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  • cells
  • More than 20 different partner genes with MLL have been cloned from leukemia cells with translocations involving chromosome 11 band q23 (11q23). (aacrjournals.org)
  • TWEAK also increased monocyte chemoattractant protein-1 secretion in human acute monocytic leukemia cell line cells, an effect blocked with an HMGB1 small interfering RNA. (ahajournals.org)
  • proliferation of leukemia
  • 3) impaired proliferation of leukemia cells and 4) increased sensitivity of leukemia cells to Doxorubicin. (aacrjournals.org)
  • Four isothiocyanates were extract from mustard seed, this research was to screen the compound that have the higher effect on the proliferation of leukemia cell k562and preliminary study the mechanism of action.Methods:the compound that have the higher effect on the proliferation of leukemia cell k562was screened from four isothiocyanates,3-methyl sulfonium phenyl isothiocyanate,3-cyano phenyl isothiocyanate,4-cyanophenyl isothiocyanate and methallyl isothiocyanate (MITC) determined by MTT. (topresearch.org)
  • The effect of MITC on k562leukemia cells in vitro determined by cell colony forming experiment and cell growth rate experiment。cell morphology observation,agarose gel electrophoresis,cell aptosis rate and the cell cycle was determined to anlysis the mechanism.Results:MITC was the compound that had the higher effect on the proliferation of leukemia cell k562determined by MTT. (topresearch.org)
  • bone
  • Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells. (wikipedia.org)
  • Although graft or bone marrow rejection can have detrimental effects, there are immunotherapy benefits when cytotoxic T lymphocytes are specific for a self antigen and can target antigens expressed selectively on leukemic cells in order to destroy these tumor cells referred to as graft-versus- leukemia effect (GVL). (wikipedia.org)
  • relapse
  • Variables associated with decreased leukemia-free survival after second-remission transplants were age greater than or equal to 16 years and relapse occurring while on therapy. (uni-bonn.de)
  • mice
  • In vivo , the combination reduced the risk of graft- versus -host disease without hampering graft- versus -leukemia effect, as shown in mice receiving graft- versus -host disease prophylaxis with sirolimus plus bortezomib being infused with tumor WEHI cells plus C57BL/6 donor BM and splenocytes. (haematologica.org)
  • For the new study, the investigators first injected mice with leukemia cells in which they had restored the two microRNAs. (innovations-report.com)
  • Mice of the leukemia strain AKR/Jax were exposed to prenatal hypoxia by subjecting their mothers for one single period of 5 hours to atmospheric pressures equivalent to conditions of 25,000 feet above sea level, usually during the 8th-14th days of gestation. (aacrjournals.org)
  • Severe congestive cardiac failure is an uncommon but recognized side effect of imatinib and mice treated with large doses of imatinib show toxic damage to their myocardium. (wikipedia.org)
  • tumors
  • RUDN University scientists, in collaboration with their colleagues from the laboratory of medical biotechnology (V.N. Orekhovich Institute of Biomedical Chemistry) and the laboratory of combined therapy of tumors (N.N. Blokhin Oncology Research Institute) discovered and investigated another, previously unknown effect of L-asparaginase. (news-medical.net)
  • graft- versus
  • Conclusions The current study reveals a synergistic effect of the combination sirolimus and bortezomib to prevent graft- versus -host disease while maintaining the graft- versus -leukemia effect. (haematologica.org)
  • Other major complication such as graft-versus-host disease (GVHD) usually occur when a conversion occurs from mixed chimerism to complete donor chimerism, which is accompanied by the graft-versus-leukemia (GVL) effect. (kjim.org)
  • chemotherapy
  • Daily online exclusives cover late breaking oncology news, safe handling and administration of chemotherapy drugs, side effect management, and new developments in specific cancers. (oncologynurseadvisor.com)
  • cells
  • Leukemia affects the body by disrupting the normal balance of cells in the blood and their ability to do their jobs. (sharecare.com)
  • The presented data demonstrate that one of the mechanisms of action for CK2 inhibitors involves increasing Ikaros activity as a transcriptional repressor in leukemia cells, resulting in enhanced tumor suppressor activity. (aacrjournals.org)
  • They have unmasked the ribosome - the molecular machine in the cell that is involved in the production of proteins - as a weak spot in leukemia cells. (vib.be)
  • The formation of white blood cells is disrupted by leukemia. (vib.be)
  • Kim De Keersmaecker (VIB/KU Leuven):"This could be a weak point of the leukemia cells: all cells need properly functioning ribosomes to survive and to grow. (vib.be)
  • These „defective‟ ribosomes in the leukemia cells could be a new suitable target for the development of targeted therapies. (vib.be)
  • These white blood cells are not fully developed and are called blasts or leukemia cells. (wikipedia.org)
  • Chronic leukemia is characterized by the excessive buildup of relatively mature, but still abnormal, white blood cells. (wikipedia.org)
  • In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (wikipedia.org)
  • GVHD
  • inclusion of corticosteroids in the regimen to prevent GVHD was associated with increased leukemia-free survival. (uni-bonn.de)
  • acutely
  • Leukemia can progress either rapidly (acutely) or slowly (chronically). (sharecare.com)
  • Yes, we are acutely aware of the issues, have been 'affected' by the shortage and are managing the situation. (go.com)
  • cell
  • The association with the human T-cell leukemia/lymphotropic virus type I is one of the distinctive etiopathogenetic features of this disease. (aacrjournals.org)
  • SHB knockdown in the APL PMLRARA cell line NB4 and the monocyte/macrophage cell line MM6 adversely affected proliferation, linking SHB gene expression to tumor cell expansion and consequently to patient survival. (diva-portal.org)
  • The DNA ladder was not appeared in the agarose gel electrophoresis of DNA lekemia cell k562.The aptosis rate determined by flow cytometry suggested that leukemia cell k562was not induced aptosis by MITC.Flow cytometry measure showed that the percent of G1phase decreased, the percent of G2phase increased.Conclusion:Leukemia cell k562proliferation was inhibited by MITC. (topresearch.org)
  • According to agarose gel electrophoresis and cell aptosis rate, leukemia cell k562was not induced aptosis by MITC. (topresearch.org)
  • Biochemical
  • This effect is reported in the Biochemical and Biophysical Research Communications . (news-medical.net)
  • They show that microRNAs can affect different biochemical pathways in different ways, and they explain at the molecular level what these two miRNAs do in this disease. (innovations-report.com)
  • cancer
  • One description of genetic factors involved in the breeding of Brassica species is the Triangle of U. Cruciferous vegetables contain glucosinolates which are under basic research for their potential properties of affecting some types of cancer. (wikipedia.org)
  • blood
  • This study is the first to show a clear dose-response effect between methotrexate concentrations in the blood during treatment and executive functioning in survivors. (oncologynurseadvisor.com)
  • cells
  • More than 20 different partner genes with MLL have been cloned from leukemia cells with translocations involving chromosome 11 band q23 (11q23). (aacrjournals.org)
  • TWEAK also increased monocyte chemoattractant protein-1 secretion in human acute monocytic leukemia cell line cells, an effect blocked with an HMGB1 small interfering RNA. (ahajournals.org)
  • bone
  • Other belief, bone, necessity, corticosterone, and generique prednisolone hospital infection in dapoxetine uk prescription scientific isoniazid: weakness to affected mice. (eyfel.de)
  • Ellis-Van Creveld syndrome is an inherited condition that affects bone growth. (nih.gov)