Adult stem cells. Medical search. Frequent questions

Although adult stem cells lack the pluripotency of embryonic stem cells, they can be reprogrammed to become cells of a specific cell type or induced pluripotent stem cells. (genengnews.com)
Induced pluripotent stem cells (iPSCs) are adult stem cells that have been genetically reprogrammed to a state resembling embryonic stem cells. (nih.gov)
Generation of progesterone-responsive endometrial stromal fibroblasts from human induced pluripotent stem cells: role of the WNT/CTNNBI Pathway. (nih.gov)
Use of induced-pluripotent (iPS) cell, embryonic stem cell, and adult stem cell research opens the door to promising new medical cell therapy applications and discoveries. (ca.gov)
Embryonic stem cell, adult stem cell and induced-pluripotent (iPS) cell research opens the door to promising new medical cell therapeutic applications to treat human diseases that would likely not be accessible by traditional small molecule therapeutics. (ca.gov)
A couple of years ago, researchers took a major step toward this goal by coaxing induced pluripotent stem cells (iPSCs), which are made from mature human cells, to differentiate into cells that closely resembled beta cells. (nih.gov)
The mechanisms underlying the low efficiency of reprogramming somatic cells into induced pluripotent stem (iPS) cells are poorly understood," write the authors. (lifesitenews.com)
This latest discovery related to induced pluripotent stem cells could prove a set-back in the efforts to use them in regenerative medicine. (lifesitenews.com)
There are several main categories: the "pluripotent" stem cells (embryonic stem cells and induced pluripotent stem cells) and nonembryonic or somatic stem cells (commonly called "adult" stem cells). (nih.gov)
Those reprogramed stem cells are called induced pluripotent stem cells (iPSCs). (nih.gov)
Induced pluripotent stem cells - Induced pluripotent stem cells, or iPS cells, are another type of stem cell that can be made in the lab from normal adult cells, such as skin cells. (ed.ac.uk)

Symmetric division gives rise to two identical daughter stem cells, whereas asymmetric division produces one stem cell and one progenitor cell with limited self-renewal potential. (wikipedia.org)
The potential to form every cell type is a moot point, as long as a stem/progenitor cell is capable of forming the cell types required for particular injury of disease. (cellmedicine.com)
While mutational status discriminates between healthy and cancerous cells, gene expression distinguishes stem cells and progenitor cell populations. (nature.com)
To our knowledge, these data represent the first outright rescue of a congenital hypomyelinating disorder by means of stem or progenitor cell transplantation," offers Dr. Goldman. (sciencedaily.com)
Mainly known for its role in immune defense and inflammation, interleukin 22 (IL-22) has emerged over the past decade as a cytokine involved in the adaptation of stem/progenitor cell activity for tissue homeostasis and repair. (mysciencework.com)

It is embryonic stem cell treatment that is most profitable, and not the best, that is getting all the exposure. (cellmedicine.com)
This has led to an intense debate that threatens to limit embryonic stem cell research. (jci.org)
Many in the international scientific community believe that the promise of stem cell-based studies or therapies will be realized only if we can derive new human embryonic stem cell (hESC) lines. (jci.org)
In August, a US federal court ruled in favor of legally funding human embryonic stem cell research at the US National Institutes of Health (NIH). (stemforlife.org)
The secreted protein factors that control embryonic stem cell differentiation has been the focus of the most recent work in the stem cell field. (cellmedicine.com)
As a result, the National Institutes of Health has approved 43 new embryonic stem-cell lines for taxpayer-funded experiments, but that is not necessarily good news for sick people. (rollcall.com)
The only approved experiment for embryonic stem-cell injections into humans, for newly injured spinal cord patients, is on hold by the Food and Drug Administration because of safety concerns. (rollcall.com)
The federal government has spent more than half a billion dollars on human embryonic stem-cell research since 2002, and funding for this controversial research has increased more than 40 percent since 2008. (rollcall.com)
In 2006, researchers identified conditions that would allow some mature human adult cells to be reprogrammed into an embryonic stem cell-like state. (nih.gov)
The university says the gift from an alumnus will fund three new endowed professorships in adult and all forms of non-embryonic stem cell research, in hopes of accelerating discovery of new treatments for heart disease, diabetes and some cancers. (ibj.com)
Although it is well past time to stop the hypocrisy over stem cell patents ( see Part I and Part II of this series), the forces aligned against the Thomson human embryonic stem cell patents refuse to do so. (patentdocs.org)

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. (wikipedia.org)
These cells are found throughout the body-in bone marrow, hair follicles, and other tissues-and they are multipotent, which means they retain the ability to differentiate into some or all of the specialized cell types of the tissue or organ in which they are embedded. (genengnews.com)
This last application area, which promises to generate replacement cells and tissues, may be the most important. (genengnews.com)
Research to elucidate the changes that take place in stem cells and their environment with normal age and age-related disease will be crucial to understanding how and why tissues, organs and organisms senesce and to eventual development of stem cell-based therapies for the aged. (nih.gov)
RESEARCH OBJECTIVES Background Stem cells have been derived from both adult and embryonic tissues in the mouse. (nih.gov)
However, human embryonic stem cells have only recently been cultured, and whether they are analogous to mouse embryonic stem cells in potential to form tissues or tumors is still unknown. (nih.gov)
This part of work in the laboratory is directed towards the growth and differentiation of adult mesenchymal stem cells into a variety of cell types that are suitable for repairing and regenerating musculoskeletal tissues. (nih.gov)
CELZ ) announced the filing of a patent application disclosing means of regenerating failing ovaries through use of a particular type of stem cell extracted from patient's own tissues. (prnewswire.com)
The findings could lead to a way to produce new uterine cells from a patient's own tissues, which could then be used to treat uterine disorders such as endometriosis, uterine factor infertility, and early-stage endometrial cancer. (nih.gov)
Endometriosis is a disease in which tissue similar to endometrial cells lining the uterus grow in other parts of the body, such as on or under the ovaries, on the fallopian tubes, and on the tissues that hold the uterus in place. (nih.gov)
The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. (biomedcentral.com)
These progenitor cells which constitute a reservoir found within the connective tissue of most organs are involved in the maintenance and repair of tissues throughout the postnatal life of an individual. (biomedcentral.com)
The fascinating discovery of tissue-resident adult stem/progenitor cells in recent years led to an explosion of interest in the development of novel stem cell-based therapies for improving the regenerative capacity of these endogenous immature cells or transplanted cells for the repair of damaged and diseased tissues. (nih.gov)
MSCs are found in adult tissues with bone marrow-derived MSCs being the most widely studied. (scitizen.com)
MSCs are generally isolated from tissues by their adherence to plastic culture surfaces and the exclusion of other contaminating cell types, such as the blood cells of the marrow. (scitizen.com)
This hampers attempts to isolate and expand purified stem cell populations or to study MSC behaviour at specific tissues sites (niches) in the body. (scitizen.com)
Our adult spermatogonial stem cells under in vitro culture conditions are comparable with respect to pluripotency to embryonic stem cells and from this pluripotent cells in culture, we can derive all different kind of tissues such as spontaneous beating hearth cells, liver cells, skin cells, and vascular cells. (scitizen.com)
Now, if we can transfer our technique to human tissues then we would be able to gain from testicular biopsy cells that are pluripotent and have the same properties than embryonic stem cells. (scitizen.com)
Tissues with high cellular turnover, such as the hematopoietic system or the intestine, depend on "professional" adult stem cells for their continuous regeneration 1 . (nature.com)
Few subjects in biomedical science have captured the imagination of both the scientific community and the public as has the use of stem cells for the repair of damaged tissues. (jci.org)
In October, The Nobel Prize in Physiology or Medicine was awarded jointly to Sir John B. Gurdon and Dr. Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent (immature cells), capable of developing into all tissues of the body. (stemforlife.org)
In the meantime, noncontroversial adult stem cells from bone marrow, umbilical cord blood and other tissues are treating thousands of patients around the globe right now. (rollcall.com)
The inner cell mass will ultimately develop into the specialized cell types, tissues, and organs of the entire body of the organism. (nih.gov)
Adult stem cells have been identified in many organs and tissues and are generally associated with specific anatomical locations. (nih.gov)
These stem cells may remain quiescent (non-dividing) for long periods of time until they are activated by a normal need for more cells to maintain and repair tissues. (nih.gov)
Stem cells have unique abilities to self-renew and to recreate functional tissues. (nih.gov)
Stem cells have the ability to recreate functional tissues. (nih.gov)
These results suggest that the strategy of using gelatin hydrogel microspheres to achieve the sustained release of growth factors holds promise for the clinical regeneration of damaged brain tissues from endogenous neural stem cells in the adult SVZ. (hindawi.com)
Our data demonstrate that both visceral and subcutaneous adipose tissues are a source of pluripotent stem cells with multigermline potential. (unifi.it)
While direct cell injection is the most convenient means of cell delivery, a scaffold-based approach is capable of producing three-dimensional engineered tissues with mechanical properties compatible with those of various musculoskeletal tissues. (biomedcentral.com)
Concurrently, cell-hydrogel and cell-nanofibrous constructs are currently being developed for the engineering of cartilaginous tissues, and information on the fabrication and biological attributes of these various tissue-engineered composites will be presented. (biomedcentral.com)
This drastically increases the supply of cells and tissues available for transplant into patients. (ed.ac.uk)
In some tissues, for example the liver and the pancreas, the existence of a resident stem-cell population remains controversial. (biomedcentral.com)

Unlike embryonic stem cells, the use of human adult stem cells in research and therapy is not considered to be controversial, as they are derived from adult tissue samples rather than human embryos designated for scientific research. (wikipedia.org)
Under normal conditions, tissue stem cells divide slowly and infrequently. (wikipedia.org)
Projects are encouraged that significantly advance research to identify and characterize adult stem cells as a function of aging, characterize the tissue environment and the interaction of adult stem cells with that environment during aging, separate, monitor and control adult stem cells from and in aging tissue, and develop or use disease models to understand the biology of adult stem cells in disease states common to aged individuals. (nih.gov)
By using EPC alone, or in combination with other cells such as mesenchymal stem cells, the treatment aims to overcome scar tissue and factors that inhibit oocyte viability. (prnewswire.com)
Tissue models and drugs need to be tested on mature tissue not embryonic cells, so the "usefulness in drug testing and disease models" is not a sensible claim. (cellmedicine.com)
The stem/progenitor cells are the only cells that survive when a transplant consists of embryonic/fetal tissue. (cellmedicine.com)
It is thought that as a consequence of cellular overgrowth or from rejection of the foreign cells/tissue derived from embryo or fetus, devastating deterioration at one year after treatment occurred in about 15% of patients in two clinical trials using embryonic/fetal tissue. (cellmedicine.com)
The artificial skin was bioengineered in the laboratory with adult stem cells derived from bone marrow, and was then grafted to the animals where the dermal layer began to regenerate and the stem cells naturally differentiated into new skin tissue. (cellmedicine.com)
As Dr. Yan Jin of the Fourth Military Medical University and a coauthor of the study states, 'We hope that this so-called 'engineered structural tissue' will someday replace plastic and metal prostheses currently used to replace damaged joints and bones by suitable materials and stem cells. (cellmedicine.com)
It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. (biomedcentral.com)
Transplantation of donated pancreatic islets-tissue that contains beta cells-holds some promise as a therapy or even a cure for type 1 diabetes. (nih.gov)
Aging of tissue-resident adult stem/progenitor cells and their pathological consequences. (nih.gov)
the ability of MSCs to traverse tissue boundaries and give rise to cells of a different (i.e. non-musculoskeletal) tissue, such as brain or liver cells. (scitizen.com)
So this would avoid completely the ethical problems associated with embryonic stem cells, provided that we will be able to develop the same system in human tissue. (scitizen.com)
Of course for medicine it is of great interest to develop regenerative strategies and our approach, if it is completely transferable to human tissue, would allow to isolate and identify pluripotent human stem cells which could be used for different kind of regenerative medicine. (scitizen.com)
Whether these cells can generate heart muscle cells or stimulate the growth of new blood vessels that repopulate the heart tissue, or help through some other mechanism is actively under investigation. (issca.us)
Cardiovascular disease can deprive heart tissue of oxygen, thereby killing cardiac muscle cells (cardiomyocytes). (issca.us)
This loss triggers a cascade of detrimental events, including formation of scar tissue, an overload of blood flow and pressure capacity, the overstretching of viable cardiac cells attempting to sustain cardiac output leading to heart failure, and eventual death. (issca.us)
Several of these have demonstrated that stem cells that are injected into the circulation or directly into the injured heart tissue appear to improve cardiac function and/or induce the formation of new capillaries. (issca.us)
The mechanism for this repair remains controversial, and the stem cells likely regenerate heart tissue through several pathways. (issca.us)
Although much more research is needed to assess the safety and improve the efficacy of this approach, these preliminary clinical experiments show how stem cells may one day be used to repair damaged heart tissue, thereby reducing the burden of cardiovascular disease. (issca.us)
Oncogenic mutations in these cells can cause cancers that maintain a hierarchical organization reminiscent of the tissue of origin. (nature.com)
Undifferentiated cells, found in a differentiated tissue, that can renew themselves and - with certain limitations - differentiate to yield all the specialized cell types of the tissue from which they originated. (michaeljfox.org)
UCLA stem cell scientists purified a subset of stem cells from fat tissue and used the stem cells to grow bone. (stemforlife.org)
The study showed that when autologous (self-donated) lung-derived mesenchymal stem cells were transplanted into adult female sheep modeled with emphysema, the sheep showed evidence of tissue regeneration with increased blood perfusion, post-transplant. (stemforlife.org)
The NIH announces a new technology wherein dental pulp stem cells from an individual's own postnatal dental pulp tissue (one or two wisdom teeth) can potentially be used to engineer healthy living teeth. (nih.gov)
This technology is based upon the discovery of a subpopulation of cells within normal human dental pulp tissue that has the ability to grow and proliferate in vitro. (nih.gov)
Suggesting that gap junction-permeable signals are necessary to maintain tissue regeneration and stem cell state, they were able to show that the adult stem cell pool disappeared along with the regenerative capabilities when one of many specific gap junction channel types was abolished. (cellmedicine.com)
Those concerns include the fact that in animal experiments, embryonic stem cells can lead to cancer or misplaced tissue formation. (rollcall.com)
Adult stem cells are found in a tissue or organ and can differentiate to yield the specialized cell types of that tissue or organ. (nih.gov)
What controls the balance between these types of divisions to maintain stem cells at an appropriate level within a given tissue is not yet well known. (nih.gov)
On the other hand, adult stem cells differentiate to yield the specialized cell types of the tissue or organ in which they reside, and may have defining morphological features and patterns of gene expression reflective of that tissue. (nih.gov)
Characterization of human adult stem cell populations isolated from visceral and subcutaneous adipose tissue. (unifi.it)
What about tissue (adult) stem cells? (eurostemcell.org)
Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
Tissue stem cells - These cells are found in your body and provide new cells to your organs. (ed.ac.uk)
They can usually only make a limited number of different cell types which are specific to the organ or tissue that they are found in. (ed.ac.uk)
A substantial part of the meeting was devoted to adult stem cells and their potential for tissue repair. (biomedcentral.com)
Adult stem cells are generally considered tissue-specific - only able to give rise to progeny cells corresponding to their tissue of origin. (biomedcentral.com)

However, one of the major obstacles in translating these basic science discoveries into safe cell based therapies for patients is the risk of acquiring mutations from viral and DNA vectors that are used to manipulate pluripotent cells into the specific cell types required to treat human diseases. (ca.gov)

However, it is known that in vitro cell culture conditions can alter the behavior of cells, proving that a particular subpopulation of cells possesses stem cell properties in vivo is challenging, and so considerable debate exists as to whether some proposed stem cell populations in the adult are indeed stem cells. (wikipedia.org)
It is clear that questions of fate restriction and cellular contribution require a new approach to label and track large populations of stem cells and their progeny in the adult brain. (jneurosci.org)
However, the stem cell populations that have been tested in these experiments vary widely, as do the conditions of their purification and application. (issca.us)
However, these approaches all measure impure populations of cells. (nature.com)
The different types of stem cell populations can be illustrated by considering the earliest stages of embryogenesis (Figure 1 ). (jci.org)
However, when cells are damaged by infection or toxic agents, the previously quiescent progenitor populations are activated to promote repair. (nih.gov)
Dr. Hogan's lab uses clonal 3D in vitro organoid cultures to identify different populations of stem cells and the niche in which they reside, and to screen for factors promoting proliferation and differentiation at steady state and during injury-induced repair. (nih.gov)
Throughout the life of the organism, populations of adult stem cells serve as an internal repair system that generates replacements for cells that are lost through normal wear and tear, injury, or disease. (nih.gov)
Immunophenotyping shows that plastic culturing selects homogeneous cell populations of V-ASCs and S-ASCs from the corresponding stromal vascular fractions (SVFs), sharing typical markers of mesenchymal stem cells. (unifi.it)
To accomplish this, appropriate culture conditions must be established so as to generate specific cell types from ES cells and obtain homogeneous populations. (biomedcentral.com)
Bruno Peault (Children's Hospital, Pittsburgh, USA and Inserm, Villejuif, France) reported the identification in his laboratory of alternative resident adult stem-cell populations in skeletal muscle. (biomedcentral.com)

In addition, this research may help in the development of therapies that overcome the limits on adult blood stem cell proliferation in a selective fashion, allowing regeneration of critical blood cells that might otherwise be irrevocably lost through disease or injury. (nih.gov)
Consequently, to clinically develop stem cell therapies, there is a great need to develop reagents and protocols that can gently alter stem biology, but do not result in either use of DNA vectors or stress the cells, both of which can lead to mutagenic events. (ca.gov)
This finding may lead to design new therapies to selectively eliminate stem cells in cancer. (nih.gov)
Therefore, the rescue or replacement of aged and dysfunctional endogenous adult stem/progenitor cells or molecular targeting of their malignant counterpart, cancer stem/progenitor cells may constitute potential anti-aging and cancer therapies. (nih.gov)
To realize the promise of novel cell-based therapies for such pervasive and debilitating diseases, scientists must be able to manipulate stem cells so that they possess the necessary characteristics for successful differentiation, transplantation, and engraftment. (issca.us)
By reprogramming mature cells, scientists and the global health care community at large see an extraordinary opportunity to study disease and develop more cellular therapies and cures. (stemforlife.org)
However, most stem cell therapies are in research or clinical trial phase. (org.in)
For lots more information and resources about stem cells and regenerative medicine, including information about using stem cells in the clinic and clinical trials of stem cell therapies, visit the EuroStemCell website. (ed.ac.uk)
Leading scientists from a range of disciplines relevant to stem-cell biology covered a gamut of current topics, including the properties of human and mouse embryonic and adult stem cells, attempts to manipulate stem cells, and the first clinical attempts at cell-based therapies. (biomedcentral.com)

Produced by either cloning via somatic cell nuclear transplant or by in vitro fertilization of human eggs, human stem cells can be acquired from human embryos. (cellmedicine.com)
At the present time, the production of new cell lines involves destruction of preimplantation embryos at the 100-200 cell (blastocyst) stage. (jci.org)
Early mammalian embryos at the blastocyst stage contain two types of cells - cells of the inner cell mass, and cells of the trophectoderm. (nih.gov)
Previous work with mouse embryos led to the development of a method in 1998 to derive stem cells from the inner cell mass of preimplantation human embryos and to grow human embryonic stem cells (hESCs) in the laboratory. (nih.gov)
Why use embryos for stem cell research? (eurostemcell.org)
These embryos are eventually discarded, but opponents of stem cell research argue that destroying embryos for research is equivalent to cruel treatment of adult human beings. (org.in)
The court ruled that the use of stem cells from human embryos is "immoral" and violates human dignity. (org.in)
Embryos which are a few days old, known as blastocysts, are used to make ES cells in the lab. (ed.ac.uk)
iPS cells are also seen as a more ethically acceptable type of stem cell than embryonic stem cells, as no embryos are destroyed in the production of iPS cells. (ed.ac.uk)
Therefore, as already suggested by experiments in amphibian embryos, no exogenous inductive stimuli (except perhaps for autocrine fibroblast growth factor signaling) seem to be required for the commitment of ES cells to a neural fate. (biomedcentral.com)
For the first time, the opponents assert that Dr. Thomson was able to make human embryonic stem cells not because the prior art made them obvious, but because he had 'unique access' to an Israeli scientist who provided him with human embryos. (patentdocs.org)

Provides an update of hematopoietic stem cell transplantation for systemic sclerosis from phase I/II studies and prospective randomized phase III trials, and introduces the concept of mesenchymal stem cells as potential therapy for autoimmune disease. (medscape.com)
Most received autologous, peripheral blood derived hematopoietic stem cell transplantation. (medscape.com)
Hematopoietic stem cell transplantation is currently being tested in prospective randomized controlled trials and appears to 'reset' autoimmunity in systemic sclerosis. (medscape.com)
The concept was supported by animal model data, [ 1 ] suggesting tolerance induction in a rat arthritis model and cases of patients receiving an hematopoietic stem cell transplantation (HSCT) for conventional indications and in whom a coincidental autoimmune disease was improved or eradicated. (medscape.com)
In patients with refractory cytopenia, hematopoietic stem cell transplantation (HSCT) from a matched related or well-matched unrelated donor early in the course of the disease is the treatment of choice, especially in those with monosomy 7, 7q-, or complex karyotype. (medscape.com)
7 Department of Hematopoietic Stem Cell Transplantation, Institute of Hematology and Transfusion Medicine, Warsaw, Poland. (nih.gov)

Bone marrow-derived mesenchymal stem cells from systemic sclerosis patients show in-vitro immunomodulatory properties equal to healthy controls. (medscape.com)
These properties can be illustrated with relative ease in vitro, using methods such as clonogenic assays, where the progeny of a single cell is characterized. (wikipedia.org)
It can be induced by modifying the growth medium when stem cells are cultured in vitro or by transplanting them to an organ of the body different from the one they were originally isolated from. (wikipedia.org)
YFP+ neurospheres could be generated in vitro after recombination in vivo , and maturing YFP+ progeny were increasingly evident in the olfactory bulb (OB) and dentate gyrus (DG) granule cell layer. (jneurosci.org)
These (dental pulp) stem cells can be induced under defined culture conditions to form calcified nodules in vitro and have been shown to differentiate into a dentin/pulp like structure in vivo. (nih.gov)
However, the visceral rather than the subcutaneous ASC could represent a more appropriate in vitro cell model for investigating the molecular mechanisms implicated in the pathophysiology of metabolic disorders such as obesity. (unifi.it)
The burgeoning preclinical and clinical experience with human adult adipose-derived cells appears to be promising but interpretation of the current literature with in vitro studies, translational research and FDA-registered investigations emphasizes the need for standardized methods to advance basic science knowledge and beneficial safe clinical outcomes. (scirp.org)
Stem cells are derived from surplus in vitro fertilised eggs donated by infertility clinics. (org.in)
The fundamental challenge of work on stem cells lies in unlocking the mechanism that directs the differentiation of pluripotent stem cells into specific cell lineages in vitro . (biomedcentral.com)

Two prospective randomized phase III studies are active: the Autologous Stem cell Transplantation International Scleroderma (ASTIS) trial in Europe and the Scleroderma Cyclophosphamide Or Transplant (SCOT) trial in the USA. (medscape.com)
Adults with severe sickle cell disease were successfully treated with a stem cell transplant approach that doesn't require extensive immune-suppressing drugs. (nih.gov)
Blood drawn from a sickle cell patient (top) and a patient after stem-cell transplant (bottom). (nih.gov)
In earlier studies, transplant recipients were found to have a mix of their own and the donor's cells in their blood. (nih.gov)
Based in part on these findings in children, as well as other preliminary work, a team at NIH's Clinical Center in Bethesda, Maryland, set out to test a modified transplant procedure in adults with sickle cell disease. (nih.gov)
They then underwent a stem cell transplant, receiving cells donated by a healthy brother or sister. (nih.gov)
Not having to permanently rely on this medication, along with use of the relatively less-toxic partial stem cell transplant, means that even older patients and those with severe sickle cell disease may be able to reverse their condition. (nih.gov)
People with sickle cell disease interested in joining NIH blood stem-cell transplant studies may call 1-800-411-1222 or visit the NIH clinical trials registry at https://clinicaltrials.gov for more information. (nih.gov)
this story features Cindy Schroeder's recovery from multiple myeloma after an adult stem cell transplant. (physiciansforlife.org)
A New Stem Cell Enters: Induced Conditional Self-Renewing Progenitor Cells (ICSP) Second Chance at Life for Adult Stem Cell Transplant Patient Genetic Abnormalities Discovered Associated With The Creation Of 'iPS' Stem Cells / More Genetic Problems with. (physiciansforlife.org)
A patient who received his own adult stem cells got results that were in striking contrast, he had almost full recovery for several years after the transplant. (cellmedicine.com)
DALLAS - June 13, 2016 - Texan Chuck Dandridge became the first adult in the U.S. to receive a newly modified stem cell transplant that uses genetically engineered blood cells from a family member, announced researchers at UT Southwestern Medical Center's Harold C. Simmons Comprehensive Cancer Center where the procedure was performed. (utsouthwestern.edu)
Texan Chuck Dandridge became the first adult in the U.S. to receive a newly modified stem cell transplant that uses genetically engineered blood cells from a family member. (utsouthwestern.edu)
He did not go into complete remission, but had an excellent response," said Dr. Vusirikala, Director of UT Southwestern's National Marrow Donor Program, part of the stem cell transplant program. (utsouthwestern.edu)
That success made him eligible for a potentially curative stem cell transplant. (utsouthwestern.edu)
Once again, Mr. Dandridge volunteered for a cutting-edge clinical trial, known as BP-001, which processed the stem cells used in the transplant to reduce the risk of rejection and engineered blood cells that can be targeted if GvHD develops after the transplant. (utsouthwestern.edu)
The study is evaluating patients with blood cell cancers who have a peripheral blood stem cell transplant from a partially matched relative. (utsouthwestern.edu)
Immune cells (T cells) from the relative (donor) are separated from the rest of the stem cells and genetically engineered in the Bellicum laboratory, and then given to the patient along with the stem cell transplant. (utsouthwestern.edu)
Recent advances in stem cell research have raised hopes of one day generating an essentially unlimited supply of replacement beta cells perfectly matched to the patient to avoid transplant rejection. (nih.gov)
Researchers are learning about mending a broken heart-that is, how to generate healthy heart muscle stem cells in the laboratory and then transplant those cells into patients with chronic heart disease. (issca.us)
The researchers found that the new transplant procedure resulted in infiltration of human glial progenitor cells throughout the brain and spinal cord. (sciencedaily.com)
Yet six and a half years after his adult stem-cell transplant, Barry is fully active and coaches a hockey team. (rollcall.com)
Transplanting genetically matched cells into a patient reduces the severity of transplant rejection by the patient's immune system. (ed.ac.uk)

BIOLOGY OF ADULT STEM CELLS IN AGING Release Date: June 6, 2001 RFA: RFA-AG-01-006 National Institute on Aging ( http://www.nih.gov/nia/ ) Letter of Intent Receipt Date: August 14, 2001 Application Receipt Date: September 11, 2001 THIS RFA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. (nih.gov)
PURPOSE This Request for Applications (RFA) is to solicit applications that address the basic biology of adult stem cells in aging. (nih.gov)
Topics of interest include fundamental stem cell biology, ontogeny, gerontology, and the therapeutic potential of stem cells. (nih.gov)
However, siRNAs are difficult to deliver into cells and current delivery approaches result in cytotoxicity, poor percentage of cells, changes in the overall transcription and biology of the cells, and even DNA damage. (ca.gov)
Over the last 9 months of funding, we have rapidly advanced this approach, called PTD-DRBD mediated siRNA delivery, and find that it is non-cytotoxic, delivers siRNAs into the entire population of all cell types, including stem cells and iPS cells, and has a minimal effect on the overall cell biology or other non-targeted gene expression profiles. (ca.gov)
To engage in this debate, it is important to have an overview of stem cell biology. (jci.org)
This provides an important road map for learning about regeneration by highlighting the importance of direct cell-cell transfer of small molecules between stem cells and their neighbors explained the paper s lead author, N stor J. Oviedo, a postdoctoral fellow in the Forsyth Center for Regenerative and Developmental Biology. (cellmedicine.com)
The Symposium's goals are to help the science and field move forward, to find consensus regarding the translation of stem cell biology and research into a clinical setting, and to inspire participants in their own work. (nih.gov)
Importantly, ependymal cells that line the caverns of the brain (called ventricles) also sit right next to neural stem cells, suggesting that they might be important regulators of neural stem cell function," says senior author on the study Jeff Biernaskie, PhD, Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing, and associate professor of stem cell biology in the Faculty of Veterinary Medicine. (ucalgary.ca)
Jeff Biernaskie, PhD, is the Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing, and associate professor of stem cell biology at UCVM. (ucalgary.ca)
The cell biology of adipocytes has led to a number of promising concepts in the last century, especially in the areas of obesity and associated diseases, lipid homeostasis and endocrine functions. (scirp.org)
Since the specialty of Plastic Surgery with its position statement on stem cells and fat grafting is committed to advancing evidence-base preclinical and clinical studies in compliance with FDA-regulations, an updated review of cell biology provides insights to achieve these goals. (scirp.org)
The stem-cell meeting held at the Institut Pasteur in December 2004 proved that the nascent field of stem-cell biology has rapidly become one of the most exciting and active fields in current research. (biomedcentral.com)

Discoveries in recent years have suggested that adult stem cells might have the ability to differentiate into cell types from different germ layers. (wikipedia.org)
Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract, and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
Mouse embryonic stem cells have the capacity to differentiate into all cell types in the body when incorporated into the early embryo. (nih.gov)
Consequently, MSCs are considered to be multipotent in that they can give rise to a restricted number of different cell types, unlike pluripotent embryonic stem cells that can differentiate into essentially all the cells of the body. (scitizen.com)
An example would be a message that maintains and instructs a stem cell to specialize and differentiate into a needed type of cell such as a heart cell or a lung cell. (cellmedicine.com)
To overcome this hurdle, characterization of the stem-cell niche is important for understanding the molecular mechanisms whereby stem cells differentiate or self-renew. (nature.com)
Pluripotent stem cells have the ability to differentiate into all of the cells of the adult body. (nih.gov)
Stem cells are endowed with the ability to perpetuate themselves through self-renewal and to differentiate into many specialized cell types. (biomedcentral.com)
A crucial question is how a stem cell decides to self-renew rather than to differentiate, and which signaling pathways are at work in the two different states. (biomedcentral.com)

It is being explored by several companies that hope to manufacture adult stem cells and thereby reinvigorate regenerative medicine. (genengnews.com)
The possibility of using stem cells for regenerative medicine has opened a new field of investigation. (biomedcentral.com)
Moreover, the changes in the intrinsic and extrinsic factors involved in the stringent control of self-renewal and multilineage differentiation capacities of these regenerative cells, including deregulated signals from the aged niche, may also contribute to their dysfunctions or loss during chronological aging. (nih.gov)
This age-associated decline in the regenerative capacity and number of functional adult stem/progenitor cells may increase the risk to develop certain diseases. (nih.gov)
Our colleagues from Human Genetics have been interested in spermatogenesis and this is how we decided to look for spermatogonial stem cells with respect to regenerative medicine. (scitizen.com)
Human embryonic stem cells offer the promise of a new regenerative medicine in which damaged adult cells can be replaced with new cells. (jci.org)
Cell-based therapy for regenerative medicine is a major field of biomedical research including its use in the treatment of degenerative joint disease. (biomedcentral.com)
It has revolutionised the fields of stem cell research and regenerative medicine. (ed.ac.uk)

If you can target that mutation and stop the abnormal protein from being produced, then cells start behaving normally," said Dr. Madhuri Vusirikala , Professor of Internal Medicine and the primary investigator of many UT Southwestern clinical trials related to bone marrow transplantation. (utsouthwestern.edu)
New studies indicate that it may be possible to direct the differentiation of human embryonic stem cells in cell culture to form insulin-producing cells that eventually could be used in transplantation therapy for persons with diabetes. (issca.us)
The finding, they believe, demonstrates the feasibility of generating large quantities of adult skeletal muscle stem cells required for use in clinical applications, such as transplantation into the damaged muscles of people with muscular dystrophy. (nih.gov)
Two weeks later, the scientists were able to remove the marked stem cells from the mdx mice that had received the transplantation. (nih.gov)
Two weeks after the second transplantation, the same kind of genetically marked cells were again successfully retrieved from the mouse muscles. (nih.gov)
Scientists report a dramatic success in what may be the first documented rescue of a congenital brain disorder by transplantation of human neural stem cells. (sciencedaily.com)
Previous studies have explored the potential utility of cell transplantation for restoring absent or lost myelination to diseased nerve fibers. (sciencedaily.com)
Yet to date, no transplantation of human neural stem cells or of their derivatives, called glial progenitor cells, have ever altered the condition or fate of recipient animals. (sciencedaily.com)
Although much work needs to be done to maximize the number of individuals that respond to transplantation, I think that these findings hold great promise for the potential of stem cell-based treatment in a wide range of hereditary and ischemic myelin disorders in both children and adults. (sciencedaily.com)
Intramyocardial transplantation of mesenchymal stem cells (MSCs) has emerged as a leading contender in the pursuit of clinical intervention and therapy. (springer.com)
Menasche P (2003) Myoblast-based cell transplantation. (springer.com)
Please note that NLM indexing policy for these three new terms above dictates that if the article discusses transplantation of a specific type of stem cells, indexers shall index the specific stem cell with the subheading /transplantation. (nih.gov)
They will not coordinate with STEM CELL TRANSPLANTATION. (nih.gov)
Allogeneic stem cell transplantation in adults 2015-21. (bvsalud.org)
Allogeneic stem cell transplantation is the only curative treatment for several malignant and non-malignant haematological diseases , and is associated with a risk of serious complications . (bvsalud.org)
The study included 589 adult patients who were treated with allogeneic stem cell transplantation for the first time at Oslo University Hospital in the period May 2015 to May 2021. (bvsalud.org)

This photograph shows Brent Bobick, Ph.D., Postdoctoral Fellow, examining a test tube for gradient centrifugation, a process that enriches adult human bone marrow-derived mesenchymal stem cells by removing smaller, unwanted cells, such as red blood cells. (nih.gov)

As a result, most workers in the field recognise that they are probably working with a mixed population of cells that only contains a small subpopulation of true stem cells and it has been suggested that MSCs isolated and grown in this manner should be termed multipotent mesenchymal stromal cells to acknowledge this fact. (scitizen.com)
Beltrami AP, Barlucchi L, Torella D et al (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. (springer.com)
2012 . Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism. (nih.gov)
Background: We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARγ and that prenatal TBT exposure predisposes multipotent mesenchymal stem cells (MSCs) to become adipocytes by epigenetic imprinting into the memory of the MSC compartment. (nih.gov)

The Company seeks to apply its clinical-stage autologous bone marrow stem cell experiences to patients suffering from a specific type of Premature Ovarian Failure, in which menopause occurs at an accelerated rate. (prnewswire.com)
Creative Medical Technologies, the Company's wholly owned subsidiary, is currently running a clinical trial utilizing its patented CAVERSTEM TM approach for treatment of erectile dysfunction using bone marrow stem cells. (prnewswire.com)
The "potential of embryonic stem cells to possibly form every cell type" in the body is remarkable but is of minute clinical significance. (cellmedicine.com)
The record for adult stem cells compared to embryonic stem cells is exceptionally impressive if one looks at human clinical trials or research using experimental animals. (cellmedicine.com)
While still quite early, these clinical trial results are very promising that the approach we are using will likely not have any unintended consequences to the cells. (ca.gov)
Now, an NIH-funded team has succeeded in finding an additional switch that enables iPSC-derived beta cells to mature and produce insulin in a dish-a significant step toward moving this work closer to the clinical applications that many diabetics have wanted. (nih.gov)
Clinical trials are ongoing to improve current adult stem-cell treatments and develop others. (rollcall.com)
In Virginia, more than 70 adult stem-cell-related FDA-approved clinical trials are taking place now or already completed. (rollcall.com)
Meanwhile, funding for human adult stem-cell research, much of which is invested in the clinical trials for patients that we mentioned, increased only 20 percent during that same time period. (rollcall.com)
The scenario is an open public hearing of a research ethics committee, to decide on granting a licence for a clinical trial using human embryonic stem cells to treat spinal cord injuries. (eurostemcell.org)
I would recommend this role play as it gave me an insight into the application for a clinical trial process and background into stem cell research. (eurostemcell.org)
Using stem cells from adults with a clinical diagnosis of depression, the University of Illinois at Chicago researchers who conducted the study also found that fish oil, when tested in the model, created an antidepressant response. (brainhealtheducation.org)

These cells can be found in either a state of quiescence or of proliferation. (nih.gov)
Their value in drug testing and disease models, their lack of rejection, their rapid proliferation, their potential to form every cell type and finally, their great promise are the most often stated advantages of embryonic stem cells. (cellmedicine.com)
MSCs are capable of secreting a large array of soluble factors, which have had demonstrated effects on pathogenic cardiac remolding, fibrosis, immune activation, and cardiac stem cell proliferation within the damaged heart. (springer.com)

By producing allogeneic mesenchymal stem cells (MSCS) from adult human bone marrow MSCs, Longeveron intends to ameliorate diseases and disabilities associated with aging. (genengnews.com)
Mesenchymal stem cells (MSCs) have attracted widespread interest as promising candidates for the cell-based treatment of different degenerative disorders. (scitizen.com)
Importantly, MSCs display immuno-suppressive characteristics and are able to reduce an immune response and promote the engraftment of different cell types, such as skin cells and blood cells. (scitizen.com)
a forum such as this provides an opportunity to advance the understand and application of MSCs so that we can optimise the potential of these valuable cells. (scitizen.com)
MSCs are also capable of differentiation into cardiomyocytes, endothelial cells, and vascular smooth muscle cells, although the relative contribution of trilineage differentiation and paracrine effectors on cardiac repair remains the subject of active investigation. (springer.com)

The patent-pending technology utilizes cells extracted from the patient's own bone marrow and processed in a manner to select for stem cells that participate in generation of new blood vessels termed "Endothelial Progenitor Cells" (EPC). (prnewswire.com)
The mammalian pituitary gland is a complex organ consisting of hormone-producing cells, anterior lobe folliculostellate cells (FSCs), posterior lobe pituicytes, vascular pericytes and endothelial cells, and Sox2-expressing stem cells. (nih.gov)
Vodyanik MA, Yu J, Zhang X et al (2010) A mesoderm-derived precursor for mesenchymal stem and endothelial cells. (springer.com)
Similar results were obtained with genuine endothelial cells sorted from human adult muscle. (biomedcentral.com)

The technique, which was successfully tested on adult mice, could avoid completely the ethical problems associated with human embryonic stem cells. (scitizen.com)
You are aware of the immunological problem associated with embryonic stem cells and, in particular, of the ethical problem associated with human embryonic stem cells. (scitizen.com)

Abstract: The parent grant of our NCI sponsored study (CA168312) focuses on how the colonic stem cell population responds to environmental factors such as diet, chronic inflammation, and carcinogen exposure. (nih.gov)

The stem cell industry took some nasty blows in the early 2000s, when the morality of using embryonic stem cells was questioned and all but a few lines of those cells were excluded from federal research grants. (genengnews.com)
Applications are being developed for basic research, drug testing, and cell-based therapeutics. (genengnews.com)
Previous research has shown that the transition from quiescence to the proliferative state requires the action of cellular structures called mitochondria, which take chemical energy from sugars and fats and convert it into fuel that is usable throughout the cell. (nih.gov)
Furthermore, research on how to control even mouse embryonic stem cells to form desired, functional cell types in the desired locations in the body has produced limited results. (nih.gov)
September - February 2010: Stem Cell Research, ETC. (physiciansforlife.org)
Adult Stem Cell Research Makes Progress for Heart Patients as Embryonic Debate Goes On Umbilical Cord Blood Stem Cell Research Treatments Help Children With Type 1 Diabetes Adult Stem Cells From Human Umbilical Cord Blood Successfully Engineered To. (physiciansforlife.org)
What are the implications of you discovery in the stem cell research field? (scitizen.com)
Preliminary research in mice and other animals indicates that bone marrow stromal cells, transplanted into a damaged heart, can have beneficial effects. (issca.us)
The use of adult-derived stem cells for cardiac repair is an active area of research. (issca.us)
Research is needed to determine the most viable stem cell lines and reliable ways to promote the differentiation of pluripotent stem cells into specific cell types (neurons, muscle cells, etc. (jci.org)
A stem cell is defined by two properties (see A stem cell research lexicon ). (jci.org)
Continuing our steadfast mission to increase public awareness of adult stem cells, SFLF regularly combs the media for trustworthy stem cell news that highlight advances in research and treatment breakthroughs. (stemforlife.org)
To foster the highest levels of scientific research on adult stem cells and explore the cultural, ethical and human implications of these cells. (adultstemcellconference.org)
The nature of the messages that control stem cell regulation may be better understood by scientists because of this research. (cellmedicine.com)
Promoting gap junction-mediated signaling as a new and tractable control point for adult, somatic cell regulation, this research demonstrates a novel role for gap-junction proteins. (cellmedicine.com)
Dr. Huard and his colleagues suggested that more research needs to be done before using adult muscle stem cell therapy in MD patients. (nih.gov)
The research, published by Cell Press in the June issue of the journal Cell Stem Cell, may lead the way to new strategies for treating certain hereditary and perinatal neurological disorders. (sciencedaily.com)
Last March, President Barack Obama opened more taxpayer funding for stem-cell research and authorized use of virtually any embryonic stem cells for research. (rollcall.com)
Biernaskie says the research not only clarifies the identity of the adult neural stem cell, it also provides a new model to study the function of ependymal cells and their role in maintaining normal brain function. (ucalgary.ca)
Participants role play members of the committee and different stakeholders in the audience, and in doing so engage in debates on the scientific and social issues surrounding stem cell research. (eurostemcell.org)
to involve people in the debates on the scientific and social issues surrounding stem cell research. (eurostemcell.org)
After completing the role play, participants should have a better understanding of the basic scientific concepts underlying stem cell research. (eurostemcell.org)
However, the main objective of this resource is to be an exploration of the social issues around stem cell research. (eurostemcell.org)
In what could hit the field of medical research, Europe's top court has banned patenting any stem-cell process that involves destroying a human embryo. (org.in)
Stem cell research has faced similar ethical bottlenecks elsewhere in the world. (org.in)
Former president George W Bush had banned federal funding of stem cell research in 2001, sending stem cell labs across the country into dismay. (org.in)
Promising as it may be, stem cell research is far from being used in hospital settings to save lives yet. (org.in)
Even in the US, which is at the forefront of this research, use of stem cells in practical settings is limited. (org.in)
The ban will not affect patenting of research techniques involving adult stem cells as well. (org.in)
We are saddened to hear that the European Court has chosen to make it far more difficult for those in the EU to benefit from the fruits of stem cell research," says B D Colen, spokesperson for The Harvard Stem Cell Institute in the US. (org.in)
Swathi Sundarraj, research scientist with Stempeutics, a Bengaluru-based firm that researches stem cells, concurs. (org.in)
This EuroStemCell video gives you a short introduction to the world of stem cells and stem cell research. (ed.ac.uk)
The cells can be grown indefinitely and used to make all kinds of different cells for both scientific research and, potentially, to replace dying cells in patients with diseases like Parkinson's. (ed.ac.uk)
The technology for making iPS cells was developed by Professor Shinya Yamanaka's research group at the University of Kyoto and was announced to the scientific community in 2006. (ed.ac.uk)
We learnt more about Christine's research in conversation at a stem cell conference in Paris in April 2011. (eurostemcell.org)
The stem cell patents, owned by the Wisconsin Alumni Research Foundation, have been involved in re-examination proceedings in the U.S. Patent and Trademark Office prompted by two groups: the Public Patent Foundation ( PUBPAT ), headed by Dan Ravicher , and The Foundation for Taxpayer and Consumer Rights ( FTCR ), a California taxpayer group. (patentdocs.org)

Despite this, a thorough characterization of these cells remains elusive and with it the ability to eradicate cancer at its source. (nature.com)
Characterization of cultured adult Corturnix japonica testicular germ stem cells using seven stem cell markers. (sandiegozoo.org)

They have the capacity to undergo dynamic endocrine-induced changes during the menstrual cycle, including cell growth and regeneration, in order to provide the unique environment required for the maintenance of male and female gamete viability, fertilization, and early embryo development as well as transport to the uterus [ 24 ]. (biomedcentral.com)
However, adult/somatic stem cell behavior in vivo or in organ regeneration has never been functionally linked to a specific gap junction protein before. (cellmedicine.com)
Montserrat N, Jopling C, Izpisua Belmonte JC (2010) Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury? (springer.com)
But are satellite cells the only source of skeletal muscle regeneration? (biomedcentral.com)

Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem cells. (wikipedia.org)

The Stem Cell Interest Group was established to enhance communication and to foster collaboration among scientists from varying disciplines interested in stem cells. (nih.gov)
Scientists that either hold key patents or are strongly supported by biotech companies pursuing embryonic cells commercially are the ones that state that embryonic stem cells hold great promise. (cellmedicine.com)
Thus, some scientists argue this dilemma as a reason for human cloning so the rejection of embryonic stem cells can be avoided, but cloning carries its own set of problems and moral dilemmas. (cellmedicine.com)
In a report recently published in Nature, a team of scientists describe a new technique to produce pluripotency stem cells from testis cells. (scitizen.com)
The following is a list of steps in successful cell-based treatments that scientists will have to learn to control to bring such treatments to the clinic. (issca.us)
An important mechanism for controlling the behavior of adult stem cells has been discovered by scientists at the Forsyth Institute. (cellmedicine.com)
The scientists showed that a subpopulation of adult muscle stem cells, obtained from skeletal muscles of normal mice, could undergo up to 300 population doublings (PDs) under laboratory conditions. (nih.gov)
The scientists also genetically marked some muscle stem cells obtained from normal mice, and transplanted them into the muscles of "mdx mice," an animal model of muscular dystrophy. (nih.gov)
Such information may also enable scientists to grow stem cells more efficiently in the laboratory. (nih.gov)
The specific factors and conditions that allow pluripotent stem cells to remain undifferentiated are of great interest to scientists. (nih.gov)
Stem cells are cells which can multiply infinitely and scientists are exploring this property in contriving cures for diseases like cancer and Parkinson's. (org.in)
By exploiting an HIV protein that readily traverses cell membranes, Carnegie Mellon University scientists have developed a new way to introduce a gene-like molecule called a peptide nucleic acid (PNA) directly into live mammalian cells, including human embryonic stem (ES) cells. (news-medical.net)
Scientists at the University of California, Berkeley, have given "blind" nerve cells the ability to detect light, paving the way for an innovative therapy that could restore sight to those who have lost it through disease. (news-medical.net)
A team of University of Sussex-led scientists has identified crucial elements necessary for repairing damaged DNA - the blueprint for all living cells. (news-medical.net)
This can allow scientists to learn more about the disease by studying the patient's cells in the lab. (ed.ac.uk)

Recently, researchers reported that during proliferative growth the mitochondria of adult blood stem cells from both female and male mice accumulate defects that limit their ability to convert food energy into cellular fuel. (nih.gov)
Finally, quantification of YFP+ cells in nestin-CreER T2 /R26R-YFP mice allowed us to estimate, for example, that stem cells and their progeny contribute to no more than 1% of the adult DG granule cell layer. (jneurosci.org)
Studies addressing these questions typically use thymidine analogs such as bromdeoxyuridine (BrdU) that target rapidly dividing cells or transgenic reporter mice that label discrete stages of adult neurogenesis. (jneurosci.org)
In addition, we quantify the diverse composition of labeled cells over months following recombination, as well as estimate the total contribution of stem cells and their progeny to adult mice. (jneurosci.org)
We managed to isolate adult spermatogonial stem cells from adult mice and we brought these cells into culture to modify those cells and under those culture conditions these cells gained pluripotency similar to embryonic stem cells. (scitizen.com)
We did it from different approaches from transgentic mice in which spermatogonial stem cells specific gene is coupled to fluorescent protein in order to be able to identify these cells and later we managed to identify these cells from different mice strain. (scitizen.com)
More than 40 years later, in 2006 Yamanaka discovered how intact mature cells in mice could be reprogrammed into pluripotent, immature stem cells. (stemforlife.org)
Researchers have recently discovered that a subpopulation of muscle-generating stem cells in adult mice can replicate themselves up to 300 times over a six-month period. (nih.gov)
Once these marked stem cells were retrieved, they were expanded (multiplied) under laboratory conditions, and then transplanted into muscles of another group of mdx mice. (nih.gov)
Successful serial transplantations of stem cells in two groups of mdx mice suggest that this type of stem cells can renew itself in the muscles of living mice. (nih.gov)
In addition, they developed a new cell delivery strategy, based on multiple injection sites, to encourage widespread and dense donor cell engraftment throughout the central nervous system of recipient mice. (sciencedaily.com)
The researchers transplanted human glial stem cells into neonatal shiverer mice that also had a genetically deficient immune system. (sciencedaily.com)
Immunodeficient mice were used to minimize the rejection of the transplanted cells. (sciencedaily.com)
Upon histological examination well over a year after the procedure, the white matter of the surviving mice had been essentially re-myelinated by human cells. (sciencedaily.com)
Conversely, the cell cycle of long-term repopulating HSCs (LT-HSCs) in Gal-3-deficient (Gal-3 -/- ) mice is accelerated, resulting in their exhaustion. (nature.com)
Conversely, loss of IL-22 in knockout mice led to a decrease in neurosphere yield, suggesting a reduction in the NSC population, which was confirmed by the decrease in cells retaining BrdU labeling in IL-22 knockout mice. (mysciencework.com)
F1 animals were exposed in utero and F2 mice were potentially exposed as germ cells in the F1, but F3 animals were never exposed to the chemicals. (nih.gov)

Multipotency or multidifferentiative potential is the ability to generate progeny of several distinct cell types, (for example glial cells and neurons) as opposed to unipotency, which is the term for cells that are restricted to producing a single cell type. (wikipedia.org)
Understanding the fate of adult-generated neurons and the mechanisms that influence them requires consistent labeling and tracking of large numbers of stem cells. (jneurosci.org)
In addition, most SVZ and SGZ YFP+ cells became neurons, underscoring a link between nestin and neuronal fate. (jneurosci.org)
Using this mouse, we explore whether adult-generated neurons are derived from the nestin lineage. (jneurosci.org)
Eventually a stem cell becomes known as a "progenitor" or "precursor" cell, committed to producing one or a few terminally differentiated cells such as neurons or muscle cells. (jci.org)
One type, astrocyte neural stem cells, can self-renew and generate new neurons, particularly following brain injury. (ucalgary.ca)
To their surprise, after tracking these cells over several months in either the normal or injured brain, they failed to find any instances of ependymal cell division or new neurons being generated from the ependymal cells (hallmark features of a neural stem cell). (ucalgary.ca)
Recent studies have shown that new neurons are continuously generated by endogenous neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain. (hindawi.com)
NSCs residing in the subventricular zone (SVZ) at the lateral walls of the lateral ventricle and in the subgranular zone (SGZ) in the dentate gyrus of the hippocampus produce new neurons and glial cells throughout adult life in mammals [ 7 - 11 ]. (hindawi.com)
Here, we report that growth factors released from biodegradable gelatin hydrogel microspheres increase new neurons in the adult mouse brain. (hindawi.com)
Many laboratories are working in this direction, and focusing their efforts on a specific cell type: Henrik Sembe (Lund University, Sweden) reported progress on the differentiation of pancreatic cells and Ron McKay (National Institute of Neurological Disorders and Stroke, Bethesda, USA) on the differentiation of dopamine neurons. (biomedcentral.com)

There have been recent exciting advances in our understanding of the stem and progenitor cells of the mammalian lung. (nih.gov)

Once qualified, Adult Stem Cells are extracted from the patient's own blood and/or fat, via a standard draw procedure. (alzinfo.org)

The adult stem cell can be labeled in vivo and tracked, it can be isolated and then transplanted back into the organism, and it can be isolated in vivo and manipulated with growth hormones. (wikipedia.org)
In addition to revealing the dynamic contribution of nestin-expressing stem cells to adult neurogenesis, this work highlights the utility of the nestin-CreER T2 /R26R-YFP mouse for inducible gene ablation in stem cells and their progeny in vivo in the two major regions of adult neurogenesis. (jneurosci.org)
Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER(T), GFAP-CreER(T2), Sox2(CreERT2), and Gli1(CreERT2) and were long-lived in vivo. (nih.gov)
To molecularly dissect conserved stem cell regulatory mechanisms in vivo, planarians have been recognized as a great model system in recent years. (cellmedicine.com)
As crucial signals that determine behavior of adult stem cells in vivo, Drs. Oviedo and Levin focused on direct cell-cell transfer of small molecules and ions. (cellmedicine.com)
Focal lesions developed in vivo resulting from these traumatic impacts will be repaired using stem cell-laden hydrogel or nanofiber constructs. (biomedcentral.com)
these cells have dramatic myogenic potential in vivo . (biomedcentral.com)

More importantly, the researchers successfully showed that these cells were able to maintain their ability to regenerate skeletal muscles when expanded to the level of 200 PDs. (nih.gov)
When expanded beyond 200 PDs, however, the cells lost some of their ability to regenerate muscles and started to demonstrate some of the characteristics of cancer cells. (nih.gov)
Unfortunately, when brain cells are damaged by trauma or disease, they don't automatically regenerate. (ucalgary.ca)
Adult skeletal muscle can regenerate following injury and this process seems to be mediated primarily by stem cells, known as myogenic satellite cells, present in adult muscle fibers. (biomedcentral.com)

We generated a nestin-CreER T2 /R26R-yellow fluorescent protein (YFP) mouse to inducibly label nestin-expressing stem cells and their progeny in the adult subventricular zone (SVZ) and subgranular zone (SGZ). (jneurosci.org)
We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast(mid)EGFR(high)PlexinB2(high)CD24(-/low)O4/PSA-NCAM(-/low)Ter119/CD45(-) (GEPCOT) cells. (nih.gov)
IL-22 is present in the brain, which harbors neural stem cells (NSC) in specific niches of which the ventricular-subventricular zone (V-SVZ) is the most important. (mysciencework.com)

Here, we report for the first time the isolation of human adipose-derived adult stem cells from visceral omental and subcutaneous fat (V-ASCs and S-ASCs, respectively) from the same subject. (unifi.it)

However, some researchers do not consider multipotency to be essential and believe that unipotency self-renewing stem cells can exist. (wikipedia.org)
In the void that remained, determined stem cell researchers found a way forward: adult stem cells. (genengnews.com)
The reprogramming technology developed by stem cell researchers is beginning to bear fruit. (genengnews.com)
Researchers at the Fourth Military Medical University in Xi'an, China, have successfully bioengineered artificial skin using adult stem cells derived from bone marrow. (cellmedicine.com)
Researchers funded by the National Institutes of Health have produced human uterine endometrial cells from adult stem cells. (nih.gov)
Pending further studies, the researchers believe that it may be possible to transform a patient's own iPSCs into endometrial stromal cells that could replace her endometrial lining. (nih.gov)
According to one of the co-researchers, Dr. Timothy J. Henrich of Brigham and Women's Hospital in Boston, cells that repopulated the patient's immune system appear to be immune from becoming re-infected with HIV because of concerns with effectiveness and safety. (stemforlife.org)
Involved in cell-to-cell communication, the proteins in the flatworm, planaria, are play a novel role as researchers have observed. (cellmedicine.com)
Work by researchers at the University of Calgary Faculty of Veterinary Medicine sheds new light on the identity of the cells that exhibit neural (brain) stem cell function. (ucalgary.ca)
In this study, the researchers developed a process allowing them to specifically label ependymal cells within the adult brain, while avoiding astrocyte stem cells. (ucalgary.ca)
Researchers study many different types of stem cells. (nih.gov)
Researchers at the University of California, Santa Cruz, have shown that rifampicin, an antibiotic used to treat leprosy and tuberculosis, can prevent the formation of protein fibrils associated with the death of brain cells in people with Parkinson's disease. (news-medical.net)

To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). (wikipedia.org)
With each round of proliferative growth, Drp1 loss therefore reduces the capacity of the blood stem cells to undergo future rounds of cell division. (nih.gov)
No significant change in the event-free survival rate is noted in splenectomized patients who undergo hematopoietic stem cell rescue. (medscape.com)
The cells also had the ability to respond to the hormone progesterone and undergo changes needed to prepare for implantation of an embryo. (nih.gov)
Second, stem cells can, on cue, undergo an asymmetric division to produce two dissimilar daughter cells. (jci.org)

Ten years ago several groups considered adopting the oncological approach of myeloablative therapy followed by haematological 'rescue' using either autologous or allogeneic hematopoietic stem cells to treat severe, therapy-resistant autoimmune disease. (medscape.com)

Like cells from the embryo, iPSCs can be programmed to develop into many different types of adult cells. (nih.gov)
In endometriosis patients with infertility, the regenerated endometrial cells might also be more receptive to implantation by an embryo, improving chances of pregnancy. (nih.gov)
Asked what the difference is between an iPS cell that has been reverted back to its pluripotent state and an embryo in its earliest, single-cell stage, Gurdon replied, "Probably none. (lifesitenews.com)
However, there are ethical issues surrounding the use of embryonic stem cells as their production results in the destruction of an embryo. (ed.ac.uk)

It is believed that the molecular distinction between symmetric and asymmetric divisions lies in the differential segregation of cell membrane proteins (such as receptors) and their associated proteins between the daughter cells. (wikipedia.org)
A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication. (brainhealtheducation.org)
Recently, thanks to the work of several groups, including those of Peter Andrews (University of Sheffield, UK), Austin Smith (University of Edinburgh, UK) and our own, the molecular signature underlying the 'stemness' state of human embryonic stem cells (hES cells) is being defined. (biomedcentral.com)
These changes may provide a selective advantage for the propagation of undifferentiated hES cells, and a detailed analysis of the genes present in these chromosomal regions might further elucidate the molecular mechanisms underlying self-renewal. (biomedcentral.com)

Other recent studies in cell culture systems indicate that it may be possible to direct the differentiation of adult bone marrow cells into heart muscle cells. (issca.us)

Dr. Steve Goldman and colleagues from the Departments of Neurology and Neurosurgery at the University of Rochester Medical Center, along with collaborators at Cornell, UCLA and Baylor, built on this earlier work by devising a more robust method for the acquisition and purification of human fetal glial progenitor cells. (sciencedaily.com)

The new genetically engineered blood cells were transplanted from his son, Jon, and thanks to the procedure, Mr. Dandridge's leukemia is in remission. (utsouthwestern.edu)

Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (nih.gov)
IL-22 Promotes Neural Stem Cell Self-Renewal in the Adult Brai. (mysciencework.com)

The first of which is their ability to divide or self-renew indefinitely, and the second their ability to generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. (wikipedia.org)
The deformed cells can block blood flow, causing severe pain, organ damage, and stroke. (nih.gov)
Side effects caused by immunosuppressants can endanger patients already weakened by years of organ damage from sickle cell disease," says senior author Dr. John Tisdale. (nih.gov)

Alternatively, iPSCs could be used to generate replacement cells for women with a damaged endometrium because of abnormal uterine development or to treat after some cases of endometrial cancer. (nih.gov)

Mesenchymal stem cells may have an immunomodulatory role in autoimmune disease. (medscape.com)
He and his team had recently conducted and published the results of a 45-patient allogenei C human mesenchymal stem cells in patients with aging f RA il T y via intraveno US delivery (CRATUS) study. (genengnews.com)
Electron microscopy and electrophysiological and real-time RTPCR analyses confirm the mesenchymal stem nature of both V-ASCs and S-ASCs, while no significant differences in a limited pattern of cytokine/chemokine expression can be detected. (unifi.it)
Recent advances in adipogenesis had provided insights into understanding of the complex cues for influencing the cytoarchitecture, epigenomic remodeling, signaling pathways and transcription regulators on gene actions for both white and brown adipogenic progression from mesenchymal stem cells to matured committed adipocytes. (scirp.org)

Importantly, adult stem cells in this model are primed to become cancer stem cells. (nih.gov)
To date, the effect of diet on cancer stem cells, deviant stem cells with cancer-causing misbehavior, has not been investigated. (nih.gov)
Furthermore, Arf1 inhibitors inhibit cancer stem cells in human cancer cell lines. (nih.gov)
Our results suggest that normal stem cells or cancer stem cells like hibernating animals may mainly rely on lipid reserves for energy supply and blocking of lipolysis can starve them to death. (nih.gov)
Cancer stem cells drive disease progression and relapse in many types of cancer. (nature.com)
Taken together, we demonstrate the power of single-cell multi-omic approaches in characterizing cancer stem cells. (nature.com)
Acute myeloid leukemia (AML) serves as a paradigm for the study of cancer stem cells 5 . (nature.com)
Here, we propose that by measuring mutational status and gene expression in single cells simultaneously, cancer stem cells can be uniquely distinguished from both mature cancer cells (based on gene expression) and healthy stem cells (based on mutational status) (Fig. 1a ). (nature.com)

In people who suffer from type 1 diabetes, the cells of the pancreas that normally produce insulin are destroyed by the patient's own immune system. (issca.us)
Clearly, a technology that offers a possible alternative to artificial dentures by designing and transplanting a set of living teeth fashioned from the patient's own pulp cells would greatly improve the individual's quality of life. (nih.gov)
This therapy consist in apply Stem Cell ( Previously collected from a patient's bone marrow) & Them implanted in the body. (alzinfo.org)
Since it is the patient's own cells, there is no possibility of the body rejecting its own stem cells. (alzinfo.org)

Here we report the first inducible nestin-CreER T2 mouse that can be used to label, track, and phenotype stem cells and their progeny in the adult SVZ and SGZ. (jneurosci.org)
Our data provide unique insight into the importance of stem cells to neurogenesis in the SVZ and SGZ and underscore the utility of this mouse in gene deletion from stem cells and their progeny in the adult brain. (jneurosci.org)
In addition, use of small molecule inhibitors that cause global changes to stem cells and their cell lineage progeny for therapeutic benefit may also result in undesirable cell stress and cytotoxicities that can permanently alter the cell's physiology in an unintended manner. (ca.gov)

Current approaches to manipulate stems cells into specific cell types or lineages requires exposure of stem cells to DNA vectors can result in integration of the DNA element into the chromosome of the stem cell and thereby potentially induce a non-desirable effect, including malignant mutation. (ca.gov)

Stem cells in adult humans may hold the potential to form needed cell types in cases where disease or injury have destroyed the original cells. (nih.gov)
Because MDS is a clonal early stem-cell disorder with very limited residual nonclonal stem cells, myeloablative therapy is the only treatment option with a realistic curative potential. (medscape.com)
The topic of stem cells is a hot issue due to all the vast potential they have, the ethical debates they entail, and the political party alignments that are associated with. (cellmedicine.com)
Furthermore, stem cells derived from adults have the same potential as numerous studies have supported. (cellmedicine.com)
In 10-20% of healthy individuals over age 70, the acquisition of pre-leukemic mutations in hematopoietic stem cells (HSCs) results in the dominance of a small number of HSC-derived clones, a process termed Clonal Hematopoiesis of Indeterminate Potential (CHIP) 6 , 7 . (nature.com)
Each potential use of stem cells promises revolutionary advances. (jci.org)
This cell contains a different set of genetic instructions (resulting in an alternative pattern of gene expression) and is characterized by a reduced proliferative capacity and more restricted developmental potential than its parent. (jci.org)
Another issue of importance is the potential of highly expanded muscle stem cells to become cancerous. (nih.gov)
Stem cells have the remarkable potential to renew themselves. (nih.gov)
Towards this goal, stem or progenitor cells have been considered a highly desirable candidate cell type, because of their expandability and potential to be induced toward specific cell differentiation lineages. (biomedcentral.com)

Myelin enhances the speed and coordination of the electrical signals by which nerve cells communicate with one another. (sciencedaily.com)
Unlike muscle cells, blood cells, or nerve cells-which do not normally replicate- stem cells may replicate many times. (nih.gov)
Yet they can give rise to all of the differentiated cells in the body, such as heart muscle cells, blood cells, and nerve cells. (nih.gov)
He held a patent (obtained in 1991) for a process that can convert human embroynic cells into nerve cells. (org.in)
For example, intestinal stem cells can produce the different types of cell found in the intestine, but not other cells in other organs like nerve cells. (ed.ac.uk)
iPS cells from patients can then be differentiated into specialised cells, for example, iPS cells from a patient with Alzheimer's disease could be turned into nerve cells. (ed.ac.uk)

A stem cell possesses two properties: Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. (wikipedia.org)
Long-term self-renewal of postnatal muscle-derived stem cells. (nih.gov)
Addition of IL-22 to V-VSZ cell cultures resulted in an increase in NSC self-renewal, associated with a shift in NSC division mode towards symmetric proliferative divisions at the expense of differentiative divisions. (mysciencework.com)
Discovering the mechanism behind self-renewal may make it possible to understand how cell fate (stem vs. non-stem) is regulated during normal embryonic development and post-natally, or misregulated as during aging, or even in the development of cancer. (nih.gov)

Patients who have undergone myeloablative therapy with stem cell rescue should be monitored for long-term sequelae, including short stature, obesity, gonadal failure, hypothyroidism, and cataracts. (medscape.com)
Myeloablative therapy with hematopoietic stem cell rescue from a human leukocyte antigen (HLA)-matched sibling is the best therapy for MDS. (medscape.com)
The cells must mature into a particular type of cell to be functional in therapy. (cellmedicine.com)
Several different methods have been studied for treating MD, including gene therapy, pharmacological therapy and cell therapy. (nih.gov)
After his doctor told him his heart attacks had damaged his heart so badly that he only had a short time to live, Doug sought out a therapy that injected his own adult stem cells into his heart, helping it rebuild damaged muscle. (rollcall.com)
Neuroregenerative therapy using endogenous NSCs in the SVZ is a highly anticipated emerging strategy for treating human brain diseases because it avoids the risk of immunological incompatibility and the ethical problems inherent in harvesting human cells, and it may reduce the risk of tumorigenesis-which are all problems associated with transplanted stem cells [ 18 , 19 ]. (hindawi.com)
Alexander, P.G., Tuan, R.S. Adult stem cell-based therapy for degenerative joint diseases. (biomedcentral.com)
Stem Cell Therapy For Alzhaimers Disease! (alzinfo.org)
Adult Stem Cell Therapy : is safe, highly effective and presents minimal risk. (alzinfo.org)

Amazing New Spinal Cord Implant Revives Legs of 4 Paralyzed Men Save a Baby's Life, Save Two Lives with Umbilical Cord Blood Error Eventually Promotes Truth … [Ed. While this is actually not a stem cell success, it is a. (physiciansforlife.org)

When injected under the skin of the adult mouse, they form tumors that contain many differentiated cell types. (nih.gov)
We have generated over 50 transducible proteins that enter the entire population of all cell types tested, including human embryonic stem cells and adult stem cells. (ca.gov)
Over the coming year, we anticipate that these technological advances will increase our productivity to gently manipulate stem cells and iPS cells into specific cell types. (ca.gov)
We present single-cell RNA sequencing and immunohistofluorescence analyses of pituitary cells of adult female rats with a focus on the transcriptomic profiles of nonhormonal cell types. (nih.gov)
Several types of adult stem cells are currently being studied to see if they are capable of regenerating skeletal muscles. (nih.gov)
Injury models have also revealed evidence for an unexpected level of epithelial cell "plasticity" in which differentiated cells change their phenotype and give rise to either new stem cells or different cell types. (nih.gov)
They can develop into many different cell types in the body during early life and growth. (nih.gov)
It has taken many years of trial and error to learn to derive and maintain pluripotent stem cells in the laboratory without the cells spontaneously differentiating into specific cell types. (nih.gov)
that is, the number of different cell types that they can form. (nih.gov)

Anatomy56

Organisms10

Diseases7

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes48

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science2

Induced-pluripotent11

Progenitor cell5

Embryonic stem11

Tissues33

Tissue40

Pluripotent cells1

Populations11

Therapies9

Embryos11

Hematopoietic stem cell trans6

Vitro9

Transplant23

Biology13

Differentiate9

Regenerative8

Transplantation16

Bone marrow-derived1

Multipotent4

Clinical12

Proliferation3

MSCs5

Endothelial4

Associated with human embryonic2

Abstract1

Research36

Characterization2

Regeneration4

Somatic stem cells1

Scientists15

Mice17

Neurons11

Mammalian1

Extracted from the patient's1

Vivo7

Regenerate4

Subventricular zone3

Adipose-derived1

Researchers12

Undergo5

Allogeneic1

Embryo4

Molecular4

Differentiation of adult1

Glial1

Genetically1

Neural stem2

Organ3

IPSCs1

Mesenchymal stem4

Cancer stem8

Patient's4

Progeny3

Including malignant1

Potential10

Nerve cells6

Self-renewal4

Therapy9

Umbilical cord1

Types9