• doripenem
  • Potential avenues for the development of resistance to doripenem are: altered PBPs (penicillin-binding protein), reduced activity in the permeability of the outer membrane especially when accepting foreign toxic substances within the cell, and deactivation of the drug by hydrolyzing enzymes from the carbapenem. (wikipedia.org)
  • cystic fibrosis
  • Adaptation to microaerobic or anaerobic environments is essential for certain lifestyles of P. aeruginosa, for example, during lung infection in cystic fibrosis and primary ciliary dyskinesia, where thick layers of lung mucus and alginate surrounding mucoid bacterial cells can limit the diffusion of oxygen. (wikipedia.org)
  • Cefepime
  • A subsequent meta-analysis published in 2006 found cefepime to be associated with more negative outcomes, and carbapenems (while causing a higher rate of pseudomembranous colitis) were the most straightforward in use. (wikipedia.org)
  • beta-lactamase
  • A 2015 meta analysis concluded that the anti-pseudomonal penicillin-beta lactamase inhibitor combination piperacillin-tazobactam gives results equivalent to treatment with a carbapenem in patients with sepsis. (wikipedia.org)
  • biosynthesis
  • The biosynthesis is thought to share features with the biosynthesis of the simple carbapenems, beginning with the condensation of malonyl-CoA with glutamate-5-semialdehyde to form the pyrroline ring. (wikipedia.org)
  • therapeutic
  • There are a number of therapeutic alternatives to carbapenems that can be applied with the aid of sensitive microbiological and/or molecular genetic testing. (aerzteblatt.de)
  • clinically
  • Rarely, the carbapenems can cause a clinically apparent acute cholestatic hepatitis that is usually self-limiting and not requiring therapy or intervention. (wikipedia.org)
  • activity
  • 0.05 mU/mg) by UV spectrophotometry with 0.1 mM of substrate, after incubation in 50 mM phosphate buffer at 30°C. This activity was lost when the enzyme extract was preincubated with 10 mM of edetic acid and was partially restored by addition of 1 mM ZnCl 2 , indicating the presence of a metallo-carbapenem hydrolyzing ß-lactamase. (cdc.gov)
  • Seizure risk: carbapenems in general have been reported to cause seizure activity in some people. (wikipedia.org)
  • bind
  • To overcome this and regulate proper intake of iron, P. aeruginosa uses siderophores, which are secreted molecules that bind and transport iron. (wikipedia.org)