine1

Inhibition2

Hormone2

Pathogens1

Lactoferrin2

Structurally1

Membranes2

Variants1

Gamma2

Tissues2

Complement1

Surface2