• Nifedipine, sold under the brand names Adalat and Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. (wikipedia.org)
  • The main ingredient in both Procardia products is Nifedipine. (healthstatus.com)
  • Procardia is just a brand name, and there are many other brands that have Nifedipine as their active ingredients and more or less work the same way. (healthstatus.com)
  • Nifedipine extended-release tablets are an extended-release tablet dosage form of the calcium channel blocker nifedipine. (nih.gov)
  • Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. (nih.gov)
  • Nifedipine selectively inhibits calcium ion influx across the cell membrane of vascular smooth muscle and cardiac muscle without altering serum calcium concentrations. (nih.gov)
  • The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
  • The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. (nih.gov)
  • Nifedipine is an antianginal drug belonging to a class of pharmacological agents, the calcium channel blockers. (nih.gov)
  • As calcium channel blocker, nifedipine has a risk of causing gingival hyperplasia A number of persons have developed toxicity due to acute overdosage with nifedipine, either accidentally or intentionally, and via either oral or parenteral administration. (wikipedia.org)
  • In the APOSTEL III trial we aimed to compare the effectiveness and safety of the calcium-channel blocker nifedipine and the oxytocin inhibitor atosiban in women with threatened preterm birth. (monash.edu)
  • Nifedipine is a calcium channel blocker that is also used in the management of hypertension at doses of 10 to 40 mg 2 times daily or 20 to 90 mg once daily, depending on the sustained-release form used. (msf.org)
  • Nifedipine is in a class of medications called calcium-channel blockers. (medlineplus.gov)
  • The Giant PANDA study is a pragmatic, open-label, multicentre, randomised controlled trial of a treatment initiation strategy with nifedipine ( calcium channel blocker ), versus labetalol (mixed alpha/beta blocker) in 2300 women with pregnancy hypertension . (bvsalud.org)
  • Short-acting calcium antagonists include nifedipine, usually 2-3 times per day. (hizy.net)
  • adverse reaction side effects indication ## Nifedipine is a calcium channel blocker that is used to treat high blood pre. (medschat.com)
  • If any of the following severe adverse reactions occur, stop taking Adalat and contact your doctor or seek emergency medical help: allergy, unusually fast or slow heartbeats, severe dizziness or fainting, psychosis, jaundice, edema of the legs or ankles. (modafinia.com)
  • Less serious adverse reactions are possible and more likely to happen, if so do not stop taking Adalat but talk to your doctor: headache, fatigue, or tiredness, flushing, insomnia, vivid or abnormal dreams, nausea or constipation or increased urination. (modafinia.com)
  • Monitor combination with cimetidine (enhances hypotensive effects), phenytoin (risk of phenytoin overdose), rifampicin (efficacy of nifedipine diminished), itraconazole (increased risk of oedema), beta-blockers (increased adverse cardiac effects). (msf.org)
  • Medications such as phenytoin, nifedipine, and cyclosporin are known to predispose to gingival overgrowth and to increase the severity of plaque formation. (medscape.com)
  • However, phenytoin has been known to have hiccups as an adverse effect. (newhealthadvisor.org)
  • Patients with hepatic impairment (liver cirrhosis) have a longer disposition half-life and higher bioavailability of nifedipine than healthy volunteers. (nih.gov)
  • Nifedipine XR Side Effects can include dizziness, headache, or flushing. (novacorp.biz)
  • Dizziness or lightheadedness is another potential side effect of using Nifedipine Xr. (novacorp.biz)
  • An exception to the avoidance of this practice is in the use of nifedipine for the treatment of hypertension associated with autonomic dysreflexia in spinal cord injury. (wikipedia.org)
  • Immediate-release forms of nifedipine should not be used in either long-term treatment of hypertension or treatment of hypertensive crisis (risk of excessive fall in blood pressure and cerebral or myocardial ischaemia in patients with coronary artery disease). (msf.org)
  • A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA). (bvsalud.org)
  • Hypertension is associated with adverse maternal and perinatal outcomes, and as treatment improves maternal outcomes, antihypertensive treatment is recommended. (bvsalud.org)
  • The primary objective is to evaluate if treatment with nifedipine compared to labetalol in women with pregnancy hypertension reduces severe maternal hypertension without increasing fetal or neonatal death or neonatal unit admission. (bvsalud.org)
  • This property increases myocardial oxygen delivery in patients with coronary artery spasm,and is responsible for the effectiveness of nifedipine in vasospastic (Prinzmetal's or variant) angina. (nih.gov)
  • This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of nifedipine in chronic stable angina. (nih.gov)
  • Nifedipine is one of the main choices for the treatment of Prinzmetal angina due to its vasodilating effects on the coronary arteries. (wikipedia.org)
  • Nifedipine is indicated for the management of vasospastic angina confirmed by any of the following criteria: 1) classical pattern of angina at rest accompanied by ST segment elevation, 2) angina or coronary artery spasm provoked by ergonovine, or 3) angiographically demonstrated coronary artery spasm. (rxlist.com)
  • Nifedipine may also be used where the clinical presentation suggests a possible vasospastic component but where vasospasm has not been confirmed, e.g., where pain has a variable threshold on exertion or when angina is refractory to nitrates and/or adequate doses of beta blockers . (rxlist.com)
  • Nifedipine is indicated for the management of chronic stable angina (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta blockers and/or organic nitrates or who cannot tolerate those agents. (rxlist.com)
  • In chronic stable angina (effort-associated angina) nifedipine has been effective in controlled trials of up to eight weeks duration in reducing angina frequency and increasing exercise tolerance, but confirmation of sustained effectiveness and evaluation of long-term safety in these patients are incomplete. (rxlist.com)
  • Controlled studies in small numbers of patients suggest concomitant use of nifedipine and beta-blocking agents may be beneficial in patients with chronic stable angina, but available information is not sufficient to predict with confidence the effects of concurrent treatment, especially in patients with compromised left ventricular function or cardiac conduction abnormalities. (rxlist.com)
  • Nifedipine is used to treat high blood pressure and to control angina (chest pain). (medlineplus.gov)
  • Nifedipine controls high blood pressure and chest pain (angina) but does not cure them. (medlineplus.gov)
  • Nifedipine XR, also referred to as extended-release nifedipine, is a commonly prescribed medication for managing high blood pressure and angina. (novacorp.biz)
  • Nifedipine is an active ingredient used for the treatment of angina, Raynaud's syndrome and high blood pressure (HBP) . (activeingredients.online)
  • Nifedipine of rapid release is contraindicated in unstable angina and in case of having suffered a myocardial infarction in the last 4 weeks. (activeingredients.online)
  • Individual patients will have headache, facial flushing, lower limb edema, palpitation and other adverse reactions. (hizy.net)
  • Urine pH changes towards alkalinic conditions may lead to an accumulation of amantadine with a possible increase in adverse reactions. (medscape.com)
  • Monitor for adverse reactions of amantadine. (medscape.com)
  • Below are a few examples of reports where side effects / adverse reactions may be related to Zosyn (Piperacillin / Tazobactam). (druglib.com)
  • Although most individuals do not experience any adverse reactions, it is still important to recognize these potential symptoms and know how to effectively manage them. (novacorp.biz)
  • Musculoskeletal assessments were seen adverse reactions was 10 weeks prior to minimize or difficulty breathing. (myjuicecup.com)
  • The administration time should be at least 1 hour, otherwise it is easy to produce adverse reactions. (gentolexgroup.com)
  • Short-acting preparations, such as nifedipine, can cause tachycardia, so medium-acting preparations are generally selected. (hizy.net)
  • The elimination half-life of nifedipine administered as nifedipine extended-release tablet is approximately 7 hours in contrast to the known 2 hour elimination half-life of nifedipine administered as an immediate-release capsule. (nih.gov)
  • Nifedipine comes as a capsule and an extended-release (long-acting) tablet to take by mouth. (medlineplus.gov)
  • Since hepatic biotransformation is the predominant route for the disposition of nifedipine, the pharmacokinetics may be altered in patients with chronic liver disease. (nih.gov)
  • After ingestion of nifedipine extended-release tablets under fasting conditions, plasma concentrations peak at about 2.5 to 5 hours with a second small peak or shoulder evident at approximately 6 to 12 hours post dose. (nih.gov)
  • Your doctor will probably start you on a low dose of nifedipine and gradually increase your dose, generally once every 7 to 14 days. (medlineplus.gov)
  • Drugs may be ineffective in older adults because clinicians under-dose (eg, because of increased concern about adverse effects) or because adherence is poor (eg, because of financial or cognitive limitations). (msdmanuals.com)
  • The peak plasma concentration of nifedipine can be increased by 42%, and if necessary, consider reducing the dose of nifedipine or discontinuing the drug. (gentolexgroup.com)
  • Nifedipine is considered safe in pregnancy and breastfeeding. (wikipedia.org)
  • The prolongation of pregnancy up to 37 weeks was 23 (46 %) and 13 (26 %) in Nifedipine and Isoxsuprine group respectively.19 (38 %) patients in Nifedipine group had side effects as compared to 42 (84 %) in Isoxsuprine group. (ijsr.net)
  • However, with an adeq battery of necf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible. (cdc.gov)
  • Nifedipine extended-release tablets contain 30 mg of nifedipine for once-a-day oral administration. (nih.gov)
  • Nifedipine is completely absorbed after oral administration. (nih.gov)
  • Nifedipine capsules are formulated as soft gelatin capsules for oral administration each containing 10 mg nifedipine. (nih.gov)
  • Nifedipine is rapidly and fully absorbed after oral administration. (nih.gov)
  • Women with threatened preterm birth (gestational age 25-34 weeks) were randomly assigned (1:1) to either oral nifedipine or intravenous atosiban for 48 h. (monash.edu)
  • tell your doctor and pharmacist if you are allergic to nifedipine, any other medications, or any of the ingredients in nifedipine. (medlineplus.gov)
  • Adverse drug reaction (ADR) of medications remains an obstacle to achieving optimal disease outcomes. (researchsquare.com)
  • Table II lists common medications with significant anticholinergic properties and potential adverse consequences, but is not all-inclusive. (wellnessresources.com)
  • medical citation needed] Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing grapefruit or grapefruit juice, as they raise blood nifedipine levels. (wikipedia.org)
  • Interpretation In women with threatened preterm birth, 48 h of tocolysis with nifedipine or atosiban results in similar perinatal outcomes. (monash.edu)
  • Nifedipine is also used sometimes to treat preterm labor and Raynaud's syndrome. (medlineplus.gov)
  • This study was undertaken to compare the efficacy of Nifedipine and Isoxsuprine for suppression of preterm labour. (ijsr.net)
  • Objectives - To compare the efficacy of Nifedipine and Isoxsuprine with respect to Days of gestation gained by tocolysis Adverse effects Neonatal outcome. (ijsr.net)
  • It also has benefits over beta-agonists and may also have some benefits over atosiban and magnesium sulfate, although atosiban results in fewer maternal adverse effects. (wikipedia.org)
  • Nifedipine decreases the elimination of digoxin (Lanoxin) by the kidneys which increases digoxin toxicity. (modafinia.com)
  • The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. (nih.gov)
  • Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. (nih.gov)
  • Nifedipine regularly reduces arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing the total peripheral resistance (afterload) against which the heart works. (nih.gov)
  • There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death. (wikipedia.org)
  • What Are Side Effects Associated with Using Nifedipine? (rxlist.com)
  • While Nifedipine XR can be an effective treatment for certain conditions, it is essential to be aware of its potential side effects and to stay vigilant in monitoring any changes in one's health while on this medication. (novacorp.biz)
  • One of the commonly experienced side effects of Nifedipine Xr is facial flushing or a reddening of the skin. (novacorp.biz)
  • In conclusion, while Nifedipine Xr effectively manages high blood pressure and chest pain, it is crucial to familiarize oneself with its possible side effects. (novacorp.biz)
  • When utilizing Nifedipine XR, some individuals may encounter mild side effects. (novacorp.biz)
  • Although uncommon, Nifedipine XR may lead to more serious side effects. (novacorp.biz)
  • They possess the necessary expertise to assess your medical history, potential drug interactions, and offer assistance in managing any side effects that may arise while consuming Nifedipine XR. (novacorp.biz)
  • When taking Nifedipine Xr, it is crucial to be aware of the possible side effects that may occur. (novacorp.biz)
  • Conclusions: In our experience, topical nifedipine/lidocaine 0.3/2% ointment is an effective and safe-first line treatment for AF, with a high cure rate and no adverse effects. (roadlesstraveledstore.com)
  • These data cannot be used to estimate causal relationships between products and reported adverse effects. (justpoint.com)
  • Adverse drug effects are effects that are unwanted, uncomfortable, or dangerous. (msdmanuals.com)
  • Among ambulatory people ≥ 65, adverse drug effects occur at a rate of about 50 events per 1000 person-years. (msdmanuals.com)
  • Adverse drug effects can occur in any patient, but certain characteristics of older adults make them more susceptible. (msdmanuals.com)
  • both increase the risk of adverse effects. (msdmanuals.com)
  • However, adverse effects are thought to be preventable in at least 25% of cases in older adults. (msdmanuals.com)
  • For example, taking a beta-blocker along with a diuretic should reduce the adverse effects of the latter drug. (prostate.net)
  • Health related question in topics Recreation .We found some answers as below for this question "Does hooka have any adverse effects if you smoke it",you can compare them. (themedicalquestions.com)
  • Introduction The research of Hatch (1) has greatly increased our understand- ing of the use and potential limitations of biological markers for adverse reproductive effects. (cdc.gov)
  • These are way that minimizes adverse effects on pa- unlikely ever to be cured, and so new indi- tients' quality of life [ 9,10 ]. (who.int)
  • Nifedipine is also used in high-altitude medicine to treat high altitude pulmonary edema. (wikipedia.org)
  • Nifedipine Xr is a commonly prescribed drug used to treat high blood pressure and specific types of chest pain. (novacorp.biz)
  • Please do not use this form to submit personal or patient medical information or to report adverse drug events. (medscape.com)
  • You are encouraged to report adverse drug event information to the FDA. (medscape.com)
  • Nifedipine extended-release tablets meet USP Dissolution Test 4 (using first derivative UV spectrophotometry at 245 nm for sample analysis). (nih.gov)
  • Two 30 mg nifedipine extended-release tablets may be interchanged with a 60 mg nifedipine extended-release tablet. (nih.gov)
  • Three 30 mg nifedipine extended-release tablets, however, result in substantially higher C max values than those after a single 90 mg nifedipine extended-release tablet. (nih.gov)
  • Despite their known efficacy, MAOIs have fallen out of favor in clinical practice, giving way to newer agents with more favorable adverse-effect profiles and improved tolerability. (psychiatrictimes.com)
  • Stop nifedipine if ischaemic chest pain occurs or existing pain increases after starting treatment. (msf.org)
  • If taken regularly, nifedipine controls chest pain, but it does not stop chest pain once it starts. (medlineplus.gov)
  • medical citation needed] Finally, nifedipine can be used in the treatment of renal calculi, which are commonly referred to as kidney stones. (wikipedia.org)
  • Nifedipine is extensively converted to inactive metabolites and approximately 80 percent of nifedipine and metabolites are eliminated via the kidneys. (nih.gov)
  • Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. (nih.gov)