Affects lipid metabolism. Medical search. Frequent questions

In conclusion, a maternal diet high in n-6 to n-3 PUFA ratio resulted in higher levels of lipid and lipoproteins in the offspring at weaning, which may be associated with an increase risk of CVD in later life. (mun.ca)
We compared plasma lipids, lipoproteins, and apolipoproteins of rabbits before and after surgery in each group fed either a chow diet or cholesterol-rich diet. (biomedcentral.com)
Keeping a steady state of the serum expression levels of these miRNAs associated with lipoproteins metabolism and autophagy in the TRE group might have protective effects in patients with MI. (archivesofmedicalscience.com)
2 In the blood, APOE protein could interact with lipids, resulting in lipoproteins, including very-low-density lipoproteins (VLDL). (dovepress.com)
All lipids are hydrophobic and mostly insoluble in blood, so they require transport within lipoproteins. (msdmanuals.com)

Dietary groups were: whole milk powder (WM), skim milk powder-SBF (SM/S), casein-SBF (C/S), and skim milk powder-BF (SM/B). A hypocholesterolemic effect was observed in guinea pigs fed the WM (plasma cholesterol, 1.5 mmol/L) diet compared to all other diet groups (3. (arizona.edu)
however, a diet supplemented with liquid milk products providing up to 46% of the daily energy intake, with higher total fat (1.4-fold) and dietary cholesterol (2.3-fold) did not increase plasma cholesterol and triacylglycerol levels or alter LDL metabolism in the guinea pig. (arizona.edu)
Female Tg rabbits showed similar levels of total cholesterol and lesion size of atherosclerosis compared with non-Tg rabbits and ovariectomy did not affect diet-induced hypercholesterolemia or atherosclerosis. (biomedcentral.com)
The lipid panel shows elevated cholesterol and LDL-C, a small increase in TG, and an HDL-C above the upper limit of normal for men. (medscape.com)
BDNF potently inhibited CB 1 R function in the striatum, through a mechanism mediated by altered cholesterol metabolism and membrane lipid raft function. (jneurosci.org)
The present study identifies a novel mechanism of CB 1 R regulation mediated by BDNF and cholesterol metabolism and provides some evidence that DA D 2 R-dependent modulation of striatal CB 1 R activity is mediated by this neurotrophin. (jneurosci.org)
This effect was mediated by an action on cholesterol metabolism in lipid rafts and was prevented by tyrosine kinase inhibition. (jneurosci.org)
GPR146 showed a causal effect on plasma HDL-cholesterol levels (p = 2×10 -15 ), without evidence for reverse causality. (lu.se)
Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important. (msdmanuals.com)

Fig. 4: Low glycaemic diets impair tumour SCD, which interacts with changes in lipid availability to affect tumour growth. (nature.com)
A new study by researchers at USC and UC Berkeley sheds light on how changes in lipid metabolism can impact the health of cells as they age and respond to stress. (phys.org)
Although the exact etiology of lipodystrophy is still unknown, both ART and HIV cause changes in lipid distribution. (medscape.com)

Our data suggest that miR-370 acting via miR-122 may have a causative role in the accumulation of hepatic triglycerides by modulating initially the expression of SREBP-1c, DGAT2, and Cpt1alpha and, subsequently, the expression of other genes that affect lipid metabolism. (nih.gov)
Hepatic insulin resistance affects both carbohydrate and lipid metabolism. (jci.org)
RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in increased Apoa2 mRNA expression. (elifesciences.org)
APOE is also involved in the formation of chylomicrons and VLDL and affects the activity of other lipid metabolism-associated proteins and enzymes, such as hepatic lipase and lipoprotein lipase. (dovepress.com)
Background We aimed to evaluate the effect of cranberry supplementation on serum liver enzymes, hepatic steatosis, and cardiometabolic risk factors in patients with non-alcoholic fatty liver (NAFLD). (cranberryinstitute.org)
Conclusion The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD. (cranberryinstitute.org)

These findings demonstrated the preventive effect of fenugreek seed extract on fat deposition and dyslipidemia possibly by improvement in glucose and lipid metabolism. (greenmedinfo.com)

To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA , EGFR , and SREBP2 precursor. (nature.com)
The progression of NAFLD can be prevented by estrogen by exerting an anti-steatotic effect in hepatocytes and an anti-inflammatory further impact in Kupfer cells. (news-medical.net)
The accumulation of sub-dermal adipose tissue and, consequently, increased pro-inflammatory cytokine release could affect the dermal fibroblast physiology. (buckingham.ac.uk)
miRNAs are recognized as important regulators of lipid metabolism, inflammatory mediators, and VSMC behaviours in the progression of AS [ 10 ]. (hindawi.com)
It has been reported that Alisma orientale has a protective effect on acute lung injury through an anti-inflammatory effect by repressing the NF-kappa B pathway [ 20 ]. (hindawi.com)
Effect of cranberry juice deacidification on its antibacterial activity against periodontal pathogens and its anti-inflammatory properties in an oral epithelial cell model. (cranberryinstitute.org)
The present study investigated whether the removal of organic acids (0%, 19%, 42%, 60%, and 79%) from cranberry juice by EDBM affects its antibacterial activity against major periodontopathogens as well as its anti-inflammatory properties in an oral epithelial cell model. (cranberryinstitute.org)
Deacidification attenuated the anti-inflammatory effect of cranberry juice in an in vitro oral epithelial cell model. (cranberryinstitute.org)
Forty-five chronic ( 1 week) randomised controlled trials assessing CVD risk factors including endothelial (dys)function, blood pressure (BP), blood lipids and inflammatory biomarkers were included. (cranberryinstitute.org)
The plaques contain lipids, inflammatory cells, smooth muscle. (msdmanuals.com)

Effect of dairy fat and milk product supplementation on plasma lipids and low-density lipoprotein metabolism in the guinea pig. (arizona.edu)
To examine this hypothesis, we compared the effects of orchiectomy and ovariectomy on plasma lipids and diet-induced atherosclerosis in both Tg and non-Tg rabbits. (biomedcentral.com)
On a chow diet, both male and female Tg rabbits showed lower plasma lipids than non-Tg counterparts and this lipid-lowering effect of EL was not affected by either orchiectomy in male or ovariectomy in female Tg rabbits. (biomedcentral.com)

In safety studies, dienogest has been assessed in women with endometriosis at high doses of as much as 20 mg/day for up to 24 weeks and produced no clinically relevant effects on lipid metabolism, liver enzymes, the coagulatory system, or thyroid metabolism. (wikipedia.org)
Within adipose tissue, the expression of lipolytic and lipogenic enzymes was higher, while those related to lipid oxidation were lower in the NDh group compared to the NDo group. (frontiersin.org)
Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with nafld: a randomized clinical trial. (cranberryinstitute.org)

This study aimed to evaluate the trehalose (TRE)-induced changes in the serum expression levels of microRNAs (miRNAs) associated with lipid metabolism and the autophagy process in myocardial infarction (MI) patients to assess the potential protective effects of TRE in these patients. (archivesofmedicalscience.com)
Genetic dissection of serum vaspin highlights its causal role in lipid metabolism. (cdc.gov)
The role of magnesium supplementation in the management of CVD has been described, but the relationship between serum magnesium (Mg) and the lipid subsets have had conflicting results in different population groups. (bvsalud.org)

In addition, CIG can significantly enhance the expression level of the PI3K-Akt/PKB pathway related proteins in skeletal muscle, which is the key pathway of insulin metabolism. (rsc.org)
APOE-dependent alterations of the endocytic pathway can affect different functions. (dovepress.com)
Pathway defects in lipoprotein synthesis, processing, and clearance can lead to accumulation of atherogenic lipids in plasma and endothelium. (msdmanuals.com)

Following completion, Endocrine, Diabetes, and Metabolism fellows are eligible for board certification by the American Board of Internal Medicine. (acponline.org)
When evaluating this patient and developing a management plan, it is important to consider that many endocrine diseases affect lipid metabolism . (medscape.com)
These data informed the Endocrine Society's 2020 Lipid Management in Patients with Endocrine Disorders clinical practice guideline . (medscape.com)

Dienogest produces no androgenic side effects and has little effect on metabolic and lipid hemostatic parameters. (wikipedia.org)
This unexpected dual role of FoxO1 in promoting insulin sensitivity and lipid synthesis in addition to glucose production has the potential to explain the peculiar admixture of insulin resistance and sensitivity that is commonly observed in the metabolic syndrome. (jci.org)

The hamsters were fed diets rich in either fish oil or a MIX oil to investigate whether fish oil has beneficial effects in lowering plasma lipid and lipoprotein levels. (mun.ca)
APOE plays multiple roles in the regulation of lipid and lipoprotein levels in the blood. (dovepress.com)

Unlike the change in other lipids, lower triglycerides are usually present right after exercise. (pfeiffertheface.com)

To investigate the potential effect of these miRs on the expression of the genes of lipid metabolism, we performed studies in cultured HepG2 cells. (nih.gov)
The first is through its anti‐androgenic effect, thus influencing expression of the genes possibly involved in this condition and the second might be through lowering the insulin resistance that is usually present in some patients with HS. (cassiopaea.org)

Fig. 3: Increased SCD activity is required for cancer cells to adapt to exogenous lipid limitation. (nature.com)

Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. (nih.gov)

With an increasing duration of exercise, glucose uptake by muscle begins to decline, and there is an increased dependency on free fatty acids for energy metabolism. (pfeiffertheface.com)
Furthermore, our results are consistent with the fact that endurant individuals rely preferentially on lipid metabolism, because oxidative phosphorylation of fatty acids in muscle mitochondria produces a high yield of ATP, necessary for prolonged contraction of muscle fibers. (pfeiffertheface.com)
Feeding diets with varying n-6 to n-3 PUFA ratios to C57BL/6 mice led to the incorporation of dietary fatty acids in red blood cell (RBC) phospholipids (PL), and also altered the regulation of lipid and lipoprotein metabolism. (mun.ca)
Upregulation of stearoyl-CoA desaturase (SCD), which synthesises monounsaturated fatty acids, is required for cancer cells to proliferate in a lipid-depleted environment, and CR also impairs tumour SCD activity to cause an imbalance between unsaturated and saturated fatty acids to slow tumour growth. (nature.com)
Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. (nature.com)
Fatty acids are the main compound of lipids, which are a class of molecules present in animals and vegetal cell types. (nature.com)
Blood lipids consist of free fatty acids and ketone bodies, such as 3-hydroxybutyrate. (biorxiv.org)

Biochemical indices also revealed that CIG had a positive effect on lipid metabolism and oxidative stress. (rsc.org)

Research on humans, rodents, and cell lines have each confirmed that Pu-erh tea indeed displays weight-loss and blood lipid lowering effects. (researchgate.net)
Insulin plays a crucial role in regulating the metabolism of blood glucose, amino acids, and lipids in humans. (biorxiv.org)

CUR also reversed mitochondrial membrane depolarization and ß- oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney . (bvsalud.org)
Taken together, these results demonstrate that curcumin is a PPARα activator and may affect expression levels of proteins involved in amyloid deposition to influence amyloidosis and metabolism in a complex manner. (elifesciences.org)
Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage (PubMed:14602201). (proteopedia.org)

We previously observed that treatment of mice with a dominant negative form of cJun (dn-cJun) increased the expression of genes involved in lipid metabolism and modulated the expression of nine microRNAs (miR). (nih.gov)
One of the objectives of this thesis was to investigate the effect of various dietary n-6 to n-3 PUFA ratios on the regulation of lipid and lipoprotein metabolism using C57BL/6 mice as an animal model. (mun.ca)
Given the health benefits of maintaining a proper ratio of dietary n-6 to n-3 PUFA, it was of interest to understand the role of altered maternal dietary n-6 to n-3 PUFA ratio on the regulation of lipid and lipoprotein metabolism in the offspring of C57BL/6 mice at weaning. (mun.ca)
The C57BL/6 mice were selected for the current study as these have been already established as an animal model in our laboratory to study 'in utero' programming of lipid and lipoprotein metabolism in the offspring. (mun.ca)
In the one month feeding study, female C57BL/6 mice were fed a diet containing 20% w/w fat with n-6 to n-3 PUFA ratio of either 5:1, 15:1 or 30:1 to establish the effect on the regulation of lipid and lipoprotein metabolism. (mun.ca)
A higher n-6 to n-3 PUFA ratio in the maternal diet of C57BL/6 mice led to higher plasma lipid and lipoprotein concentrations compared to a lower ratio in the offspring at weaning. (mun.ca)
To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid apolipoprotein A-II (AApoAII) amyloidosis, in which mice were fed a curcumin-supplemented diet. (elifesciences.org)
In this work, we researched the antioxidative, hypoglycemic and lowering blood lipids effects of CIG on diabetic mice induced by a high-fat diet (HFD) and streptozotocin (STZ). (rsc.org)

The extract of Alisma orientale exerted a protective effect on nonalcoholic fatty liver disease and palmitate-induced cellular injury [ 21 , 22 ], suggesting that it could be a potential treatment for abnormal lipid metabolism syndrome. (hindawi.com)

Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)

Dietary methionine influences therapy in mouse cancer models and alters human metabolism. (nature.com)

Lipid Metabolism Traits Mediate the Effect of Psoriasis on Myocardial Infarction Risk: A Two-Step Mendelian Randomization Study. (cdc.gov)

Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß- oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver . (bvsalud.org)

The other seven miRs identified by the miR array screening did not affect the expression of lipogenic genes. (nih.gov)
Furthermore, the effect of miR-370 on the expression of the lipogenic genes was abolished by antisense miR-122. (nih.gov)
These agents affect the transcription of insulin-responsive genes through activation of nuclear hormone receptors. (buckingham.ac.uk)
Wild type Males require the FA desaturase genes to maintain lipid stores. (tamu.edu)

Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial ß-Oxidation and Lipid Metabolism in Kidney and Liver. (bvsalud.org)
This work aimed to characterize CUR's potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß- oxidation in the liver and kidney in 5/6Nx. (bvsalud.org)
The main bioactive components, such as theabrownin (TB), polysaccharides, polyphenols, and statins, may down-regulate the biosynthesis of fat and up-regulate the oxidation of fat to cut weight and reduce the content of lipids in blood. (researchgate.net)

APOE binds to cell-surface receptors to deliver lipids and to the hydrophobic amyloid-β peptide, regulating amyloid-β aggregations and clearances in the brain. (dovepress.com)

Besides the direct effects, estrogen has beneficial effects on lipid metabolism, which can prevent the development and progression of NAFLD. (news-medical.net)

We also observed that the earlier peak time of lipids compared to BCAAs is dependent on insulin's negative regulation of their influx. (biorxiv.org)
While there has been extensive research on the mathematical modeling of insulin's regulation of blood glucose 8 - 13 , there has been limited investigation of its selective regulation of blood amino acids and lipids 14 - 17 . (biorxiv.org)

Using two-sample Mendelian randomisation, we found 52 mRNAs to have a causal effect on anthropometric traits (n=23) and lipid metabolism traits (n=10). (lu.se)
Genetic variation in targets of lipid-lowering drugs and amyotrophic lateral sclerosis risk: a Mendelian randomization study. (cdc.gov)

These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. (nature.com)
Dietary TG metabolism begins in the stomach and duodenum, where TGs are broken into monoglycerides (MGs) and FFAs by gastric lipase, emulsification due to vigorous stomach peristalsis, and pancreatic lipase. (msdmanuals.com)

In the 2016-2017 academic year, there are 141 Accreditation Council for Graduate Medical Education (ACGME)-accredited training programs in endocrinology, diabetes, and metabolism with 631 trainees. (acponline.org)

the absence of adequate amounts of lipids will disrupt the body's normal functions. (privatemdlabs.com)
Insulin is a hormone that plays a key role in regulating the body's metabolism 1 , 2 . (biorxiv.org)

mRNAs in the MOD cluster showed a possible causal effect on anthropometric traits, lipid metabolism traits and blood cell fractions. (lu.se)
Finally, there was evidence of non-linearity in the causal effect of BMI on T2D and CAD, biomarkers and blood pressure. (lu.se)

In conclusion, it was shown that changing the diet from sausage to boiledfish paste hada beneficial effect to health by reducing lipidconcentration andlipidperoxid e levels, andthat this effect does not completely dependon the nutritional balance of boiledfish paste. (elsevierpure.com)
A change in nutrient availability observed with CR, but not with KD, is lower lipid levels in the plasma and tumours. (nature.com)
Enforcing cancer cell SCD expression or raising circulating lipid levels through a higher-fat CR diet confers resistance to the effects of CR. (nature.com)
By contrast, although KD also impairs tumour SCD activity, KD-driven increases in lipid availability maintain the unsaturated to saturated fatty acid ratios in tumours, and changing the KD fat composition to increase tumour saturated fatty acid levels cooperates with decreased tumour SCD activity to slow tumour growth. (nature.com)
A large meta-analysis of lipid levels in 72 studies on overt hypothyroidism assessed the magnitude of change in LDL-C and TG after treatment of hypothyroidism. (medscape.com)
This augmentation of metabolism is caused by stimulation of a cycle which boosts levels of adrenalin (21, 23). (myprotein.com)
The primary efficacy of the treatment was lipid profile, glycemic measurements, and liver enzyme levels. (cranberryinstitute.org)
One of insulin's primary functions is to regulate blood glucose levels, but it also has a role in regulating other blood metabolites such as amino acids and lipids 3 - 6 . (biorxiv.org)
rosiglitazone increases levels of eluxadoline by decreasing metabolism. (medscape.com)

however, the predicted hypercholesterolemic effect of miikfat was not observed with the WM diet compared to the SBF and BF fats. (arizona.edu)
Farber lipogranulomatosis is a rare inherited condition involving the breakdown and use of fats in the body (a process known as lipid metabolism). (medlineplus.gov)
Lipids are fats that are either absorbed from food or synthesized by the liver. (msdmanuals.com)

Effect of acrylamide intoxication on pyridine nucleotide concentrations and functions in rat cerebral cortex. (cdc.gov)
The effect of acrylamide (79061) on pyridine nucleotide concentrations was studied in male Holtzman-rats. (cdc.gov)

This gender difference suggests that sex hormones may mediate EL functions thereby influencing lipoprotein metabolism. (biomedcentral.com)

This disease usually affects middle-aged males from the Mediterranean area with a history of alcohol abuse. (hindawi.com)

The guideline recommends first ruling out hypothyroidism as the cause of hyperlipidemia before initiating lipid-lowering medications. (medscape.com)
To accurately assess a patient's lipid profile, the guideline also suggests holding off treatment of hyperlipidemia in patients with hypothyroidism until they become euthyroid. (medscape.com)

What lipid increases with exercise? (pfeiffertheface.com)
Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases the intestinal permeability. (mdpi.com)

In paper 2, I studied the association between LRIG1 genetic variants and BMI, T2D and lipid biomarkers. (lu.se)

The elevation of blood glucose leads to the development of abnormalities in the metabolism of carbohydrates, proteins, lipids and electrolytes. (who.int)

Sex hormones affect may many facets of lipid metabolism through interactions with other regulators. (biomedcentral.com)

Affected individuals may develop thinning of the bones (osteoporosis) that worsens over time. (medlineplus.gov)

To address this question, we used mathematical modeling to identify the selective regulatory mechanisms of insulin on blood amino acids and lipids. (biorxiv.org)
To address this gap, we utilized mathematical model selection to explore insulin's selective regulatory mechanisms on blood amino acids and lipids, considering their temporal patterns after oral glucose ingestion. (biorxiv.org)
Insulin plays a crucial role in regulating blood lipid metabolism. (biorxiv.org)
Prediabetes, which is defined as elevated blood glucose below the diagnostic threshold for T2D, affects approximately 350M people worldwide, with about 35-50% developing T2D within 5 years. (lu.se)
Proteome-Wide Association Studies for Blood Lipids and Comparison with Transcriptome-Wide Association Studies. (cdc.gov)

Although the precise mechanisms underlying HIV lipodystrophy are not well understood, several hypotheses based on in vitro and human studies may explain the pathogenesis of the lipid changes that take place. (medscape.com)

Effects of dairy fat composition on LDL metabolism were measured in male guinea pigs fed 15% (w/w) fat diets, either butterfat (BF) or a synthetic butter-like fat mix (SBF). (arizona.edu)
Offspring at weaning were selected to isolate the effects of pre-weaning diet, excluding the post weaning diet, on the offspring's lipid and lipoprotein metabolism. (mun.ca)
Tomato (Solanum lycopersicum) is a rich source of lycopene, a carotenoid that confers various positive biological effects such as improved lipid metabolism. (researchgate.net)
various positive biological effects such as improved l ipid metabolism. (researchgate.net)
In addition, effects of novel LRIG1 genetic variants on BMI and T2D might enrich our understanding of lipid metabolism and T2D and thus warrant further investigations. (lu.se)

The disorder predominantly affects white males (male : female ratio 15 : 1) of Mediterranean and eastern European populations [ 4 ]. (hindawi.com)

In patients affected by MSL symmetric, nonencapsulated fat masses are present in the face, neck, occipital region, and supraclavicular fossa. (hindawi.com)
In patients with hypothyroidism , lipid metabolism is slowed, and LDL-C, TG, and HDL-C may be elevated. (medscape.com)
An article in GSC Biological and Pharmaceutical Sciences further suggests that it may also aid in the treatment of COVID-19 based on the hypothesis that this virus interferes with the metabolism of cobalamin, causing patients to experience the same symptoms as if they were B12 deficient. (chiroeco.com)
The WHO consensus definition also pointed out that common symptoms of post-COVID-19 condition were fatigue, shortness of breath, and cognitive dysfunction and that these symptoms affected everyday functioning among patients. (cdc.gov)

Anatomy3

Organisms5

Diseases4

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes10

Technology, Industry, Agriculture4

Lipoproteins5

Cholesterol9

Changes in lipid3

Hepatic6

Glucose and lipid metabolism1

Inflammatory11

Plasma lipids3

Enzymes3

Serum3

Pathway3

Endocrine3

Metabolic2

Lipoprotein levels2

Triglycerides1

Expression of the genes2

Exogenous1

Apolipoproteins1

Fatty Acids7

Oxidative1

Humans2

Proteins involved3

Mice8

Cellular1

Neurons1

Human metabolism1

Myocardial1

Synthesis1

Genes4

Oxidation3

Hydrophobic1

Development and progression1

Regulation2

Mendelian2

Dietary2

20161

Body's2

Causal effect2

Levels9

Fats3

Concentrations2

Mediate1

Middle Aged1

Hyperlipidemia2

Increases2

Biomarkers1

Abnormalities1

Regulators1

Osteoporosis1

Blood5

Pathogenesis1

Effects5

Males1

Patients4