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  • toxicity
  • 3. The administration of 10 mg pyridoxine hydrochloride/kg body-weight also reduced the production of 14CO2 from both positional isomers of 14C]tryptophan, suggesting some toxicity of such a high dose of the vitamin. (ucl.ac.uk)
  • Conventional medicine does not have an effective evidence-based treatment for arsenic-induced toxicity, although some chelators, like DMSA and DTPA, have been tried without success. (homeopathicassociates.com)
  • fetal
  • During the 2013 debate on the abortion restrictions bill, Davis offered an amendment to the abortion bill which retained the 20-week ban, but which deleted the unconstitutional facility restrictions, and instead incorporated exceptions for cases of rape, incest, danger to the mother's life and severe fetal abnormalities. (wikipedia.org)
  • arterial
  • Corneal uno azithromycin presentation with blood studies, canadian traumatic months, and/ormodafinil induces it arterial reaction 500 offender business via ratio many after main child. (espacerugby.com)
  • receptor
  • We are concentrating on hippocampal α7 and α4β2 nicotinic receptor subtypes and how they interact with dopamine D1 and D2, serotonin 5HT2, GABA and glutamate NMDA systems with regard to memory, attention and nicotine self-administration. (duke.edu)
  • EP4 is the major receptor associated with PGE2-induced dilation of the DA and can be found across the DA in smooth muscle cells. (wikipedia.org)
  • Drugs used to treat obesity are called anorectics and generally include drugs that follow the general definition of a stimulant, but other drugs such as CB1 receptor antagonists exist in this class too. (wikipedia.org)
  • Due to its hydrophilic character, IP3 can travel to the endoplasmic reticulum, where it induces, via fixation on its receptor, the opening of calcium channels increasing in this way the cytosolic calcium concentrations. (wikipedia.org)
  • dose
  • 4. In animals which had received the supplementary dose of vitamin B6, the administration of oestradiol led to further reduction in the production of 14CO2 from [ring-2-14C]tryptophan, suggesting a further reduction in the activity of tryptophan oxygenase, and an increase in the production of 14CO2 from [methylen-14C]tryptophan, but with a delay in the peak of production. (ucl.ac.uk)
  • 5. These results confirm that there is no induction of tryptophan oxygenase by oestradiol, but rather reduced activity of the enzyme after the administration of a relatively high dose of the hormone. (ucl.ac.uk)
  • Symptomatic hepatitis (fatal and non-fatal) has been reported at various dose levels of the drug. (drugs.com)
  • The absorption of Dantrium after oral administration in humans is incomplete and slow but consistent, and dose-related blood levels are obtained. (drugs.com)
  • Methamphetamine is known to possess a high addiction liability (i.e., a high likelihood that long-term or high dose use will lead to compulsive drug use) and high dependence liability (i.e. a high likelihood that withdrawal symptoms will occur when methamphetamine use ceases). (wikipedia.org)
  • liver
  • While tiapride does not affect positive symptoms of psychosis such as hallucinosis or delirium sometimes manifested in alcohol withdrawal syndrome, if combined with a drug such as carbamazepine that addresses those symptoms, it is ideal for treating alcohol dependency because its metabolism does not depend on liver function and it has low potential for abuse. (wikipedia.org)
  • Drugs that may interact with paricalcitol include: Ketoconazole, as it may interfere with paricalcitol's metabolism in the liver. (wikipedia.org)
  • metabolic
  • Low blood pressure is initially treated with fluids along with bicarbonate to reverse metabolic acidosis (if present), if the blood pressure remains low despite fluids then further measures such as the administration of epinephrine, norepinephrine, or dopamine can be used to increase blood pressure. (wikipedia.org)
  • deficiency
  • 1. The effects of the administration of oestradiol and vitamin B6 on tryptophan metabolism in the rat have been assessed by measurement of the release of 14CO2 from [14C]tryptophan, in vivo, in order to determine whether, and to what extent, the abnormalities of tryptophan metabolism that are associated with oestrogen administration can be attributed to drug-induced vitamin B6 deficiency or depletion. (ucl.ac.uk)
  • 6. It is suggested that the abnormal results of the tryptophan load test that have been reported in women receiving oestrogens, and which have been interpreted as indicating some extent of drug-induced vitamin B6 deficiency, can be accounted for by the inhibition of tryptophan metabolism by oestrogens or their metabolites. (ucl.ac.uk)
  • cocaine
  • Drugs such as ephedrine, pseudoephedrine, amphetamine and methylphenidate have well documented ergogenic effects, while drugs such as cocaine and methamphetamine have the opposite effect. (wikipedia.org)
  • dosage
  • CONCLUSIONS: Minimizing the risks of benzodiazepine therapy among pregnant or lactating women involves using drugs that have established safety records at the lowest dosage for the shortest possible duration, avoiding use during the first trimester, and avoiding multidrug regimens. (biomedsearch.com)
  • When serum level determinations are necessary, they should be obtained at least 5 to 7 half-lives after treatment initiation, dosage change, or addition or subtraction of another drug to the regimen so that equilibrium or steady-state will have been achieved. (drugs.com)
  • efficacy
  • One clinical study in agitated elderly patients compared the effects of tiapride, haloperidol and placebo and found that while the two drugs had comparable efficacy superior to the placebo effect, tiapride had fewer and less severe side effects than haloperidol. (wikipedia.org)
  • It is rarely prescribed due to concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy. (wikipedia.org)
  • treatment
  • 2. The administration of 500 μg oestradiol/kg body-weight led to a reduction in the release of 14CO2 from both positional isomers of tryptophan, suggesting that the activities of both tryptophan oxygenase and kynureninase are reduced following oestrogen treatment. (ucl.ac.uk)
  • They will take the study drug once a day for 4 weeks followed by a 2 week rest period (no study drug treatment). (clinicaltrials.gov)
  • Subsequently, ibogaine and 18-methoxycoronaridine have been studied for the treatment of drug addiction. (drugs.com)
  • Phenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. (drugs.com)
  • Building on his work, research both in China and the West eventually led to the development of the drug Trisenox by PolaRx Biopharmaceuticals, Inc through NDA, which was approved for leukemia treatment by the US FDA in 2000 and subsequently marketed and sold by Cell Therapeutics, Inc., before being acquired by Cephalon. (wikipedia.org)
  • The combination therapy of arsenic trioxide and all-trans retinoic acid (ATRA) has been approved by the U.S. Food and Drug Administration (FDA) for treatment of certain leukemias. (wikipedia.org)
  • Methamphetamine (contracted from N-methylamphetamine) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. (wikipedia.org)
  • Marketed by Abbott Laboratories under the trade name Zemplar) is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. (wikipedia.org)
  • blood
  • The 10 hour and 14 hour blood samples were obtained if the subject still had the study drug in place at those timepoints. (clinicaltrials.gov)
  • However
  • However, serum drug levels are not useful for evaluating risk of arrhythmia or seizure in tricyclic overdose. (wikipedia.org)
  • disorders
  • The ever-increasing hypersensitivity disorders, multiple chemical sensitivities, and allergies or immune reactions to drugs, foods, toxins and radiation of various kinds form a related group of disorders. (homeopathicassociates.com)
  • Interestingly, most conventional medical practice appears to have very little interest in investigating medically induced causes of disorders and finding ways to remove them. (homeopathicassociates.com)
  • Drugs used to treat sleep disorders such as excessive daytime sleepiness are called eugeroics and include notable stimulants such as modafinil. (wikipedia.org)
  • metabolism
  • Therefore it seems likely that the practice of administering supplements of vitamin B6 to women receiving oestrogens may not be appropriate, and indeed may exacerbate the changes in tryptophan metabolism that result from the administration of oestrogens. (ucl.ac.uk)
  • Since Dantrium is probably metabolized by hepatic microsomal enzymes, enhancement of its metabolism by other drugs is possible. (drugs.com)
  • methamphetamine
  • While dextromethamphetamine is a more potent drug, racemic methamphetamine is sometimes illicitly produced due to the relative ease of synthesis and limited availability of chemical precursors. (wikipedia.org)
  • As methamphetamine is associated with a high potential for misuse, the drug is regulated under the Controlled Substances Act and is listed under Schedule II in the United States. (wikipedia.org)
  • involves
  • Content frequently involves animate objects, although perceptual abnormalities such as changes in lighting, shading, streaks, or lines may be seen. (wikipedia.org)
  • side effects
  • Moreover, its selectivity for the dopaminergic system is thought to account for its avoidance of the side effects typically associated with other neuroleptic drugs, such as chlorpromazine, which act on a number of neurotransmitter systems. (wikipedia.org)
  • enzymes
  • Congenital adrenal hyperplasia (CAH) is an inherited disorder that leads to insufficient production of cortisol caused by abnormality in 1 of the 5 enzymes that are necessary for its biosynthesis. (aappublications.org)
  • stimulants
  • Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. (elsevier.com)
  • Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. (elsevier.com)
  • Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects. (wikipedia.org)
  • Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or illicitly) as performance-enhancing or recreational drugs. (wikipedia.org)
  • Neurocognitive enhancing effects of stimulants, specifically modafinil, amphetamine and methylphenidate have been documented in healthy adolescents, and is a commonly cited reason among illicit drug users for use, particularly among college students in the context of studying. (wikipedia.org)
  • Most drugs classified as stimulants are sympathomimetics, that is they stimulate the sympathetic branch of the autonomic nervous system. (wikipedia.org)
  • Patients
  • Moxifloxacin should also be avoided in patients with uncorrected hypokalemia, or concurrent administration of other medications known to prolong the QT interval (antipsychotics and tricyclic antidepressants). (wikipedia.org)
  • calcium
  • Thiazide diuretics or calcium supplements as hypercalcaemia may be induced by this combination Magnesium-containing products such as antacids may increase the risk of hypermagnesemia. (wikipedia.org)
  • risk
  • Dosages above approximately 300 mg/day risk inducing tardive dyskinesia. (wikipedia.org)
  • A significant number of drugs found within this class, including moxifloxacin, are not licensed by the FDA for use in children due to the risk of permanent injury to the musculoskeletal system. (wikipedia.org)
  • interference
  • In 2011, Davis voted against a bill to require physicians to conduct intra-vaginal sonograms, prior to even pharmaceutically induced abortions, citing her opposition to legislative interference in the doctor-patient relationship. (wikipedia.org)
  • effects
  • This therapy also had beneficial effects outside the eye in diabetes, as evidenced by the inhibition of a diabetes-induced hypersensitivity of peripheral nerves to light touch (tactile allodynia). (arvojournals.org)
  • In addition, ibogaine is stored in fat and a slow release from fat stores has been hypothesized to further contribute to the protracted effects of the drug. (drugs.com)
  • nasal
  • Levomethamphetamine is available as an over-the-counter (OTC) drug for use as an inhaled nasal decongestant in the United States. (wikipedia.org)
  • selective
  • LY-341,495 and MGS-0039 are drugs that act as a selective antagonist blocking both of the group II metabotropic glutamate receptors, mGluR2 and mGluR3. (wikipedia.org)
  • females
  • In age effect studies we have shown that adolescents self-administer greater amounts of nicotine than adults and that particularly in females greater adolescent-onset of nicotine self-administration continues into adulthood. (duke.edu)
  • Persistence of the ductus may be associated with other abnormalities, and is much more common in females. (wikipedia.org)
  • initiation
  • Using knockout mice, we have found that β2-containinc nicotinic receptors appear to be more important for the initiation of nicotine self-administration during the first few weeks, whereas α7 nicotinic receptors appear to be more important for the long-term consumption of nicotine over a period of 5 months. (duke.edu)
  • list
  • Furosemide is on the World Anti-Doping Agency's banned drug list due to concerns that it may mask other drugs. (wikipedia.org)
  • characteristic
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • An experiment with genetically-altered mice that could not produce calcineurin showed similar symptoms as in humans with schizophrenia: impairment in working memory, attention deficits, aberrant social behavior, and several other abnormalities characteristic of schizophrenia. (wikipedia.org)
  • profound
  • Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death [see WARNINGS , DRUG INTERACTIONS ]. (rxlist.com)
  • Mechanical stress due to pressure and volume overload and metabolic dysfunction also induce profound changes in ECM composition that contribute to the pathogenesis of heart failure. (jci.org)
  • By the 1890s, the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. (wikipedia.org)
  • severe
  • Moderate and more severe zinc deficiencies are associated with behavioral abnormalities, such as irritability, lethargy, and depression (e.g., involving anhedonia). (wikipedia.org)
  • In 2017 the U.S. Food and Drug Administration (FDA) approved L-glutamine oral powder (Endari, Emmaus Medical Inc) to reduce severe complications of sickle cell disease in people aged 5 years and older with the disorder. (wikipedia.org)
  • Smoke inhalation injury, either by itself but more so in the presence of body surface burn, can result in severe lung-induced morbidity and mortality. (wikipedia.org)
  • death
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • body
  • Symptoms caused chemically by drugs such as cannabis, magic mushrooms, or cocaine tend to dissipate after the chemical compound has been excreted from the body. (wikipedia.org)
  • includes
  • Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporin, voclosporin, pimecrolimus and tacrolimus. (wikipedia.org)
  • food
  • This drug/food mixture should be swallowed immediately without chewing and followed with a glass of water to ensure complete swallowing of the pellets (spheroids). (rxlist.com)
  • group
  • Patients with AIDS Clinical Trials Group (ACTG) grade IV liver function test abnormalities, grade III or higher renal insufficiency, grade III or higher leucopenia, or dementia thought to impair adherence were excluded. (biomedcentral.com)
  • LY-341,495 and MGS-0039 are drugs that act as a selective antagonist blocking both of the group II metabotropic glutamate receptors, mGluR2 and mGluR3. (wikipedia.org)
  • combination
  • Calcineurin inhibitors are prescribed for adult rheumatoid arthritis (RA) as a single drug or in combination with methotrexate. (wikipedia.org)
  • In the United States, primidone is approved for adjunctive (in combination with other drugs) and monotherapy (by itself) use in generalized tonic-clonic seizures, simple partial seizures, and complex partimple partial seizures, and myoclonic seizures. (wikipedia.org)
  • effective
  • Even though it is an effective sedative, hypnotic, and anxiolytic, it shares virtually none of the abuse, dependence, addiction, and toxicity potential of other drugs used for the same range of therapeutic reasons. (wikipedia.org)
  • skin
  • In C57BL/6 mice selfgrooming and allo-grooming is observed (Militzer and Wecker, 1986) Drugs Susceptible to skin ulceration by DMBA (Thomas et al, 1973). (spotidoc.com)
  • The drug patch is placed on the skin, and if the patient is infected with O. volvulus microfilaria, localized pruritus and urticaria are seen at the application site. (wikipedia.org)
  • basis
  • Comparison of the cited figures, however, can provide the prescriber with some basis for estimating the relative contributions of drug and nondrug factors to the untoward event incidence rate in the population studied. (rxlist.com)