Affects antigen presenting cells granuloma plasma cell. Medical search. Frequent questions

Eosinophilic granuloma, also known as pulmonary histiocytosis X (PHX) or pulmonary Langerhans cell histiocytosis X (PLCH), is an uncommon interstitial lung disease that is epidemiologically related to tobacco smoking. (medscape.com)
See also Imaging in Eosinophilic Granuloma of the Skeleton and Langerhans Cell Histiocytosis Imaging . (medscape.com)

Our previous studies found that high sodium enters antigen-presenting cells (APCs) via the epithelial sodium channel and leads to the production of isolevuglandins and hypertension. (bvsalud.org)
Gene expression in APCs was analyzed using cellular indexing of transcriptomes and epitopes by sequencing analysis of blood mononuclear cells. (bvsalud.org)
As controls for male-specific reactivity and the presence of hUTY-derived peptides in the canine-DLA-context, different male-cell types were investigated (see 'Generation of UTY-specific-CTL responses in vitro using peptide-pulsed-autologous-female DCs (APCs)') showing natural presentation of the chosen hUTY-peptides in the dog via cDLA. (raf-signal.com)

cytoplasmic antigens by MHC class II molecules have been made. (cd31-signal.com)

It is characterized by the presence of invasive and anaplastic trophoblastic tissue composed of intermediate trophoblastic cells, cytotrophoblasts and syncytiotrophoblasts, abundant vascularity, and secretion of human chorionic gonadotropin. (nih.gov)
participating in processing and antigen presentation, cytokine secretion, and elimination of the pathogen. (internationaltextbookofleprosy.org)
T2DM is characterized by insulin resistance and impaired insulin secretion due to pancreatic β-cell dysfunction, resulting in relative insulin deficiency. (amboss.com)
Virulence factors related to membrane, LPS and surface component modifications, cell motility, toxins and secretion systems also varied between the infection stages. (preprints.org)

The granulomatous infiltrates seen in PLCH are composed of Langerhans cells, eosinophils, lymphocytes, macrophages, plasma cells, and fibroblasts, which form nodules centered on the terminal and respiratory bronchioles, causing destruction of the airway walls. (medscape.com)
The genes follow an autosomal dominant mode of inheritance and are involved in making parts of a protein that help in the growth and division of white blood cells, particularly the B-cell and T-cell lymphocytes. (info4pi.org)
Pulmonary Langerhans cell histiocytosis is a disease in which monoclonal CD1a-positive Langerhans cells (a type of histiocyte) infiltrate the bronchioles and alveolar interstitium, accompanied by lymphocytes, plasma cells, neutrophils, and eosinophils. (merckmanuals.com)
A recent study suggests that this may be related to a loss of function of regulatory T lymphocytes in such individuals, which may result in unchecked proliferation of lymphocytes that are normally restrained by these regulatory cells. (medscape.com)
The exaggerated immune response to repeated inhalation of these particles leads to infiltration and proliferation of activated pulmonary macrophages and lymphocytes, resulting in lymphocytic alveolitis and bronchiolitis with noncaseating granulomas. (cdc.gov)
In vitro studies show that the virus can infect various cell types such as endothelial cells and B-lymphocytes 15 . (bvsalud.org)

Alum induces strong innate immune responses at the site of injection, as assessed by an influx of neutrophils, monocyte/macrophages, eosinophils, and MHC-II + antigen presenting cells, mainly dendritic cells (DCs) ( 8 ). (frontiersin.org)

BCG can activate the pattern recognition receptor (PRR) on the surface of alveolar epithelial cells. (ijbs.com)
There is passive diffusion of the glucocorticoids through the cell membrane, followed by binding to soluble receptor proteins in the cytoplasm. (slideshare.net)
Myasthenia Gravis (MG) is an uncommon B-cell-mediated autoimmune disease that affects the post-synaptic receptor and the mechanism of neurotransmission at the Neuromuscular Junction (NMJ). (clinicalschizophrenia.net)
Of note, newborn screening (NBS) for severe combined immunodeficiency (SCID) that relies on the identification of reduced T-cell receptor excision circle (TREC) levels in blood spots most likely identifies about 50% of children with classic A-T, who require immediate subspecialty evaluation at a center with expertise in the diagnosis of SCID, its causes, and its treatment. (nih.gov)
Although T cell receptor (TCR) activation is key for IL-17 production by CD4 + and CD8 + T cells, IL-17 production by innate immune cells is primarily driven by inflammatory cytokines, especially IL-1β and IL-23 (Box 2 ). (nature.com)
p class=\'abstract\'>PURPOSE OF REVIEW: The current review highlights how inborn errors of immunity (IEI) due to IL-2 receptor (IL-2R) subunit defects may result in children presenting with a wide variety of infectious and inflammatory presentations beyond typical X-linked severe combined immune deficiency (X-SCID) associated with IL-2Rgamma.RECENT FINDINGS: Newborn screening has made diagnosis of typical SCID presenting with severe infections less common. (stanford.edu)
These new insights coupled with the X-ray crystallographic solution of several peptide/MHC-T-cell receptor structures have revealed mechanisms of histoincompatibility. (cd31-signal.com)

Hypersensitivity pneumonitis results from a type III (immune-complex mediated) or type IV (T-cell mediated) hypersensitivity response and is thus a form of immunologic disease. (medscape.com)
Advances in our knowledge of antigen-specific immunologic reactions in the lung are particularly evident in disorders secondary to beryllium and nickel exposure, where immunologic mechanisms have been well characterized. (nih.gov)
It is typically thought to be some sort of an immunologic reaction to some exogenous antigen. (cybersight.org)

Langerhans cells are differentiated cells of the dendritic cell system and are closely related to the monocyte-macrophage line. (medscape.com)
Genetic loss of function of all immunoproteasome subunits or conditional deletion of LMP7 in dendritic cell (DCs) or endothelial cells (ECs) attenuated hypertension, reduced aortic T cell infiltration, and reduced isoLG-adduct MHC-I interaction. (bvsalud.org)

Thromboses result most probably from activation of both platelets (leading to the formation of microparticles) and endothelial cells. (shengsci.com)

Muscle-resident macrophages mainly located in fascias are among the first cells to sense disturbance in muscle homeostasis ( 9 ). (frontiersin.org)
Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (merckmanuals.com)
Regarding the subcellular localisation of Mal itself, it has been shown that although Mal concentrates at membrane ruffles in macrophages, Mal-positive intracellular vesicles are also present throughout the cell 29 to allow shuttling of Mal between the intracellular vesicles and the plasma membrane and this shuttling event may facilitate Mal:IRF7 interaction. (fakpathway.com)
lt;p>In the infection sites, resident macrophages and dendritic cells participate in the initial interaction between pathogen and host. (internationaltextbookofleprosy.org)

The engagement of TLR2 and TLR4 on surface of epithelial cells by BCG can activate the glycogen synthase kinase-3 (GSK3) by PI3K-Akt and promote the production of IL-10 and IL-22 [ 17 ]. (ijbs.com)
In physiopathogeny: cytopathic effect induced directly on epithelial cells. (biodermameetings.com)

The emphasis of this update is on parenchymal diseases caused by metal inhalation, including granulomatous disease, giant cell interstitial pneumonitis, chemical pneumonitis, and interstitial fibrosis, among others. (nih.gov)

However, the inflammatory functions of IL-17 were originally described in mouse models of autoimmune disease, where the initial focus was on IL-17-secreting CD4 + T cells - T helper 17 (T H 17) cells - as a key producer of this cytokine. (nature.com)
These studies and others detailing pathological roles of IL-17 in human diseases eventually culminated in the development of monoclonal antibodies (mAbs) that target IL-17A, both IL-17A and IL-17F, IL-17RA, or IL-23, a cytokine produced by innate immune cells that promotes the expansion of T H 17 cell populations. (nature.com)
Following 4 days of stimulation, cells were analysed for expression of IFN-γ, IL-17A and IL-10 by intracellular cytokine staining. (rafinhibitors.com)

The spike protein of the virus binds to the ACE2 receptors of the cell, which enables the virus to enter and subsequently replicate within the cells. (xiahepublishing.com)
For example, current evidence suggests that beryllium acts as an antigen, or hapten, and is presented by antigen-presenting cells to CD4+ T cells, which possess specific surface antigen receptors. (nih.gov)
the antigen has been shown to be most often platelet factor 4 bound to heparin while the antibody is recognized by platelet Fc gamma RII receptors. (shengsci.com)

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells. (stanford.edu)
The virus, after its entry, induces an inflammatory response and virus-specific T cells are attracted to the site of infection. (xiahepublishing.com)

and (ii) demonstration of their apparent capacity to migrate in lymphoid organs and then disseminate throughout the body within monocyte-lineage cells and progressively accumulate in the brain ( 5 ). (frontiersin.org)
Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (merckmanuals.com)
which can affect many organs (most notably the lungs, skin, bones, pituitary, and lymph nodes) in isolation or simultaneously. (merckmanuals.com)
The most commonly and severely affected organs include the upper and lower respiratory tract and the kidneys. (medilib.ir)

Assessment of the ability to produce functional antibodies can be obtained by measuring antibody responses to natural antigens or those antigens to which the population commonly is exposed. (medscape.com)
Isohemagglutinins are IgM antibodies to ABO blood group antigens that are polysaccharide. (medscape.com)
In children who have completed immunizations with diphtheria, pertussis, and tetanus (DPT) or Hib-conjugated vaccines, the antibody response to protein antigens can be tested in adults and older children by measuring IgG antibodies to tetanus or diphtheria toxoid and H influenzae type b (Hib) polysaccharide antigen. (medscape.com)
Approximately 80% of children have detectable antibodies to these antigens after 3 immunizations during their first year of life. (medscape.com)
of Treg cells as seen in patients treated with CD25-blocking antibodies [16-18]. (fakpathway.com)

This clinical form is characterized by single or multiple lesions that are usually located in the lower extremities and affects elderly men 28 . (bvsalud.org)

MMF revealed an unexpectedly long-lasting biopersistence of alum within immune cells in presumably susceptible individuals, stressing the previous fundamental misconception of its biodisposition. (frontiersin.org)
Hypersensitivity pneumonitis, also known as hypersensitivity pneumonia and extrinsic allergic alveolitis, is a form of interstitial lung disease characterized by an immunologically mediated inflammatory response (hypersensitivity reaction) to inhaled organic antigens in susceptible individuals. (medscape.com)

IL-17A and IL-17F are produced by CD4 + and CD8 + T cells, γδ T cells, and various innate immune cell populations in response to IL-1β and IL-23, and they mediate protective immunity against fungi and bacteria by promoting neutrophil recruitment, antimicrobial peptide production and enhanced barrier function. (nature.com)
We now know that CD8 + T cells, γδ T cells, innate lymphoid cells (ILCs), natural killer (NK) cells, invariant NK T cells, mucosal associated invariant T cells, mast cells and Paneth cells can also be sources of IL-17. (nature.com)
Type I IFN are one of the early mediators of the innate immune response and influence the adaptive immune response through direct and indirect actions on DC, T and B cells, and natural killer cells. (fakpathway.com)
By comparing the infected and un-infected proteome of SHK-1 cells, we observed changes in cellular and ROS homeostasis, innate immune response, microtubules and actin cytoskeleton organization and dynamics, alteration in phagosome components, iron transport and metabolism, and amino acids, nucleoside and nucleotide metabolism, together with an overall energy and ATP production alteration. (preprints.org)

[ 7 ] In a significant proportion of cases of hypersensitivity pneumonitis (25%-38%), an inciting antigen cannot be identified. (medscape.com)
Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an uncommon non-immunoglobulin E (IgE), T-helper cell type 1 (Th1)-mediated inflam- matory pulmonary disease with systemic symptoms resulting from repeated inhalation and subsequent sensitization to a large variety of aerosolized antigenic organic dust particles. (cdc.gov)
The earliest forms of hypersensitivity pneumonitis were related to farming and, each year, new antigens causing occupational disease are described. (cdc.gov)
More than a dozen outbreaks of hypersensitivity pneumonitis affecting hundreds of workers exposed to contaminated airborne synthetic metalworking fluids (MWF) have been reported since the mid-1990s. (cdc.gov)

Peripheral neuropathy is an important, and often the presenting, clinical feature of the vasculitides. (medlink.com)
CLINICAL MANIFESTATIONS - The small blood vessels in almost any organ or tissue can be involved in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), but the upper and lower respiratory tracts and the kidneys are most commonly affected. (medilib.ir)
Since then, this disease can be classified into four different clinical forms that have identical histologicalfeatures, but affecting specific populations. (bvsalud.org)
Whereas the brain and/or eyes are only involved in 9% of the wet cases, neurological and-or ocular disease is seen as the main presenting clinical sign in 70% of cats with dry FIP. (treatfip.org)

Alum is able to adsorb vaccine antigens on its surface. (frontiersin.org)
Protein conjugated pneumococcal vaccine elicit antibody responses that are T-cell dependent. (medscape.com)
Therefore, antibody responses should be measured to polysaccharide antigens that are not present in the protein-conjugated pneumococcal vaccine. (medscape.com)
Alternatively antibody response to typhoid-Vi antigen can be measured following typhoid vaccine administration. (medscape.com)

Bone-marrow samples were aspirated from the dogs' iliac-crests under general anaesthesia and bone-marrow-mononuclear cells were isolated corresponding to canine-PBMCs. (raf-signal.com)

The peak incidence of pulmonary Langerhans cell histiocytosis X (PLCH) occurs in the 20- to 40-year age bracket. (medscape.com)
Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)
This is a common condition of the cells of the cervix and often occurs when the HPV wart virus is present. (com.ng)
This change in the cells of the cervix often occurs from cervical cap or diaphragm use or from infection. (com.ng)

This is a retrospective study on 201 cases of cervical neoplasm comprising of 129 cervical intraepithelial neoplasia (CIN) and 72 squamous cell carcinoma (SCC). (ijpmonline.org)
We investigated p16 expression in CIN and invasive squamous cell carcinoma (SCC) which has not been reported in the Indian population previously. (ijpmonline.org)
All except one squamous cell carcinoma stained strongly positive for p16. (ijpmonline.org)
ASCUS (say "ask-us") stands for atypical squamous cells of undetermined significance. (com.ng)
The squamous cells of your cervix were slightly abnormal on your Pap smear. (com.ng)
However, these cells appear smaller than a koilocyte and the classical nuclear features of the latter are also missing, Squamous cells with a large single vacuole pushing the nucleus to the periphery, giving a soap bubble appearance, are also seen in the Pap smear collected from the IUCD wearers. (com.ng)

Pulmonary Langerhans cell histiocytosis X (PLCH) is histologically characterized by parenchymal infiltration of the lungs by activated Langerhans cells. (medscape.com)
The accumulation of Langerhans cells in the lungs is hypothesized to occur in response to exposure to cigarette smoke. (medscape.com)
No occupational causes or geographic predispositions are recognized for pulmonary Langerhans cell histiocytosis X (PLCH). (medscape.com)
Pulmonary Langerhans cell histiocytosis X (PLCH) is a rare disorder and the true prevalence is unknown. (medscape.com)
[ 5 ] A large Japanese study estimated the prevalence of pulmonary Langerhans cell histiocytosis X (PLCH) at 0.27 males and 0.07 females per 100,000 population based on hospital discharge diagnoses over a 1-year period. (medscape.com)
Because of the rarity of pulmonary Langerhans cell histiocytosis X (PLCH) , no definitive epidemiologic data related to racial background are available. (medscape.com)
No sex predilection is recognized for pulmonary Langerhans cell histiocytosis X (PLCH). (medscape.com)
The prognosis for pulmonary Langerhans cell histiocytosis X (PLCH) varies and is related to smoking cessation. (medscape.com)
Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (merckmanuals.com)
Pulmonary Langerhans cell histiocytosis is suspected based on history and chest x-ray and is confirmed by HRCT and bronchoscopy with biopsy and bronchoalveolar lavage. (merckmanuals.com)

These antigens include organic dusts containing bacteria, fungi,4 animal or plant proteins, or low-molecular-weight chemicals. (cdc.gov)

Initially, it was found that depletion of CD4+CD25+ T cells from adoptive cell transfer experiments into nude mice resulted in systemic autoimmune disease [9]. (fakpathway.com)
This idea is supported by studies of mice deficient Selleckchem Midostaurin in CD25 or IL-2, which have low numbers of Treg cells and develop severe systemic autoimmune disease as they age [14, 15]. (fakpathway.com)
The physiopathogeny is apparently due to autoimmune cross-reactivity, activating keratinocytes which in turn induce production of IL 1, IFN-g and TNF-a, recruiting cytotoxic and NK cells which are believed to then target the patient's own keratinocytes. (biodermameetings.com)
Type 1 diabetes mellitus ( T1DM ) is the result of an autoimmune response that triggers the destruction of insulin -producing β cells in the pancreas and results in an absolute insulin deficiency. (amboss.com)

5%) are the most common manifestations of extrapulmonary involvement and occur in up to 15% of patients, rarely being the presenting symptoms of PLCH. (merckmanuals.com)
Specific mutations that allow FECV to escape the cells lining the lower intestine and infect the most basic cell of the immune system, the macrophage, will occur in about 10% of infections. (treatfip.org)
AGUS can occur with infections or with a change in the cells on the surface of your cervix or in the canal of your cervix. (com.ng)

Hematopoietic stem cell transplant (HSCT) is curative for IL-2Ralpha, IL-2Rbeta, and IL-2Rgamma defects, but gene therapy may yield comparable results for X-SCID.SUMMARY: Defects in IL-2R subunits present with infectious and inflammatory phenotypes that should raise clinician's concern for IEI. (stanford.edu)

in wild birds, it appears to be sporadic, frequently affecting only an individual bird. (beautyofbirds.com)

Biopsy: mild spongiosis, oedema of the papillar dermis, extravasation of red blood cells, perivascular and interstitial lymphocytic inflammatory infiltrate and epithelial swelling, with no signs of vasculitis. (biodermameetings.com)

NOMENCLATURE - Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are both necrotizing vasculitides predominantly affecting small-sized arteries that present variably in terms of organ manifestations and disease severity. (medilib.ir)

This condition is fatal if those affected do not receive treatment through hematopoietic stem cell transplantation (HSCT). (info4pi.org)
IL-10 can be produced by hematopoietic and non-hematopoietic cells in response to Mycobacterium tuberculosis Complex infection (Figure 1 ). (ijbs.com)

Development of Kaposi sarcoma in the oral cavity also has prognostic implications for untreated HIV patients, who are found to have higher death rates than patients affected only by cutaneous disease. (bvsalud.org)
hospital-based design by accessing iodine deficient area, and the size of the thyroid to hospital patients records and obtaining affected is relevant to the increase in the deficient (3). (egyptianjournal.xyz)

In the United States, the most common are avian antigens (derived from birds), mycobacterial antigens (in aerosols derived from hot tub water), and bacteria (derived from moldy hay). (medscape.com)
The MACPF domain is present in the components of the terminal complement pathway (C6, C7, C8 and C9), which form the membrane attack complex (MAC) directly targeting gram-negative bacteria and certain pathogenic parasites by forming pores on their cell membranes [ 1 ]. (karger.com)

It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures. (nih.gov)
Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)
The development of reagents capable of identifying disease-specific mutated proteins along with the ability to evaluate multiple subsets of immune cells and their function, such as respiratory burst, proliferation or phosphorylation, simultaneously, facilitated the incorporation of multi-color and functional flow cytometry into the diagnostic work-up for PIDs. (biomedcentral.com)

Interstitial lung disease is a group of disorders affecting pulmonary parenchyma . (wikidoc.org)

When methylprednisolone from the plasma or interstitial fluid diffuses passively across the cell membrane, it binds to the GR inducing a conformational change and GC-GR dimerization. (wikipedia.org)

Two subfamilies exist based on the biological effect, immune regulatory cytokines including IL-10 only, and IL-20 subfamily consisting of the remaining five members (IL-19, IL-20, IL-22, IL-24 and IL-26) [ 8 ]. (ijbs.com)
Physiopathogeny shows complement activation and formation of ROS (reactive oxygen species) and cytokines, with aberrant activation and degranulation of mast cells, which may produce endothelial activation and micro- occlusive disease, leading to urticarial vasculitis in predisposed individuals. (biodermameetings.com)

It chiefly affects young adults, primarily occurring in the third or fourth decades of life. (medscape.com)
Though the target organ for the virus is primarily the lungs, with the recent understanding of the pathobiology of this disease and the immune dysregulation associated with it, it is now clear that COVID-19 affects multiple organ systems. (xiahepublishing.com)

It is characterized by the presence of spindle cells with myoblastic differentiation, a myxoid stroma, and fibrous septa. (nih.gov)

It affects young adults and black children 7 . (bvsalud.org)

has an exclusive ability to infect Schwann cells in peripheral nerves. (internationaltextbookofleprosy.org)

We have also determined that CD4+ CD44loCD62Lhi naive T-cell and CD4+ Foxp3+ T-reg cell populations express the G-1 target GPER (R. L. Brunsing and E. R. Prossnitz, manuscript in preparation). (rafinhibitors.com)

Considering that gene expression not always corresponds with observed phenotype, and bacteriological culture studies inadequately reflect infection conditions, to improve the existing knowledge for the pathogenicity of P. salmonis we present here a global proteomic profiling of Salmon salar macrophage-like cell cultures infected with P. salmonis LF-89. (preprints.org)
Previously described virulence-related genes in P. salmonis plasmids were identified by proteomic assays during infection in SHK-1 cells, accompanied by an increase of mobile-related elements. (preprints.org)

This assessment can also be done by measuring antibody responses following active immunization with protein or polysaccharide antigens. (medscape.com)
Microvesicles loaded with MCs encoding a thymidine kinase (TK)/nitroreductase (NTR) fusion protein produced prolonged TK-NTR expression in mammary carcinoma cells. (regenerativemedicine.net)

The strongest adsorption phenomenon results from ligand exchange, which involves the replacement of a surface hydroxyl on the adjuvant by a terminal phosphate group of the antigen ( 7 ). (frontiersin.org)
Our study demonstrates that comparable IL-6 and TNF-α induction were evident in Mal-deficient cells and WT cells following stimulation with the TLR ligand, poly(I:C). On the contrary, we show for the first time that Type I IFN-β gene induction is significantly enhanced in Mal-deficient cells, following poly(I:C) stimulation and following treatment of cells with the Mal-inhibitory peptide. (fakpathway.com)

Given that G-1 can protect mice from EAE38,39 and the importance of the the Th17 lineage to this model,3 we began by determining the effects of G-1 on naive T-cell differentiation under Th17-polarizing conditions (TGF-β/IL-6 ± IL-23). (rafinhibitors.com)

Coronavirus disease (COVID)-19 caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected millions worldwide and the numbers of cases are consistently rising. (xiahepublishing.com)

Some therapeutic interventions treat symptoms, whereas others treat factors that affect survival. (medscape.com)

Moreover they define a role of LMP7 as a regulator of T cell activation and tissue infiltration in hypertension. (bvsalud.org)

monomorphic vesicles on the trunk and extremities, varicella-like but presenting different stages. (biodermameetings.com)

Other organ systems are only rarely affected. (medscape.com)

Anatomy6

Organisms2

Diseases26

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Eosinophilic Granuloma2

APCs3

Cytoplasmic1

Secretion4

Lymphocytes6

Eosinophils1

Receptor7

Immunologic3

Dendritic cell2

Endothelial cells1

Macrophages4

Epithelial cells2

Fibrosis1

Cytokine3

Receptors3

Induces2

Organs4

Antibodies5

Lesions1

Susceptible2

Innate4

Hypersensitivity4

Clinical4

Vaccine4

Mononuclear cells1

Occurs4

Squamous6

Langerhans10

Organic1

Autoimmune4

Occur3

SCID1

Bird1

Lymphocytic1

Granulomatosis1

Hematopoietic2

Patients2

Bacteria2

Proliferation3

Lung1

Membrane1

Cytokines2

Primarily2

Spindle cells1

Adults1

Infect1

Populations1

Infection2

Protein2

Ligand2

Differentiation1

Respiratory1

Symptoms1

Infiltration1

Vesicles1

Rarely1