Adverse azathioprine. Medical search. Frequent questions

Azathioprine , sold under the brand name Imuran , among others, is an immunosuppressive medication . (wikizero.com)
Antimetabolites include mycophenolate mofetil (CellCept), azathioprine (Imuran). (medscape.com)
tell your doctor if you are taking azathioprine (Azasan, Imuran) or mercaptopurine (Purinethol, Purixan). (medlineplus.gov)

The recommended maintenance immunosuppression during pregnancy includes calcineurin inhibitors (tacrolimus and cyclosporine), azathioprine, and low-dose prednisone. (forbesindia.com)
In veterinary medicine most immunomodulation relies on chemotherapies such as glucocorticoids, azathioprine, leflunomide, cyclosporine and mycophenolate mofetil. (vetbloom.com)
Unlike cyclosporine, azathioprine can take weeks to take full effect and this varies between animals. (vetbloom.com)
Not recommended in combination with other biologic DMARDs, or potent immunosuppressants (eg, azathioprine, cyclosporine). (cancertherapyadvisor.com)

We investigated whether exposure to cyclophosphamide in patients with generalized vasculitis could be reduced by substitution of azathioprine at remission. (nih.gov)
After remission, patients were randomly assigned to continued cyclophosphamide therapy (1.5 mg per kilogram of body weight per day) or a substitute regimen of azathioprine (2 mg per kilogram per day). (nih.gov)
Of 155 patients studied, 144 (93 percent) entered remission and were randomly assigned to azathioprine (71 patients) or continued cyclophosphamide (73 patients). (nih.gov)
Severe adverse events occurred in 15 patients during the induction phase (10 percent), in 8 patients in the azathioprine group during the remission phase (11 percent), and in 7 patients in the cyclophosphamide group during the remission phase (10 percent, P=0.94 for the comparison between groups during the remission phase). (nih.gov)
In patients with generalized vasculitis, the withdrawal of cyclophosphamide and the substitution of azathioprine after remission did not increase the rate of relapse. (nih.gov)
I found myself browsing the second or third page of azathioprine related google results and an abstract about withdrawing from azathioprine when Crohn's is in remission. (rxisk.org)
Background & Aims: An open study reported that patients with Crohn's disease in remission who have taken azathioprine for longer than 3.5 years are at low risk of relapse when azathioprine is discontinued. (rxisk.org)
Methods: Patients who were in clinical remission on azathioprine for ≥42 months were randomized to continue azathioprine or to receive an equivalent placebo for 18 months. (rxisk.org)
Conclusions: This study shows that azathioprine withdrawal is not equivalent to continued therapy with azathioprine for maintenance of remission in patients with Crohn's disease who have been in remission on azathioprine for ≥3.5 years. (rxisk.org)
Based on the evidence here's the conclusion I would think is more responsible to give a Crohn's patient: There was as trial done which included a fairly small number of patients and it showed that if you've been in remission (a Crohn's Disease Activity Index score of less than 150) for at least 42 months and are still taking azathioprine then you can consider stopping. (rxisk.org)
You stand an absolute chance of 9 out of 43 (21%) of coming out of remission but only a 6 out of 43 chance (14%) of coming out of remission because you stopped azathioprine. (rxisk.org)
Further consider you're one of the 34 patients in the placebo group who remained in remission for 18 months and then your doctor tells you that you were in the placebo group but to start taking your azathioprine again. (rxisk.org)
Main outcome measures evaluated were remission rate, relapse rate, rate of visual loss, steroid-sparing rate, adverse effects and discontinuation of medication due to adverse effects. (bmj.com)
Despite the development new agents for inflammatory bowel disease (IBD) therapy, azathioprine (AZA) is widely used as both as monotherapy and as combination therapy for induction and maintenance of remission both Crohn's disease (CD) and ulcerative colitis (UC). (ecco-ibd.eu)
Azathioprine has been used in the management of moderate to severe chronically active Crohn's disease, [17] to maintain clinical remission (absence of disease activity) in corticosteroid-dependent patients, [18] and to provide benefit in people with fistulizing Crohn's disease. (wikizero.com)
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. (druglib.com)
CONCLUSIONS: Azathioprine and 6-mercaptopurine are effective therapy for inducing remission in active Crohn's disease. (druglib.com)

azathioprine, ciclosporin, methotrexate and mycophenolate mofetil (OISA group). (bmj.com)
Because of the increased specificity of mycophenolate mofetil, azathioprine is rarely used in current transplant immunosuppression regimens. (medscape.com)
However, because of the potential for serious adverse reactions in nursing infants from mycophenolate mofetil, breast-feeding is not recommended while you are receiving it. (transplantliving.org)

Eleven relapses occurred in the azathioprine group (15.5 percent), and 10 occurred in the cyclophosphamide group (13.7 percent, P=0.65). (nih.gov)

This study was conducted to determine the types and prevalence of adverse events related with azathioprine in patients with ocular BS. (researchsquare.com)
Aim of this study is to investigate the long-term safety of AZA, to document the prevalence of adverse events of AZA in patients with IBD. (ecco-ibd.eu)

Below are a few examples of reports where side effects / adverse reactions may be related to Prednisolone. (druglib.com)
Adverse reactions in pediatric patients were similar. (nih.gov)
To report SUSPECTED ADVERSE REACTIONS, contact Apotex at 1-800-706-5575 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (nih.gov)
monitor for changes in renal function and mesalamine-related adverse reactions. (nih.gov)
Dosage errors in the use of Metoject PEN (methotrexate) can result in serious adverse reactions, including death. (medicines.org.uk)
Patients treated with infliximab products are at increased risk for developing serious infections that may lead to hospitalization or death [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS ]. (rxlist.com)
It is recommended not to initiate therapy with maximum doses in these patients due to the likely increase frequency of adverse reactions. (pdr.net)

A second-line treatment, mainly low-dose methotrexate and azathioprine, is indicated in case of corticosteroid resistance, intolerance, or contraindication or more often as a corticosteroid-sparing agent when a prolonged treatment of more than 10 mg/d equivalent prednisone is expected. (medscape.com)

Azathioprine is used to prevent rejections of kidney or liver allografts , usually in conjunction with other therapies including corticosteroids , other immunosuppressants, and local radiation therapy . (wikizero.com)
[16] Nonsteroidal anti-inflammatory drugs and corticosteroids may be combined or continued (if they were already in use) with azathioprine, but the combination with other DMARDs is not recommended. (wikizero.com)
Eligible patients also remained on steady doses of standard UC therapies including mesalamine, oral corticosteroids and azathioprine. (nutraingredients.com)
In an effort to increase the growth of pediatric recipients of kidney transplants and to avoid adverse effects, some centers taper and ultimately discontinue corticosteroids within 1 year of transplantation. (medscape.com)
Corticosteroids remain the cornerstone for the treatment of sarcoidosis particularly at induction with a rapid response in most patients and the potential occurrence of adverse events. (medscape.com)

[4] Azathioprine belongs to the purine analogues subclass of antimetabolites family of medications. (wikizero.com)
Azathioprine impedes purine synthesis, thus impairing cell division and proliferation in all replicating cells. (medscape.com)
Azathioprine is a purine analog that works by antagonizing purine metabolism, and inhibiting RNA, DNA synthesis and mitosis. (vetbloom.com)

Among numerous immunosuppressants, azathioprine (AZA) is a well-established medication that plays a useful role in the treatment of various autoimmune diseases, and recent studies have confirmed its efficacy in patients with BS, particularly in individuals with ocular pathology. (researchsquare.com)

azathioprine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
azathioprine decreases effects of anthrax vaccine by pharmacodynamic antagonism. (medscape.com)
Thirty-nine per cent withdrew due to adverse effects. (nih.gov)
ITPase deficiency is a predictor of adverse effects and TGN concentrations above 100 correlate with clinical response. (nih.gov)
For the pharmacogenetic associations listed in this table, the FDA has evaluated and believes there is sufficient scientific evidence to suggest that subgroups of patients with certain genetic variants, or genetic variant-inferred phenotypes (such as affected subgroup in the table below), are likely to have altered drug metabolism, and in certain cases, differential therapeutic effects, including differences in risks of adverse events. (fda.gov)
Nevertheless, few studies have evaluated the advantages and disadvantages of the AZA in patients who suffer ocular manifestation of BS, as a way to assess the benefits of the drug in comparison to its adverse outcomes and effects. (researchsquare.com)
however, therapy is also associated with severe adverse effects. (medscape.com)
Before any immunosuppressive medication is started, the potential adverse effects, the duration of therapy, and the chances of success should be discussed with the patient. (medscape.com)
The incidence of adverse effects in the CYC group was comparable with that of the OISA group (61.9% vs 41.4%, p=0.15). (bmj.com)
[20] Lower doses of azathioprine are used as a therapy in children with refractory or corticosteroid-dependent Crohn's disease, without causing many side effects. (wikizero.com)
Medications for these diseases and their adverse side effects. (cheatography.com)
No adverse biochemical or clinical effects were observed. (nutraingredients.com)
Most Parkinson's disease experts now recommend that l-dopa therapy be started as late as possible after diagnosis of Parkinson's disease so as to postpone the day when it no longer works and to limit its many serious adverse effects. (digitalnaturopath.com)
Careful management of immunosuppression is critical in renal transplant recipients before and during pregnancy because of the risks of teratogenicity and other adverse effects. (forbesindia.com)
Panellists developed consensus recommendations for adverse event management, and reached consensus that RCI should be down-titrated or discontinued if other interventions for the adverse effects fail or if the adverse effect is severe. (ersjournals.com)
Long-term corticosteroid therapy has a substantial number of adverse effects. (medscape.com)
Use of mefenamic acid longer than 7 days increases the risk of adverse effects and is not recommended. (pdr.net)
Each of these medications has a unique mechanism of action, set of potential adverse effects and variable onset of action. (vetbloom.com)
In most cases adverse effects can be minimized by tapering to every other day dosing after a 5-7 day loading period of once daily dosing. (vetbloom.com)
they give rapid results, sometimes with serious, incremental adverse effects. (medscape.com)

There is no certainty that the reported event (adverse event or medication error) was actually due to the product. (hipaaspace.com)
Further, FDA does not receive reports for every adverse event or medication error that occurs with a product. (hipaaspace.com)

In addition, adverse event reports submitted to FDA showed severe and symptomatic hypocalcemia, including hospitalization and death, is occurring in patients with advanced kidney disease treated with Prolia. (medlineplus.gov)

This provides more specific immunosuppression for transplantation than azathioprine. (medscape.com)

Specific information regarding therapeutic management is provided for some pharmacogenetic associations listed in the table, but most of the associations listed have not been evaluated in terms of the impact of genetic testing on clinical outcomes, such as improved therapeutic effectiveness or increased risk of specific adverse events. (fda.gov)

Let's look at the azathioprine group, they experienced 3 relapses out of 40. (rxisk.org)

6 months on thiopurine monotherapy including azathioprine, 6-mercaptopurine or tioguanine. (ecco-ibd.eu)

At 18 months, 3 patients had a relapse in the azathioprine group, and 9 had a relapse in the placebo group. (rxisk.org)
Data were collected retrospectively on disease-related characteristics and events including severity, recurrence, relapse, recovery and flare-up, as well as on azathioprine dosage and the duration of use. (researchsquare.com)

Azathioprine has a slow onset of action and myleosuppression is a major potential adverse effect. (allergylosangeles.com)

Being a disease-modifying antirheumatic drug (DMARD), azathioprine has been used for the management of the signs and symptoms of adult rheumatoid arthritis . (wikizero.com)

However, the risk of thiopurine-related adverse events decreases after the initiation phase. (ecco-ibd.eu)

Azathioprine treatment is associated with an increased risk of lymphoma , but if this is due to the drug or a predisposition related to Crohn's disease is unclear. (wikizero.com)

If you apply that knowledge to the placebo group it implies that not 9 people relapsed because of azathioprine withdrawal but only 6 relapsed. (rxisk.org)
Azathioprine withdrawal or dose reduction was needed in 47 (21%) patients. (ecco-ibd.eu)

Results: Forty patients were randomly assigned to receive azathioprine and 43 to receive placebo. (rxisk.org)

Conclusion Administration of azathioprine with due attention to the signs, symptoms, and severity of the disease, results in a reduced rate of adverse events and resolution of the ocular involvement in patients with BS. (researchsquare.com)
According to this retrospective observational study, approximately one-third of IBD patients receiving AZA presented clinical significant adverse event during follow-up. (ecco-ibd.eu)
At baseline, 47 patients were treated with azathioprine (55.3%), 25 with 6-mercaptopurine (29.4%) and 13 with tioguanine (15.3%) for a median duration of 6.7 years. (ecco-ibd.eu)
In patients treated with repository corticotrophin injection (RCI) for pulmonary sarcoidosis, effective management of adverse events may improve adherence. (ersjournals.com)
Almost all patients had received treatment with azathioprine or 6-mercaptopurine concomitantly with a TNF-blocker at or prior to diagnosis. (rxlist.com)
Adverse events were more common among patients on active therapy. (druglib.com)

This version of the table is limited to pharmacogenetic associations that are related to drug metabolizing enzyme gene variants, drug transporter gene variants, and gene variants that have been related to a predisposition for certain adverse events. (fda.gov)
Despite its advantages, the safety of AZA is still a topic of debate among clinicians regarding its adverse events. (researchsquare.com)
Common products may have a higher number of adverse events due to the higher total number of people using the product. (hipaaspace.com)
In recent years the FDA has undertaken efforts to increase collection of adverse events. (hipaaspace.com)
Increases in the total number of adverse events is likely caused by improved reporting. (hipaaspace.com)
The primary outcome was thiopurine-related adverse events (AE) requiring change or discontinuation of thiopurine therapy after 104 weeks of follow-up. (ecco-ibd.eu)
However, management of adverse events may be challenging due to limitations in real-world clinical experience with RCI and available published guidelines. (ersjournals.com)
Major adverse cardiovascular events (MACE). (cancertherapyadvisor.com)
Grade 2 per Common Terminology Criteria for Adverse Events (CTCAE) v.5 at screening. (who.int)

febuxostat increases levels of azathioprine by decreasing metabolism. (medscape.com)
allopurinol increases levels of azathioprine by decreasing metabolism. (medscape.com)

In this paper, a modified Delphi method was used to develop an expert consensus on the use of repository corticotrophin injection therapy for pulmonary sarcoidosis, including dosing, concomitant medications, contraindications and adverse event management. (ersjournals.com)

A reduction in platelet number or function can occur through a variety of mechanisms, including autoimmune destruction, spleen sequestration, bone marrow infiltration by tumor cells, infection (e.g. dengue fever), and adverse drug reaction. (bvsalud.org)

This field can be used to identify or find a specific adverse event report. (hipaaspace.com)

Anatomy1

Organisms1

Diseases12

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes2

Information Science1

Health Care2

Imuran3

Cyclosporine4

Remission17

Mycophenolate3

Cyclophosphamide1

Prevalence of adverse events2

Reactions7

Methotrexate1

Corticosteroids5

Purine3

Immunosuppressants1

Effects21

Medication2

Severe1

Transplantation1

Therapeutic1

Relapses1

Monotherapy1

Relapse2

Onset of action1

Rheumatoid Arthritis1

Decreases1

Crohn's1

Withdrawal2

Randomly assigned1

Patients6

Events9

Increases2

Medications1

Drug reaction1

Specific adverse1