• DHEA
  • The marked reduction in DHEA by the adrenals during aging results in a dramatic fall in the formation of active sex steroids in peripheral target tissues - a situation which is thought to be associated with a long series of age related decreases such as insulin resistance, obesity, muscle mass, bone health. (supplementcentral.com)
  • Epiandrosterone is naturally produced by the enzyme 5α-reductase from the adrenal hormone DHEA. (wikipedia.org)
  • crystalline
  • They distilled over 17,000 litres of male urine, from which they got 50 milligrams of crystalline androsterone (most likely mixed isomers), which was sufficient to find that the chemical formula was very similar to estrone. (wikipedia.org)
  • breasts
  • In these studies, prior to administration of estrone, amenorrhea, atrophy of the breasts (as well as flaccidity and small and non-erectile nipples), vagina, and endometrium, vaginal dryness, and subjective symptoms of ovariectomy (e.g., hot flashes, mood changes) were all present in the women. (wikipedia.org)
  • zona
  • within the normal adrenal, this neuroendocrine differentiation seems to be restricted to cells of the zona glomerulosa and might be important for an autocrine regulation of adrenocortical function. (wikipedia.org)
  • uterus
  • Treatment with estrone was found to dose- and time-dependently produce a variety of effects, including breast changes, reproductive tract changes of the vagina, cervix, and endometrium/uterus, and relief from the subjective symptoms of ovariectomy, as well as increased libido. (wikipedia.org)
  • corticosterone
  • Glucocorticoid therapy suppresses the ACTH-induced adrenal hyperplasia and the excess of DOC and corticosterone that play a central role in the pathogenesis of the condition. (medscape.com)
  • Recent research shows that corticosterone inhibits the fat mobilizing effects of oleoyl-estrone in female rats that had their adrenal glands removed. (wikipedia.org)
  • affinity
  • According to one in vitro study, the relative binding affinity of estrone for the human ERα and ERβ was 4% and 3.5% of that estradiol, respectively, and the relative transactivational capacity of estrone at the ERα and ERβ was 2.6% and 4.3% of that of estradiol, respectively. (wikipedia.org)
  • respectively
  • Ogen is available as tablets for oral administration containing either 0.75 mg (Ogen .625), 1.5 mg (Ogen 1.25), or 3 mg (Ogen 2.5) estropipate (Calculated as sodium estrone sulfate 0.625 mg, 1.25 mg, and 2.5 mg, respectively). (drugs.com)
  • women
  • Estrone was previously marketed in intramuscular and vaginal formulations and was used as an estrogen in the treatment of symptoms of hypoestrogenism such as hot flashes and atrophic vaginitis in menopausal or ovariectomized women. (wikipedia.org)
  • body
  • This led to the postulation that oleoyl-estrone can reduce the body's bodyfat setpoint which would allow the body to maintain a reduced bodyfat without experiencing a hormonal milieu that aims to regain the lost bodyfat by reducing energy expenditure and increasing energy intake. (wikipedia.org)
  • This led to the theory that administering oleoyl-estrone to bring plasma OE levels up to normal would signal to the body that there is an excess amount of bodyfat and therefore there would be a bodyfat loss. (wikipedia.org)
  • levels
  • The research group discovered that oleoyl-estrone levels correlated with bodyfat stores except for obese organisms where there was less oleoyl-estrone circulating than would be predicted based on bodyfat levels. (wikipedia.org)
  • addition
  • Oleoyl-estrone functions by reducing energy-intake without prescribed dietary restriction (forced dietary restriction in addition to OE actually led to protein losses) while maintaining energy expenditure (which normally falls as part of the adaptations to calorie restriction). (wikipedia.org)