• antigen
  • Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called PAMPs, which include liposomes, lipopolysaccharide (LPS), molecular cages for antigen, components of bacterial cell walls, and endocytosed nucleic acids such as double-stranded RNA (dsRNA), single-stranded DNA (ssDNA), and unmethylated CpG dinucleotide-containing DNA. (wikipedia.org)
  • mechanism
  • No matter what the mechanism is, alum is not a perfect adjuvant because it does not work with all antigens (e.g. malaria and tuberculosis). (wikipedia.org)
  • combination
  • To evaluate safety, pharmacokinetics, immunologic parameters and neurocognitive data for three dosages of AS-101 in combination with zidovudine (AZT) in patients with AIDS or AIDS related complex (ARC). (clinicaltrials.gov)
  • However
  • However, when Quillaia saponins, cholesterol and phospholipids are mixed under the specific stoichiometry that forms ISCOMs, this haemolytic activity is practically eliminated, while the adjuvant activity is retained. (wikipedia.org)
  • activity
  • Success has been limited in synthetically producing QS-21 with similar adjuvant activity to the isolated natural product. (wikipedia.org)
  • cells
  • This is related to the induction of Th17 cells by adjuvant treatment and these cells produce Interleukin-22 (IL-22). (wikipedia.org)
  • Safety
  • The purpose of this long term extension study is to assess safety, tolerability and immunogenicity of ACC-001 with QS-21 adjuvant in Japanese subjects with mild to moderate AD who were randomized in the preceding P2 double blind studies. (clinicaltrials.gov)
  • addition
  • In addition, concerns have been raised regarding whether adjuvants may be able to trigger responses to self-proteins causing autoimmunity. (wikipedia.org)