• The lipidation states of apolipoproteins and Aβ peptides in the brain differ depending on APOE genotype and cognitive diagnosis. (nih.gov)
  • We investigated the independent and interactive impact of the common APOE genotype and marine n-3 polyunsaturated fatty acids (PUFA) on the development of obesity and associated cardiometabolic dysfunction in a murine model. (uea.ac.uk)
  • The aim of this investigation was to assess the effect of galantamine, an acetylcholinesterase inhibitor and allosteric modulator of nicotinic receptors, on brain atrophy in individuals with mild cognitive impairment (MCI), and to assess effect modification by apolipoprotein E (APOE) genotype. (biomedcentral.com)
  • Additionally, we performed stratified analyses according to APOE genotype. (biomedcentral.com)
  • This protective effect of galantamine on whole brain atrophy rate in MCI was only present in APOE ϵ4 carriers. (biomedcentral.com)
  • Methods: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other APOE genotypes for relevant confounders (n = 223). (lu.se)
  • We investigated the molecular basis of CBS deficiency in 29 Dutch patients from 21 unrelated pedigrees and studied the possibility of a genotype-phenotype relationship with regard to biochemical and clinical expression and response to homocysteine-lowering treatment. (nih.gov)
  • Limited information on phenotypes attributable to RAD21 variants and genotype-phenotype relationships is currently published. (springer.com)
  • Variants were frequently familial, and genotype-phenotype analyses demonstrated striking interfamilial and intrafamilial variability. (springer.com)
  • Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844-848. (bvsalud.org)
  • To date, only two clinically relevant intragenic genotype-phenotype correlations have been reported for NF1 missense mutations affecting p.Arg1809 and a single amino acid deletion p.Met922del. (bvsalud.org)
  • A genotype-phenotype correlation at the NF1 region 844-848 exists and will be valuable in the management and genetic counseling of a significant number of individuals. (bvsalud.org)
  • The aim of this study was toassess genotype- phenotype correlations, focusing on the cardiac features and out-comes of interventions for cardiac conditions, in a single-center cohort of116 patients with molecularly confirmed diagnosis of RASopathy, and compare thesefindings with previously published data. (unicatt.it)
  • How genotype is translated into phenotype depends on penetrance and expressivity. (msdmanuals.com)
  • The enormous variants and mutations found mean that we are still far from being able to concretely clarify a genotype-phenotype relationship. (bvsalud.org)
  • Leukocyte adhesion deficiency (LAD) type II/carbohydrate deficient glycoprotein (CDG) IIc founder effect and genotype/phenotype correlation. (lu.se)
  • Fig. 2: Effect of plant genotype on the leaf endosphere community. (nature.com)
  • In this study we present evidence that plant genotype and hybridization influence the population dynamics of the poplar bud gall mite, Aceria parapopuli. (nau.edu)
  • We detected significant differences in gall population growth rates (intrinsic rate of increase, r) among hybrid genotypes across four years of study, ranging from r = 0 to r = 1.5, demonstrating that plant genotype influences a fundamental component of population dynamics. (nau.edu)
  • We argue that plant genotype should also impact metapopulation dynamics, because plant genotype affected the number of available colonists and directly affected mite extinction rates. (nau.edu)
  • McIntyre, PJ & Whitham, TG 2003, ' Plant genotype affects long-term herbivore population dynamics and extinction: Conservation implications ', Ecology , vol. 84, no. 2, pp. 311-322. (nau.edu)
  • We evaluated how past HV cultivationaffected nodulation and BNF across host genotypes. (uncg.edu)
  • Because mite population growth and extinction are so closely tied to rare host genotypes, to conserve such species we must preserve rare host genotypes, which would represent a major challenge to current conservation practices that target species rather than genotypes. (nau.edu)
  • The MolDX Team has determined Apolipoprotein (Apo) E genotype testing, developed to assess the risk of cardiovascular disease, has insufficient evidence to support the required clinical utility for the established Medicare benefit category. (cms.gov)
  • As reviewed, the developers described the indication to perform an Apolipoprotein (Apo) E genotype test as a risk assessment for developing a disease or condition. (cms.gov)
  • In both genotypes, strong correlations were detected among IL-1β responses to the Gram-negative stimulants and to LTA. (umn.edu)
  • Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. (ox.ac.uk)
  • We evaluated the genetic variation in rs8099917, substitutions in core amino acid (aa) 70, and the number of aa substitutions in the interferon sensitivity-determining region (ISDR) on the prediction of sustained virological response (SVR) in treatment-naïve hepatitis C virus (HCV) genotype 1b (G1b) patients. (hindawi.com)
  • This study aimed to compare the foot pad and carcass lesions as well as the behavior and plumage conditions of one egg-type slow-growing (SG) genotype (Brown Classic Lohman) and two meat-type strains, medium- (MG) (Naked neck Kabir) and fast-growing (FG) (Cobb 700), reared under organic conditions. (unibo.it)
  • This can most likely be explained by intergenotype sequence diversity leading to the loss of the immunodominant HLA-B27 epitope in viral strains other than genotype 1. (ox.ac.uk)
  • In conclusion, it is hypothesized that the dominance of genotype 2 HCV strains may be an important factor explaining the high rate of recovery from HCV infections in Ghana via an efficient contribution of HLA-B*57 which is relatively frequent in the population. (ox.ac.uk)
  • Among the 150 patients in whom the final virological response was determined, only genotype TT in rs8099917 was identified as a pretreatment predictor ( P = 7.38 × 10 −4 ). (hindawi.com)
  • This treatment provides rates of sustained virological response (SVR, undetectable serum levels of HCV RNA at least 6 months after completion of therapy) of 40-50% among patients with HCV genotype 1 (G1) who have not received previous treatment (treatment-naïve patients) [ 1 - 3 ]. (hindawi.com)
  • Higher planting density could be used to select genotypes with lodging resistance in irrigated environments. (cgiar.org)
  • On the basis of minimum reduction in observed traits, genotypes KPF 103, DMR 15, IPFD 4-6, were found to be having comparatively higher amount of resistance towards high temperature stress. (arccjournals.com)
  • There have been some genotypes that have demonstrated some resistance to this disease. (wikipedia.org)
  • There are currently 3 sets of targeted genotyping: - ESR1 (13 resistance mutations related to standard hormone therapy) - PIK3CA (11 variants related to Alpelisib treatment) - DPYD (6 variants related to fluoropyrimidine-associated toxicity) == Searching == The variant database uses Apache Lucene instead of PostgreSQL. (lu.se)
  • This study confirms that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool. (who.int)
  • conditions such as insulin resistance in the most prevalent genotype in Egypt patients with HCV infection. (who.int)
  • Adding to this grow- genotype 4, to assess factors associated proportion of Egyptians estimated to be ing body of evidence, it is now suggested with insulin resistance in those patients chronically infected was 9.8% ( 1 ). (who.int)
  • Five genotypes were selected based on yield performance and nutrient content. (uwi.edu)
  • Iron-processing genotypes, nutrient intakes, and cadmium levels in the Normative Aging Study: evidence of sensitive subpopulations in cadmium risk assessment. (cdc.gov)
  • Even the crudest transcriptional network is shown to substantially increase the fitness of the organism, and this effect persists even when the range of nutrient levels is kept very narrow. (lu.se)
  • Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children. (ox.ac.uk)
  • RESULTS: Nevirapine pharmacokinetics was best described using a one-compartment disposition model with elimination through a well-stirred liver model accounting for a first-pass effect and transit-compartment absorption. (ox.ac.uk)
  • Effect of foliage removal on root yield, dry matter, and proximate composition of five sweetpotato genotypes in Ghana. (uwi.edu)
  • Preliminary studies were conducted in Ghana in 1995 to identify high-yielding sweetpotato genotypes suitable for foliage removal without reducing root yield. (uwi.edu)
  • These genotypes were used to test the effect of foliage removal on root yield, dry matter, and proximate composition of sweetpotato in two villages in the Akatsi District of the Volta region of Ghana. (uwi.edu)
  • However, genotypes tested showed variation in yield response for all root grades. (uwi.edu)
  • To address this issue, we investigated differences in complex emotion recognition between participants ( n = 181) that had been a priori genotyped for functional polymorphisms of the COMT (Val158Met) and serotonin transporter (5-HTTLPR) gene. (frontiersin.org)
  • We were, thus, able to analyze differences in face processing on basis of participants' COMT genotype while controlling for participants' 5-HTTLPR genotype. (frontiersin.org)
  • Variations of participants' COMT but not 5-HTTLPR genotype accounted for differences in participants' emotion recognition performance: Met/Met carriers and Met/Val carriers were more accurate in the recognition of negative, but not neutral or positive, expressions than Val/Val carriers. (frontiersin.org)
  • No significant differences in HR were seen between genotype groups. (ku.dk)
  • Digit grass generally is also frost sensitive, where many genotypes show differences in frost tolerance. (wikipedia.org)
  • RNA-sequencing (RNA-seq) is a powerful technique for the identification of genetic variants that affect gene-expression levels, either through expression quantitative trait locus (eQTL) mapping or through allele-specific expression (ASE) analysis. (biomedcentral.com)
  • We reveal that repeated ecological and morphological diversification along a common environmental axis is associated with both genome-wide allele frequency shifts and a specific, larger effect, locus, associated with the gene edar . (biorxiv.org)
  • A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
  • A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)
  • Many factors can affect gene expression (and thus phenotypes). (msdmanuals.com)
  • We, therefore, revealed a similar negativity bias during the behavioral processing of faces that has already been demonstrated during the neural processing of faces, indicating that genotype-dependent changes in catecholamine metabolism may affect face processing on the behavioral and neural level. (frontiersin.org)
  • Certain genetic variations, SNPs, also affect warfarin sensitivity and metabolism. (news-medical.net)
  • Catalina Musrri, PhD candidate at the University of Sydney, aims to find the populations of crayweed (genotypes) that are best adapted to temperature by comparing the responses of crayweed genotypes from northern edge and central populations. (sims.org.au)
  • 20%) in western populations but reaches 50% in West Africa where genotype 2 infection is predominant. (ox.ac.uk)
  • On the other hand, eQTL analyses can be used for any genetic variant, but typically require the use of dozens of samples in order to have sufficient individuals in the different genotype classes. (biomedcentral.com)
  • Results: HFE and Transferrin genotypes were not associated with toenail cadmium concentrations in the main effect analyses, but there were significant interactions between HFE H63D and hemoglobin (pinteraction=0.021), as well as HFE H63D and vitamin C intake (pinteraction=0.048). (cdc.gov)
  • Conclusions: These findings suggest that sensitive subpopulations defined by diet, hemoglobin level, and genotype may absorb more cadmium from their environment and thus should be considered in cadmium risk analyses. (cdc.gov)
  • So far, she has run experiments in the SIMS research aquarium and tested the responses of juvenile crayweed (~6 months) and germlings (a week old) from Port Macquarie, Forster, Palm Beach and Cronulla to marine heatwaves to understand if different genotypes have varying tolerance to increasing temperature. (sims.org.au)
  • High temperature effect on grain growth in wheat cultivars: an evaluation of responses. (arccjournals.com)
  • CONCLUSIONS: Polymorphisms of the 5-HTTLPR differentially affect responses to mild stress and ATD, suggesting greater vulnerability of S'/S' carriers to serotonergic manipulations and supporting increased depression vulnerability. (reproductive-revolution.com)
  • Furthermore, patients with acute or chronic infection with HCV genotype 3a did not mount T-cell responses to this epitope region, and their autologous viral sequences showed no evidence of T-cell pressure. (ox.ac.uk)
  • Responses to LPS, LTA and the Gram-negative stimulants were greater in UH than in CH cows while responses to the Gram-positive bacteria did not differ between Holstein genotypes. (umn.edu)
  • In order to define the relative contribution of a specific HLA-B27-restricted epitope to the natural course of HCV infection, we compared the biological impact of the highly conserved HCV genotype 1 epitope, for which the protective role has been described, with the corresponding region in genotype 3 that differs in its sequence by three amino acid residues. (ox.ac.uk)
  • Finally, we found a significantly higher frequency of HLA-B27 positivity in patients with chronic HCV genotype 3a infection compared to genotype 1 infection, indicating that there is no protection by HLA-B27 in HCV genotype 3 infection. (ox.ac.uk)
  • CONCLUSION: Our data indicate that the protective effect of HLA-B27 is limited to HCV genotype 1 infection and does not expand to other genotypes such as genotype 3a. (ox.ac.uk)
  • Our results underline the central role of a single HLA-B27-restricted epitope-specific CD8+ T-cell response in mediating protection in HCV genotype 1 infection. (ox.ac.uk)
  • Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population. (ox.ac.uk)
  • Eighty-one percentage of subjects with chronic infection (RNA positive) carried genotype 2 HCV. (ox.ac.uk)
  • HCV antibody was confirmed by Western blot using genotype 2 recombinant core, E2 and NS3 proteins. (ox.ac.uk)
  • in terms of sample size (e.g., inclusion of more than 100 participants), genotype frequencies (e.g., consideration of COMT and 5-HTTLPR polymorphisms), task design (e.g., presentation of expressions with varying emotional intensity) and data analysis (e.g., control of multiple comparisons). (frontiersin.org)
  • Researchers from the Ohio State University have developed a rapid, multiplexed genotyping method to identify the single nucleotide polymorphisms (SNPs) that affect warfarin dose. (news-medical.net)
  • Fivegroups of similar HV genotypes were inoculated with soildilutions from six paired fields, three with 10-year HV cultivationhistory (HV+) and three with no history (HV-), andused to determine efficiency of rhizobia nodulation and BNF.Nodulation was equated to nodule number and mass, BNF toplant N and Rhizobium leguminosarum biovar viceae (Rlv)soil cell counts using qPCR to generate an amplicon of targetedRlv nodD genes. (uncg.edu)
  • We investigated to what extent the cuticle inward barrier function depends on the genotype, comprising mitochondrial and nuclear genes in the fruit fly Drosophila melanogaster, and investigated the contribution of interactions between mitochondrial and nuclear genotypes (mito-nuclear interactions) on this function. (peerj.com)
  • In a joint analysis on the 1,262 samples with high quality genotypes, we identified cis- eQTLs effects for 8,034 unique genes (at a false discovery rate ≤0.05). (biomedcentral.com)
  • 1 in 25 people had a genotype linked to short lifetime, which includes BRCA2 and LDLR genes, that reduced lifespan by seven years, and six years respectively. (medindia.net)
  • Major superficial plexiform neurofibromas and symptomatic spinal neurofibromas were more prevalent in these individuals compared with classic NF1-affected cohorts (both p (bvsalud.org)
  • For the significant interactions, we also evaluated genotype specific effect estimates. (cdc.gov)
  • Viral load and genotype were determined. (ox.ac.uk)
  • Multiple different genotypes/serotypes exist, and the neutralizing antibodies are serotype specific and provide minimal or no protection against viral infections from different serotype. (porkcheckoff.org)
  • We also derived genotypes using the RNA-seq reads and used imputation to infer non-coding variants. (biomedcentral.com)
  • Additionally, variants in this region seem to confer a high predisposition to develop malignancies compared with the general NF1-affected population (p = 0.0061). (bvsalud.org)
  • Variants (targeted)**: This index contain the results from the targeted genotyping and include results for both when a variant is found and when it is not found. (lu.se)
  • 100`: Find variants where at least 100 alternate alleles have been found * `af:>0.8`: Find variants where the alternate allele frequency is larger than 0.8 * `effect:synonymous`: Find variants where the predicted effect is synonymous **Tip! (lu.se)
  • 8 mg/L. Cmin was not markedly affected by administration time, but was altered by unequal splitting of the daily dose. (ox.ac.uk)
  • Flower emasculation and pollination also influenced ovule senescence, and this impact was unequal by genotypes, i.e. those having better ovule vitality in general, had also better ovule vitality in the conditions of emasculation, and pollination absence. (ac.rs)
  • In S'/S' genotypes, mild acute stress increased depressive mood and in L'/L' genotypes increased feelings of vigor. (reproductive-revolution.com)
  • CONCLUSIONS: Diurnal variation does not greatly affect nevirapine exposure. (ox.ac.uk)
  • The observed parameters showed significant variation for seeding dates, genotypes and their interactive effects. (arccjournals.com)
  • At diagnosis, homozygotes for this mutation (n=12) tended to have higher homocysteine levels than those seen in patients with other genotypes (n=17), but similar clinical manifestations. (nih.gov)
  • Our findings demonstrate that an APOE3 genotype predisposes mice to develop obesity and its metabolic complications, which was attenuated by n-3 PUFA supplementation. (uea.ac.uk)
  • We fit age-adjusted models to estimate associations between genotypes and toenail cadmium concentrations. (cdc.gov)
  • Our results were validated using samples for which DNA-seq genotypes were available. (biomedcentral.com)
  • RESULTS: ATD lowered mood in all subjects independent of genotype. (reproductive-revolution.com)
  • The results imply different adaptation of cultivars to higher temperatures before and during the flowering, pointing to the further investigation related to the good adaptability of genotypes to air temperatures in reproductive sense, which is a basic indicator of good adaptability in general. (ac.rs)
  • Results: Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. (lu.se)
  • Two separate field studies were conducted to evaluate the effect of genotype, planting date, and plug spacing on zoysiagrass establishment. (ashs.org)
  • The overall project's objective was to evaluate the effect of different protocols of feedback (natural planned exposure) to rotavirus A and C on gilt immunity and passive immunity in their piglets from a study that occurred with a swine producer over the summer. (porkcheckoff.org)
  • Collectively, these recurrent missense mutations affect â ¼0.8% of unrelated NF1 mutation -positive probands in the University of Alabama at Birmingham (UAB) cohort. (bvsalud.org)
  • This trial confirms that genotype has a great effect on behavior and welfare conditions of birds and that MG and SG chickens are more suitable for organic rearing system. (unibo.it)
  • Background-Associations between genotype and intellectual outcome in patients with phenylketonuria are complicated because intelligence is influenced by many variables, including environmental factors and other genetic determinants. (qub.ac.uk)
  • Some genotypes have become more tolerant than others, more specifically D. setivalva in Malaysia is rated medium for shade tolerance. (wikipedia.org)
  • Effects of Holstein genotype on interleukin-1β response were assessed by ex-vivo stimulation of whole blood with lipopolysaccharide (LPS), lipoteichoic acid (LTA), or sonicated, heat-killed Gram-negative or Gram-positive bacteria. (umn.edu)
  • Holstein genotypes were unselected Holsteins (UH, n = 14) not subjected to selection pressures since the mid-1960s and contemporary Holsteins (CH, n = 13). (umn.edu)
  • These genotypes were ITS2, 91/198, and 83/123 which are improved genotypes from the University of Ghana, and 'Agbeyeye' and 'Damadami' which are two local genotypes currently cultivated by the farmers in the Akatsi District. (uwi.edu)
  • A group led by Dr. Haifeng M. Wu of the Ohio State University has developed a new rapid method to genotype SNPs that will help clinicians to choose appropriate doses of warfarin for individual patients. (news-medical.net)
  • Congenital heart disease (CHD) and hypertrophic cardiomyopathy (HCM) are com-mon features in patients affected by RASopathies. (unicatt.it)
  • The majority of patients in Japan who are infected with HCV genotype 1b (G1b) are older than the patients in the United States and/or Europe and the frequency of patients who discontinued due to adverse events was reported to be as high as 11.1-16.7% [ 7 - 9 ]. (hindawi.com)
  • This study aims to determine whether a significant association exists between genotype and change in intelligence after relaxation of diet. (qub.ac.uk)
  • Another test was conducted within this study to determine how herbicide application timing affected the growth and survival of the hybrid gum varieties, as they break dormancy earlier than native sweetgum, and it has been documented that mortality can occur when herbicide is applied over actively growing sweetgum. (latech.edu)
  • The susceptibility of these hybrids ranged several orders of magnitude and affected the population dynamics of A. parapopuli across the five years of study. (nau.edu)
  • Effect of smoking regulations in local restaurants environment: a pilot study: evaluating the Al-Delaimy WK (2002). (who.int)
  • Genotype specific effect estimates suggested: 1) an inverse relationship between hemoglobin and cadmium levels among HFE H63D homozygotes, and 2) an inverse relationship between vitamin C intake and cadmium levels that strengthens with the number of HFE H63D variant alleles a subject carries. (cdc.gov)
  • The related report by Yang et al, 'Rapid Genotyping of SNPs Influencing Warfarin Drug Response by SELDI-TOF Mass Spectrometry,' appears in the March 2010 issue of the Journal of Molecular Diagnostics . (news-medical.net)
  • We studied the effect of the ADRB1 Arg389Gly polymorphism on plasma renin activity (PRA) and heart rate (HR) and the genotype-dependent response to metoprolol and exercise. (ku.dk)
  • Lodging performance of 28 genotypes, including 24 released cultivars and four advanced lines, was evaluated at 250 plants per square meter and 500 plants per square meter in Shandong province during the 2008-2009 and 2009-2010 crop seasons. (cgiar.org)
  • ii) their admixed status, determined through a Bayesian method of genetic clustering and (iii) their mating probability, studied via the detection, isolation and genotyping of sperm in female spermathecae. (datadryad.org)
  • Given increasing numbers of RNA-seq samples in the public domain, we here studied to what extent eQTLs and ASE effects can be identified when using public RNA-seq data while deriving the genotypes from the RNA-sequencing reads themselves. (biomedcentral.com)
  • Finally, through stochastic simulations, we illustrate how genotyping errors can lead to erroneous inferences when measures of LD between two samples are compared. (princeton.edu)
  • Because the dorsal PVE was depleted of progenitors but the ganglionic eminences were not affected in Fgf2 −/− mice, we predicted that these mice should lack a population of pyramidal neurons, but their cortical GABA interneurons should have remained unchanged. (jneurosci.org)
  • Using surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF MS), which can determine the elemental composition of a sample, Yang et al could determine the genotype of three warfarin-related SNPs in under five hours with high levels of accuracy. (news-medical.net)
  • We have found that genotyping error rates as small as 3% can have serious affects on these LD measures, depending on the allele frequencies and the assumed error model. (princeton.edu)
  • The effect of metoprolol concentration on PRA in Gly/Gly subjects was enhanced by exercise (P = 0.044). (ku.dk)
  • Resting PRA was lower in Gly/Gly than in Arg/Arg subjects, and the effect of exercise and metoprolol concentration on PRA was stronger in Gly/Gly subjects than with the other two genotypes. (ku.dk)
  • Basic fibroblast growth factor (Fgf2) is required for the generation of founder cells within the dorsal pseudostratified ventricular epithelium, which will generate the cerebral cortex, but the ganglionic eminences are not affected. (jneurosci.org)
  • By deriving and imputing genotypes from RNA-seq data, it is possible to identify both eQTLs and ASE effects. (biomedcentral.com)
  • The plant microbiota consists of a multitude of microorganisms that can affect plant health and fitness. (nature.com)