• hirsutism
  • Hirsutism is usually the result of an underlying endocrine imbalance, which may be adrenal, ovarian, or central. (wikipedia.org)
  • Features that would be most concerning for an androgen-producing tumor include severe hirsutism (pattern of hair growth as seen in a male), onset outside the peripubertal period, sudden onset with rapid progression, and concomitant signs of virilization such as clitoromegaly, voice deepening, male pattern alopecia and a male patterned escutcheon. (clinicalpainadvisor.com)
  • Deficiency
  • Patients with 'classic' or the most severe form of CAH due to 21-hydroxylase deficiency (21OHD) present during the neonatal period and early infancy with adrenal insufficiency with or without salt-losing, or as toddlers with virilization. (uptodate.com)
  • Wilms
  • It's been shown that binding of three transcription factors, Steroidogenic factor 1 (SF1), Specificity Protein 1 (Sp1 transcription factor) and Wilms tumor protein 1 (WT1), to the human promoter sequence, influence expression of SRY. (wikipedia.org)
  • males
  • The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development in genetic males with the condition. (wikipedia.org)
  • The cells of unaffected genetic males then masculinize by, among other things, enlarging the genital tubercle into a penis but in females it becomes the clitoris, while what in females becomes the labia fuses to become the scrotum of males (where the testicles will later descend). (wikipedia.org)
  • hormone
  • Inhibin B and anti-Müllerian hormone were used as Sertoli cell markers. (semanticscholar.org)
  • This action of androgens is supported by a hormone from Sertoli cells, Müllerian inhibitory hormone (MIH), which prevents the embryonic Müllerian ducts from developing into fallopian tubes and other female reproductive tract tissues in male embryos. (wikipedia.org)
  • benign
  • Pilomatrixoma, malignant Pilomatricoma, malignant Matrical carcinoma M8120/0 Transitional cell papilloma, benign Transitional papilloma M8120/1 Urothelial papilloma, NOS Papilloma of baldder (C67. (wikipedia.org)
  • androgens
  • Partial androgen insensitivity syndrome (PAIS) is a condition that results in the partial inability of the cell to respond to androgens. (wikipedia.org)
  • Adrenal androgens function as weak steroids (though some are precursors), and the subset includes dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), androstenedione (A4), and androstenediol (A5). (wikipedia.org)
  • Soon after they differentiate, Leydig cells begin to produce androgens. (wikipedia.org)
  • syndrome
  • Androgen insensitivity syndrome (AIS) is an intersex condition in which there is a partial or complete inability of many cells in the affected genetic male to respond to androgenic hormones. (wikipedia.org)
  • Blau syndrome Chronic infantile neurologic cutaneous and articular syndrome Familial cold urticaria (familial cold autoinflammatory syndrome) Familial Mediterranean fever Hyper-IgD syndrome Majeed syndrome Muckle-Wells syndrome TNF receptor associated periodic syndrome (familial Hibernian fever, TRAPS, tumor necrosis factor receptor associated periodic syndrome) Chronic blistering cutaneous conditions have a prolonged course and present with vesicles and bullae. (wikipedia.org)
  • basal
  • The ratio between basal testosterone levels and testosterone levels 72 h after beta-human chorionic gonadotropin (5000 U/m2) treatment [(T72- T0)/Twas used to evaluate Leydig cell response. (semanticscholar.org)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • M8090/3) Basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Basal cell epithelioma Rodent ulcer Pigmented basal cell carcinoma M8091/3 Multifocal superficial basal cell carcinoma (C44. (wikipedia.org)
  • Multicentric basal cell carcinoma M8092/3 Infriltrating basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Infiltrating basal cell carcinoma, non-sclerosing Infiltrating basal cell carcinoma, sclerosing Basal cell carcinoma, morpheic Basal cell carcinoma, desmoplastic type M8093/3 Basal cell carcinoma, fibroepithelial (C44. (wikipedia.org)
  • Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS M8094/3 Basosquamous carcinoma (C44. (wikipedia.org)
  • Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
  • M8097/3 Basal cell carcinoma, nodular (C44. (wikipedia.org)
  • Basal cell carcinoma, micronodular M8098/3 Adenoid basal carcinoma (C53. (wikipedia.org)
  • about two weeks are needed for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum corneum. (wikipedia.org)
  • carcinoma
  • Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
  • Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
  • M8082/3 Lymphoepithelial carcinoma Lymphoepithelioma Lymphoepithelioma-like carcinoma Schmincke tumor (C11. (wikipedia.org)
  • Trichilemmal carcinoma M8103/0 Pilar tumor (C44. (wikipedia.org)
  • Transitional cell papilloma, NOS M8120/2 Transitional cell carcinoma in situ Urothelial carcinoma in situ M8120/3 Transitional cell carcinoma, NOS Urothelial carcinoma, NOS Transitional carcinoma M8121/0 Schneiderian papilloma, NOS (C30.0, C31. (wikipedia.org)
  • Cylindrical cell carcinoma M8122/3 Transitional cell carcinoma, spindle cell Transitional cell carcinoma, sarcomatoid M8123/3 Basaloid carcinoma M8124/3 Cloacogenic carcinoma (C21.2) M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67. (wikipedia.org)
  • Papillary urothelial neoplasm of low malignant potential M8130/2 Papillary transitional cell carcinoma, non-invasive (C67. (wikipedia.org)
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • Papillary urothelial carcinoma M8131/3 Transitional cell carcinoma, micropapillary ( C67. (wikipedia.org)
  • receptor
  • There may also be an effect of high levels of insulin to activate insulin-like growth factor 1 (IGF-1) receptor in those same cells. (wikipedia.org)
  • diseases
  • Other conditions: Various other lesions and diseases, such as CNS tumors, temporal lobe seizures, and many drugs (eg, dopamine antagonists) may interrupt the hypothalamic-pituitary axis at the hypothalamus. (taseerlabs.com)
  • The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. (wikipedia.org)
  • functional
  • While the fetal pancreas has functional beta cells by 14 to 24 weeks of gestation, the amount of insulin that is released into the bloodstream is relatively low. (wikipedia.org)
  • partial
  • The partial unresponsiveness of the cell to the presence of androgenic hormones impairs the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development. (wikipedia.org)
  • ratio
  • From the middle stage until term, the beta cells continue to increase in number until they reach an approximate 1:1 ratio with the alpha cells. (wikipedia.org)
  • Function
  • Osteonectin also increases the production and activity of matrix metalloproteinases, a function important to invading cancer cells within bone. (wikipedia.org)
  • precursor
  • One part is from the thickening of the pharyngeal floor, which serves as the precursor of the thyroxine (T4) producing follicular cells. (wikipedia.org)
  • levels
  • High levels of immunodetectable osteonectin are found in active osteoblasts and marrow progenitor cells, odontoblasts, periodontal ligament and gingival cells, and some chondrocytes and hypertrophic chondrocytes. (wikipedia.org)