• Berger
  • Berger subsequently referred to this sedating or "tranquilizing" effect in a now-historic article, published by The British Journal of Pharmacology in 1946. (wikipedia.org)
  • In May 1950, after moving to Carter Products in New Jersey, Berger and a chemist, Bernard John Ludwig, synthesized a chemically related tranquilizing compound, meprobamate, that was able to overcome these three drawbacks. (wikipedia.org)
  • doses
  • Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. (wikipedia.org)
  • GABA
  • Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA), which are brain chemicals performing communication between brain cells. (wikipedia.org)
  • medication
  • Meprobamate may also be used for purposes not listed in this medication guide. (healthbanks.com)
  • what is the medication ativan used for For optimum effect, intravenous drug should be reduced! (nikolaevskii-sobor.ru)
  • Treatment: general-provide symptomatic and supportive treatment, as with sedatives in general, possess a significant additive effect in this medication do not stop using this medication by mouth with or without metabolizing enzymes. (thetunnel-art.co.uk)
  • drug
  • Never share meprobamate with another person, especially someone with a history of drug abuse or addiction. (healthbanks.com)
  • Meprobamate is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. (healthbanks.com)
  • In December 1967, meprobamate was placed under abuse control amendments to the Food, Drug and Cosmetic Act. (wikipedia.org)
  • The mean age was about 41 years old and had to have a given effect, [citation needed] is useful in other pain situations and is also especially useful with opioids of the amount of pro-drug converted into the active ingredient in soma, and martial arts) may reduce your! (thetunnel-art.co.uk)
  • This provides an insight at a possible mechanism of action, as it is known what certain functional components of the drug are responsible for interacting with a certain area on a protein, thus, leading to a therapeutic effect. (wikipedia.org)
  • When a psychoactive drug enters the user's body, it induces an intoxicating effect. (wikipedia.org)
  • risks
  • The Agency's Committee for Medicinal Products for Human Use (CHMP) "concluded that the benefits of meprobamate do not outweigh its risks. (wikipedia.org)
  • make
  • The U.S. government sought an order mandating that Carter make its meprobamate patent available at no charge to any company desiring to use it. (wikipedia.org)
  • Depressants
  • Blonanserin: CNS Depressants may enhance the CNS depressant effect of Blonanserin. (drugs.com)
  • Buprenorphine: CNS Depressants may enhance the CNS depressant effect of Buprenorphine. (drugs.com)
  • Dronabinol: May enhance the CNS depressant effect of CNS Depressants. (drugs.com)