• A Beta-2 adrenergic antagonist (β2-adrenoceptor antagonist) is an adrenergic antagonist which blocks the beta-2 adrenergic receptors of cells, with either high specificity (an antagonist which is selective for β2 adrenoceptors) like Butaxamine and ICI-118,551, or non-specifically (an antagonist for β2 and for β1 or β3 adrenoceptors) like the non-selective betablocker Propranolol. (wikipedia.org)
  • The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. (citizendium.org)
  • Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. (citizendium.org)
  • They express a high level of beta2-adrenergic receptors but their function is unknown. (mysciencework.com)
  • Beta-blockers act as competitive inhibitors of catecholamines, exerting their effects at both central and peripheral receptors. (medscape.com)
  • Blockade of beta-receptors results in decreased production of intracellular cyclic adenosine monophosphate (cAMP) with a resultant blunting of multiple metabolic and cardiovascular effects of circulating catecholamines. (medscape.com)
  • Propranolol is a nonselective beta-blocker, demonstrating equal affinity for both beta1- and beta2-receptors. (medscape.com)
  • Although their agonist property is weaker than that of catecholamines, they are capable of stimulating beta-receptors, especially when catecholamine levels are low. (medscape.com)
  • Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. (druglib.com)
  • In this case, positive inotropes (dobutamine 1-5 mcg/kg/min IV - an agonist of beta-adrenergic receptors) and diuretics are administered depending on the cardiomyopathy. (vin.com)
  • It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent. (bvsalud.org)
  • Propranolol is the most common beta-blocker involved in severe beta-blocker poisoning. (medscape.com)
  • In this study, the authors report that in mice, blocking beta-adrenoreceptors with propranolol and simultaneously inhibiting PG synthesis with etodolac significantly improves recurrence-free survival rates following 3LL or B16 primary tumor excision. (brainimmune.com)
  • This reduction in QTc derived entirely from a decrease in the QTc among patients with a baseline abnormal QTc, in whom the shortening in the QTc was greater with propranolol than with either nadolol or metoprolol (p=0.04) since the change in QTc was comparable in all three beta blocker groups with a normal or borderline baseline QTc (p=0.8). (acc.org)
  • Likewise, beta-adrenergic antagonists (e.g. propranolol (Inderal)) can induce depression and fatigue. (hedweb.com)
  • Topical beta-blockers that reduce elevated and normal IOP, with or without glaucoma. (medscape.com)
  • Beta-blockers have been in use for nearly 50 years. (medscape.com)
  • In addition to their traditional role in treating hypertension and other cardiovascular disorders, beta-blockers are also used for additional purposes such as migraine headaches, hyperthyroidism, glaucoma, anxiety, and various other disorders. (medscape.com)
  • much of the clinical and overdose experience that exists with beta-blockers was provided by case reports and clinical studies of this drug. (medscape.com)
  • Other nonselective beta-blockers include nadolol, timolol, and pindolol. (medscape.com)
  • Nonselective beta-blockers exert a wider variety of extracardiac manifestations. (medscape.com)
  • Some beta-blockers, such as pindolol and acebutolol, also have beta-agonist properties. (medscape.com)
  • Not All Beta-Blockers Are Equal in the Management of Long QT Syndrome Types 1 and 2: Higher Recurrence of Events Under Metoprolol. (acc.org)
  • Although a number of approaches (e.g., beta blockers, permanent pacing, left cervicothoracic sympathectomy, ICD implantation) have been proposed as therapeutic options for patients with the congenital long QT syndromes (LQTS), beta blocker therapy has served as the mainstay of treatment for the majority of these patients. (acc.org)
  • 1-4 Furthermore, the published guidelines recommended an ICD only for LQTS patients who experience syncope or VT while taking a beta blocker (class IIa indication, level of evidence B). 5 However, there is a paucity of data on both the differential electrophysiological and clinical effects of the available beta blockers. (acc.org)
  • Although clinicians often view beta blockers as similar in their pharmacological characteristics, electrocardiographic manifestations, electrophysiologic properties, and clinical efficacy, it has been established that there are a number of important differences among beta blockers. (acc.org)
  • The findings of this study provide evidence in support of the hypothesis that not all beta blockers are equal in their electrocardiographic effects upon the QTc and their ability to provide protection against potentially serious arrhythmic events. (acc.org)
  • We sought to use an electronic medical record to assess use of beta-adrenergic antagonist medications (beta-blockers) following myocardial infarction, to compare a standardized manual assessment with assessment using electronic medical records, and to discuss potential for future integration of performance indicators into electronic records. (nih.gov)
  • Administration of beta-blockers and cases excluded from use of beta-blockers were measured, based on Medicare criteria. (nih.gov)
  • Of 68 hospital admissions for myocardial infarction that did not meet exclusion criteria, physicians prescribed beta-blockers in 49 (72%) on admission and 42 (62%) at discharge. (nih.gov)
  • CONCLUSIONS: An electronic medical records system can be used instead of chart review to measure use of beta-blockers after myocardial infarction. (nih.gov)
  • Researchers tested the capacity of adrenergic antagonists, drugs such as alpha and beta blockers, to disrupt the receptor's sensing ability. (sciencedaily.com)
  • receptor blockers reduce myocardial oxygen demand by reducing the increases in heart rate and contractility due to adrenergic activity. (pharmacology2000.com)
  • These effects are blocked by beta-adrenergic receptor blockers. (pharmacology2000.com)
  • Beta-adrenergic receptor blockers increase AV conduction time and increase AV nodal refractoriness, thereby helping to terminate nodal reentrant arrhythmias. (pharmacology2000.com)
  • beta-Blockers, especially metoprolol, appear beneficial in some patients with heart failure, possibly related to their reduction in sympathetic nervous activity and restoration of beta-receptor population, with resultant improved contractile performance, enhanced myocardial relaxation, and overall increase in cardiac efficiency. (duke.edu)
  • Beta blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. (druglib.com)
  • If replacing clonidine by beta-blocker therapy, the introduction of beta blockers should be delayed for several days after clonidine administration has stopped. (druglib.com)
  • Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers. (druglib.com)
  • Data from several studies, ie, TIMI-II, ISIS-2, currently do not suggest any clinical interaction between aspirin and beta blockers in the acute myocardial infarction setting. (druglib.com)
  • While taking beta blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. (druglib.com)
  • Purpose: To determine whether there were ocular surface changes in glaucomatous patients treated with preservatives beta-blockers who switched to preservative-free beta-blockers. (unimi.it)
  • Results: No significant difference was found for IOP before switching from preserved beta-blockers to preservative-free ones. (unimi.it)
  • Ocular surface changes in glaucomatous patients treated with and without preservatives beta-blockers / M. Iester, S. Telani, P. Frezzotti, I. Motolese, M. Figus, P. Fogagnolo, A. Perdicchi. (unimi.it)
  • All patients were treated with beta-blockers, diuretics and ACE inhibitors. (bvsalud.org)
  • A broad group of drugs can cause dry mouth and are cited by the literature, i.e.: anticholinergics, tricyclicant idepressants, antihistamines, benzodiazepines and beta-blockers. (bvsalud.org)
  • We propose that the mechanism for the pro-motogenic effect of the beta-adrenergic antagonist is blockade of the beta2-adrenergic receptor preventing autocrine catecholamine binding. (mysciencework.com)
  • Understanding the direct and indirect effects of beta-receptor blockade is crucial to rapid identification and appropriate treatment of beta-blocker toxicity. (medscape.com)
  • Other than the direct effects of the beta-adrenoreceptor blockade, toxicity may result from other mechanisms, including sodium and calcium channel blockade, centrally mediated cardiac depression, and alteration of cardiac myocyte energy metabolism. (medscape.com)
  • i.v. administration is used for rapid beta-receptor blockade in treatment of atrial fibrillation with high ventricular following rates. (pharmacology2000.com)
  • Antiarrhythmic effects are due mainly to beta-adrenergic receptor blockade. (pharmacology2000.com)
  • β-adrenergic receptor blockade can also help reduce ventricular following rates in atrial flutter and fibrillation, again by acting at the AV node. (pharmacology2000.com)
  • The two-drug cocktail, which includes a generic version of a beta-adrenergic antagonist and a COX2 inhibitor- used to treat hypertension and anxiety, and to inhibit inflammation and pain - will be administered to patients over a twenty day period before, during and after surgery. (eurekalert.org)
  • Beta-adrenergic receptor agonists delay while antagonists acce. (mysciencework.com)
  • Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epithelium. (mysciencework.com)
  • Beta-adrenergic receptor agonists delay CEC migration via a protein phosphatase 2A-mediated mechanism and decrease both electric field-directed migration and corneal wound healing. (mysciencework.com)
  • Centrally-acting sympatholytic agent/agents (alpha2 adrenergic receptor agonists). (pharmacology2000.com)
  • Injections of beta-adrenergic substances in the locus coeruleus affect the gain of vestibulospinal reflexes in decerebrate cats. (architalbiol.org)
  • Nonselective beta-adrenergic receptor blocking with intrinsic sympathomimetic activity. (medscape.com)
  • Nonselective beta-adrenergic receptor blocking agent. (medscape.com)
  • We demonstrate that CECs express key enzymes required for epinephrine (beta-adrenergic receptor agonist) synthesis in the cytoplasm and can detect epinephrine in cell extracts. (mysciencework.com)
  • Bupivacaine Hydrochloride Injection contains bupivacaine, an amide local anesthetic, and Bupivacaine Hydrochloride and Epinephrine Injection is a combination of bupivacaine, an amide local anesthetic, and epinephrine, an alpha and beta-adrenergic agonist. (pfizermedicalinformation.com)
  • Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. (druglib.com)
  • Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles. (druglib.com)
  • Cardioselective beta1-adrenergic receptor blocking agent with minimal effect on pulmonary and cardiovascular parameters. (medscape.com)
  • Esmolol is a very short acting, cardioselective beta-adrenergic receptor antagonist. (pharmacology2000.com)
  • A widely used non-cardioselective beta-adrenergic antagonist. (bvsalud.org)
  • Treatment with monoaminoxidase inhibitors, tricyclic antidepressants or Beta-adrenergic receptor antagonists or long acting anticholinergic bronchodilators who are unable to be discontinued for at least seven days before enrollment. (nih.gov)
  • In their excellent article, "Physiologic Approach to the Treatment of Angina Pectoris" (N.E.J.M. 281: 1225-1228, 1969) Mason and his associates discuss nitrites, beta-adrenergic receptor blocking agents and carotid-sinus nerve stimulation as means of lessening myocardial oxygen demand and thus reducing anginal pain. (psu.edu)
  • Fármaco utilizado en el tratamiento de la angina de pecho, insuficiencia cardíaca, alteraciones de la conducción e infarto del miocardio. (bvsalud.org)
  • Catecholamine-depleting drugs (eg, reserpine) may have an additive effect when given with beta-blocking agents. (druglib.com)
  • We evaluated whether dobutamine gated blood pool scintigraphy (DOB-GBP) can predict improvement in cardiac sympathetic nerve activity and cardiac function after beta-blocker therapy in patients with dilated cardiomyopathy (DCM). (nih.gov)
  • Beta-blocker toxicity in children usually results from exposure to an adult's unattended medications. (medscape.com)
  • Pursuing integration of performance measures into electronic medical records: beta-adrenergic receptor antagonist medications. (nih.gov)
  • Several 12- and 24-hour adrenergic agents and several long-acting antimuscarinic agents are now available, both singly and in fixed combinations. (medscape.com)
  • Used as adjunct to miotic or beta-blocker therapy. (medscape.com)
  • Is the Subject Area "Beta-adrenergic antagonist therapy" applicable to this article? (plos.org)
  • In follow-up, the risk reduction for a BCE was correlated with greater QTc shortening on beta blocker therapy. (acc.org)
  • Angiotensin converting enzyme inhibitor/angiotensin type 1 receptor blocker based therapy was associated with lower follow-up mortality when beta blocker was not used in pulse pressure (scirp.org)
  • Adverse effects of beta blocker therapy can lead to fatigue, bronchospasm, depression, impotence, and attenuation of hypoglycemic symptoms in diabetic patients and worsening of congestive heart failure. (pharmacology2000.com)
  • If the two drugs are coadministered, the beta blocker should be withdrawn several days before the gradual withdrawal of clonidine. (druglib.com)
  • A retrospective cohort study was conducted to evaluate the independent and interactive effects of pulse pressure and antihypertensive class (specifically angiotensin converting enzyme inhibitor/angiotensin type 1 receptor blocker, or beta blocker) on mortality following acute ischemic stroke. (scirp.org)
  • Kaltman JR, Ro PS, Stephens P, McBride MG, Cohen MI, Tanel RE, Vetter VL, Rhodes LA: Effects of beta-adrenergic antagonists on the QT measurements from exercise stress tests in pediatric patients with long QT syndrome. (chop.edu)
  • Its lead product candidate is Gencaro, a pharmacogenetically-targeted beta-adrenergic receptor antagonist that has completed Phase IIb trial for the treatment of atrial fibrillation in patients with chronic heart failure. (watchlistnews.com)
  • Beta-blocking agents, angiotensin-converting enzyme inhibitors, aspirin, and thrombolytic therapy are also effective in the treatment of CVD amongst diabetic patients. (nih.gov)
  • Although the combined use of an inotropic agent with a β-adrenergic receptor antagonist may seem counterintuitive, we also highlight the distinct, complementary pharmacology of these agents and propose a mechanism by which their combination may produce myocardial responses not attainable with either agent alone. (medscape.com)
  • These inhibit chronotropic, inotropic, and vasodilatory responses to beta-adrenergic activity observed in hyperthyroidism. (medscape.com)
  • Negative inotropic effects are augmented if beta-adrenergic receptor antagonists are concurrently administered. (pharmacology2000.com)
  • Beta blockers inhibit cardiac stimulation thereby show negative inotropic effect. (egpat.com)
  • The alpha adrenergic agonist phenylephrine, on the other hand, either attenuated or had no effects on the GABA-induced depressions of cerebellar Purkinje neurons, and a subsequent application of ethanol did not potentiate GABA responses in the presence of phenylephrine. (aspetjournals.org)
  • Emerphed ( ephedrine sulfate) is an alpha- and beta- adrenergic agonist and a norepinephrine-releasing agent used to treat clinically important low blood pressure ( hypotension ) occurring in the setting of anesthesia . (rxlist.com)
  • As has been previously observed, iontophoretic applications of isoproterenol (ISO), a beta adrenergic agonist, facilitated GABA-induced depressions of cerebellar Purkinje neurons. (aspetjournals.org)
  • The ethanol-induced augmentation of the ISO-modulated GABA responses was diminished both by terminating the beta adrenergic agonist application as well as by administering the beta adrenergic antagonist timolol. (aspetjournals.org)
  • The purpose of this study was to investigate and compare the effects of the beta-adrenergic agonist, isoproterenol, on induced increase in melatonin production in the pineal gland of young and old rats, at different circadian stages. (nel.edu)
  • Recently we published the efficacy of a novel PPARγ antagonist (SR1664) and a potent and selective inverse agonist of RORγ (SR2211). (scripps.edu)
  • Adrenergic beta-Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • Comparative effectiveness of beta-adrenergic antagonists (atenolol, metoprolol tartrate, carvedilol) on the risk of rehospitalization in adults with heart failure. (umassmed.edu)
  • Did you mean topic:"adrenergic beta-antagonists - therapeutic use" ? (nshealth.ca)
  • The excretion of beta-adrenergic blocking drugs into breastmilk is largely determined by their protein binding. (drugs.com)
  • Furthermore, the catecholaminergic sensitization of GABA responses to these potentiative effects of ethanol is mediated by a beta adrenergic mechanism. (aspetjournals.org)
  • It appears that inhibition of beta(1)-adrenergic pathway is able to shut off the physiologic mechanisms of male differentiation of SDN-POA, and the subsequent beta(2)-adrenergic stimulation activates an alternative mechanism of masculinization. (nel.edu)
  • Selective beta-1 - adrenergic receptor blocker that decreases automaticity of contractions. (medscape.com)
  • Switching to another beta-blocker after metoprolol related acute liver injury should be done with caution and prospective monitoring. (nih.gov)
  • Esmolol is one of the short acting beta blocker given by infusion. (egpat.com)
  • The common Arg389gly ADRB1 polymorphism affects heart rate response to the ultra-short-acting ß(1) adrenergic receptor antagonist esmolol in healthy individuals. (cdc.gov)
  • It is significant to note, however, that early phosphodiesterase inhibitor trials occurred before the benefits of β- adrenergic receptor antagonists in heart failure were widely established. (medscape.com)
  • A widely used non-cardioselective beta- adrenergic antagonist . (online-medical-dictionary.org)
  • Metiamide, the specific H2-receptor antagonist inhibited the responses to histamine and 4-MH, while mepyramine maleate, the specific H1- receptor antagonist did not produce any significant effect. (ijp-online.com)
  • No use of beta-adrenergic antagonists for other indications. (who.int)
  • Sensitization of gamma-aminobutyric acid-induced depressions of cerebellar Purkinje neurons to the potentiative effects of ethanol by beta adrenergic mechanisms in rat brain. (aspetjournals.org)
  • We investigated electrophysiologic, morphologic, and physiologic roles for subsets of cardiac-specific neurons and found that three of five adrenergic SGN subtypes innervate the heart. (elifesciences.org)
  • Permanent effects of postnatal administration of beta-adrenergic ligands on the volume of sexually dimorphic nucleus of the preoptic area (SDN-POA) in rats. (nel.edu)
  • Female rats treated by beta(2)-adrenergic stimulating ligands exhibit an increased, male type SDN-POA volume while male rats treated by beta1-adrenergic antagonists show a decreased, female type of SDN-POA volume. (nel.edu)
  • From the presented data it may be concluded that beta adrenoreceptors participate in sexual differentiation of preoptic area in rats and the modulation of their activity in postnatal period permanently influences the morphology of the sexually differentiated nucleus of the preoptic area. (nel.edu)
  • Izdebska-Straszak G, Gubala E, Jedrzejowska-Szypulka H, Klencki M, Wiczkowski A, Jarzab B. Permanent effects of postnatal administration of beta-adrenergic ligands on the volume of sexually dimorphic nucleus of the preoptic area (SDN-POA) in rats. (nel.edu)
  • Preliminary findings from ongoing clinical and preclinical investigations of phosphodiesterase activity suggest that combined use of phosphodiesterase inhibitors with β-adrenergic antagonists may prevent these adverse outcomes. (medscape.com)
  • As β-adrenergic receptor antagonists exert a significant protective effect on heart failure mortality, sudden cardiac death, and proarrhythmia (principal adverse events in phosphodiesterase inhibitor trials), the addition of β-adrenergic receptor antagonists to phosphodiesterase inhibitors may constitute a valuable contribution to heart failure pharmacotherapy. (medscape.com)
  • Manara Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β 3 ) β-adrenoceptors. (bio-techne.com)