OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
AdrenomedullinCalcitoninReceptors, AdrenomedullinCalcitonin Gene-Related PeptideReceptors, CalcitoninCalcitonin Receptor-Like ProteinReceptors, Calcitonin Gene-Related PeptideReceptor Activity-Modifying ProteinsReceptor Activity-Modifying Protein 2Receptor Activity-Modifying Protein 3PeptidesReceptor Activity-Modifying Protein 1Receptors, PeptideReceptors, Islet Amyloid PolypeptideVasodilator AgentsMioticsCyclic AMPRadioimmunoassayRats, Sprague-DawleySalmonRNA, MessengerPeptide FragmentsSubstance PNeuropeptidesIslet Amyloid PolypeptideCarcinoma, MedullaryAtrial Natriuretic FactorIntracellular Signaling Peptides and ProteinsAntihypertensive AgentsRats, WistarDose-Response Relationship, DrugCapsaicinImmunoradiometric AssayThyroid NeoplasmsMembrane Proteins
CGRPReceptorsAmylinPeptidesIntermedinCRLRGeneLigandsProteinVasodilatory peptidePeptide hormoneNmolCalciumAimsAcuteSuggestEffectsPatientsTargetActionsDevelopmentMember of the calcitoninHormone calcitoninVasoactiveCALCRLProteinsAtrialPolymorphismsSignaling pathwayVasodilatorConcentrationsVascularPreeclampsiaHumanExpressionBoneCellsIncludesDataRecentResultsSimilar
CGRP32
  • Calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and adrenomedullin 2 (AM2) are related peptides, which are potent vasodilators. (coventry.ac.uk)
  • The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, (the CGRPR), whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor (AM1 and AM2 receptors). (coventry.ac.uk)
  • CGRP is also a potent agonist at the AMY1(a) receptor, a heterodimer between the calcitonin receptor (CTR) and RAMP1. (coventry.ac.uk)
  • Calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) receptors are heteromers of the calcitonin receptor-like receptor (CLR), a class B G protein-coupled receptor, and one of three receptor activity-modifying proteins (RAMPs). (essex.ac.uk)
  • Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. (wikipedia.org)
  • Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. (wikipedia.org)
  • α-CGRP is a 37-amino acid neuropeptide and is formed by alternative splicing of the calcitonin/CGRP gene located on chromosome 11. (wikipedia.org)
  • The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY). (wikipedia.org)
  • CGRP mediates its effects through a heteromeric receptor composed of a G protein-coupled receptor called calcitonin receptor-like receptor (CALCRL) and a receptor activity-modifying protein (RAMP1). (wikipedia.org)
  • Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated protein kinases (MAPK) signaling pathway, cytokines such as TNFα and iNOS. (wikipedia.org)
  • The CGRP receptor has three subunits: receptor activity-modifying protein 1 (RAMP1), calcitonin-like receptor (CLR) and receptor component protein (RCP). (wikipedia.org)
  • The complex central receptor is the G protein-coupled receptor calcitonin receptor-like receptor (CALCRL) which is necessary for CGRP and adrenomedullin (AM receptors). (wikipedia.org)
  • However, the progresses in unravelling the migraine pathophysiology allowed identifying novel putative targets as calcitonin gene-related peptide (CGRP). (iasp-pain.org)
  • α-CGRP and β-CGRP, also known as CGRP I and II, respectively, belong to the calcitonin family of peptides comprising such members as calcitonin, amylin, calcitonin receptor-stimulating peptide, adrenomedullin 1, and intermedin. (bachem.com)
  • α-CGRP mRNAs are derived from the calcitonin/CGRP gene by alternative tissue specific splicing of the primary RNA transcripts whereas β-CGRP is encoded by a separate gene with high homology to the calcitonin/CGRP gene. (bachem.com)
  • In dogs, pigs and numerous other species, variants of the CGRP-like calcitonin receptor-stimulating peptide (CRSP) are expressed in place of β-CGRP. (bachem.com)
  • Interaction with RAMP1 resulted in a CGRP receptor, which is sensitive to α-CGRP (8-37), whereas binding to RAMP2 and RAMP3 led to receptors for adrenomedullin known as AM1 and AM2 receptors, respectively. (bachem.com)
  • CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. (antikoerper-online.de)
  • Excitatory Effects of Calcitonin Gene-Related Peptide (CGRP) on Superficial Sp5C Neurons in Mouse Medullary Slices. (antikoerper-online.de)
  • Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease: CGRP in diverticular disease. (antikoerper-online.de)
  • We examined the roles of central adrenomedullin, proadrenomedullin N- terminal 20 peptide (PAMP), and calcitonin gene-related peptide (CGRP) on the baroreceptor reflex in conscious rabbits. (elsevierpure.com)
  • Intracerebroventricular infusion of CGRP (1 nmol/300 μL per hour), which is structurally homologous to adrenomedullin, also enhanced the baroreflex controls of renal sympathetic nerve activity and heart rate. (elsevierpure.com)
  • These results suggest that central adrenomedullin and CGRP, but not PAMP, participate in cardiovascular regulation to augment the baroreflex controls of renal sympathetic nerve activity and heart rate in conscious rabbits. (elsevierpure.com)
  • Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CT/CGRP) family identified from human and other vertebrate tissues. (phoenixpeptide.com)
  • Intermedin is a calcitonin/CGRP family peptide acting through the CRLR/RAMP receptor complexes. (phoenixpeptide.com)
  • Upon activation, peripheral projections of the trigeminal nerve release neurotransmitters that elicit vasodilation and modulate nociceptive transmission, e.g. calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) [3]. (ouenhoumon.com)
  • The following peptides have been implicated in migraine pathogenesis [31]: adrenomedullin (ADM), amylin, calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), and vasoactive intestinal polypeptide (VIP). (ouenhoumon.com)
  • Biochemical and functional evidence suggest that the calcitonin receptor-like receptor (CRLR) interacts with receptor activity-modifying protein-1 (RAMP1) to generate a calcitonin gene-related peptide (CGRP) receptor. (acs.org)
  • 1. The ability of the CGRP antagonist BIBN4096BS to antagonize CGRP and adrenomedullin has been investigated on cell lines endogenously expressing receptors of known composition. (aston.ac.uk)
  • CGRP 8-37 had a pA 2 of 6.72 against adrenomedullin. (aston.ac.uk)
  • At concentrations of up to 10 μM, it has no antagonist actions at the adrenomedullin, CRLR/RAMP2 receptor, unlike CGRP 8-37 . (aston.ac.uk)
  • Migraine prophylactic therapy has changed over recent years with the development and approval of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway. (biomedcentral.com)
Receptors5
  • The best characterized receptor complexes formed by RAMPs and GPCRs are the calcitonin peptide family receptors. (nih.gov)
  • The association of RAMP1 with the calcitonin receptor-like receptor (CL) constitutes the calcitonin gene-related peptide receptor, whereas RAMP2 or 3 with CL generates adrenomedullin receptors. (nih.gov)
  • Other receptors include the calcitonin receptor, which is important for bone formation and function, and the glucagon receptor, which is relevant to diabetes. (unchealthcare.org)
  • G-protein-coupled cell surface receptors for ADRENOMEDULLIN. (bvsalud.org)
  • The study aimed to evaluate the transcriptional levels of the natriuretic peptides (NP), endothelin (ET)-1, adrenomedullin (ADM), their receptors and long non-coding (Lnc) RNA MIAT, MALAT-1, CARMEN and XIST in rat cardiac tissue as cardiovascular biomarkers of aging. (unipi.it)
Amylin2
Peptides3
  • Becker KL, Nylén ES, White JC, Müller B, Snider RH Jr. Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. (jamanetwork.com)
  • The ADM showed an opposite trend to that of the other peptides decreasing significantly as a function of age and presenting a counter-regulation of calcitonin receptor-like receptor (CLR) and receptor activity modifying protein (RAMP)-2. (unipi.it)
  • Among the neuropeptides two groups of peptides can be discriminated: pro-inflammatory peptides like tumour necrosis factor alpha (TNFα), the interleukins IL-1β, IL-2, IL-6 and IL-12 and -on the other hand- anti-inflammatory peptides such as urocortin, adrenomedullin, vasoactive intestinal peptide VIP, and GHrelin. (biomedres.us)
Intermedin1
CRLR5
  • Recent studies have shown that the previously cloned G protein-coupled orphan receptor, named calcitonin receptor-like receptor (CRLR), can interact with members of a new family of three single-transmembrane domain receptor activity-modifying proteins (RAMPs). (bachem.com)
  • RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. (antikoerper-online.de)
  • AM co-localizes with its receptor components such as calcitonin receptor-like receptor (CRLR), receptor activity modifying protein (RAMP)2 and RAMP3 in the heart, vessels and kidneys, suggesting that it plays an important role in the regulation of cardiovascular function through an autocrine and/or paracrine mechanism. (eurekaselect.com)
  • 2. On human SK-N-MC cells (expressing human calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1)), BIBN4096BS had a pA 2 of 9.95 although the slope of the Schild plot (1.37±0.16) was significantly greater than 1. (aston.ac.uk)
  • 5. On Rat 2 cells, expressing rat CRLR and RAMP2, BIBN4096BS was unable to antagonize adrenomedullin at concentrations up to 10 μM. (aston.ac.uk)
Gene5
Ligands1
  • Although the RAMPs themselves are not responsive to calcitonin peptide family ligands, there is clear evidence that they participate in ligand binding, although it is still unclear whether this is by directly participating in binding or through allosteric modulation of CL or CTR. (nih.gov)
Protein1
Vasodilatory peptide2
Peptide hormone1
  • Adrenomedullin (ADM) as a highly conserved peptide hormone has been reported to increase significantly in the uterine lumen during the peri-implantation period of pregnancy in pigs, but its functional roles in growth and development of porcine conceptus (embryonic/fetus and its extra-embryonic membranes) as well as underlying mechanisms remain largely unknown. (bvsalud.org)
Nmol1
  • Intracerebroventricular injection of adrenomedullin (0.2 and 1 nmol/80 μL) elicited dose-related increases in arterial pressure and renal sympathetic nerve activity. (elsevierpure.com)
Calcium1
  • Based on these targets, different treatments were designed and produced such as estrogen replacement therapy, administration of different bisphosphonates, raloxifene, calcitonin, sodium fluoride, calcium, and vitamin D. As a result, new applicable drugs for treatment of related bone problems can be proposed for clinical approach especially in the early stage of diseases. (biomedcentral.com)
Aims1
  • This study aims to establish whether adrenomedullin (ADM) is capable to restore the steroidogenic functions of Leydig cells by suppressing transforming growth factor-ß1 (TGF-ß1) through Hippo signaling. (bvsalud.org)
Acute1
  • Levels of plasma total adrenomedullin are related with two acute phase inflammatory reactants (fibrinogen and sialic acid) but not with markers of endothelial dysfunction in Type 1 diabetes Adrenomedullin and vascular risk factors in Type 1 DM. (phoenixpeptide.com)
Suggest2
Effects2
Patients2
  • CONCLUSION: Mid-regional pro-adrenomedullin is an independent predictor of mortality in CHF patients, which adds prognostic information to NT-proBNP. (phoenixpeptide.com)
  • In NYHA II- and III-patients urocortin, adrenomedullin and VIP were elevated, while Ghrelin, TNFα, IL-12 and IL-2 were unchanged. (biomedres.us)
Target1
  • Adrenomedullin: a new target for the design of small moleculemodulators with promising pharmacological activities. (phoenixpeptide.com)
Actions1
  • Adrenomedullin (AM), an ubiquitous regulatory peptide with different actions, is known to be elevated in different clinical situations, including diabetes mellitus (DM), but its potential role in the pathogenesis of diabetic vascular complications is not clear. (phoenixpeptide.com)
Development1
  • Caron's lab, in prior work, showed that adrenomedullin signaling is crucial for the normal development of the mouse lymphatic system - a network of special vessels that help manage the flow of lymph, a watery liquid that bathes the organs of the body, helps drain their molecular wastes, and helps protect them from microbes. (unchealthcare.org)
Member of the calcitonin1
Hormone calcitonin2
Vasoactive2
CALCRL1
  • We measured the extent to which genetic polymorphisms in the adrenomedullin signaling pathway are associated with birth weight, glycemic regulation, and preeclampsia risk.We genotyped 1,353 women in the Pregnancy, Infection, and Nutrition Postpartum Study for 37 ancestry-informative markers and for single-nucleotide polymorphisms in adrenomedullin (ADM), complement factor H variant (CFH), and calcitonin receptor-like receptor (CALCRL). (nih.gov)
Proteins1
Atrial2
  • In general Internal medicine study, his work on Adrenomedullin, Atrial natriuretic peptide, Vasodilation and Peptide hormone often relates to the realm of Spinal cord, thereby connecting several areas of interest. (research.com)
  • Hisayuki Matsuo mostly deals with Internal medicine, Endocrinology, Adrenomedullin, Cardiology and Atrial natriuretic peptide. (research.com)
Polymorphisms1
  • Adrenomedullin signaling pathway polymorphisms and adverse pregnancy outcomes. (nih.gov)
Signaling pathway1
  • CFH rs1061170 was associated with higher GLT results and increased preeclampsia risk.Consistent with studies of plasma adrenomedullin and adverse pregnancy outcomes, we found associations between variants in the adrenomedullin signaling pathway and birth weight, glycemic regulation, and preeclampsia. (nih.gov)
Vasodilator1
  • Reduced maternal plasma levels of the peptide vasodilator adrenomedullin have been associated with adverse pregnancy outcomes. (nih.gov)
Concentrations1
  • Reporter cells were transfected with either the expression plasmid for human calcitonin receptor (CALCR) or the mock plasmid and treated with various concentrations of calcitonin. (tansobio.com)
Vascular1
  • Hisayuki Matsuo interconnects Calcitonin, Peptide sequence and Vascular smooth muscle in the investigation of issues within Receptor. (research.com)
Preeclampsia1
  • The possible role of adrenomedullin in the etiology of gestational hypertension and preeclampsia. (cdc.gov)
Human1
  • Adrenomedullin (ADM) was first isolated from human pheochromocytoma [ 6 ]. (hindawi.com)
Expression2
  • Adrenomedullin(22-52) was more effective than adrenomedullin in modulating cytokine content and enhanced Treg cell function without changing Treg cell expression compared to controls. (heightquest.com)
  • Expression of adrenomedullin and its receptor by chondrocyte phenotype cells. (heightquest.com)
Bone3
  • Adrenomedullin is also produced locally in bone. (heightquest.com)
  • Adrenomedullin(22-52) combats inflammation and prevents systemic bone loss in murine collagen-induced arthritis. (heightquest.com)
  • Adrenomedullin(22-52) completely prevented systemic bone loss by preserving osteoblastic activity, but without changes in osteoclastic activity. (heightquest.com)
Cells2
  • We] investigate the secretion of adrenomedullin (AM) by chondrocyte phenotype cells and whether or not AM effects this proliferation in a cAMP-dependent fashion. (heightquest.com)
  • Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. (ox.ac.uk)
Includes1
Data1
  • Developments of the Wellcome research programme have led to pilot data that provided proof of concept for the development of small molecule antagonists of the AM1 adrenomedullin receptor, and at reversing the catastrophic low blood pressure in septic shock. (sheffield.ac.uk)
Recent1
  • Below are the most recent publications written about "Calcitonin" by people in Profiles. (rush.edu)
Results2
Similar1