Drug ApprovalUnited States Food and Drug AdministrationDrug TherapyAdministration, OralDrug Therapy, CombinationDrug Administration ScheduleTime FactorsDose-Response Relationship, DrugAnti-Arrhythmia AgentsInjections, IntravenousTreatment OutcomeRats, Sprague-DawleyDrug Administration RoutesAntihypertensive AgentsDisease Models, AnimalAdministration, IntranasalPharmacogeneticsRats, WistarDrug InteractionsAnticonvulsantsInjections, IntraperitonealLiverPharmacists