• androgen-produ
  • Features that would be most concerning for an androgen-producing tumor include severe hirsutism (pattern of hair growth as seen in a male), onset outside the peripubertal period, sudden onset with rapid progression, and concomitant signs of virilization such as clitoromegaly, voice deepening, male pattern alopecia and a male patterned escutcheon. (clinicalpainadvisor.com)
  • Deficiency
  • Patients with 'classic' or the most severe form of CAH due to 21-hydroxylase deficiency (21OHD) present during the neonatal period and early infancy with adrenal insufficiency with or without salt-losing, or as toddlers with virilization. (uptodate.com)
  • males
  • The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development in genetic males with the condition. (wikipedia.org)
  • The cells of unaffected genetic males then masculinize by, among other things, enlarging the genital tubercle into a penis but in females it becomes the clitoris, while what in females becomes the labia fuses to become the scrotum of males (where the testicles will later descend). (wikipedia.org)
  • syndrome
  • Partial androgen insensitivity syndrome (PAIS) is a condition that results in the partial inability of the cell to respond to androgens. (wikipedia.org)
  • Androgen insensitivity syndrome (AIS) is an intersex condition in which there is a partial or complete inability of many cells in the affected genetic male to respond to androgenic hormones. (wikipedia.org)
  • Blau syndrome Chronic infantile neurologic cutaneous and articular syndrome Familial cold urticaria (familial cold autoinflammatory syndrome) Familial Mediterranean fever Hyper-IgD syndrome Majeed syndrome Muckle-Wells syndrome TNF receptor associated periodic syndrome (familial Hibernian fever, TRAPS, tumor necrosis factor receptor associated periodic syndrome) Chronic blistering cutaneous conditions have a prolonged course and present with vesicles and bullae. (wikipedia.org)
  • ovarian
  • For instance, TAFIIs 105 is now encoded, a subunit of the TATA binding protein for RNA polymerase in ovarian follicle cells. (wikipedia.org)
  • Squamous
  • This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. (wikipedia.org)
  • androgenic
  • The partial unresponsiveness of the cell to the presence of androgenic hormones impairs the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development. (wikipedia.org)
  • receptor
  • There may also be an effect of high levels of insulin to activate insulin-like growth factor 1 (IGF-1) receptor in those same cells. (wikipedia.org)
  • diseases
  • The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. (wikipedia.org)
  • functional
  • While the fetal pancreas has functional beta cells by 14 to 24 weeks of gestation, the amount of insulin that is released into the bloodstream is relatively low. (wikipedia.org)
  • ratio
  • From the middle stage until term, the beta cells continue to increase in number until they reach an approximate 1:1 ratio with the alpha cells. (wikipedia.org)